| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tangliang Zhao, Yulin Zhou, Qingyun Wang, Xiaoming Yi, Silun Ge, Haowei He, Song Xue, Bowen Du, Jingping Ge, Jie Dong, Le Qu, Linhui Wang, Wenquan Zho. QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. International journal of oncology. vol 59. issue 1. 2021-06-19. PMID:34036385. |
on the whole, the data from the present study suggest that qpct, ccctc‑binding factor (ctcf) and phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit alpha (pik3ca) may be used as targets for predicting, reversing and treating sunitinib‑resistant rcc. |
2021-06-19 |
2023-08-13 |
Not clear |
| Silvia Rita Vitale, Federica Martorana, Stefania Stella, Gianmarco Motta, Nicola Inzerilli, Michele Massimino, Elena Tirrò, Livia Manzella, Paolo Vigner. PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance. Critical reviews in oncology/hematology. vol 162. 2021-06-15. PMID:33865994. |
somatic mutations of the pi3k alpha catalytic subunit (pik3ca) are the most common cause of pathway hyperactivation. |
2021-06-15 |
2023-08-13 |
human |
| Yumiko Hori, Katsutoshi Hirose, Noriko Aramaki-Hattori, Sachi Suzuki, Robert Nakayama, Masanori Inoue, Takahiro Matsui, Masaharu Kohara, Satoru Toyosawa, Eiichi Mori. Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of rapamycin (mTOR) pathway. Diagnostic pathology. vol 15. issue 1. 2021-06-08. PMID:32711543. |
fibro-adipose vascular anomaly (fava) is a new entity of vascular anomalies with somatic and mosaic gain-of-function mutations of the phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca). |
2021-06-08 |
2023-08-13 |
Not clear |
| Xue Yang, Yang Xia, Liyan Xu, Li Liang, Minglei Zhuo, Meina Wu, Tongtong An, Ziping Wang, Yuyan Wang, Jianjie Li, Jia Zhong, Hanxiao Chen, Bo Jia, Jingjing Wang, Jun Zha. Efficacy and Safety of Combination Treatment With Apatinib and Osimertinib After Osimertinib Resistance in Epidermal Growth Factor Receptor-Mutant Non-small Cell Lung Carcinoma-A Retrospective Analysis of a Multicenter Clinical Study. Frontiers in molecular biosciences. vol 8. 2021-05-26. PMID:34026823. |
the spectrum of resistance to osimertinib mechanisms included c-mesenchymal-epithelial transition factor (c-met) amplification, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) gain-of-function mutation, phosphatase and tensin homolog (pten) loss-of-function mutation, erb-b2 receptor tyrosine kinase 2 (erbb2) amplification, and insulin-like growth factor 1 receptor (igf1r) mutation. |
2021-05-26 |
2023-08-13 |
Not clear |
| Yusuke Morii, Masanobu Tsubaki, Tomoya Takeda, Rie Otubo, Shiori Seki, Yuta Yamatomo, Motohiro Imano, Takao Satou, Kazunori Shimomura, Shozo Nishid. Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation. European journal of pharmacology. vol 898. 2021-05-19. PMID:33662352. |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutation in colon cancer contributes to the poor prognosis of the disease and chemoresistance of tumors. |
2021-05-19 |
2023-08-13 |
Not clear |
| Sara Elena Rebuzzi, Lodovica Zullo, Giovanni Rossi, Massimiliano Grassi, Veronica Murianni, Marco Tagliamento, Arsela Prelaj, Simona Coco, Luca Longo, Maria Giovanna Dal Bello, Angela Alama, Chiara Dellepiane, Elisa Bennicelli, Umberto Malapelle, Carlo Genov. Novel Emerging Molecular Targets in Non-Small Cell Lung Cancer. International journal of molecular sciences. vol 22. issue 5. 2021-04-22. PMID:33807876. |
this review aims to cover the molecular alterations with a potential clinical impact in nsclc, including amplifications or mutations of the mesenchymal-epithelial transition factor (met), fusions of rearranged during transfection (ret), rearrangements of the neurotrophic tyrosine kinase (ntrk) genes, mutations of the kirsten rat sarcoma viral oncogene (kras) and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca), as well as amplifications or mutations of human epidermal growth factor receptor 2 (her2). |
2021-04-22 |
2023-08-13 |
human |
| Gayathri Nagaraj, Cynthia X M. Clinical Challenges in the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: A Literature Review. Advances in therapy. vol 38. issue 1. 2021-04-14. PMID:33190190. |
this review aims to provide practical guidance for the management of hr+, her2- mbc based on available data and the utility of genomic biomarkers, including germline breast cancer genes 1 and 2 (brca1/2) mutations, and somatic estrogen receptor alpha gene (esr1), her2, and pik3ca mutations. |
2021-04-14 |
2023-08-13 |
human |
| Jing Yang, Zhifeng Liu, Bin Zeng, Guangsheng Hu, Runliang Ga. Epstein-Barr virus-associated gastric cancer: A distinct subtype. Cancer letters. vol 495. 2021-03-25. PMID:32979463. |
the molecular profile of ebvagc is that of ebv driving dna hypermethylation, frequent phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) mutations, and the overexpression of janus kinase 2 (jak2), programmed death ligand-1 (pd-l1), and pd-l2. |
2021-03-25 |
2023-08-13 |
Not clear |
| Clara Mayo-de-Las-Casas, Ana Velasco, Douglas Sanchez, Alejandro Martínez-Bueno, Mónica Garzón-Ibáñez, Sònia Gatius, Maria Ruiz-Miró, Xavier Gonzalez-Tallada, Ivana Llordella, Francesc Tresserra, Sonia Rodríguez, Erika Aldeguer, Berta Roman-Canal, Jordi Bertran-Alamillo, Beatriz García-Peláez, Rafael Rosell, Miguel A Molina-Vila, Xavier Matias-Gui. Detection of somatic mutations in peritoneal lavages and plasma of endometrial cancer patients: A proof-of-concept study. International journal of cancer. vol 147. issue 1. 2021-03-23. PMID:31953839. |
human genes discussed: kras, kras proto-oncogene, gtpase; pik3ca, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. |
2021-03-23 |
2023-08-13 |
human |
| Qi Ding, Wenxiang Zhu, Yirui Diao, Gonghao Xu, Lu Wang, Sihao Qu, Yuanyuan Sh. Elucidation of the Mechanism of Action of Ginseng Against Acute Lung Injury/Acute Respiratory Distress Syndrome by a Network Pharmacology-Based Strategy. Frontiers in pharmacology. vol 11. 2021-03-23. PMID:33746744. |
signal transducer and activator of transcription (stat) 3, vascular endothelial growth factor a (vegfa), fibroblast growth factor (fgf) 2, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), mapk1, and interleukin (il) 2 were the top six nodes identified by analyses of a compound-target-pathway network. |
2021-03-23 |
2023-08-13 |
mouse |
| Arman Ali Ghodsinia, J-Ann Marie T Lego, Reynaldo L Garci. Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants. Cells. vol 9. issue 5. 2021-03-16. PMID:32365913. |
phosphatidylinositol 3-kinase, catalytic subunit alpha (pik3ca) is an oncogene often mutated in colorectal cancer (crc). |
2021-03-16 |
2023-08-13 |
Not clear |
| Arman Ali Ghodsinia, J-Ann Marie T Lego, Reynaldo L Garci. Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants. Cells. vol 9. issue 5. 2021-03-16. PMID:32365913. |
in silico docking suggested these mutations negatively affect binding of the p85 alpha regulatory subunit to pik3ca, thereby relieving pik3ca inhibition. |
2021-03-16 |
2023-08-13 |
Not clear |
| Xiaohui Zhang, Huanwen Wu, Zhe Wang, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Zhiyong Liang, Qiang Su. Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature review. Gland surgery. vol 10. issue 2. 2021-03-13. PMID:33708566. |
furthermore, this study used the next-generation sequencing (ngs) technique to identify concurrent isocitrate dehydrogenase 2 (idh2) and phosphatidylinositol 3-kinase catalytic alpha (pik3ca) hotspot mutations. |
2021-03-13 |
2023-08-13 |
Not clear |
| Feng Zhu, Jianfu Li, Caichen Li, Shan Xiong, Zhuxing Chen, Bo Cheng, Ran Zhong, Wenhua Lian. Concealed driver in lung adenocarcinoma with single PIK3CA mutation: a case report and single-center genotyping review. Annals of translational medicine. vol 9. issue 3. 2021-03-13. PMID:33708898. |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutation has a prevalence of approximately 2% in lung adenocarcinoma. |
2021-03-13 |
2023-08-13 |
Not clear |
| Chi Sun, Annan Hu, Shengxing Wang, Bo Tian, Libo Jiang, Yun Liang, Houlei Wang, Jian Don. ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma. International journal of oncology. vol 57. issue 1. 2021-03-08. PMID:32319605. |
cx3cl1 enhanced the activation of the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit alpha (pik3ca)/akt serine/threonine kinase 1 (akt1) and ras homolog family member a (rhoa)/rho associated coiled‑coil containing protein kinase 2 (rock2) signaling pathways through the src/ptk2 signaling pathway. |
2021-03-08 |
2023-08-13 |
mouse |
| Hiroya Taniguchi, Keisuke Uehara, Goro Nakayama, Hiroshi Nakayama, Toshisada Aiba, Norifumi Hattori, Masato Kataoka, Yasuyuki Nakano, Yoshihisa Kawase, Osamu Okochi, Hiroshi Matsuoka, Setsuo Utsunomiya, Eiji Sakamoto, Yoshinori Mori, Shinichi Umeda, Toshio Shikano, Koji Komori, Masahiro Tajika, Shigenori Kadowaki, Kei Muro, Yasushi Yatab. Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan. Translational oncology. vol 13. issue 7. 2021-01-10. PMID:32428838. |
however, the association between the incidence of braf and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutations and primary tumor location remains unclear. |
2021-01-10 |
2023-08-13 |
Not clear |
| Philippe Jamme, Marie Fernandes, Marie-Christine Copin, Clotilde Descarpentries, Fabienne Escande, Angela Morabito, Valérie Grégoire, Matthieu Jamme, Simon Baldacci, David Tulasne, Zoulika Kherrouche, Alexis B Corto. Alterations in the PI3K Pathway Drive Resistance to MET Inhibitors in NSCLC Harboring MET Exon 14 Skipping Mutations. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 15. issue 5. 2021-01-06. PMID:32169477. |
we found a phosphatidylinositol 3-kinase catalytic subunit alpha (pik3ca) mutation in two of 65 samples (3%) and loss of pten in six of 26 samples (23%). |
2021-01-06 |
2023-08-13 |
Not clear |
| Siddarth Agrawal, Marta Woźniak, Mateusz Łuc, Sebastian Makuch, Ewa Pielka, Anil Kumar Agrawal, Joanna Wietrzyk, Joanna Banach, Andrzej Gamian, Monika Pizon, Piotr Ziółkowsk. Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2. Scientific reports. vol 9. issue 1. 2020-11-10. PMID:31719636. |
the results indicate that the downregulation of pik3ca (phosphatidylinositol 3-kinase catalytic subunit alpha), which plays a critical role in cell signaling and grb2 (growth factor receptor-bound protein 2), a regulator of cell proliferation and differentiation may be responsible for the sensitizing effect of ins. |
2020-11-10 |
2023-08-13 |
mouse |
| Odekunle Florence Fem. Genetic alterations and PIK3CA gene mutations and amplifications analysis in cervical cancer by racial groups in the United States. International journal of health sciences. vol 12. issue 1. 2020-09-29. PMID:29623014. |
however, the associations of tumor genomic patterns such as phosphatidylinositol 3-kinase catalytic subunit alpha (pik3ca) gene mutations and amplifications with cervical cancer racial disparities are largely unexplored. |
2020-09-29 |
2023-08-13 |
Not clear |
| Sara Alomar, Rewana E Khedr, Saad Alajla. CLOVES Syndrome in a Nine-month-old Infant. Cureus. vol 11. issue 9. 2020-09-28. PMID:31723531. |
genetically, it is characterized by a somatic gain-of-function mutation of the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) gene. |
2020-09-28 |
2023-08-13 |
Not clear |