| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sangamithra Vardhan, Tyler Jordan, Shelly Sakiyama-Elber. Stem cell engineering approaches for investigating glial cues in central nervous system disorders. Current opinion in biotechnology. vol 87. 2024-04-10. PMID:38599012. |
in this review, we focus on sc differentiation protocols for deriving three types of glial cells, astrocytes, oligodendrocytes, and microglia. |
2024-04-10 |
2024-04-13 |
Not clear |
| Alon Lai, Denise Iliff, Kashaf Zaheer, Jennifer Gansau, Damien M Laudier, Venetia Zachariou, James C Iatridi. Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339040. |
specifically, af injury elevated macrophages in the spine (cd68) and drgs (iba1) that peaked at 3 days post-injury, and increased microglia (iba1) in sc that peaked at 2 weeks post-injury. |
2024-02-10 |
2024-02-12 |
rat |
| Zhi-Ling Zhang, Zhi-Tong Wang, Jing Shi, Xiao-Ping Pu, Suo-Di Zha. Tetrandrine attenuates SNI-induced mechanical allodynia by inhibiting spinal CKLF1. Neuropharmacology. 2023-07-30. PMID:37517461. |
moreover, immunofluorescence double-labeling results revealed that cklf1 was predominantly colocalized with microglia of the spinal cord (sc) in sni mice. |
2023-07-30 |
2023-08-14 |
mouse |
| Hyelin Ji, Kyung-Ran Kim, Jang-Joon Park, Ju Youn Lee, Yeomoon Sim, Heonsik Choi, Sujeong Ki. Combination gene delivery reduces spinal cord pathology in rats with peripheral neuropathic pain. The journal of pain. 2023-07-13. PMID:37442406. |
moreover, kls-2031 restored the in vivo hypersensitivity of wide dynamic range neurons and mitigated neuroinflammation in the sc by regulating microglia and astrocytes. |
2023-07-13 |
2023-08-14 |
rat |
| Fredrik H G Ahlstrà M, Hanna Viisanen, Leena Karhinen, Kert Mã Tlik, Kim J Blomqvist, Tuomas Lilius, Yulia A Sidorova, Vinko Palada, Pekka Rauhala, Eija Kals. The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord. Molecular pain. 2023-06-07. PMID:37285551. |
in experiment ii, the transcriptome of microglia from the lumbar sc was analysed. |
2023-06-07 |
2023-08-14 |
rat |
| Fredrik H G Ahlstrà M, Hanna Viisanen, Leena Karhinen, Kert Mã Tlik, Kim J Blomqvist, Tuomas Lilius, Yulia A Sidorova, Vinko Palada, Pekka Rauhala, Eija Kals. The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord. Molecular pain. 2023-06-07. PMID:37285551. |
high-dose morphine administration also associated with several changes in gene expression in sc microglia, e.g. |
2023-06-07 |
2023-08-14 |
rat |
| Taylor C Clarkson, Nao Iguchi, Alison Xiaoqiao Xie, Anna P Malykhin. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus. PloS one. vol 17. issue 12. 2022-12-09. PMID:36490282. |
transcriptome analysis of sc identified a significantly changed expression of >150 genes in cie mice known to regulate astrocyte, microglia and oligodendrocyte functions, neuroinflammation and immune responses. |
2022-12-09 |
2023-08-14 |
mouse |
| Sarah Katharina Steffens, Tarja Helena Stenberg, Henna-Kaisa Margareta Wigre. Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse. Glia. 2022-10-05. PMID:36196985. |
as microglia express regional heterogeneity and are influenced by local neuronal activity, we chose to investigate three interconnected and functionally well-characterized brain areas: the somatosensory cortex (sc), the dorsal hippocampus (hc), and the basal forebrain (bf). |
2022-10-05 |
2023-08-14 |
mouse |
| Jiale Cai, Jiayin Liang, Yutong Zhang, Lin Shen, Huiting Lin, Tao Hu, Sikai Zhan, Meixia Xie, Shengwang Liang, Minghua Xian, Shumei Wan. Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic stroke reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways. Pharmacological research. 2022-04-28. PMID:35483515. |
the protective effects of sc were dependent on the junb and sox5 to inhibit inflammation and apoptosis in microglia. |
2022-04-28 |
2023-08-13 |
rat |
| Andrew Gao, Hannah M McCoy, Vandana Zaman, Donald C Shields, Naren L Banik, Azizul Haqu. Calpain activation and progression of inflammatory cycles in Parkinson's disease. Frontiers in bioscience (Landmark edition). vol 27. issue 1. 2022-01-29. PMID:35090325. |
this review focuses on pd pathology and the role of calpain, a neutral protease, as a regulator of various immune cells such as t-cells, microglia and astrocytes which lead to persistent neuroinflammatory responses and neuronal loss in both the brain and spinal cord (sc). |
2022-01-29 |
2023-08-13 |
Not clear |
| Catherine Brégère, Bernd Schwendele, Boris Radanovic, Raphael Guzma. Microglia and Stem-Cell Mediated Neuroprotection after Neonatal Hypoxia-Ischemia. Stem cell reviews and reports. 2021-08-12. PMID:34382141. |
our review points to an impact of scs on the microglial phenotype, but heterogeneity in experimental designs and methodological limitations hamper our understanding of a potential contribution of microglia to sc associated benefits. |
2021-08-12 |
2023-08-13 |
human |
| Season K Wyatt-Johnson, Alexandra L Sommer, Kevin Y Shim, Amy L Brewste. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Frontiers in neurology. vol 12. 2021-06-29. PMID:34149593. |
both plx3397-treated control and se groups had significantly decreased numbers of microglia in the hippocampus (60%) compared to those in sc. |
2021-06-29 |
2023-08-13 |
rat |
| Season K Wyatt-Johnson, Alexandra L Sommer, Kevin Y Shim, Amy L Brewste. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Frontiers in neurology. vol 12. 2021-06-29. PMID:34149593. |
thus, despite drastic reductions in microglial cells, memory was unaffected in the plx3397-treated groups compared to those in sc, suggesting that remaining microglia may be sufficient to help maintain hippocampal functions. |
2021-06-29 |
2023-08-13 |
rat |
| Fang-Ling Xuan, Keerthana Chithanathan, Kersti Lilleväli, Xiaodong Yuan, Li Tia. Differences of Microglia in the Brain and the Spinal Cord. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31803021. |
however, accumulating evidences show that microglia in the brain and sc are quite different in development, cellular phenotypes and biological functions. |
2020-10-01 |
2023-08-13 |
Not clear |
| José Javier Miguel-Hidalgo, Kathleen Carter, Preston Hardin Deloach, Leon Sanders, Yi Pan. Glucocorticoid-Induced Reductions of Myelination and Connexin 43 in Mixed Central Nervous System Cell Cultures Are Prevented by Mifepristone. Neuroscience. vol 411. 2020-02-04. PMID:31163207. |
two primary cell culture models, myelination culture from rat embryonic spinal cord (sc) or cerebral cortex (cc) consisting of neurons and glial cells (oligodendrocytes, microglia and astrocytes), and mixed astrocyte-and-oligodendrocyte culture prepared from postnatal rat cc, were used in this study. |
2020-02-04 |
2023-08-13 |
rat |
| Xiyu Mei, Tianyu Zhang, Hao Ouyang, Bin Lu, Zhengtao Wang, Lili J. Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy. Biochemical pharmacology. vol 159. 2019-09-03. PMID:30447218. |
sc reduced microglia cells activation both in vivo and in vitro. |
2019-09-03 |
2023-08-13 |
mouse |
| Xiyu Mei, Tianyu Zhang, Hao Ouyang, Bin Lu, Zhengtao Wang, Lili J. Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy. Biochemical pharmacology. vol 159. 2019-09-03. PMID:30447218. |
the results of transendothelial/transepithelial electrical resistance (teer/ter) and fluorescein isothiocyanate (fitc)-conjugated dextran cell permeability assay showed that sc attenuated brb damage induced by d-glucose (25 mm)-stimulated microglia bv2 cells. |
2019-09-03 |
2023-08-13 |
mouse |
| Xiyu Mei, Tianyu Zhang, Hao Ouyang, Bin Lu, Zhengtao Wang, Lili J. Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy. Biochemical pharmacology. vol 159. 2019-09-03. PMID:30447218. |
in conclusion, sc alleviates brb breakdown via abrogating retinal inflammatory responses and subsequent oxidative stress injury initiated by microglia cells that is activated by hyperglycemia during dr development. |
2019-09-03 |
2023-08-13 |
mouse |
| Dekun Yin, Yonglin Chen, Yao Li, Rongxiang Lu, Binbin Wang, Shunxing Zhu, Bingbing Fan, Zhongling X. Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats. Neurochemical research. vol 44. issue 5. 2019-06-11. PMID:30859436. |
the staining further confirmed that irak1 was mainly co-located in the drg astrocytes or sc neurons, but less in the drg microglia or sc astrocytes. |
2019-06-11 |
2023-08-13 |
rat |
| Zeinab Namjoo, Fateme Moradi, Roya Aryanpour, Abbas Piryaei, Mohammad Taghi Joghataei, Yusef Abbasi, Amir Hosseini, Sajad Hassanzadeh, Fatemeh Ranjbar Taklimie, Cordian Beyer, Adib Zendede. Combined effects of rat Schwann cells and 17β-estradiol in a spinal cord injury model. Metabolic brain disease. vol 33. issue 4. 2019-04-01. PMID:29658057. |
moreover, e2 and sc significantly decreased the number of iba-1+ (microglia) and gfap |
2019-04-01 |
2023-08-13 |
rat |