| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiah Yeom, Yoonju Cho, Seoungyob Ahn, Soyoung Jeun. Anticancer effects of alpelisib on PIK3CA-mutated canine mammary tumor cell lines. Frontiers in veterinary science. vol 10. 2023-11-30. PMID:38033642. |
therefore, in this study, we established new cmt cell lines by isolating cells from tumor tissues and investigated phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), a target for human breast cancer. |
2023-11-30 |
2023-12-10 |
human |
| William J Gibson, Ananthan Sadagopan, Veronika M Shoba, Amit Choudhary, Matthew Meyerson, Stuart L Schreibe. Bifunctional Small Molecules That Induce Nuclear Localization and Targeted Transcriptional Regulation. Journal of the American Chemical Society. 2023-11-22. PMID:37992275. |
proteins shown to be substrates for nuclear transport include oncogenic mutant nucleophosmin (npm1c) and mutant pi3k catalytic subunit alpha (pik3ca |
2023-11-22 |
2023-11-29 |
Not clear |
| Shujuan Zhang, Jun Wang, Hailong Zhan. Integrated bioinformatics and network pharmacology to explore the therapeutic target and molecular mechanisms of Taxus chinensis against non-small cell lung cancer. Medicine. vol 102. issue 44. 2023-11-07. PMID:37933017. |
proto-oncogene tyrosine-protein kinase src (src), mitogen-activated protein kinase 1, phosphoinositide-3-kinase, regulatory subunit 1 (pik3r1), akt serine/threonine kinase 1 (akt1), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), and lymphocyte-specific protein tyrosine kinase were identified as the hub genes. |
2023-11-07 |
2023-11-08 |
human |
| Yeong Gyu Jeong, Nar Bahadur Katuwal, Min Sil Kang, Mithun Ghosh, Sa Deok Hong, Seong Min Park, Seul-Gi Kim, Tae Hoen Kim, Yong Wha Moo. Combined PI3K Inhibitor and Eribulin Enhances Anti-Tumor Activity in Preclinical Models of Paclitaxel-Resistant, PIK3CA-Mutated Endometrial Cancer. Cancers. vol 15. issue 19. 2023-10-14. PMID:37835582. |
based on the high prevalence of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutation, reaching 50%, in endometrial cancer, we preclinically investigated the effectiveness of a combination of a phosphatidylinositol 3-kinase (pi3k) inhibitor with eribulin, a post-paclitaxel therapy for breast cancer, in treating paclitaxel-resistant, pik3ca-mutated endometrial cancer. |
2023-10-14 |
2023-10-15 |
Not clear |
| Navdeep Malik, Hualong Yan, Young-Im Kim, Gamze Ayaz, Shasha Wang, Payel Mondal, Ji Luo, Jing Huan. Autophagy Inhibition as a Potential Therapeutic Strategy for Breast Cancer with Mitochondrial Translation Defect Caused by CBFB-Deficiency. Autophagy. vol 19. issue 11. 2023-10-03. PMID:37115099. |
ampk, amp-activated protein kinase; bioid, biotinylation identification; cbfb, core-binding factor subunit beta; hcq, hydroxychloroquine; hnrnpk, heterogeneous nuclear ribonucleoprotein k; pdx, patient-derived xenograft; pik3ca, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; tufm, tu translation elongation factor, mitochondrial; etc, electron transport chain. |
2023-10-03 |
2023-10-07 |
Not clear |
| H D Wijesinghe, M D S Lokuhett. Liquid biopsy in breast carcinoma: Are we there yet? The Malaysian journal of pathology. vol 45. issue 2. 2023-09-02. PMID:37658527. |
most of these are still in the research stage and only the cellsearch method for the detection of ctcs and therascreen pik3ca rgq polymerase chain reaction (pcr) assay for the detection of pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) mutations in liquid biopsy have approval of the united states, food and drug administration. |
2023-09-02 |
2023-09-07 |
Not clear |
| Stephanie A Haddad, Don S Dizon, Stephanie L Graf. Sequencing systemic therapy in hormone-receptor positive metastatic breast cancer: a modern paradigm. Chinese clinical oncology. 2023-08-13. PMID:37574571. |
treatments discussed include cyclin-dependent kinase 4/6 inhibitors, antibody drug conjugates, and targeted therapies against phosphatidylinositol-4,5-bisphosphate-3-kinase catalytic subunit alpha (pik3ca), estrogen receptor 1 (esr1), and poly[adp-ribose] polymerase (parp), among others. |
2023-08-13 |
2023-08-16 |
Not clear |
| William J Gibson, Ananthan Sadagopan, Veronika M Shoba, Amit Choudhary, Matthew Meyerson, Stuart L Schreibe. Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. bioRxiv : the preprint server for biology. 2023-07-18. PMID:37461636. |
proteins shown to be substrates for nuclear transport include oncogenic mutant nucleophosmin (npm1c) and mutant pi3k catalytic subunit alpha (pik3ca |
2023-07-18 |
2023-08-14 |
Not clear |
| Pedro Antônio Bronhara Pimentel, Antonio Giuliano, Paweł Marek Bęczkowski, Rodrigo Dos Santos Hort. Molecular Profile of Canine Hemangiosarcoma and Potential Novel Therapeutic Targets. Veterinary sciences. vol 10. issue 6. 2023-06-28. PMID:37368773. |
the most common genetic abnormalities in canine hsa have been found in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) and neuroblastoma ras viral oncogene homolog (nras) pathways. |
2023-06-28 |
2023-08-14 |
human |
| Yiming Li, Xinglin Du, Wen Li, Qichen Jiang, Yucong Ye, Ying Yang, Xingguo Liu, Yunlong Zhao, Xuan Ch. Two genes related to apoptosis in the hepatopancreas of juvenile prawn, Macrobrachium nipponense: Molecular characterization and transcriptional response to nanoplastic exposure. The Science of the total environment. 2023-03-17. PMID:36931509. |
to study the effects of exposure to nanoplastics on hepatopancreas cell apoptosis, c-jun n-terminal kinase (jnk) and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) genes were selected, and hepatotoxic enzyme activities and toll pathway- and apoptosis-related gene expression were determined. |
2023-03-17 |
2023-08-14 |
human |
| Sameh Daher, Alona Zer, Roi Tschernichovsky, Rinat Yacobi, Iris Barshack, Shani Tsabari, Yakir Rottenberg, Aviad Zick, Teodor Gottfried, Anastasiya Lobachov, Edith M Marom, Damien Urban, Akram Saad, Hadas Gantz-Sorotsky, Amir Onn, Jair Ba. Driver mutation characteristics of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in advanced non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). vol 178. 2023-03-10. PMID:36898331. |
driver mutation characteristics of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) in advanced non-small cell lung cancer. |
2023-03-10 |
2023-08-14 |
Not clear |
| Jessica W Chen, William Jacot, Javier Cortés, Ian E Krop, Susan Dent, Nadia Harbeck, Michelino De Laurentiis, Véronique Diéras, Young-Hyuck Im, Thomas J Stout, Frauke Schimmoller, Heidi M Savage, Katherine E Hutchinson, Timothy R Wilso. ER+, HER2- advanced breast cancer treated with taselisib and fulvestrant: genomic landscape and associated clinical outcomes. Molecular oncology. 2023-03-09. PMID:36892268. |
taselisib is a potent β-sparing phosphatidylinositol 3-kinase (pi3k) inhibitor that, with endocrine therapy, improves outcomes in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca)-mutated (pik3camut) advanced breast cancer. |
2023-03-09 |
2023-08-14 |
human |
| Larisa Debelenko, Mahesh M Mansukhani, Fabrizio Remott. Papillary Intralymphatic Angioendothelioma in a Child With Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2023-02-13. PMID:36775953. |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca)-related overgrowth spectrum (pros) is a heterogeneous group of disorders caused by mosaicism for activating mutations of |
2023-02-13 |
2023-08-14 |
Not clear |
| Ya Ma, Xiaohua Chen, Ting Ding, Hanqun Zhang, Qiuning Zhang, Huanyu Dai, Haibo Zhang, Jianming Tang, Xiaohu Wan. KAT7 promotes radioresistance through upregulating PI3K/AKT signaling in breast cancer. Journal of radiation research. 2023-02-01. PMID:36724120. |
mechanistically, kat7 activated phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) transcription, leading to enhanced pi3k/akt signaling and radioresistance. |
2023-02-01 |
2023-08-14 |
Not clear |
| Lei Jiang, Meng Wang, Youxun Li, Shuyuan Zhang, Xiudong Zhu, Junjie Zhong, Jingtao Sun, Miguel Tinoco, Xiaowei Che. Enzyme-Free Colorimetric Method for Fast Detection of PIK3CA Gene Mutation by Praseodymia Nanorods. Analytical chemistry. 2023-01-26. PMID:36701639. |
the frequently mutated phosphatidylinositol 3-kinase catalytic subunit alpha (pik3ca) gene is associated with multiple tumors and endocytosis of viruses. |
2023-01-26 |
2023-08-14 |
Not clear |
| Elissa R Engel, Adrienne Hammill, Denise Adams, Roderic J Phillips, Michael Jeng, Megha M Tollefson, Ionela Iacobas, Deborah Schiff, Shoshana Greenberger, Michael Kelly, Ilona Frieden, Nibal Zaghloul, Beth Drolet, Amy Geddis, Dov Goldenberg, Kiersten Ricc. Response to sirolimus in capillary lymphatic venous malformations and associated syndromes: Impact on symptomatology, quality of life, and radiographic response. Pediatric blood & cancer. 2023-01-18. PMID:36651691. |
identification of pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [gene]) mutations in clvm has made targeted medications, such as sirolimus, attractive treatment options. |
2023-01-18 |
2023-08-14 |
Not clear |
| Yu-Chan Chang, Chien-Hsiu Li, Ming-Hsien Chan, Chih-Yeu Fang, Zhi-Xuan Zhang, Chi-Long Chen, Michael Hsia. Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells. Molecular oncology. 2023-01-18. PMID:36652260. |
in addition, the rab3c-dystrophin axis is positively correlated with the phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (pik3ca) genetic alterations in crc patients. |
2023-01-18 |
2023-08-14 |
Not clear |
| Na Shen, Yanfang Yu, Ruiying Zhang, Ying Guo, Mei Liu, Mengtian Tan, Jianxia Liu, Jing Bai, Li Li, Keyu Liu, Ran Wang, Jinglan H. Expression and Prognostic Value of PIK3CA, VEGF, IL-8, IL-10, and RIP2 in Diffuse Large B-Cell Lymphoma. International journal of clinical practice. vol 2022. 2022-12-26. PMID:36567775. |
to explore clinical features and prognostic value of vascular endothelial growth factor (vegf), interleukin (il) 8, il-10, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca), and receptor-interacting protein-2 (rip2) in diffuse large b-cell lymphoma (dlbcl). |
2022-12-26 |
2023-08-14 |
Not clear |
| Maya Nourieh, Roseline Vibert, Mathilde Saint-Ghislain, Joanna Cyrta, Anne Vincent-Salomo. Next-generation sequencing in breast pathology: real impact on routine practice over a decade since its introduction. Histopathology. vol 82. issue 1. 2022-12-09. PMID:36482269. |
human epidermal growth factor receptor 2 (her2) overexpression is widely determined based on immunohistochemistry, while next-generation sequencing (ngs) is currently employed to assess the presence of molecular alterations, including breast cancer gene 1 (brca1) and 2 or phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) mutations, which are targets of these new approved therapies. |
2022-12-09 |
2023-08-14 |
human |
| Hope S Rugo, Kira Raskina, Alexa B Schrock, Russell W Madison, Ryon P Graf, Ethan S Sokol, Smruthy S Sivakumar, Jessica K Lee, Virginia Fisher, Geoffrey R Oxnard, Hanna Tukachinsk. Biology and targetability of the extended spectrum of PIK3CA mutations (PIK3CAm) detected in breast carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022-11-02. PMID:36321996. |
alpelisib is a phosphatidylinositol 3-kinase alpha (pi3kα)-selective inhibitor approved for the treatment of hormone receptor positive/her2 negative (hr+/her2-) pik3ca-mutated advanced breast cancer (abc) based on the solar-1 trial, which defined 11 substitutions in exons 7, 9, and 20 in pik3ca (solar1m). |
2022-11-02 |
2023-08-14 |
Not clear |