| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nizar I Mourad, Pierre Gianell. Enhanced Insulin Production From Porcine Islets: More Insulin, Less Islets. Transplant international : official journal of the European Society for Organ Transplantation. vol 37. 2025-01-02. PMID:39744044. |
neonatal and even adult porcine islets are known for their low secretory response to physiological stimulation, a shortcoming that is often overcome by implanting extremely large numbers of such islets to compensate for insulin requirement incompatibilities between donor pigs and rodent, non-human primate or human recipients. |
2025-01-02 |
2025-01-04 |
human |
| Nizar I Mourad, Pierre Gianell. Enhanced Insulin Production From Porcine Islets: More Insulin, Less Islets. Transplant international : official journal of the European Society for Organ Transplantation. vol 37. 2025-01-02. PMID:39744044. |
compared to their wild-type counterparts, islets from these transgenic pigs have proven to be better insulin secretors in their native pancreas environment, |
2025-01-02 |
2025-01-04 |
human |
| Katherine Swanson, Jimmy Bell, David Hendrix, Duo Jiang, Michelle Kutzler, Brandon Batty, Melanie Hanlon, Massimo Biona. Bovine milk consumption affects the transcriptome of porcine adipose stem cells: Do exosomes play any role? PloS one. vol 19. issue 12. 2024-12-20. PMID:39705291. |
the downregulation of insulin resistance and inflammatory-related pathways in the asc of milk-fed pigs should be further explored in relation to milk and human health. |
2024-12-20 |
2024-12-23 |
human |
| Nizar I Mourad, Andrea Perota, Daela Xhema, Roberto Duchi, Irina Lagutina, Cesare Galli, Pierre Gianell. Double transgenic neonatal porcine islets as an alternative source for beta cell replacement therapy. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 46. 2024-11-04. PMID:39495930. |
here, we describe in vitro characterization of the secretory function of pancreatic islets, derived from transgenic pigs expressing the glp-1m3r cassette under the porcine insulin promoter (insglp-1m3r), and their usage to treat insulin-dependent diabetes in an immunodeficient mouse model. |
2024-11-04 |
2024-11-07 |
mouse |
| Nizar I Mourad, Andrea Perota, Daela Xhema, Roberto Duchi, Irina Lagutina, Cesare Galli, Pierre Gianell. Double transgenic neonatal porcine islets as an alternative source for beta cell replacement therapy. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 46. 2024-11-04. PMID:39495930. |
our results show that insglp-1m3r islets isolated from neonatal and adult pigs secrete up to 15-fold more insulin in response to glucose stimulation compared to wild-type (wt) islets. |
2024-11-04 |
2024-11-07 |
mouse |
| Michael S Edmonds, Jon R Bergstrom, Thomas E Webe. Efficacy of phytase and/or chromium tripicolinate supplementation on dry matter and nitrogen digestibility and blood metabolites in grower pigs. Journal of animal science. 2024-11-02. PMID:39487755. |
phytase supplementation is widely used throughout the world for enhancing nutrient use efficiencies in pigs, while added chromium has been shown to help stabilize glucose metabolism by enhancing insulin sensitivity. |
2024-11-02 |
2024-11-05 |
Not clear |
| S Cánovas, S Heras, J Romero-Aguirregomezcorta, A A Quintero-Moreno, J Gadea, P Coy, R Roma. Metabolic profile and glycemic response in fully-grown sows born using assisted reproductive technologies. Theriogenology. vol 230. 2024-10-05. PMID:39368453. |
ogtt revealed a different glucose curve pattern (monophasic in ai and biphasic in ivp group), a lower mean concentration of cholesterol, glucose, lactate, triglycerides in ivp compared to ai pigs (p < 0.01), and a higher mean concentration of albumin, creatinine and insulin in ivp compared to ai group (p < 0.05). |
2024-10-05 |
2024-10-08 |
Not clear |
| Kateryna Pierzynowska, Piotr Wychowański, Kamil Zaworski, Jarosław Woliński, Janine Donaldson, Dominika Szkopek, Katarzyna Roszkowicz-Ostrowska, Agata Kondej, Stefan G Pierzynowsk. Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test, proof of acini-islet-acinar interactions. World journal of experimental medicine. vol 14. issue 3. 2024-09-23. PMID:39312707. |
the possible existence of an acini-islet-acinar (aia) reflex, involving mutual amylase and insulin interactions, was investigated in the current acute experiment on pigs. |
2024-09-23 |
2024-09-26 |
Not clear |
| Kangfan Ji, Xiangqian Wei, Anna R Kahkoska, Juan Zhang, Yang Zhang, Jianchang Xu, Xinwei Wei, Wei Liu, Yanfang Wang, Yuejun Yao, Xuehui Huang, Shaoqian Mei, Yun Liu, Shiqi Wang, Zhengjie Zhao, Ziyi Lu, Jiahuan You, Guangzheng Xu, Youqing Shen, John B Buse, Jinqiang Wang, Zhen G. An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs. Nature nanotechnology. 2024-09-02. PMID:39223256. |
an orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs. |
2024-09-02 |
2024-09-05 |
mouse |
| Edith J Mayorga, Erin A Horst, Brady M Goetz, Sonia Rodriguez-Jimenez, Megan A Abeyta, Mohmmad Al-Qaisi, Robert P Rhoads, Joshua T Selsby, Lance H Baumgar. Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows. Journal of animal science. 2024-06-11. PMID:38860702. |
heat-stressed pigs had decreased circulating insulin relative to their tn counterparts (47%; p=0.04); however, the insulin:feed intake ratio tended to increase in hs relative to tn pigs (p=0.09). |
2024-06-11 |
2024-06-14 |
Not clear |
| Ingrid Anna Teigen, Marte Kierulf Åm, Misbah Riaz, Sverre Christian Christiansen, Sven Magnus Carlse. Effects of Low-Dose Glucagon on Subcutaneous Insulin Absorption in Pigs. Current therapeutic research, clinical and experimental. vol 100. 2024-03-21. PMID:38511103. |
effects of low-dose glucagon on subcutaneous insulin absorption in pigs. |
2024-03-21 |
2024-03-23 |
Not clear |
| Lei Liu, Wei Wang, Weiwei Liu, Xingzheng Li, Guoqiang Yi, Adeyinka Abiola Adetula, Haibo Huang, Zhonglin Tan. Comprehensive Atlas of Alternative Splicing Reveals NSRP1 Promoting Adipogenesis through International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474122. |
adipose deposition in eastern pigs might be linked to the down-regulation of immune-inflammation-related pathways and reduced insulin resistance. |
2024-03-13 |
2024-03-15 |
Not clear |
| Ditte Olsen Lützhøft, Cecilie Bækgård, Elizabeth Wimborne, Ellen Marie Straarup, Karen-Margrethe Pedersen, Jonathan R Swann, Henrik Duelund Pedersen, Kim Kristensen, Line Morgills, Dennis Sandris Nielsen, Axel Kornerup Hansen, Marianne Kronborg Bracken, Susanna Cirera, Berit Østergaard Christofferse. High fat diet is associated with gut microbiota dysbiosis and decreased gut microbial derived metabolites related to metabolic health in young Göttingen Minipigs. PloS one. vol 19. issue 3. 2024-03-01. PMID:38427692. |
the hfd-fed pigs presented with metabolic syndrome, gut microbial dysbiosis and a marked decrease in healthy gut microbial products and thus displayed marked parallels to human obesity and insulin resistance. |
2024-03-01 |
2024-03-04 |
human |
| Evelyn J Salvaris, Nella Fisicaro, Stephen McIlfatrick, Adwin Thomas, Erin Fuller, Andrew M Lew, Mark B Nottle, Wayne J Hawthorne, Peter J Cowa. Characterisation of transgenic pigs expressing a human T cell-depleting anti-CD2 monoclonal antibody. Xenotransplantation. 2023-11-14. PMID:37961013. |
in this study, we generated ggta1 knock-in pigs in which mhcip was replaced by the β-cell-specific porcine insulin promoter (pip), and compared the pattern of diliximab expression in the two lines. |
2023-11-14 |
2023-11-20 |
human |
| Sathiya Varadarajan, Arumugam Muruganandam, V Ramesh Kuma. Development and Characterization of Guinea Pig Anti-Insulin Polyclonal Antibody. Applied biochemistry and biotechnology. 2023-09-15. PMID:37713062. |
the paper describes the use of insulin as a target antigen and the development of target (insulin) specific antibodies in guinea pigs for use as a positive control for immunogenicity kit validation. |
2023-09-15 |
2023-10-07 |
Not clear |
| Sathiya Varadarajan, Arumugam Muruganandam, V Ramesh Kuma. Development and Characterization of Guinea Pig Anti-Insulin Polyclonal Antibody. Applied biochemistry and biotechnology. 2023-09-15. PMID:37713062. |
anti-insulin polyclonal antibody was raised against insulin in the dunkin hartley guinea pigs host. |
2023-09-15 |
2023-10-07 |
Not clear |
| Mahdi Ghavami, Jesper Pedersen, Rolf Bech Kjeldsen, Aage Kristian Olsen Alstrup, Zhongyang Zhang, Vasiliki Koulianou, Johan Palmfeldt, Thomas Vorup-Jensen, Lasse Højlund Eklund Thamdrup, Anja Boise. A self-unfolding proximity enabling device for oral delivery of macromolecules. Journal of controlled release : official journal of the Controlled Release Society. 2023-07-28. PMID:37506850. |
one device version is a self-unfolding foil that we have used to deliver insulin and nisin to rats and pigs respectively. |
2023-07-28 |
2023-08-14 |
rat |
| Mahdi Ghavami, Jesper Pedersen, Rolf Bech Kjeldsen, Aage Kristian Olsen Alstrup, Zhongyang Zhang, Vasiliki Koulianou, Johan Palmfeldt, Thomas Vorup-Jensen, Lasse Højlund Eklund Thamdrup, Anja Boise. A self-unfolding proximity enabling device for oral delivery of macromolecules. Journal of controlled release : official journal of the Controlled Release Society. 2023-07-28. PMID:37506850. |
in our study, this device has shown a great potential for delivering peptides, with a significant increase in the absorption of solid dosage of insulin by ~12 times and nisin by ~4 times in rats and pigs, respectively. |
2023-07-28 |
2023-08-14 |
rat |
| He Zhang, Xiaoxi Yan, Ailian Lin, Pengke Xia, Yong S. Inhibition of ghrelin activity by the receptor antagonist [D-Lys3]-GHRP-6 enhances hepatic fatty acid oxidation and gluconeogenesis in a growing pig model. Peptides. 2023-06-10. PMID:37301480. |
dlys treatment significantly increased serum nefa and insulin levels, hepatic glucose level and homa-ir, and significantly decreased serum tba level of growing pigs after fasting. |
2023-06-10 |
2023-08-14 |
Not clear |
| Huanqi Peng, Kaiyi Zhang, Jiakun Miao, Yu Yang, Shuang Xu, Tianwen Wu, Cong Tao, Yanfang Wang, Shulin Yan. SnRNA-Seq of Pancreas Revealed the Dysfunction of Endocrine and Exocrine Cells in Transgenic Pigs with Prediabetes. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175407. |
compared to wild-type (wt) pigs, piginh11 pigs showed similar pathological manifestations to type 2 diabetes patients, such as insulin deficiency, fatty deposition, inflammatory infiltration, fibrosis tissue necrosis, double positive cells, endoplasmic reticulum (er) and mitochondria damage. |
2023-05-14 |
2023-08-14 |
human |