| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriella V Hernandez, Victoria A Smith, Megan Melnyk, Matthew A Burd, Kimberly A Sprayberry, Mark S Edwards, Daniel G Peterson, Darin C Bennet, Rob K Fanter, Daniel A Columbus, Juan P Steibel, Hunter Glanz, Chad Immoos, Margaret S Rice, Tasha M Santiago-Rodriguez, Jason Blank, Jennifer J VanderKelen, Christopher L Kitts, Brian D Piccolo, Michael R La Frano, Douglas G Burrin, Magdalena Maj, Rodrigo Manjari. Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH. American journal of physiology. Gastrointestinal and liver physiology. vol 318. issue 3. 2020-08-03. PMID:32003601. |
hff-fed pigs developed nash, cholestasis, and impaired enterohepatic farnesoid-x receptor (fxr)-fibroblast growth factor 19 (fgf19) signaling in the absence of obesity and insulin resistance. |
2020-08-03 |
2023-08-13 |
Not clear |
| Caitlin L Maikawa, Anton A A Smith, Lei Zou, Gillie A Roth, Emily C Gale, Lyndsay M Stapleton, Sam W Baker, Joseph L Mann, Anthony C Yu, Santiago Correa, Abigail K Grosskopf, Celine S Liong, Catherine M Meis, Doreen Chan, Megan Troxell, David M Maahs, Bruce A Buckingham, Matthew J Webber, Eric A Appe. A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs. Nature biomedical engineering. vol 4. issue 5. 2020-07-21. PMID:32393892. |
a co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs. |
2020-07-21 |
2023-08-13 |
rat |
| Caitlin L Maikawa, Anton A A Smith, Lei Zou, Gillie A Roth, Emily C Gale, Lyndsay M Stapleton, Sam W Baker, Joseph L Mann, Anthony C Yu, Santiago Correa, Abigail K Grosskopf, Celine S Liong, Catherine M Meis, Doreen Chan, Megan Troxell, David M Maahs, Bruce A Buckingham, Matthew J Webber, Eric A Appe. A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs. Nature biomedical engineering. vol 4. issue 5. 2020-07-21. PMID:32393892. |
here, we show that the supramolecular modification of insulin and pramlintide with cucurbit[7]uril-conjugated polyethylene glycol improves the pharmacokinetics of the dual-hormone therapy and enhances postprandial glucagon suppression in diabetic pigs. |
2020-07-21 |
2023-08-13 |
rat |
| Haiyang Hao, Rutao Lin, Zhiyuan Li, Wenshu Shi, Tongtong Huang, Jianqin Niu, Jianyong Han, Qiuyan L. MC4R deficiency in pigs results in hyperphagia and ultimately hepatic steatosis without high-fat diet. Biochemical and biophysical research communications. vol 520. issue 3. 2020-07-13. PMID:31629472. |
we found that pigs lacking mc4r exhibited hyperorexia, insulin resistance, hyperinsulinemia, disordered lipid metabolism and their livers accumulated significant amounts of fat. |
2020-07-13 |
2023-08-13 |
mouse |
| Bumrae Cho, Eun-Jin Lee, Sun Mi Ahn, Ghangyong Kim, Sang Hoon Lee, Dal-Young Ji, Jung-Taek Kan. Production of genetically modified pigs expressing human insulin and C-peptide as a source of islets for xenotransplantation. Transgenic research. vol 28. issue 5-6. 2020-06-29. PMID:31473874. |
production of genetically modified pigs expressing human insulin and c-peptide as a source of islets for xenotransplantation. |
2020-06-29 |
2023-08-13 |
human |
| Bumrae Cho, Eun-Jin Lee, Sun Mi Ahn, Ghangyong Kim, Sang Hoon Lee, Dal-Young Ji, Jung-Taek Kan. Production of genetically modified pigs expressing human insulin and C-peptide as a source of islets for xenotransplantation. Transgenic research. vol 28. issue 5-6. 2020-06-29. PMID:31473874. |
a recent study reported the generation of transgenic pigs expressing human insulin rather than porcine insulin by changing one amino acid at the end of the β-chain in insulin. |
2020-06-29 |
2023-08-13 |
human |
| Bumrae Cho, Eun-Jin Lee, Sun Mi Ahn, Ghangyong Kim, Sang Hoon Lee, Dal-Young Ji, Jung-Taek Kan. Production of genetically modified pigs expressing human insulin and C-peptide as a source of islets for xenotransplantation. Transgenic research. vol 28. issue 5-6. 2020-06-29. PMID:31473874. |
in this study, we generated transgenic pigs expressing human proinsulin to express human insulin and c-peptide using fibroblasts from proinsulin knockout pigs as donor cells for somatic cell nuclear transfer. |
2020-06-29 |
2023-08-13 |
human |
| Bumrae Cho, Eun-Jin Lee, Sun Mi Ahn, Ghangyong Kim, Sang Hoon Lee, Dal-Young Ji, Jung-Taek Kan. Production of genetically modified pigs expressing human insulin and C-peptide as a source of islets for xenotransplantation. Transgenic research. vol 28. issue 5-6. 2020-06-29. PMID:31473874. |
in conclusion, human insulin- and c-peptide-expressing pigs without porcine insulin and c-peptide were successfully established. |
2020-06-29 |
2023-08-13 |
human |
| Karin J Bosma, Kristen E Syring, James K Oeser, Jason D Lee, Richard K P Benninger, Matthew E Pamenter, Richard M O'Brie. Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species. Journal of molecular evolution. vol 87. issue 4-6. 2020-06-16. PMID:31273433. |
very low islet zinc levels in guinea pigs were thought to be driven by evolution of the ins gene that resulted in the generation of an isoform lacking a histidine at amino acid 10 in the b chain of insulin that is unable to bind zinc. |
2020-06-16 |
2023-08-13 |
rat |
| Melanie A Fontaine, Abdoulaye Diane, Vijay P Singh, Rabban Mangat, Jacqueline A Krysa, Randy Nelson, Benjamin P Willing, Spencer D Procto. Low birth weight causes insulin resistance and aberrant intestinal lipid metabolism independent of microbiota abundance in Landrace-Large White pigs. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 8. 2020-06-01. PMID:31144992. |
low birth weight causes insulin resistance and aberrant intestinal lipid metabolism independent of microbiota abundance in landrace-large white pigs. |
2020-06-01 |
2023-08-13 |
Not clear |
| Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Xudong Zhang, Anna R Kahkoska, Guojun Chen, Zejun Wang, Wujin Sun, Lulu Cai, Zhaowei Chen, Chenggen Qian, Qundong Shen, Ali Khademhosseini, John B Buse, Zhen G. Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs. Science advances. vol 5. issue 7. 2020-05-05. PMID:31309150. |
charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs. |
2020-05-05 |
2023-08-13 |
mouse |
| T Dylan Olver, Zachary I Grunewald, Thaysa Ghiarone, Robert M Restaino, Allan R K Sales, Lauren K Park, Pamela K Thorne, Rama Rao Ganga, Craig A Emter, Peter W R Lemon, J Kevin Shoemaker, Camila Manrique-Acevedo, Luis A Martinez-Lemus, Jaume Padill. Persistent insulin signaling coupled with restricted PI3K activation causes insulin-induced vasoconstriction. American journal of physiology. Heart and circulatory physiology. vol 317. issue 5. 2020-04-06. PMID:31603345. |
last, we examined in isolated resistance arteries from pigs the dual roles of persistent insulin signaling and blunted pi3k activation in modulating vasomotor responses to insulin. |
2020-04-06 |
2023-08-13 |
human |
| Shichun Li, Bo Shi, Kexin Huang, Ying Wan. Different intracellular signalling sensitivity and cell behaviour of porcine insulin with aging. Peptides. vol 127. 2020-03-23. PMID:32109654. |
here, we isolated porcine hepatocytes from young and aged pigs, which endogenously express the ir, as a model to study the intracellular signalling properties and cellular behaviour of insulin with aging. |
2020-03-23 |
2023-08-13 |
Not clear |
| Shichun Li, Bo Shi, Kexin Huang, Ying Wan. Different intracellular signalling sensitivity and cell behaviour of porcine insulin with aging. Peptides. vol 127. 2020-03-23. PMID:32109654. |
firstly, we analysed the intracellular signal transduction that is triggered by insulin in porcine hepatocytes that were isolated from young and aged pigs and found that insulin can strongly activate insulin receptor subunit (irs), protein kinase b (akt), and gsk in a time- and dose-dependent manner in hepatocytes from young pigs. |
2020-03-23 |
2023-08-13 |
Not clear |
| Shichun Li, Bo Shi, Kexin Huang, Ying Wan. Different intracellular signalling sensitivity and cell behaviour of porcine insulin with aging. Peptides. vol 127. 2020-03-23. PMID:32109654. |
on the contrary, the signalling response to insulin in hepatocytes from aged pigs was significantly reduced compared to that of the young pig. |
2020-03-23 |
2023-08-13 |
Not clear |
| Shichun Li, Bo Shi, Kexin Huang, Ying Wan. Different intracellular signalling sensitivity and cell behaviour of porcine insulin with aging. Peptides. vol 127. 2020-03-23. PMID:32109654. |
we found that insulin can translocate into cell nuclei in the hepatocytes of the young pigs; however, insulin/insulin receptor fails to transports into the cell nucleus in hepatocytes from aged pigs, although insulin/insulin receptor could internalize into cell cytoplasm. |
2020-03-23 |
2023-08-13 |
Not clear |
| Shichun Li, Bo Shi, Kexin Huang, Ying Wan. Different intracellular signalling sensitivity and cell behaviour of porcine insulin with aging. Peptides. vol 127. 2020-03-23. PMID:32109654. |
furthermore, we found that the insulin signalling response in hepatocytes was significantly reduced with age; more importantly, we found that the cell behaviour of insulin was changed significantly in the hepatocytes from aged pigs compared to young pigs, and it is noteworthy that insulin/ir cannot translocate into the cell nuclei in the hepatocytes from the aged pig. |
2020-03-23 |
2023-08-13 |
Not clear |
| Masaki Nagaya, Asuka Hayashi, Kazuaki Nakano, Michiyo Honda, Koki Hasegawa, Kazutoshi Okamoto, Shiori Itazaki, Hitomi Matsunari, Masahito Watanabe, Kazuhiro Umeyama, Hiroshi Nagashim. Distributions of endocrine cell clusters during porcine pancreatic development. PloS one. vol 14. issue 5. 2020-01-27. PMID:31075154. |
islets in juvenile pigs are smaller than those in young adult pigs, but the insulin content is very similar. |
2020-01-27 |
2023-08-13 |
Not clear |
| J Colpoys, D Van Sambeek, C Bruns, A Johnson, J Dekkers, F Dunshea, N Gable. Responsiveness of swine divergently selected for feed efficiency to exogenous adrenocorticotropic hormone and glucose challenges. Domestic animal endocrinology. vol 68. 2020-01-06. PMID:30784946. |
as cortisol and insulin are important energy control and growth regulators, our objective was to evaluate the role of the adrenocorticotropic hormone (acth)-cortisol and the glucose-insulin axes in pigs divergently selected for rfi. |
2020-01-06 |
2023-08-13 |
Not clear |
| Dane M Horton, David A Saint, Kathryn L Gatford, Karen L Kind, Julie A Owen. Sex-specific programming of adult insulin resistance in guinea pigs by variable perinatal growth induced by spontaneous variation in litter size. American journal of physiology. Regulatory, integrative and comparative physiology. vol 316. issue 4. 2019-12-30. PMID:30735437. |
sex-specific programming of adult insulin resistance in guinea pigs by variable perinatal growth induced by spontaneous variation in litter size. |
2019-12-30 |
2023-08-13 |
Not clear |