| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siv Mjos, Henrica M J Werner, Even Birkeland, Frederik Holst, Anna Berg, Mari K Halle, Ingvild L Tangen, Kanthida Kusonmano, Karen K Mauland, Anne M Oyan, Karl-Henning Kalland, Aurélia E Lewis, Gordon B Mills, Camilla Krakstad, Jone Trovik, Helga B Salvesen, Erling A Hoivi. PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28860563. |
mutations of the phosphoinositide-3-kinase (pi3k) catalytic subunit alpha gene (pik3ca) are frequent in endometrial cancer. |
2019-06-11 |
2023-08-13 |
Not clear |
| Songlin Liu, Yunhong Tang, Maomao Yan, Weixi Jian. PIK3CA mutation sensitizes breast cancer cells to synergistic therapy of PI3K inhibition and AMPK activation. Investigational new drugs. vol 36. issue 5. 2019-06-03. PMID:29504069. |
what is more, it is rather remarkable that the synergistic effect was much more dramatic in pik3ca (pi3k catalytic subunit alpha) mutated (e545k) cells (mcf-7 and mda-mb-361) than in pik3ca wild-type cells (hcc38), which implied there is a relationship between pi3k genetic status and the efficacy of combination therapy. |
2019-06-03 |
2023-08-13 |
Not clear |
| An Na Seo, Byung Woog Kang, Han Ik Bae, Oh Kyoung Kwon, Ki Bum Park, Seung Soo Lee, Ho Young Chung, Wansik Yu, Seong Woo Jeon, Hyojeung Kang, Jong Gwang Ki. Exon 9 Mutation of Anticancer research. vol 39. issue 4. 2019-04-15. PMID:30952761. |
exon 9 mutation of epstein-barr virus (ebv)-associated gastric cancer (gc) is known to harbor a significant enrichment of of phosphatidylinositol 4, 5-biphosphate 3- kinase catalytic subunit alpha isoform (pik3ca). |
2019-04-15 |
2023-08-13 |
Not clear |
| Hannah Blesinger, Silke Kaulfuß, Thiha Aung, Sonja Schwoch, Lukas Prantl, Jochen Rößler, Jörg Wilting, Jürgen Becke. PIK3CA mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations. PloS one. vol 13. issue 7. 2019-01-17. PMID:29985963. |
recent studies performed on lm specimens in the united states of america have identified activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) gene in lm. |
2019-01-17 |
2023-08-13 |
Not clear |
| Pieter Denorme, Marie-Anne Morren, Silke Hollants, Marijke Spaepen, Kate Suaer, Nele Zutterman, Veerle Labarque, Eric Legius, Hilde Brem. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA)-related overgrowth spectrum: A brief report. Pediatric dermatology. vol 35. issue 3. 2018-08-16. PMID:29493003. |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca)-related overgrowth spectrum: a brief report. |
2018-08-16 |
2023-08-13 |
Not clear |
| Qian Zeng, Li Xie, Na Zhou, Min Liu, Xianrang Son. Detection of PIK3CA Mutations in Plasma DNA of Colorectal Cancer Patients by an Ultra-Sensitive PNA-Mediated PCR. Molecular diagnosis & therapy. vol 21. issue 4. 2018-04-05. PMID:28247181. |
mutant phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) has been shown to be associated with the occurrence, development and prognosis in colorectal cancer (crc). |
2018-04-05 |
2023-08-13 |
Not clear |
| Xiao-Qing Ge, Yan-Zheng Yang, Sha-Sha Li, Lu Hou, Jing-Li Ren, Kun-Peng Yang, Xian-En F. No significant association between PIK3CA mutation and survival of esophageal squamous cell carcinoma: A meta-analysis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 37. issue 3. 2018-03-16. PMID:28585132. |
the prognostic value of phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) in patients with esophageal squamous cell carcinoma (escc) is controversial. |
2018-03-16 |
2023-08-13 |
Not clear |
| Kathryn E Yoh, Kausik Regunath, Asja Guzman, Seung-Min Lee, Neil T Pfister, Olutosin Akanni, Laura J Kaufman, Carol Prives, Ron Prywe. Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 41. 2018-01-30. PMID:27681615. |
we found that activated forms of the harvey rat sarcoma virus gtpase (h-ras) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) oncogenes strongly repress expression of ∆np63α, the predominant p63 isoform in basal mammary epithelial cells. |
2018-01-30 |
2023-08-13 |
rat |
| Sibylle Loibl, Silvia Darb-Esfahani, Jens Huober, Alexander Klimowicz, Jenny Furlanetto, Bianca Lederer, Arndt Hartmann, Holger Eidtmann, Berit Pfitzner, Peter A Fasching, Katharina Tiemann, Christian Jackisch, Keyur Mehta, Gunter von Minckwitz, Michael Untch, Carsten Denker. Integrated Analysis of PTEN and p4EBP1 Protein Expression as Predictors for pCR in HER2-Positive Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 22. issue 11. 2018-01-22. PMID:26758558. |
we investigated the correlation between phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), pten, p4ebp1 (phosphorylated e4 binding protein 1), and pathologic complete response (pcr) in patients receiving neoadjuvant therapy. |
2018-01-22 |
2023-08-13 |
Not clear |
| Timothy F Day, Rajshree R Mewani, Joshua Starr, Xin Li, Debyani Chakravarty, Habtom Ressom, Xiaojun Zou, Ofer Eidelman, Harvey B Pollard, Meera Srivastava, Usha N Kasi. Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression. Methods in molecular biology (Clifton, N.J.). vol 1513. 2018-01-11. PMID:27807832. |
tnfaip8 knockdown cells also exhibited decreased expression of multiple onco-proteins (e.g., pik3ca, src, egfr, il5, abl1, gap43), and increased expression of the orphan nuclear receptor nr4a1 and alpha 1 adaptin subunit of the adaptor-related protein complex 2 ap2 critical to clathrin-mediated endocytosis. |
2018-01-11 |
2023-08-13 |
human |
| William Wang, Jiapei Lv, Lingyan Wang, Xiangdong Wang, Ling Y. The impact of heterogeneity in phosphoinositide 3-kinase pathway in human cancer and possible therapeutic treatments. Seminars in cell & developmental biology. vol 64. 2017-12-25. PMID:27582428. |
phosphatidylinositol 3-kinase catalytic subunit alpha (pik3ca) plays a crucial role in the initiation and progress of cancerous tumors through the overexpression of the pi3k pathway promoting uncontrollable levels of cell proliferation. |
2017-12-25 |
2023-08-13 |
human |
| Jiayun Hou, Yong Zhang, Zhitu Zh. Gene heterogeneity in metastasis of colorectal cancer to the lung. Seminars in cell & developmental biology. vol 64. 2017-12-25. PMID:27590223. |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutation was associated with lung metastases in metastatic colorectal cancer. |
2017-12-25 |
2023-08-13 |
Not clear |
| Vivek Asati, Sanjay K Bharti, Debarshi Kar Mahapatra, Vikas Asati, Ashok K Budhwan. Triggering PIK3CA Mutations in PI3K/Akt/mTOR Axis: Exploration of Newer Inhibitors and Rational Preventive Strategies. Current pharmaceutical design. vol 22. issue 39. 2017-12-04. PMID:27296758. |
pik3ca gene was found in generation of p110 alpha (p110α) protein through an instruction process. |
2017-12-04 |
2023-08-13 |
human |
| Xiuning Le, Rajee Antony, Pedram Razavi, Daniel J Treacy, Flora Luo, Mahmoud Ghandi, Pau Castel, Maurizio Scaltriti, Jose Baselga, Levi A Garrawa. Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer. Cancer discovery. vol 6. issue 10. 2017-10-27. PMID:27604488. |
pik3ca (which encodes the pi3k alpha isoform) is the most frequently mutated oncogene in breast cancer. |
2017-10-27 |
2023-08-13 |
Not clear |
| Douglas D Fang, Cathy C Zhang, Yin Gu, Jitesh P Jani, Joan Cao, Konstantinos Tsaparikos, Jing Yuan, Melissa Thiel, Amy Jackson-Fisher, Qing Zong, Patrick B Lappin, Tomoko Hayashi, Richard B Schwab, Anthony Wong, Annette John-Baptiste, Shubha Bagrodia, Geritt Los, Steve Bender, James Christensen, Todd Vanarsdal. Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation. PloS one. vol 8. issue 6. 2017-10-17. PMID:23826249. |
pik3ca (phosphoinositide-3-kinase, catalytic, alpha polypeptide) mutations can help predict the antitumor activity of phosphatidylinositol-3-kinase (pi3k)/mammalian target of rapamycin (mtor) pathway inhibitors in both preclinical and clinical settings. |
2017-10-17 |
2023-08-12 |
mouse |
| Kazuto Harada, Yoshifumi Baba, Hironobu Shigaki, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Ryuma Tokunaga, Daisuke Izumi, Mayuko Ohuchi, Kenichi Nakamura, Yuki Kiyozumi, Junji Kurashige, Masaaki Iwatsuki, Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Bab. Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review. BMC cancer. vol 16. 2017-10-03. PMID:27388016. |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) mutations that activate the pi3k/akt signaling pathway have been observed in several types of carcinoma and have been associated with patient prognosis. |
2017-10-03 |
2023-08-13 |
human |
| Matthias B Stope, Dominique Koensgen, Jörg Weimer, Madeleine Paditz, Martin Burchardt, Dirk Bauerschlag, Alexander Muste. The future therapy of endometrial cancer: microRNA's functionality, capability, and putative clinical application. Archives of gynecology and obstetrics. vol 294. issue 5. 2017-08-09. PMID:27637583. |
the available biomarkers, such as cellular tumor antigen p53 (tp53), phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (pten), and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) genes alone might not be sufficient, and thus, new predictive and prognostic biomarkers are urgently required. |
2017-08-09 |
2023-08-13 |
Not clear |
| Poornima Bhat-Nakshatri, Chirayu P Goswami, Sunil Badve, Luca Magnani, Mathieu Lupien, Harikrishna Nakshatr. Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer. Cancer research. vol 76. issue 13. 2017-07-27. PMID:27197157. |
pik3ca gene mutations or amplifications that affect the pi3k p110α subunit account for activation of this pathway in 20% to 40% of cases, particularly in estrogen receptor alpha (erα)-positive breast cancers. |
2017-07-27 |
2023-08-13 |
Not clear |
| Sapan J Patel, Gaurang L Trivedi, Costel C Darie, Bayard D Clarkso. The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer. Journal of cellular and molecular medicine. vol 21. issue 3. 2017-07-17. PMID:27680505. |
we found that bcnp1 is highly altered in some types of cancers and that bcnp1 copy-number changes and mutations co-occur with other molecular alteration events for tp53 (tumour protein p53), pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), mapk1 (mitogen-activated protein kinase-1; erk: extracellular signal regulated kinase), kras (kirsten rat sarcoma viral oncogene homolog) and akt2 (v-akt murine thymoma viral oncogene homolog 2). |
2017-07-17 |
2023-08-13 |
rat |
| Derek B Allison, Mohammed T Lilo, Susan Geddes, Aparna Pallavajjalla, Frederic Askin, Edward Gabrielson, Gang Zheng, Qing Kay L. Detection of PIK3CA mutations, including a novel mutation of V344G in exon 4, in metastatic lung adenocarcinomas: A retrospective study of 115 FNA cases. Cancer cytopathology. vol 124. issue 7. 2017-02-21. PMID:27007084. |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutations and amplification are detected in 1% of primary lung adenocarcinomas (adcs) and in 38% of primary lung squamous cell carcinomas. |
2017-02-21 |
2023-08-13 |
Not clear |