| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Kook Park, Dae Young Hur, Sang-Hwa Ur. Effects of dexamethasone or methotrexate on chitinolytic activity in nasal polyps. American journal of rhinology & allergy. vol 26. issue 3. 2012-10-05. PMID:22643941. |
chitinolytic activity is significantly increased in nasal polyps (nps) compared with that in normal turbinate mucosa. |
2012-10-05 |
2023-08-12 |
Not clear |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
ciliary beat frequency (cbf) study demonstrated that thiolated nps can be considered as suitable additives for nasal drug delivery systems. |
2012-09-27 |
2023-08-12 |
rat |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
compared to leuprolide solution, unmodified nps and thiolated nps provoked increased leuprolide transport through porcine nasal mucosa by 2.0 and 5.2 folds, respectively. |
2012-09-27 |
2023-08-12 |
rat |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
thiolated nps had a 6.9-fold increase in area under the curve, more than 4-fold increase in elimination half-life, and a ∼3.8-fold increase in maximum plasma concentration compared to nasal solution alone. |
2012-09-27 |
2023-08-12 |
rat |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
the relative nasal bioavailability (versus s.c. injection) of leuprolide thiolated nps calculated on the basis of auc((0-6)) was about 19.6% as compared to leuprolide solution 2.8%. |
2012-09-27 |
2023-08-12 |
rat |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
here, we compared the effects of nps on both social and non-social memory, in male rats, and on social preference/social anxiety versus non-social anxiety after either intracerebroventricular (icv) or nasal application. |
2012-08-13 |
2023-08-12 |
mouse |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
intranasal application of neuropeptides has been successfully employed to alter behavioral parameters in humans and rodents, but studies concerning nasal application of nps are lacking so far. |
2012-08-13 |
2023-08-12 |
mouse |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
third, nasal nps (4-40 nmol applied topically on the rhinarium) facilitated object discrimination in a dose-dependent manner. |
2012-08-13 |
2023-08-12 |
mouse |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
also, the anxiolytic effect of nps on the elevated plus-maze could be confirmed after nasal administration (40 nmol). |
2012-08-13 |
2023-08-12 |
mouse |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
the effects of icv nps were replicated by nasal application of the neuropeptide. |
2012-08-13 |
2023-08-12 |
mouse |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
thus, nasal application of nps seems to be a useful method in rodents for screening for behavioral or physiological effects before more specific and time-consuming, intracerebral methods are employed, and may represent a viable therapeutic approach for nps treatment of patients with psychiatric illnesses such as anxiety or panic disorders. |
2012-08-13 |
2023-08-12 |
mouse |
| Sarah Peterson, Julie A Poposki, Deepti R Nagarkar, Regina T Chustz, Anju T Peters, Lydia A Suh, Roderick Carter, James Norton, Kathleen E Harris, Leslie C Grammer, Bruce K Tan, Rakesh K Chandra, David B Conley, Robert C Kern, Robert P Schleimer, Atsushi Kat. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. The Journal of allergy and clinical immunology. vol 129. issue 1. 2012-07-03. PMID:21943944. |
chronic rhinosinusitis with nasal polyps (crswnp) is associated with t(h)2-dominant inflammation, including eosinophilia, which is in contrast to chronic rhinosinusitis (crs) without nasal polyps (nps). |
2012-07-03 |
2023-08-12 |
Not clear |
| Deepa Patel, Sachin Naik, Ambikanandan Misr. Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain. Journal of pharmaceutical sciences. vol 101. issue 2. 2012-05-11. PMID:22006260. |
the aim of this study was to prepare and characterize thiolated chitosan (tc) nanoparticles (nps) of tizanidine hcl (tz) and to evaluate its transport across monolayer of rpmi 2650 cells (human nasal septum carcinoma cell line) followed by assessment of their pharmacokinetic and pharmacodynamic attributes, after intranasal (i.n.) |
2012-05-11 |
2023-08-12 |
mouse |
| Deepa Patel, Sachin Naik, Ambikanandan Misr. Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain. Journal of pharmaceutical sciences. vol 101. issue 2. 2012-05-11. PMID:22006260. |
nps were prepared using ionotropic gelation and evaluated for mucoadhesion using sheep nasal mucosa for drug permeation and cytotoxicity using monolayer of rpmi 2650 cells. |
2012-05-11 |
2023-08-12 |
mouse |
| Deepa Patel, Sachin Naik, Ambikanandan Misr. Improved transnasal transport and brain uptake of tizanidine HCl-loaded thiolated chitosan nanoparticles for alleviation of pain. Journal of pharmaceutical sciences. vol 101. issue 2. 2012-05-11. PMID:22006260. |
high mucoadhesion and permeation of drug were observed for tc nps with least toxicity to nasal epithelial cells. |
2012-05-11 |
2023-08-12 |
mouse |
| Metin Onerci, Cagdas Elsurer, Elif E Guzel, Attila Dagdevire. Distribution of inflammatory cells, adhesion molecules, intermediate filaments, and chemokine receptors in subgroups of nasal polyp patients. American journal of rhinology & allergy. vol 25. issue 5. 2012-05-09. PMID:21619732. |
the pathogenesis of nasal polyps (nps) is incompletely understood. |
2012-05-09 |
2023-08-12 |
Not clear |
| Ajnacska Rozsasi, Akos Heinemann, Tilman Kec. Cyclooxygenase 2 and lipoxin A₄ in nasal polyps in cystic fibrosis. American journal of rhinology & allergy. vol 25. issue 6. 2012-05-09. PMID:22185734. |
the etiology of nasal polyps (nps) and sinusitis in cystic fibrosis (cf) patients is still unknown. |
2012-05-09 |
2023-08-12 |
Not clear |
| Sevim Bavbek, Berna Dursun, Engin Dursun, Hakan Korkmaz, Durdu Sertkaya Karaso. The prevalence of aspirin hypersensitivity in patients with nasal polyposis and contributing factors. American journal of rhinology & allergy. vol 25. issue 6. 2012-05-09. PMID:22185746. |
aspirin (acetylsalicylic acid [asa]) hypersensitivity is frequent in patients with nasal polyps (nps) and is called aspirin exacerbated respiratory disease, previously known as samter's syndrome. |
2012-05-09 |
2023-08-12 |
Not clear |
| Ji Heui Kim, Hyun Ja Kwon, Yong Ju Jan. Levocetirizine inhibits rhinovirus-induced up-regulation of fibrogenic and angiogenic factors in nasal polyp fibroblasts. American journal of rhinology & allergy. vol 25. issue 6. 2012-05-09. PMID:22185747. |
up-regulation of matrix metalloproteinases (mmps), vascular endothelial growth factor (vegf), and transforming growth factor (tgf) beta, may contribute to the formation of nasal polyps (nps). |
2012-05-09 |
2023-08-12 |
Not clear |
| Xiao-Dan Jiang, Guang-Yu Li, Lin Li, Zhen Dong, Dong-Dong Zh. The characterization of IL-17A expression in patients with chronic rhinosinusitis with nasal polyps. American journal of rhinology & allergy. vol 25. issue 5. 2012-05-09. PMID:22186234. |
more recently, we have shown that the expression of il-17 may be involved in the development of nasal polyps (nps). |
2012-05-09 |
2023-08-12 |
Not clear |