| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joie N Marhefka, Rula A Abbud-Antak. Validation of the Cancer BioChip System as a 3D siRNA screening tool for breast cancer targets. PloS one. vol 7. issue 9. 2013-04-10. PMID:23049944. |
both cell lines were also suppressed by phosphoinositide-3-kinase catalytic, alpha polypeptide (pik3ca) sirna. |
2013-04-10 |
2023-08-12 |
human |
| Yi-he Wu, Jue Wang, Ding-xu Gong, Hai-yong Gu, Sheng-shou Hu, Hao Zhan. Effects of low-level laser irradiation on mesenchymal stem cell proliferation: a microarray analysis. Lasers in medical science. vol 27. issue 2. 2013-03-08. PMID:21956279. |
real-time pcr confirmed that the expression levels of v-akt murine thymoma viral oncogene homolog 1 (akt1), the cyclin d1 gene (ccnd1) and the phosphatidylinositol 3-kinase, catalytic alpha polypeptide gene (pik3ca) were upregulated after llli, whereas those of protein tyrosine phosphatase non-receptor type 6 (ptpn6) and serine/threonine kinase 17b (stk17b) were downregulated. |
2013-03-08 |
2023-08-12 |
rat |
| Qingbo Lang, Changquan Lin. MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. Biochemical and biophysical research communications. vol 426. issue 2. 2013-01-31. PMID:22940133. |
in this study, we report that phosphoinositide 3-kinase catalytic subunit alpha (pik3ca) is a novel target of mir-124 in hepg2 cells. |
2013-01-31 |
2023-08-12 |
human |
| Sho Isoyama, Hisashi Yoshimi, Shingo Dan, Mutsumi Okamura, Mariko Seki, Tatsuro Irimura, Takao Yamor. Development of an immunohistochemical protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for phosphatidylinositol 3-kinase inhibitors. Biological & pharmaceutical bulletin. vol 35. issue 9. 2013-01-24. PMID:22975517. |
the phosphatidylinositol 3-kinase (pi3k) pathway is frequently activated in human cancers by gain-of-function mutations of phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca) or dysfunction of phosphatase and tensin homolog deleted on chromosome 10 (pten). |
2013-01-24 |
2023-08-12 |
human |
| K Muffak-Granero, C Olmedo, F Garcia-Alcalde, A Comino, T Villegas, J M Villar, D Garrote, A Blanco, P Bueno, J-A Ferro. Gene network profiling before and after transplantation in alcoholic cirrhosis liver transplant recipients. Transplantation proceedings. vol 44. issue 6. 2013-01-03. PMID:22841193. |
selected genes up-regulated before transplantation were: tnfrsf9 (tumor necrosis factor [tnf] receptor superfamily, member 9); il2rb (interleukin-2 receptor beta); bcl2l2 (bcl2-like 2); nox5 (nadph) oxidase, ef-hand calcium binding domain 5); pex5 (peroxisomal biogenesis factor 5); pparg (peroxisome proliferator-activated receptor gamma); nibp (ikk2 binding protein); nkiras2 (nfkappabeta inhibitor interacting ras-like 2); il4 (interleukin-4); il-4r (interleukin 4 receptor); adh1a (alcohol dehydrogenase 1a, class 1); aldh1l1 (aldehyde dehydrogenase 1 family, member l1); mpo (myeloperoxidase); nppa (natriuretic peptide precursor a); bcl2a1 (bcl2-related protein a1); gadd45a (growth arrest and dna-damage-inducible alpha); tegt (bax inhibitor 1); pik3ca (phosphoinositide-3-kinase, catalytic, alpha polypeptide); ifngr2 (interferon gamma receptor 2); jak2 (janus kinase 2); fas (fas, tnf receptor superfamily, member 6); tank (traf family member-associated nfkb activator); ttrap (traf and tnf receptor-associated protein); and anxa5 (annexin a5). |
2013-01-03 |
2023-08-12 |
Not clear |
| Wen-Sheng Huang, Tian-Bao Wang, Yao He, Yu-Jun Chen, Shi-Long Zhong, Min Ta. Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948. World journal of gastroenterology. vol 18. issue 26. 2012-12-06. PMID:22807617. |
to investigate the gene knock-down effect by the phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca)-targeted double-stranded rna (dsrna) and its effect on cell proliferation and cycle distribution in sw948. |
2012-12-06 |
2023-08-12 |
Not clear |
| Nuria Juanpere, Laia Agell, Marta Lorenzo, Silvia de Muga, Laura López-Vilaró, Raquel Murillo, Sergi Mojal, Sergio Serrano, José A Lorente, Josep Lloreta, Silvia Hernánde. Mutations in FGFR3 and PIK3CA, singly or combined with RAS and AKT1, are associated with AKT but not with MAPK pathway activation in urothelial bladder cancer. Human pathology. vol 43. issue 10. 2012-11-29. PMID:22417847. |
we analyzed mutations in fgfr3, phosphoinositide 3 kinase catalytic alpha polypeptide (pik3ca), v-akt murine thymoma viral oncogene homolog 1 (akt1), v-ki-ras2 kirsten rat sarcoma viral oncogene homolog (kras), v-ha-ras harvey rat sarcoma viral oncogene homolog (hras), and v-raf murine sarcoma viral oncogene homolog b1 (braf) in 88 urothelial cell carcinomas and the immunohistochemical expression of phospho-v-akt murine thymoma viral oncogene homolog (akt) and mitogen-activated protein kinase 1 and 2 (perk1/2) in 80 and 77 urothelial cell carcinomas, respectively. |
2012-11-29 |
2023-08-12 |
rat |
| Xiaoyun Liao, Paul Lochhead, Reiko Nishihara, Teppei Morikawa, Aya Kuchiba, Mai Yamauchi, Yu Imamura, Zhi Rong Qian, Yoshifumi Baba, Kaori Shima, Ruifang Sun, Katsuhiko Nosho, Jeffrey A Meyerhardt, Edward Giovannucci, Charles S Fuchs, Andrew T Chan, Shuji Ogin. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. The New England journal of medicine. vol 367. issue 17. 2012-11-13. PMID:23094721. |
we hypothesized that the effect of aspirin on survival and prognosis in patients with cancers characterized by mutated pik3ca (the phosphatidylinositol-4,5-bisphosphonate 3-kinase, catalytic subunit alpha polypeptide gene) might differ from the effect among those with wild-type pik3ca cancers. |
2012-11-13 |
2023-08-12 |
Not clear |
| Jamie E Chaft, Maria E Arcila, Paul K Paik, Christopher Lau, Gregory J Riely, M Catherine Pietanza, Maureen F Zakowski, Valerie Rusch, Camelia S Sima, Marc Ladanyi, Mark G Kri. Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22135231. |
phosphoinositide-3-kinase catalytic alpha polypeptide (pik3ca) encodes the p110α subunit of the mitogenic signaling protein phosphoinositide 3-kinase (pi3k). |
2012-06-18 |
2023-08-12 |
human |
| K N Stevens, M Garcia-Closas, Z Fredericksen, M Kosel, V S Pankratz, J L Hopper, G S Dite, C Apicella, M C Southey, M K Schmidt, A Broeks, L J Van 't Veer, R A E M Tollenaar, P A Fasching, M W Beckmann, A Hein, A B Ekici, N Johnson, J Peto, I dos Santos Silva, L Gibson, E Sawyer, I Tomlinson, M J Kerin, S Chanock, J Lissowska, D J Hunter, R N Hoover, G D Thomas, R L Milne, J I Arias Pérez, A González-Neira, J Benítez, B Burwinkel, A Meindl, R K Schmutzler, C R Bartrar, U Hamann, Y D Ko, T Brüning, J Chang-Claude, R Hein, S Wang-Gohrke, T Dörk, P Schürmann, M Bremer, P Hillemanns, N Bogdanova, J V Zalutsky, Y I Rogov, N Antonenkova, A Lindblom, S Margolin, A Mannermaa, V Kataja, V-M Kosma, J Hartikainen, G Chenevix-Trench, X Chen, P Peterlongo, B Bonanni, L Bernard, S Manoukian, X Wang, J Cerhan, C M Vachon, J Olson, G G Giles, L Baglietto, C A McLean, G Severi, E M John, A Miron, R Winqvist, K Pylkäs, A Jukkola-Vuorinen, M Grip, I Andrulis, J A Knight, G Glendon, A M Mulligan, A Cox, I W Brock, G Elliott, S S Cross, P P Pharoah, A M Dunning, K A Pooley, M K Humphreys, J Wang, D Kang, K-Y Yoo, D-Y Noh, S Sangrajrang, V Gabrieau, P Brennan, J McKay, H Anton-Culver, A Ziogas, F J Couch, D F Easto. Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk. British journal of cancer. vol 105. issue 12. 2012-01-19. PMID:22033276. |
somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (pik3ca) are frequent in breast tumours and have been associated with oestrogen receptor (er) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. |
2012-01-19 |
2023-08-12 |
human |
| Filip Janku, Ignacio Garrido-Laguna, Lubos B Petruzelka, David J Stewart, Razelle Kurzroc. Novel therapeutic targets in non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 6. issue 9. 2011-12-19. PMID:21849857. |
critical targets activating procancer pathways include, but are not limited to, epidermal growth factor receptor (egfr), hepatocyte growth factor receptor (met), vascular endothelial growth factor (vegf), vegf receptor, gtpase kras (kras), receptor tyrosine protein kinase erbb-2 (her2), echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (eml4-alk), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (pik3ca), serine/threonine-protein kinase b-raf (braf), and insulin-like growth factor 1 receptor (igf-1r). |
2011-12-19 |
2023-08-12 |
Not clear |
| Cynthia X Ma, Robert J Crowder, Matthew J Elli. Importance of PI3-kinase pathway in response/resistance to aromatase inhibitors. Steroids. vol 76. issue 8. 2011-10-03. PMID:21420991. |
interestingly, mutations in pik3ca, the alpha catalytic subunit of the class ia pi3k, which renders cells dependent on pi3k pathway signaling, is the most common genetic abnormality identified in hormone receptor positive breast cancer. |
2011-10-03 |
2023-08-12 |
Not clear |
| b' Vienna Ludovini, Fortunato Bianconi, Lorenza Pistola, Rita Chiari, Vincenzo Minotti, Renato Colella, Dario Giuffrida, Francesca Romana Tofanetti, Annamaria Siggillino, Antonella Flacco, Elisa Baldelli, Daniela Iacono, Maria Grazia Mameli, Antonio Cavaliere, Lucio Crin\\xc3\\xb. Phosphoinositide-3-kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 6. issue 4. 2011-09-27. PMID:21258250.' |
the aim of this study was to investigate the role of phosphoinositide-3-kinase catalytic alpha (pik3ca), egfr, and kras gene mutations in predicting response and survival in patients with non-small cell lung cancer (nsclc) treated with egfr-tkis. |
2011-09-27 |
2023-08-12 |
rat |
| M Ehrenschwender, D Siegmund, A Wicovsky, M Kracht, O Dittrich-Breiholz, V Spindler, J Waschke, H Kalthoff, A Trauzold, H Wajan. Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation. Cell death and differentiation. vol 17. issue 9. 2011-01-13. PMID:20379197. |
constitutively active pi3k catalytic subunit alpha (pik3ca) interfered with apoptosis induction downstream of death receptor-signaling complex formation allowing robust caspase-8 activation without triggering the execution steps of apoptosis. |
2011-01-13 |
2023-08-12 |
Not clear |
| Xu-Feng Zhang, Xinping Tan, Gang Zeng, Amalea Misse, Sucha Singh, Youngsoo Kim, James E Klaunig, Satdarshan P S Mong. Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology (Baltimore, Md.). vol 52. issue 3. 2010-10-07. PMID:20583210. |
this accelerated tumorigenesis is due to increased injury and inflammation, unrestricted oxidative stress, fibrosis, and compensatory increase in hepatocyte proliferation secondary to platelet-derived growth factor receptor alpha (pdgfralpha)/phosphoinositide 3-kinase (pik3ca)/akt activation and c-myc overexpression. |
2010-10-07 |
2023-08-12 |
mouse |
| Federica Di Nicolantonio, Sabrina Arena, Josep Tabernero, Stefano Grosso, Francesca Molinari, Teresa Macarulla, Mariangela Russo, Carlotta Cancelliere, Davide Zecchin, Luca Mazzucchelli, Takehiko Sasazuki, Senji Shirasawa, Massimo Geuna, Milo Frattini, José Baselga, Margherita Gallicchio, Stefano Biffo, Alberto Bardell. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. The Journal of clinical investigation. vol 120. issue 8. 2010-09-02. PMID:20664172. |
here we have identified oncogenic variants of phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca) and kras as determinants of response to the mtor inhibitor everolimus. |
2010-09-02 |
2023-08-12 |
human |
| Morassa Mohseni, Ben Ho Par. PIK3CA and KRAS mutations predict for response to everolimus therapy: now that's RAD001. The Journal of clinical investigation. vol 120. issue 8. 2010-09-02. PMID:20664174. |
new work by di nicolantonio and colleagues in this issue of the jci demonstrates that pi3k catalytic alpha subunit (pik3ca) mutations can sensitize cancer cells to the mammalian target of rapamycin (mtor) inhibitor everolimus. |
2010-09-02 |
2023-08-12 |
Not clear |
| George C Kostakis, Nikos Papadogeorgakis, Vasiliki Koumaki, Smaragda Kamakari, Dimitra Koumaki, Constantinos Alexandridi. Absence of hotspot mutations in exons 9 and 20 of the PIK3CA gene in human oral squamous cell carcinoma in the Greek population. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. vol 109. issue 5. 2010-07-16. PMID:20416519. |
recent studies have reported high frequencies of somatic hotspot mutations in the phosphatidylinositol-3 kinase catalytic alpha (pik3ca) gene, which encodes for one of these kinases, in several human solid tumors, including oral squamous cell carcinoma (oscc). |
2010-07-16 |
2023-08-12 |
human |
| Amanda Psyrri, Sotirios Papageorgiou, Elisavet Liakata, Andreas Scorilas, Dimitra Rontogianni, Christos K Kontos, Pinelopi Argyriou, Dimitrios Pectasides, Nikolaos Harhalakis, Vassiliki Pappa, Aggeliki Kolialexi, Christina Economopoulou, Frida Kontsioti, Eirini Maratou, George Dimitriadis, Panagiota Economopoulou, Theofanis Economopoulo. Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 15. issue 18. 2010-03-30. PMID:19723646. |
the genetic change in phosphatidylinositol 3'-kinase catalytic subunit alpha (pik3ca) in mcl has not been identified. |
2010-03-30 |
2023-08-12 |
Not clear |
| Matthew J Ellis, Li Lin, Robert Crowder, Yu Tao, Jeremy Hoog, Jacqueline Snider, Sherri Davies, Katherine DeSchryver, Dean B Evans, Jutta Steinseifer, Raj Bandaru, WeiHua Liu, Humphrey Gardner, Vladimir Semiglazov, Mark Watson, Kelly Hunt, John Olson, José Baselg. Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer. Breast cancer research and treatment. vol 119. issue 2. 2010-03-10. PMID:19844788. |
mutations in the alpha catalytic subunit of phosphoinositol-3-kinase (pik3ca) occur in approximately 30% of er positive breast cancers. |
2010-03-10 |
2023-08-12 |
Not clear |