| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A I Camacho, J M Irache, J de Souza, S Sánchez-Gómez, C Gamaz. Nanoparticle-based vaccine for mucosal protection against Shigella flexneri in mice. Vaccine. vol 31. issue 32. 2014-02-05. PMID:23727423. |
when vaccine was delivered by nasal route, encapsulation into nps resulted beneficial in increasing protection from 40% up to 100% when low dose was administered. |
2014-02-05 |
2023-08-12 |
mouse |
| Francisco de Borja Callejas, Cesar Picado, Asunción Martínez-Antón, Isam Alobid, Laura Pujols, Antonio Valero, Jordi Roca-Ferrer, Joaquim Mullo. Differential expression of remodeling markers by tissue structure in nasal polyposis. American journal of rhinology & allergy. vol 27. issue 3. 2013-12-30. PMID:23710947. |
the aim of this study was to establish a qualitative/semiquantitative method of analysis on the expression of these remodeling markers in different tissue structures and eosinophils in both nps and nasal mucosa (nm). |
2013-12-30 |
2023-08-12 |
Not clear |
| Cynthia R Fountain, Pamela A Mudd, Vijay R Ramakrishnan, Stefan H Sillau, Todd T Kingdom, Rohit K Katia. Characterization and treatment of patients with chronic rhinosinusitis and nasal polyps. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. vol 111. issue 5. 2013-12-11. PMID:24125137. |
patients with chronic rhinosinusitis (crs) and nasal polyps (nps) may be subdivided into aspirin-sensitive (as) and aspirin-tolerant (at) populations. |
2013-12-11 |
2023-08-12 |
Not clear |
| Deepti R Nagarkar, Julie A Poposki, Bruce K Tan, Michael R Comeau, Anju T Peters, Kathryn E Hulse, Lydia A Suh, James Norton, Kathleen E Harris, Leslie C Grammer, Rakesh K Chandra, David B Conley, Robert C Kern, Robert P Schleimer, Atsushi Kat. Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis. The Journal of allergy and clinical immunology. vol 132. issue 3. 2013-11-12. PMID:23688414. |
although increased tslp mrna levels have been found in nasal polyps (nps), expression of tslp protein and its function in patients with chronic rhinosinusitis (crs) have not been fully explored. |
2013-11-12 |
2023-08-12 |
Not clear |
| Ferhat Bozkus, Turgay Ulas, Imran San, Yavuz Yesilova, Ismail Iynen, Muhammed Emin Guldur, Nurten Akso. Evaluation of ceruloplasmin levels in patients undergoing surgical interventions with nasal polyps. Auris, nasus, larynx. vol 40. issue 3. 2013-10-18. PMID:23121920. |
oxidative stress is believed to have a role in the development of nasal polyps (nps). |
2013-10-18 |
2023-08-12 |
Not clear |
| Yoshiko Fukuyama, Daisuke Tokuhara, Shinichi Sekine, Kazuyoshi Aso, Kosuke Kataoka, Julia Davydova, Masato Yamamoto, Rebekah S Gilbert, Yuka Tokuhara, Keiko Fujihashi, Jun Kunisawa, Yoshikazu Yuki, Hiroshi Kiyono, Jerry R McGhee, Kohtaro Fujihash. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PloS one. vol 8. issue 4. 2013-09-23. PMID:23565250. |
subsequently, this dc subset became resident in submandibular glands (smgs) and nasal passages (nps) in response to high levels of ccr-ligands produced in these tissues. |
2013-09-23 |
2023-08-12 |
mouse |
| Hong Wook Cho, Seong Kook Park, Kyung Wook Heo, Dae Young Hu. Methotrexate induces apoptosis in nasal polyps via caspase cascades and both mitochondria-mediated and p38 mitogen-activated protein kinases/Jun N-terminal kinase pathways. American journal of rhinology & allergy. vol 27. issue 1. 2013-08-07. PMID:23406595. |
methotrexate (mtx) is a very effective treatment for chronic inflammatory diseases that induces apoptosis in nasal polyps (nps). |
2013-08-07 |
2023-08-12 |
Not clear |
| Tetsuji Takabayashi, Atsushi Kato, Anju T Peters, Kathryn E Hulse, Lydia A Suh, Roderick Carter, James Norton, Leslie C Grammer, Seong H Cho, Bruce K Tan, Rakesh K Chandra, David B Conley, Robert C Kern, Shigeharu Fujieda, Robert P Schleime. Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression. American journal of respiratory and critical care medicine. vol 187. issue 1. 2013-03-17. PMID:23155140. |
nasal polyps (nps) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. |
2013-03-17 |
2023-08-12 |
Not clear |
| S Aversa, C Ondolo, G Abbadessa, F Piccione, V Carriero, A Fulcheri, A Lauria, S De Francia, S Racc. Steroid resistance in nasal polyposis: role of glucocorticoid receptor and TGF-beta1. Rhinology. vol 50. issue 4. 2013-03-01. PMID:23193535. |
glucocorticoids (gcs) are considered drugs of choice for treating nasal polyps (nps). |
2013-03-01 |
2023-08-12 |
Not clear |
| Weiping Wen, Wenlong Liu, Luo Zhang, Jing Bai, Yunping Fan, Wentong Xia, Qing Luo, Jing Zheng, Hongtian Wang, Zuwang Li, Jiahong Xia, Hongyan Jiang, Zheng Liu, Jianbo Shi, Huabin Li, Geng X. Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy. The Journal of allergy and clinical immunology. vol 129. issue 6. 2013-01-23. PMID:22460066. |
nasal polyps (nps) are characterized by eosinophilic inflammation, which is generally considered sensitive to corticosteroid treatment. |
2013-01-23 |
2023-08-12 |
Not clear |
| Mohsen Tafaghodi, Vinay Saluja, Gideon F A Kersten, Heleen Kraan, Bram Slütter, Jean-Pierre Amorij, Wim Jiskoo. Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics. Vaccine. vol 30. issue 36. 2012-12-21. PMID:22749834. |
immunization, tmc:hb nps in hypotonic medium and cht:hb nps in all media induced higher serum and nasal antibody titers compared with hb solution (p<0.001). |
2012-12-21 |
2023-08-12 |
Not clear |
| Tsuguhisa Nakayama, Daiya Asaka, Mamoru Yoshikawa, Tetsushi Okushi, Yoshinori Matsuwaki, Hiroshi Moriyama, Nobuyoshi Otor. Identification of chronic rhinosinusitis phenotypes using cluster analysis. American journal of rhinology & allergy. vol 26. issue 3. 2012-10-05. PMID:22449557. |
although nasal polyps (nps) are a critical factor, many other factors also contribute to the pathogenesis of crs. |
2012-10-05 |
2023-08-12 |
Not clear |
| Seong Kook Park, Dae Young Hur, Sang-Hwa Ur. Effects of dexamethasone or methotrexate on chitinolytic activity in nasal polyps. American journal of rhinology & allergy. vol 26. issue 3. 2012-10-05. PMID:22643941. |
chitinolytic activity is significantly increased in nasal polyps (nps) compared with that in normal turbinate mucosa. |
2012-10-05 |
2023-08-12 |
Not clear |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
ciliary beat frequency (cbf) study demonstrated that thiolated nps can be considered as suitable additives for nasal drug delivery systems. |
2012-09-27 |
2023-08-12 |
rat |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
compared to leuprolide solution, unmodified nps and thiolated nps provoked increased leuprolide transport through porcine nasal mucosa by 2.0 and 5.2 folds, respectively. |
2012-09-27 |
2023-08-12 |
rat |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
thiolated nps had a 6.9-fold increase in area under the curve, more than 4-fold increase in elimination half-life, and a ∼3.8-fold increase in maximum plasma concentration compared to nasal solution alone. |
2012-09-27 |
2023-08-12 |
rat |
| Gul Shahnaz, Anja Vetter, Jan Barthelmes, Deni Rahmat, Flavia Laffleur, Javed Iqbal, Glen Perera, Wolfgang Schlocker, Sarah Dünnhaput, Patrick Augustijns, Andreas Bernkop-Schnürc. Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization. International journal of pharmaceutics. vol 428. issue 1-2. 2012-09-27. PMID:22421322. |
the relative nasal bioavailability (versus s.c. injection) of leuprolide thiolated nps calculated on the basis of auc((0-6)) was about 19.6% as compared to leuprolide solution 2.8%. |
2012-09-27 |
2023-08-12 |
rat |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
here, we compared the effects of nps on both social and non-social memory, in male rats, and on social preference/social anxiety versus non-social anxiety after either intracerebroventricular (icv) or nasal application. |
2012-08-13 |
2023-08-12 |
mouse |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
intranasal application of neuropeptides has been successfully employed to alter behavioral parameters in humans and rodents, but studies concerning nasal application of nps are lacking so far. |
2012-08-13 |
2023-08-12 |
mouse |
| Michael Lukas, Inga D Neuman. Nasal application of neuropeptide S reduces anxiety and prolongs memory in rats: social versus non-social effects. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21871467. |
third, nasal nps (4-40 nmol applied topically on the rhinarium) facilitated object discrimination in a dose-dependent manner. |
2012-08-13 |
2023-08-12 |
mouse |