| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Mandelker, Sandra B Gabelli, Oleg Schmidt-Kittler, Jiuxiang Zhu, Ian Cheong, Chuan-Hsiang Huang, Kenneth W Kinzler, Bert Vogelstein, L Mario Amze. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 40. 2010-01-15. PMID:19805105. |
the pik3ca oncogene, which encodes p110alpha, the catalytic subunit of phosphatidylinositol 3-kinase alpha (pi3kalpha), is one of the two most frequently mutated oncogenes in human cancers. |
2010-01-15 |
2023-08-12 |
human |
| Peng Liu, Da-Jiang Li, Hai-De Qin, Ru-Hua Zhang, Li-Zhen Chen, Yi-Xin Zen. [Screening for mutations in the hotspot mutation regions of PIK3CA gene in nasopharyngeal carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 1. 2009-09-24. PMID:17222361. |
recent studies showed high frequency of phosphatidylinositol 3-kinase catalytic alpha polypeptide (pik3ca) mutations in various human cancers; notably, these mutations frequently locate in the hotspot mutation regions of pik3ca exon 9 and exon 20 with functional significance in tumorigenesis, invasion, and anti-apoptosis. |
2009-09-24 |
2023-08-12 |
human |
| Barry Fine, Cindy Hodakoski, Susan Koujak, Tao Su, Lao H Saal, Matthew Maurer, Benjamin Hopkins, Megan Keniry, Maria Luisa Sulis, Sarah Mense, Hanina Hibshoosh, Ramon Parson. Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science (New York, N.Y.). vol 325. issue 5945. 2009-09-18. PMID:19729658. |
p-rex2a mrna was more abundant in human cancer cells and significantly increased in tumors with wild-type pten that expressed an activated mutant of pik3ca encoding the p110 subunit of phosphoinositide 3-kinase subunit alpha (pi3kalpha). |
2009-09-18 |
2023-08-12 |
human |
| Parminder K Mankoo, Saraswati Sukumar, Rachel Karchi. PIK3CA somatic mutations in breast cancer: Mechanistic insights from Langevin dynamics simulations. Proteins. vol 75. issue 2. 2009-05-29. PMID:18951408. |
somatic mutations in pik3ca (phosphatidylinositol-3 kinase, catalytic subunit, alpha isoform) are reported in breast and other human cancers to concentrate at hotspots within its kinase and helical domains. |
2009-05-29 |
2023-08-12 |
human |
| Ian R Radford, Pavel N Lobachevsk. Clustered DNA lesion sites as a source of mutations during human colorectal tumourigenesis. Mutation research. vol 646. issue 1-2. 2009-01-06. PMID:18824008. |
we used statistical analyses to search for sets of dinucleotide sequences (designated target sequences) that are present at and in close proximity to mutation sites in four genes associated with human colorectal tumourigenesis (adenomatosis polyposis coli (apc), v-ki-ras2 kirsten rat sarcoma viral oncogene homolog (kras), phosphoinositide-3-kinase, catalytic, alpha polypeptide (pik3ca), and tumour protein p53 (tp53)). |
2009-01-06 |
2023-08-12 |
human |
| Vincent Ching-Shian Leong, Mohd Faizal Jabal, Pooi Pooi Leong, Maizaton Atmadini Abdullah, Yunus Alif Gul, Heng Fong Seo. PIK3CA gene mutations in breast carcinoma in Malaysian patients. Cancer genetics and cytogenetics. vol 187. issue 2. 2008-12-09. PMID:19027487. |
somatic mutations of phosphoinositide-3-kinase, catalytic, alpha; pik3ca gene have been reported in several types of human cancers. |
2008-12-09 |
2023-08-12 |
human |
| C Garcia-Echeverria, W R Seller. Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene. vol 27. issue 41. 2008-10-08. PMID:18794885. |
notable in this regard are the prevalent somatic genetic alterations leading to the inactivation of the tumor suppressor gene pten and gain-of-function mutations targeting pik3ca--the gene encoding the catalytic phosphosinositide-3 kinase subunit p110 alpha. |
2008-10-08 |
2023-08-12 |
human |
| Eli R Zunder, Zachary A Knight, Benjamin T Houseman, Beth Apsel, Kevan M Shoka. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer cell. vol 14. issue 2. 2008-08-28. PMID:18691552. |
p110 alpha (pik3ca) is the most frequently mutated kinase in human cancer, and numerous drugs targeting this kinase are currently in preclinical development or early-stage clinical trials. |
2008-08-28 |
2023-08-12 |
human |
| Cornelia Liedtke, Luca Cardone, Attila Tordai, Kai Yan, Henry L Gomez, Luis J Barajas Figureoa, Rebekah E Hubbard, Vicente Valero, Eduardo A Souchon, W Fraser Symmans, Gabriel N Hortobagyi, Alberto Bardelli, Lajos Puszta. PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer. Breast cancer research : BCR. vol 10. issue 2. 2008-07-21. PMID:18371219. |
in vitro evidence suggests that pik3ca (phosphatidylinositol 3-kinase, catalytic, alpha polypeptide) activation may be associated with altered chemotherapy sensitivity in cancer. |
2008-07-21 |
2023-08-12 |
Not clear |
| Ruth E Board, Nicola J Thelwell, Paul F Ravetto, Stephen Little, Malcolm Ranson, Caroline Dive, Andrew Hughes, David Whitcomb. Multiplexed assays for detection of mutations in PIK3CA. Clinical chemistry. vol 54. issue 4. 2008-05-12. PMID:18375489. |
mutations in the pik3ca gene (phosphoinositide-3-kinase, catalytic, alpha polypeptide) have recently been described in a number of cancers, and their detection is currently limited because of the low sensitivity of conventional sequencing techniques. |
2008-05-12 |
2023-08-12 |
Not clear |
| Chuan-Hsiang Huang, Diana Mandelker, Oleg Schmidt-Kittler, Yardena Samuels, Victor E Velculescu, Kenneth W Kinzler, Bert Vogelstein, Sandra B Gabelli, L Mario Amze. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science (New York, N.Y.). vol 318. issue 5857. 2007-12-31. PMID:18079394. |
pik3ca, one of the two most frequently mutated oncogenes in human tumors, codes for p110alpha, the catalytic subunit of a phosphatidylinositol 3-kinase, isoform alpha (pi3kalpha, p110alpha/p85). |
2007-12-31 |
2023-08-12 |
human |
| Koji Okudela, Masaya Suzuki, Shinji Kageyama, Tomoyasu Bunai, Kiyoko Nagura, Hisaki Igarashi, Kazuya Takamochi, Kazuya Suzuki, Takeshi Yamada, Hiroshi Niwa, Riuko Ohashi, Hiroshi Ogawa, Hiroki Mori, Hitoshi Kitamura, Takeshi Kaneko, Toshihiro Tsuneyoshi, Haruhiko Sugimur. PIK3CA mutation and amplification in human lung cancer. Pathology international. vol 57. issue 10. 2007-11-13. PMID:17803655. |
to explore the significance of phosphatidylinositol-3-kinase, catalytic, alpha (pik3ca) in the carcinogenesis in human lung, mutations and copy number changes were investigated in 148 japanese patients with primary cancer of the lung. |
2007-11-13 |
2023-08-12 |
human |
| Semir Vranić, Nurija Bilalović, Lisa M J Lee, Bozo Kruslin, Stan L Lilleberg, Zoran Gatalic. PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. Human pathology. vol 38. issue 9. 2007-10-29. PMID:17669465. |
a detailed molecular genetic analysis of the primary and metastatic tumors demonstrated somatic mutations in 2 well-known cancer genes associated with regulation of pi3k/akt signaling pathway: (1) pik3ca, which encodes the catalytic alpha subunit of the phosphoinositide-3-kinase, and (2) pten, which encodes phosphatase and tensin homolog. |
2007-10-29 |
2023-08-12 |
Not clear |
| Christian Hafner, Elena López-Knowles, Nuno M Luis, Agustí Toll, Eulàlia Baselga, Alex Fernández-Casado, Silvia Hernández, Adriana Ribé, Thomas Mentzel, Robert Stoehr, Ferdinand Hofstaedter, Michael Landthaler, Thomas Vogt, Ramòn M Pujol, Arndt Hartmann, Francisco X Rea. Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 33. 2007-10-24. PMID:17673550. |
activating mutations of the p110 alpha subunit of pi3k (pik3ca) oncogene have been identified in a broad spectrum of malignant tumors. |
2007-10-24 |
2023-08-12 |
Not clear |
| Irina Fenic, Klaus Steger, Christin Gruber, Christoph Arens, Joachim Woenckhau. Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma. Oncology reports. vol 18. issue 1. 2007-08-16. PMID:17549376. |
in the present study, we investigated the occurrence of pik3ca hot-spot mutations in exons 9 and 20, the genomic gain and amplification of pik3ca, the expression of pik3ca mrna and the p110 alpha protein, as well as the expression of phosphorylated-akt (pakt) in 33 cases of hnscc and compared the results with the clinicopathological data. |
2007-08-16 |
2023-08-12 |
Not clear |
| Katsuhiko Nosho, Hiroyuki Yamamoto, Taiga Takahashi, Masashi Mikami, Hiroaki Taniguchi, Nobuki Miyamoto, Yasushi Adachi, Yoshiaki Arimura, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomur. Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers. Carcinogenesis. vol 28. issue 6. 2007-08-07. PMID:17183069. |
mutations of kras, braf, catalytic subunit alpha of phosphatidylinositol 3'-kinase (pik3ca) and beta-catenin were detected in 25.4, 4.6, 1.6 and 9.4% of those tumors, respectively. |
2007-08-07 |
2023-08-12 |
Not clear |
| Joachim Woenckhaus, Klaus Steger, Klaus Sturm, Karsten Münstedt, Folker E Franke, Irina Feni. Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer. Virchows Archiv : an international journal of pathology. vol 450. issue 4. 2007-06-19. PMID:17377809. |
gain and/or amplification of pik3ca gene, encoding the catalytic subunit of phosphatidylinositol 3-kinase (p110 alpha) and its increased expression are associated with enhanced pi3k activity in ovarian cancer cell lines. |
2007-06-19 |
2023-08-12 |
Not clear |
| Tomoko Goto, Masashi Takano, Hidenori Sasa, Hitoshi Tsuda, Kazuhiro Yamauchi, Yoshihiro Kikuch. Clinical significance of immunocytochemistry for PIK3CA as a carcinogenesis-related marker on liquid-based cytology in cervical intraepithelial neoplasia. Oncology reports. vol 15. issue 2. 2006-06-01. PMID:16391859. |
the catalytic subunit alpha of phosphatidylinositol 3-kinase (pik3ca) has been expected to play a role as an important oncogene in uterine cervical carcinoma, whose expression in non-invasive lesions has received considerable attention. |
2006-06-01 |
2023-08-12 |
human |
| Wanglong Qiu, Frank Schönleben, Xiaojun Li, Daniel J Ho, Lanny G Close, Spiros Manolidis, Boyce P Bennett, Gloria H S. PIK3CA mutations in head and neck squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 5. 2006-05-03. PMID:16533766. |
recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic alpha (pik3ca) gene in several human solid tumors. |
2006-05-03 |
2023-08-12 |
human |
| Katsutoshi Oda, David Stokoe, Yuji Taketani, Frank McCormic. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer research. vol 65. issue 23. 2006-01-25. PMID:16322209. |
in addition to inactivation of the pten tumor suppressor gene, mutations or amplifications of the catalytic subunit alpha of pi3k (pik3ca) have been reported. |
2006-01-25 |
2023-08-12 |
human |