| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreea Violeta Grosu, Roxana-Olimpia Gheorghe, Alexandru Filippi, Alexandru Florian Deftu, Manon Isler, Marc Suter, Violeta Ristoi. Dorsal root ganglia CSF1 Journal of the peripheral nervous system : JPNS. 2024-11-24. PMID:39581686. |
dorsal root ganglia csf1 colony-stimulating factor 1 (csf1) is a growth factor secreted by dorsal root ganglia (drg) neurons important for drg macrophages and spinal cord (sc) microglia injury-induced proliferation and activation, specifically released after spared nerve injury (sni). |
2024-11-24 |
2024-11-27 |
mouse |
| Ethan J Goodman, Damon J DiSabato, John F Sheridan, Jonathan P Godbou. Novel microglial transcriptional signatures promote social and cognitive deficits following repeated social defeat. Communications biology. vol 7. issue 1. 2024-09-29. PMID:39341879. |
using single-cell (sc)rnaseq, we identify novel, to the best of our knowledge, stress-associated microglia in the hippocampus defined by rna profiles of cytokine/chemokine signaling, cellular stress, and phagocytosis. |
2024-09-29 |
2024-10-01 |
mouse |
| Sangamithra Vardhan, Tyler Jordan, Shelly Sakiyama-Elber. Stem cell engineering approaches for investigating glial cues in central nervous system disorders. Current opinion in biotechnology. vol 87. 2024-04-10. PMID:38599012. |
in this review, we focus on sc differentiation protocols for deriving three types of glial cells, astrocytes, oligodendrocytes, and microglia. |
2024-04-10 |
2024-04-13 |
Not clear |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
specifically, af injury elevated macrophages in the spine (cd68) and drgs (iba1) that peaked at 3 days post-injury, and increased microglia (iba1) in sc that peaked at 2 weeks post-injury. |
2024-02-10 |
2024-02-12 |
rat |
| Zhi-Ling Zhang, Zhi-Tong Wang, Jing Shi, Xiao-Ping Pu, Suo-Di Zha. Tetrandrine attenuates SNI-induced mechanical allodynia by inhibiting spinal CKLF1. Neuropharmacology. 2023-07-30. PMID:37517461. |
moreover, immunofluorescence double-labeling results revealed that cklf1 was predominantly colocalized with microglia of the spinal cord (sc) in sni mice. |
2023-07-30 |
2023-08-14 |
mouse |
| Hyelin Ji, Kyung-Ran Kim, Jang-Joon Park, Ju Youn Lee, Yeomoon Sim, Heonsik Choi, Sujeong Ki. Combination gene delivery reduces spinal cord pathology in rats with peripheral neuropathic pain. The journal of pain. 2023-07-13. PMID:37442406. |
moreover, kls-2031 restored the in vivo hypersensitivity of wide dynamic range neurons and mitigated neuroinflammation in the sc by regulating microglia and astrocytes. |
2023-07-13 |
2023-08-14 |
rat |
| Fredrik H G Ahlstrà M, Hanna Viisanen, Leena Karhinen, Kert Mã Tlik, Kim J Blomqvist, Tuomas Lilius, Yulia A Sidorova, Vinko Palada, Pekka Rauhala, Eija Kals. The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord. Molecular pain. 2023-06-07. PMID:37285551. |
in experiment ii, the transcriptome of microglia from the lumbar sc was analysed. |
2023-06-07 |
2023-08-14 |
rat |
| Fredrik H G Ahlstrà M, Hanna Viisanen, Leena Karhinen, Kert Mã Tlik, Kim J Blomqvist, Tuomas Lilius, Yulia A Sidorova, Vinko Palada, Pekka Rauhala, Eija Kals. The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord. Molecular pain. 2023-06-07. PMID:37285551. |
high-dose morphine administration also associated with several changes in gene expression in sc microglia, e.g. |
2023-06-07 |
2023-08-14 |
rat |
| Taylor C Clarkson, Nao Iguchi, Alison Xiaoqiao Xie, Anna P Malykhin. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus. PloS one. vol 17. issue 12. 2022-12-09. PMID:36490282. |
transcriptome analysis of sc identified a significantly changed expression of >150 genes in cie mice known to regulate astrocyte, microglia and oligodendrocyte functions, neuroinflammation and immune responses. |
2022-12-09 |
2023-08-14 |
mouse |
| Sarah Katharina Steffens, Tarja Helena Stenberg, Henna-Kaisa Margareta Wigre. Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse. Glia. 2022-10-05. PMID:36196985. |
as microglia express regional heterogeneity and are influenced by local neuronal activity, we chose to investigate three interconnected and functionally well-characterized brain areas: the somatosensory cortex (sc), the dorsal hippocampus (hc), and the basal forebrain (bf). |
2022-10-05 |
2023-08-14 |
mouse |
| Jiale Cai, Jiayin Liang, Yutong Zhang, Lin Shen, Huiting Lin, Tao Hu, Sikai Zhan, Meixia Xie, Shengwang Liang, Minghua Xian, Shumei Wan. Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic stroke reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways. Pharmacological research. 2022-04-28. PMID:35483515. |
the protective effects of sc were dependent on the junb and sox5 to inhibit inflammation and apoptosis in microglia. |
2022-04-28 |
2023-08-13 |
rat |
| Andrew Gao, Hannah M McCoy, Vandana Zaman, Donald C Shields, Naren L Banik, Azizul Haqu. Calpain activation and progression of inflammatory cycles in Parkinson's disease. Frontiers in bioscience (Landmark edition). vol 27. issue 1. 2022-01-29. PMID:35090325. |
this review focuses on pd pathology and the role of calpain, a neutral protease, as a regulator of various immune cells such as t-cells, microglia and astrocytes which lead to persistent neuroinflammatory responses and neuronal loss in both the brain and spinal cord (sc). |
2022-01-29 |
2023-08-13 |
Not clear |
| Catherine Brégère, Bernd Schwendele, Boris Radanovic, Raphael Guzma. Microglia and Stem-Cell Mediated Neuroprotection after Neonatal Hypoxia-Ischemia. Stem cell reviews and reports. 2021-08-12. PMID:34382141. |
our review points to an impact of scs on the microglial phenotype, but heterogeneity in experimental designs and methodological limitations hamper our understanding of a potential contribution of microglia to sc associated benefits. |
2021-08-12 |
2023-08-13 |
human |
| Season K Wyatt-Johnson, Alexandra L Sommer, Kevin Y Shim, Amy L Brewste. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Frontiers in neurology. vol 12. 2021-06-29. PMID:34149593. |
both plx3397-treated control and se groups had significantly decreased numbers of microglia in the hippocampus (60%) compared to those in sc. |
2021-06-29 |
2023-08-13 |
rat |
| Season K Wyatt-Johnson, Alexandra L Sommer, Kevin Y Shim, Amy L Brewste. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Frontiers in neurology. vol 12. 2021-06-29. PMID:34149593. |
thus, despite drastic reductions in microglial cells, memory was unaffected in the plx3397-treated groups compared to those in sc, suggesting that remaining microglia may be sufficient to help maintain hippocampal functions. |
2021-06-29 |
2023-08-13 |
rat |
| Fang-Ling Xuan, Keerthana Chithanathan, Kersti Lilleväli, Xiaodong Yuan, Li Tia. Differences of Microglia in the Brain and the Spinal Cord. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31803021. |
however, accumulating evidences show that microglia in the brain and sc are quite different in development, cellular phenotypes and biological functions. |
2020-10-01 |
2023-08-13 |
Not clear |
| José Javier Miguel-Hidalgo, Kathleen Carter, Preston Hardin Deloach, Leon Sanders, Yi Pan. Glucocorticoid-Induced Reductions of Myelination and Connexin 43 in Mixed Central Nervous System Cell Cultures Are Prevented by Mifepristone. Neuroscience. vol 411. 2020-02-04. PMID:31163207. |
two primary cell culture models, myelination culture from rat embryonic spinal cord (sc) or cerebral cortex (cc) consisting of neurons and glial cells (oligodendrocytes, microglia and astrocytes), and mixed astrocyte-and-oligodendrocyte culture prepared from postnatal rat cc, were used in this study. |
2020-02-04 |
2023-08-13 |
rat |
| Xiyu Mei, Tianyu Zhang, Hao Ouyang, Bin Lu, Zhengtao Wang, Lili J. Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy. Biochemical pharmacology. vol 159. 2019-09-03. PMID:30447218. |
sc reduced microglia cells activation both in vivo and in vitro. |
2019-09-03 |
2023-08-13 |
mouse |
| Xiyu Mei, Tianyu Zhang, Hao Ouyang, Bin Lu, Zhengtao Wang, Lili J. Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy. Biochemical pharmacology. vol 159. 2019-09-03. PMID:30447218. |
the results of transendothelial/transepithelial electrical resistance (teer/ter) and fluorescein isothiocyanate (fitc)-conjugated dextran cell permeability assay showed that sc attenuated brb damage induced by d-glucose (25 mm)-stimulated microglia bv2 cells. |
2019-09-03 |
2023-08-13 |
mouse |
| Xiyu Mei, Tianyu Zhang, Hao Ouyang, Bin Lu, Zhengtao Wang, Lili J. Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy. Biochemical pharmacology. vol 159. 2019-09-03. PMID:30447218. |
in conclusion, sc alleviates brb breakdown via abrogating retinal inflammatory responses and subsequent oxidative stress injury initiated by microglia cells that is activated by hyperglycemia during dr development. |
2019-09-03 |
2023-08-13 |
mouse |