| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jane Kohlhoff, Sara Cibralic, David Hawes, Valsamma Eape. Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: a systematic narrative review. Neuroscience and biobehavioral reviews. 2022-02-12. PMID:35149102. |
this study systematically reviewed available evidence regarding associations between polymorphisms of the oxytocin receptor (oxtr) gene and socio-emotional and behavioral functioning in children and adolescents. |
2022-02-12 |
2023-08-13 |
Not clear |
| Scott E Counts, John S Beck, Erin C McKa. Sex differences in the therapeutic efficacy of oxytocin receptor signaling in a rat model of vascular cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109144. |
we recently demonstrated a de novo upregulation of the oxytocin receptor (oxtr) in astrocytes located in the peri-infarct region of both male and female subjects who died with vascular dementia (multi-infarct subtype). |
2022-02-03 |
2023-08-13 |
human |
| Fei Wang, Xiang-Sha Yin, Jie Lu, Cheng Cen, Yun Wan. Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory. Science signaling. vol 15. issue 719. 2022-02-01. PMID:35104164. |
it is fundamental to social behaviors that can be mediated by the oxytocin receptor (oxtr), such as forming relationships. |
2022-02-01 |
2023-08-13 |
Not clear |
| Manasi Malik, Yingye Fang, Monali Wakle-Prabagaran, Michelle Roh, Kevin Prifti, Antonina I Frolova, Princess I Imoukhuede, Sarah K Englan. Pharmacological chaperones for the oxytocin receptor increase oxytocin responsiveness in myometrial cells. The Journal of biological chemistry. 2022-01-30. PMID:35093385. |
previously, we showed that the v281m variant in the oxytocin receptor (oxtr) gene impairs oxtr trafficking to the cell surface, leading to a decreased oxytocin response in cells. |
2022-01-30 |
2023-08-13 |
human |
| Manasi Malik, Yingye Fang, Monali Wakle-Prabagaran, Michelle Roh, Kevin Prifti, Antonina I Frolova, Princess I Imoukhuede, Sarah K Englan. Pharmacological chaperones for the oxytocin receptor increase oxytocin responsiveness in myometrial cells. The Journal of biological chemistry. 2022-01-30. PMID:35093385. |
here, we sought to identify pharmacological chaperones that increased oxytocin response in cells expressing wild type (wt) or v281m oxtr. |
2022-01-30 |
2023-08-13 |
human |
| Manasi Malik, Yingye Fang, Monali Wakle-Prabagaran, Michelle Roh, Kevin Prifti, Antonina I Frolova, Princess I Imoukhuede, Sarah K Englan. Pharmacological chaperones for the oxytocin receptor increase oxytocin responsiveness in myometrial cells. The Journal of biological chemistry. 2022-01-30. PMID:35093385. |
we screened nine small molecule agonists and antagonists of the oxytocin/vasopressin receptor family and identified two, sr49059 and l371,257, that restored both oxtr trafficking and oxytocin response in hek293t cells transfected with v281m oxtr. |
2022-01-30 |
2023-08-13 |
human |
| Yukiko U Inoue, Hideki Miwa, Kei Hori, Ryosuke Kaneko, Yuki Morimoto, Eriko Koike, Junko Asami, Satoshi Kamijo, Mitsuhiko Yamada, Mikio Hoshino, Takayoshi Inou. Targeting neurons with functional oxytocin receptors: A novel set of simple knock-in mouse lines for oxytocin receptor visualization and manipulation. eNeuro. 2022-01-27. PMID:35082173. |
oxytocin receptor (oxtr) is abundantly expressed in the brain and its relationship to socio-behavioral controls has been extensively studied using mouse brains. |
2022-01-27 |
2023-08-13 |
mouse |
| Minwoo Lee, John Lindo, James K Rillin. Exploring gene-culture coevolution in humans by inferring neuroendophenotypes: A case study of the oxytocin receptor gene and cultural tightness. Genes, brain, and behavior. 2022-01-19. PMID:35044077. |
we present a case study where we explored a gcc dynamics between the oxytocin receptor gene (oxtr) and cultural tightness-looseness. |
2022-01-19 |
2023-08-13 |
human |
| Magdalena Meyer, Benjamin Jurek, Mercedes Alfonso-Prieto, Rui Ribeiro, Vladimir M Milenkovic, Julia Winter, Petra Hoffmann, Christian H Wetzel, Alejandro Giorgetti, Paolo Carloni, Inga D Neuman. Structure-function relationships of the disease-linked A218T oxytocin receptor variant. Molecular psychiatry. 2022-01-04. PMID:34980886. |
various single nucleotide polymorphisms (snps) in the oxytocin receptor (oxtr) gene have been associated with behavioral traits, autism spectrum disorder (asd) and other diseases. |
2022-01-04 |
2023-08-13 |
Not clear |
| Joanna Peris, Katye Totten, Darrice Montgomery, Hannah Lester, Arnika Weatherington, Brian Piotrowski, Sam Sowell, Kristen Doyle, Karen Scott, Yalun Tan, Kaley A MacFadyen, Hannah Engle, Annette D de Kloet, Eric G Kraus. Conditioned social preference and reward value of activating oxytocin-receptor-expressing ventral tegmental area neurons following repeated daily binge ethanol intake. Alcoholism, clinical and experimental research. 2021-12-29. PMID:34964139. |
patients with alcohol use disorder (aud) exhibit disruption of social behavior and dysregulation of oxytocin signaling in the brain, possibly reflecting decreased activation of oxytocin receptors (oxtr) in reward pathways in response to social stimuli. |
2021-12-29 |
2023-08-13 |
Not clear |
| Yiang Yu, Jingxin Li, Chuanyong Li. Oxytocin suppresses epithelial cell-derived cytokines production and alleviates intestinal inflammation in food allergy. Biochemical pharmacology. vol 195. 2021-12-11. PMID:34863977. |
these functions of oxt were abolished by oxytocin receptor (oxtr) depletion. |
2021-12-11 |
2023-08-13 |
mouse |
| Junjie Sun, Zhenyu Xu, Yong Mao, Ting Zhang, Yan Qin, Dong Hu. Prognostic role of oxytocin receptor in colon adenocarcinoma. Open medicine (Warsaw, Poland). vol 16. issue 1. 2021-12-11. PMID:34877409. |
the oxytocin receptor (oxtr) is directly involved in the pathological mechanisms of multiple cancers, including breast cancer, prostate cancer, and ovarian cancer; however, the role of oxtr in the modulation of colon adenocarcinoma (coad) growth, metastasis, and clinical prognosis remains to be elucidated. |
2021-12-11 |
2023-08-13 |
Not clear |
| M L Oliveira, B P Mello, A M Gonella-Diaza, S C Scolari, G Pugliesi, T Martins, I R Feltrin, R Sartori, A M O Canavessi, M Binelli, C M B Membriv. Unravelling the role of 17β-estradiol on advancing uterine luteolytic cascade in cattle. Domestic animal endocrinology. vol 78. 2021-12-09. PMID:34455235. |
except for the well-established upregulation of oxytocin receptor gene (oxtr), molecular mechanisms of e2-induced pgf2α release in vivo remain unknown. |
2021-12-09 |
2023-08-13 |
cattle |
| Keisuke Noto, Akihito Suzuki, Toshinori Shirata, Yoshihiko Matsumoto, Haruka Muraosa, Kaoru Goto, Koichi Otan. Oxytocin receptor polymorphism influences characterization of harm avoidance by moderating susceptibility to affectionless control parenting. Brain and behavior. vol 11. issue 11. 2021-12-09. PMID:34661982. |
oxytocin receptor (oxtr) gene polymorphism reportedly moderates effects of negative environments during childhood on mental function and behavior such as depressive symptoms and externalizing problems. |
2021-12-09 |
2023-08-13 |
human |
| Daniel Almeida, Laura M Fiori, Gary G Chen, Zahia Aouabed, Pierre-Eric Lutz, Tie-Yuan Zhang, Naguib Mechawar, Michael J Meaney, Gustavo Tureck. Oxytocin receptor expression and epigenetic regulation in the anterior cingulate cortex of individuals with a history of severe childhood abuse. Psychoneuroendocrinology. vol 136. 2021-12-09. PMID:34839083. |
we, therefore, aimed to characterize the relationship between early-life adversity and oxytocin receptor (oxtr) expression in the brain, using post-mortem human samples, as well as a rodent model of naturally occurring variation in early-life environment. |
2021-12-09 |
2023-08-13 |
human |
| Manal Tabbaa, Ashley Moses, Elizabeth A D Hammoc. Oxytocin receptor disruption in Avil-expressing cells results in blunted sociability and increased inter-male aggression. PloS one. vol 16. issue 11. 2021-12-03. PMID:34847180. |
oxytocin (oxt) is a neuroactive hormone that regulates social behaviors through its receptor (oxtr), with all previously identified social behavior effects attributed to the central nervous system, which has developmental origins in the neural tube. |
2021-12-03 |
2023-08-13 |
mouse |
| Elena V Kozlova, Matthew C Valdez, Maximillian E Denys, Anthony E Bishay, Julia M Krum, Kayhon M Rabbani, Valeria Carrillo, Gwendolyn M Gonzalez, Gregory Lampel, Jasmin D Tran, Brigitte M Vazquez, Laura M Anchondo, Syed A Uddin, Nicole M Huffman, Eduardo Monarrez, Duraan S Olomi, Bhuvaneswari D Chinthirla, Richard E Hartman, Prasada Rao S Kodavanti, Gladys Chompre, Allison L Phillips, Heather M Stapleton, Bernhard Henkelmann, Karl-Werner Schramm, Margarita C Curras-Collaz. Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71. Archives of toxicology. 2021-11-26. PMID:34687351. |
moreover, f1 l-de-71 displayed downregulated mrna transcripts for oxytocin (oxt) in the bed nucleus of the stria terminalis (bnst) and supraoptic nucleus, and vasopressin (avp) in the bnst and upregulated avp1ar in bnst, and oxtr in the paraventricular nucleus. |
2021-11-26 |
2023-08-13 |
mouse |
| Iris C Reiner, Gerald Gimpl, Manfred E Beutel, Marian J Bakermans-Kranenburg, Helge Frielin. OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study. Journal of molecular neuroscience : MN. 2021-11-25. PMID:34822109. |
we investigated stability and change of plasma and urinary oxytocin as well as oxtr dna methylation patterns through psychotherapy. |
2021-11-25 |
2023-08-13 |
human |
| Iris C Reiner, Gerald Gimpl, Manfred E Beutel, Marian J Bakermans-Kranenburg, Helge Frielin. OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study. Journal of molecular neuroscience : MN. 2021-11-25. PMID:34822109. |
serum and urine oxytocin was measured using standard elisa, and dna methylation of the oxtr gene was assessed using bisulfite sequencing at the time of admission (baseline) and at discharge and from controls at matched time points. |
2021-11-25 |
2023-08-13 |
human |
| Iris C Reiner, Gerald Gimpl, Manfred E Beutel, Marian J Bakermans-Kranenburg, Helge Frielin. OXTR-Related Markers in Clinical Depression: a Longitudinal Case-Control Psychotherapy Study. Journal of molecular neuroscience : MN. 2021-11-25. PMID:34822109. |
plasma oxytocin, urinary oxytocin, and oxtr dna methylation patterns were intrapersonally relatively stable. |
2021-11-25 |
2023-08-13 |
human |