| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Hsien Chu, Chia-Hao Su, Ya-Hsin Hsiao, Chun-Chieh Yu, Yi-Chun Liao, Pin-Cheng Mao, Jia-Shing Chen, H Sunny Su. Overexpression of TIAM2S, a critical regulator for the hippocampal-medial prefrontal cortex network, progresses age-related spatial memory impairment. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024-08-02. PMID:39093820. |
tiam rac1 associated gef 2 short-form protein (tiam2s) is abundant in specific brain tissues, especially in the hippocampus, a brain region critical for processing and consolidation of spatial memory. |
2024-08-02 |
2024-08-06 |
mouse |
| Jaebin Kim, Edwin Bustamante, Peter Sotonyi, Nicholas Maxwell, Pooja Parameswaran, Julie K Kent, William C Wetsel, Erik J Soderblom, Bence Rácz, Scott H Soderlin. Presynaptic Rac1 in the hippocampus selectively regulates working memory. eLife. vol 13. 2024-07-24. PMID:39046788. |
presynaptic rac1 in the hippocampus selectively regulates working memory. |
2024-07-24 |
2024-07-26 |
mouse |
| Jaebin Kim, Edwin Bustamante, Peter Sotonyi, Nicholas D Maxwell, Pooja Parameswaran, Julie K Kent, William C Wetsel, Erik J Soderblom, Bence Rácz, Scott H Soderlin. Presynaptic Rac1 in the hippocampus selectively regulates working memory. bioRxiv : the preprint server for biology. 2024-04-02. PMID:38562715. |
presynaptic rac1 in the hippocampus selectively regulates working memory. |
2024-04-02 |
2024-04-04 |
Not clear |
| Juliana F Dalto, Jorge H Medin. Time-dependent inhibition of Rac1 in the VTA enhances long-term aversive memory: implications in active forgetting mechanisms. Scientific reports. vol 13. issue 1. 2023-08-19. PMID:37598223. |
immediate post-training micro-infusion of rac1 inhibitor into the dorsal hippocampus, or the amygdala did not affect memory. |
2023-08-19 |
2023-09-07 |
rat |
| Lingyong Li, Qin Ru, Yungang Lu, Xing Fang, Guanxing Chen, Ali Bin Saifullah, Changqun Yao, Kimberley F Tolia. Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain. Neuron. 2023-05-05. PMID:37146610. |
tiam1 is a rac1 guanine nucleotide exchange factor (gef) that promotes dendritic and synaptic growth during hippocampal development by inducing actin cytoskeletal remodeling. |
2023-05-05 |
2023-08-14 |
Not clear |
| Li Hao, Yiming Wu, Jin Xie, Xinwang Che. Electroacupuncture Enhances Cognitive Deficits in a Rat Model of Rapid Eye Movement Sleep Deprivation via Targeting MiR-132. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-09-26. PMID:36159559. |
p250gap, ras-related c3 botulinum toxin substrate 1 (rac1), and cell division cycle 42 (cdc42) expression levels in hippocampal tissues were evaluated by immunohistochemistry and western blot. |
2022-09-26 |
2023-08-14 |
rat |
| Haiwang Zhang, Youssif Ben Zablah, Haorui Zhang, An Liu, Radu Gugustea, Dongju Lee, Xiao Luo, Yanghong Meng, Song Li, Changxi Zhou, Tao Xin, Zhengping Ji. Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936771. |
inhibition of rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity. |
2022-08-08 |
2023-08-14 |
mouse |
| Haiwang Zhang, Youssif Ben Zablah, Haorui Zhang, An Liu, Radu Gugustea, Dongju Lee, Xiao Luo, Yanghong Meng, Song Li, Changxi Zhou, Tao Xin, Zhengping Ji. Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936771. |
in this study, we used local injections of aav virus containing a dominant-negative (dn) rac1 under the control of camkiiα promoter and found that the reduction of rac1 hyperactivity in ventral hippocampal excitatory neurons improves social recognition memory in app/ps1 mice. |
2022-08-08 |
2023-08-14 |
mouse |
| Haiwang Zhang, Youssif Ben Zablah, Haorui Zhang, An Liu, Radu Gugustea, Dongju Lee, Xiao Luo, Yanghong Meng, Song Li, Changxi Zhou, Tao Xin, Zhengping Ji. Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936771. |
our results suggest that overactivation of rac1 in hippocampal excitatory neurons contributes to social memory deficits in app/ps1 mice and that manipulating rac1 activity may provide a potential therapeutic strategy to treat social deficits in ad. |
2022-08-08 |
2023-08-14 |
mouse |
| Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Ma. Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats. Frontiers in molecular neuroscience. vol 15. 2022-07-05. PMID:35782392. |
time of day-dependent alteration of hippocampal rac1 activation regulates contextual fear memory in rats. |
2022-07-05 |
2023-08-14 |
rat |
| Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Ma. Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats. Frontiers in molecular neuroscience. vol 15. 2022-07-05. PMID:35782392. |
here, we report that hippocampal rac1 activity undergoes a time of day-dependent alteration both in nocturnal rats and diurnal tree shrews and that training at the lower hippocampal rac1 activation period during the night leads to better contextual fear memory in rats. |
2022-07-05 |
2023-08-14 |
rat |
| Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Ma. Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats. Frontiers in molecular neuroscience. vol 15. 2022-07-05. PMID:35782392. |
furthermore, day and night reversion by 24 h darkness/24 h light housing inverses the external clock time of hippocampal rac1 activation, but the better contextual fear memory still coincides with the lower rac1 activation in rats during the night. |
2022-07-05 |
2023-08-14 |
rat |
| Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Ma. Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats. Frontiers in molecular neuroscience. vol 15. 2022-07-05. PMID:35782392. |
interestingly, exogenous melatonin treatment promotes hippocampal rac1 activity and impairs better contextual fear memory acquired at the lower rac1 activation period during the night, and rac1-specific inhibitor nsc23766 compromises the effect of melatonin. |
2022-07-05 |
2023-08-14 |
rat |
| Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Ma. Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats. Frontiers in molecular neuroscience. vol 15. 2022-07-05. PMID:35782392. |
these results suggest that the time of day-dependent alteration of hippocampal rac1 activation regulates contextual fear memory in rats by forgetting. |
2022-07-05 |
2023-08-14 |
rat |
| Mihika Bose, Mohammad Sarfaraz Nawaz, Rakhi Pal, Sumantra Chattarj. Stress Elicits Contrasting Effects on Rac1-Cofilin Signaling in the Hippocampus and Amygdala. Frontiers in molecular neuroscience. vol 15. 2022-05-20. PMID:35592113. |
since the activity of the rho gtpase rac1 and the actin-depolymerizing factor cofilin are known to play a pivotal role in spine morphogenesis, we investigated if alterations in this signaling pathway reflect the differential effects of stress on spine plasticity in the hippocampus and amygdala. |
2022-05-20 |
2023-08-13 |
rat |
| Mihika Bose, Mohammad Sarfaraz Nawaz, Rakhi Pal, Sumantra Chattarj. Stress Elicits Contrasting Effects on Rac1-Cofilin Signaling in the Hippocampus and Amygdala. Frontiers in molecular neuroscience. vol 15. 2022-05-20. PMID:35592113. |
a day after the end of chronic immobilization stress (2 h/day for 10 days), we found a reduction in the activity of rac1, as well as its effector p21-activated kinase 1 (pak1), in the rat hippocampus. |
2022-05-20 |
2023-08-13 |
rat |
| Bo Lei, Li Lv, Shiqiang Hu, Yikai Tang, Yi Zhon. Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-04. PMID:35377811. |
social experiences switch states of memory engrams through regulating hippocampal rac1 activity. |
2022-04-04 |
2023-08-13 |
human |
| Bo Lei, Li Lv, Shiqiang Hu, Yikai Tang, Yi Zhon. Social experiences switch states of memory engrams through regulating hippocampal Rac1 activity. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 15. 2022-04-04. PMID:35377811. |
here, we show that social experiences stimulated switching between latent and silent engrams to achieve flexible memory accessibility and also reveal the basic molecular mechanism of: 1) social reward turning silent engram to latent via suppression of rac1 activity in ca1 neurons of the hippocampus; and 2) social stress switching latent memory engram into silent through activating rac1. |
2022-04-04 |
2023-08-13 |
human |
| Xianlin Zhu, Fan Zhang, Yufeng You, Hongbai Wang, Su Yuan, Banglin Wu, Rongyu Zhu, Dawei Liu, Fuxia Yan, Zaiping Wan. S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. Cellular and molecular neurobiology. 2022-01-27. PMID:35083636. |
s-ketamine exerts antidepressant effects by regulating rac1 gtpase mediated synaptic plasticity in the hippocampus of stressed rats. |
2022-01-27 |
2023-08-13 |
rat |
| Xianlin Zhu, Fan Zhang, Yufeng You, Hongbai Wang, Su Yuan, Banglin Wu, Rongyu Zhu, Dawei Liu, Fuxia Yan, Zaiping Wan. S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. Cellular and molecular neurobiology. 2022-01-27. PMID:35083636. |
in this study, we observe the effects of s-ketamine on the expression of rac1, neuronal morphology, and synaptic transmission function in the hippocampus of stressed rats. |
2022-01-27 |
2023-08-13 |
rat |