| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vieri Piazzini, Elisa Landucci, Mario D'Ambrosio, Laura Tiozzo Fasiolo, Lorenzo Cinci, Gaia Colombo, Domenico E Pellegrini-Giampietro, Anna Rita Bilia, Cristina Luceri, Maria Camilla Bergonz. Chitosan coated human serum albumin nanoparticles: A promising strategy for nose-to-brain drug delivery. International journal of biological macromolecules. vol 129. 2019-07-24. PMID:30726749. |
nps were loaded with sulforhodamine b sodium salt as model drug and the effect of cs coating was investigated performing release studies, permeation and uptake experiments using caco-2 and hcmec/d3 cells as model of the nasal epithelium and blood-brain barrier, respectively. |
2019-07-24 |
2023-08-13 |
human |
| Yakuto Kaneko, Takayuki Kohno, Takuya Kakuki, Ken-Ichi Takano, Noriko Ogasawara, Ryo Miyata, Shin Kikuchi, Takumi Konno, Tsuyoshi Ohkuni, Ryoto Yajima, Akito Kakiuchi, Shin-Ichi Yokota, Tetsuo Himi, Takashi Kojim. The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells. Scientific reports. vol 7. issue 1. 2019-05-28. PMID:28883651. |
disruption of nasal epithelial tight junctions (tjs) and ciliary dysfunction are found in patients with chronic rhinosinusitis (crs) and nasal polyps (nps), along with an increase of p63-positive basal cells and histone deacetylase (hdac) activity. |
2019-05-28 |
2023-08-13 |
human |
| Tamiru Negash Alkie, Alexander Yitbarek, Khaled Taha-Abdelaziz, Jake Astill, Shayan Shari. Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens. PloS one. vol 13. issue 11. 2019-04-19. PMID:30383798. |
in the second study, the ability of chitosan and mannan coated plga nps that encapsulated aiv and cpg odn was evaluated for inducing antibody responses when delivered via nasal and ocular routes in one-week-old spf layer-type chickens. |
2019-04-19 |
2023-08-13 |
Not clear |
| Robert C Kern, J Pablo Stolovitzky, Stacey L Silvers, Ameet Singh, Jivianne T Lee, David M Yen, Alfred M C Iloreta, Francis P J Langford, Boris Karanfilov, Keith E Matheny, James W Stambaugh, Anna K Gawlick. A phase 3 trial of mometasone furoate sinus implants for chronic sinusitis with recurrent nasal polyps. International forum of allergy & rhinology. vol 8. issue 4. 2019-04-08. PMID:29350840. |
topical intranasal corticosteroid sprays (incss) are standard treatment for nasal polyps (nps), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. |
2019-04-08 |
2023-08-13 |
Not clear |
| Hyun Jung, Dae-Sung Lee, Seong Kook Park, Jung Sik Choi, Won-Kyo Jung, Won Sun Park, Il-Whan Cho. Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways. Marine drugs. vol 16. issue 9. 2019-02-04. PMID:30201895. |
nasal polyps (nps) are a multifactorial disorder associated with a chronic inflammatory state of the nasal mucosa. |
2019-02-04 |
2023-08-13 |
Not clear |
| F Lebre, M C Pedroso de Lima, Ed C Lavelle, O Borge. Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles. International journal of pharmaceutics. vol 552. issue 1-2. 2019-02-04. PMID:30244149. |
importantly, after subcutaneous immunization with ch-al nps combined with the hepatitis b surface antigen (hbsag), mice developed antigen-specific igg titers in serum, nasal and vaginal washes. |
2019-02-04 |
2023-08-13 |
mouse |
| Linmei Pan, Jing Zhou, Feng Ju, Huaxu Zh. Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification. Drug delivery and translational research. vol 8. issue 1. 2018-10-15. PMID:29134552. |
toxicity of nps on nasal mucosal cilia and epithelial cells was also decreased by lf. |
2018-10-15 |
2023-08-13 |
Not clear |
| Qianhui Qiu, Yang Peng, Zhenchao Zhu, Zhuo Chen, Chi Zhang, Hsiao Hui Ong, Kai Sen Tan, Haiyu Hong, Yan Yan, Haoqi Huang, Jing Liu, Xianqing Li, H N Nam, N T N Dung, Li Shi, Qintai Yang, Colin D Bingle, De-Yun Wan. Absence or mislocalization of DNAH5 is a characteristic marker for motile ciliary abnormality in nasal polyps. The Laryngoscope. vol 128. issue 3. 2018-10-09. PMID:29148098. |
motile cilia impairment is a common condition in patients with chronically inflamed airways, such as is seen in nasal polyps (nps). |
2018-10-09 |
2023-08-13 |
Not clear |
| Peng Tian, Fan Wu, Jingyi Wang, Huashuang Ou, Xiang Liu, Qiujian Chen, Hua Dang, Yiqing Zheng, Xianghong Zhang, Hua Zo. Intralesional bleomycin A5 injection for the treatment of nasal polyps through inducing apoptosis. Acta oto-laryngologica. vol 138. issue 5. 2018-09-26. PMID:29490557. |
an intralesional bleomycin a5 (ble) injection might be used as an alternative therapy for eosinophilic-type nasal polyps (nps). |
2018-09-26 |
2023-08-13 |
Not clear |
| Wei Zhang, Jie Zhang, Lei Cheng, Haosheng Ni, Bo You, Ying Shan, Lili Bao, Di Wu, Ting Zhang, Huijun Yue, Jing Che. A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29484441. |
abnormal angiogenesis and vascular permeability is important for the formation of nasal polyps (nps). |
2018-08-30 |
2023-08-13 |
human |
| Aarti Belgamwar, Shagufta Khan, Pramod Yeol. Intranasal chitosan-g-HPβCD nanoparticles of efavirenz for the CNS targeting. Artificial cells, nanomedicine, and biotechnology. vol 46. issue 2. 2018-08-14. PMID:28423949. |
nps appeared histocompatible with porcine nasal mucosa and non-toxic to l929 cell line. |
2018-08-14 |
2023-08-13 |
Not clear |
| Abdur Rauf Khan, Mengrui Liu, Muhammad Wasim Khan, Guangxi Zha. Progress in brain targeting drug delivery system by nasal route. Journal of controlled release : official journal of the Controlled Release Society. vol 268. 2018-07-25. PMID:28887135. |
novel ddss such as nanoparticles (nps), liposomes and polymeric micelles have gained potential as useful tools for targeting the brain without toxicity in nasal mucosa and central nervous system (cns). |
2018-07-25 |
2023-08-13 |
Not clear |
| Trang H D Nguyen, Peng Zhou, Azlin Mustapha, Mengshi Li. Use of aminothiophenol as an indicator for the analysis of silver nanoparticles in consumer products by surface-enhanced Raman spectroscopy. The Analyst. vol 141. issue 18. 2018-07-18. PMID:27349813. |
four dietary supplement products and one nasal spray were selected to evaluate the performance of sers in the detection of ag nps. |
2018-07-18 |
2023-08-13 |
Not clear |
| Jong-Yeup Kim, Dong-Kyu Kim, Myeong Sang Yu, Min-Ji Cha, Seong-Lan Yu, Jaeku Kan. Role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps. Molecular medicine reports. vol 17. issue 1. 2018-07-05. PMID:29115522. |
crs can be divided into two main categories, crs with nasal polyps (nps; crswnp) and crs without nps (crssnp). |
2018-07-05 |
2023-08-13 |
Not clear |
| Jintao Du, Luo Ba, Jiao Zhou, Lingyu Yu, Ruowu Liu, Jie Zhang, Feng Liu, Junming Xian, Shixi Liu, Yafeng Li. The role of cysteinyl leukotrienes and their receptors in refractory nasal polyps. Prostaglandins, leukotrienes, and essential fatty acids. vol 126. 2018-05-31. PMID:29031394. |
nevertheless, the expression of cysteinyl leukotrienes (cyslts) and its receptors (cysltrs) in different types of nasal polyps (nps), and the role of their antagonist in the treatment of refractory chronic rhinosinusitis with nasal polyps (crswnp) are not well understood. |
2018-05-31 |
2023-08-13 |
Not clear |
| Li Xiao, Lei Jia, Lu Bai, Long He, Binyan Yang, Changyou Wu, Huabin L. Phenotypic and functional characteristics of IL-21-expressing CD8(+) T cells in human nasal polyps. Scientific reports. vol 6. 2018-05-18. PMID:27468819. |
although cd4(+) t cells are recognized to play an important role in the inflammatory response of nasal polyps (nps), the biological functions of cd8(+) t cells in polypogenesis remain unclear. |
2018-05-18 |
2023-08-13 |
human |
| Péter Gieszinger, Ildikó Csóka, Edina Pallagi, Gábor Katona, Orsolya Jójárt-Laczkovich, Piroska Szabó-Révész, Rita Ambru. Preliminary study of nanonized lamotrigine containing products for nasal powder formulation. Drug design, development and therapy. vol 11. 2018-05-10. PMID:28860716. |
nasal powders (nps) have better adhesion due to the additive polymers that may be, eg, gelling or good wettability agents; thus, their bioavailability is better compared to the liquid formulations. |
2018-05-10 |
2023-08-13 |
Not clear |
| Daniella Calderon-Nieva, Kalhari Bandara Goonewardene, Susantha Gomis, Marianna Foldvar. Veterinary vaccine nanotechnology: pulmonary and nasal delivery in livestock animals. Drug delivery and translational research. vol 7. issue 4. 2018-04-18. PMID:28639138. |
this review presents promising nps administered via the nasal or pulmonary routes for veterinary applications specifically focusing on livestock animals including poultry. |
2018-04-18 |
2023-08-13 |
human |
| Jintao Du, Luo Ba, Bo Li, Feng Liu, Xianting Hu, Jie Zhang, Yafeng Liu, Junming Xian, Sixi Liu, Huabin L. Distinct expression of NK2 homeobox 1 (NKX2-1) and goblet cell hyperplasia in nasal polyps with different endotypes. International forum of allergy & rhinology. vol 7. issue 7. 2018-04-06. PMID:28318118. |
however, the expression and role of nkx2-1 in nasal polyps (nps) with different endotypes were undefined yet. |
2018-04-06 |
2023-08-13 |
Not clear |
| L Zhao, Y Y Li, C W Li, S S Chao, J Liu, H N Nam, N T N Dung, L Shi, D Y Wan. Increase of poorly proliferated p63 Allergy. vol 72. issue 6. 2018-03-07. PMID:27807867. |
increase of poorly proliferated p63 aberrant epithelial remodeling with the ectopic expression of p63 (basal cell markers) is an important pathologic phenomenon seen in chronically inflamed airway epithelium such as in nasal polyps (nps). |
2018-03-07 |
2023-08-13 |
Not clear |