| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melody C Iacino, Taylor A Stowe, Elizabeth G Pitts, Lacey L Sexton, Shannon L Macauley, Mark J Ferri. A unique multi-synaptic mechanism involving acetylcholine and GABA regulates dopamine release in the nucleus accumbens through early adolescence in male rats. eLife. vol 13. 2024-06-11. PMID:38860652. |
here, we utilized fast scan cyclic voltammetry and microdialysis to examine differences in dopamine release as well as mechanisms that underlie differential dopamine signaling in the nucleus accumbens (nac) core of adolescent (p28-35) and adult (p70-90) male rats. |
2024-06-11 |
2024-06-14 |
rat |
| Yan-Ping Lan, Chen-Zhe Ding, Jian-Xue Xia, Yun-Zhen Yang, Yan-Bin Zha. Analysis of the functional role and mRNA expression of GABABR in the nucleus accumbens of cocaine-addicted rats. Journal of the Chinese Medical Association : JCMA. 2024-06-11. PMID:38860774. |
the nucleus accumbens (nac) is closely related to addiction-related learning memory, and γ-aminobutyric acid type b receptor (gababr) is a potential target for the treatment of drug addiction. |
2024-06-11 |
2024-06-14 |
rat |
| Pan Xu, Gyeongah Park, Xiaoqian Sun, Qian Ge, Zhen Jin, Chien-Hsien Lai, Xiaojie Liu, Qingsong Liu, Rahul Simha, Chen Zeng, Jianyang Du, Hui L. Different emotional states engage distinct descending pathways from the prefrontal cortex. bioRxiv : the preprint server for biology. 2024-06-10. PMID:38853906. |
using in vivo calcium imaging, electrophysiology, and optogenetics, we examined neural circuit dynamics in the medial prefrontal cortex (mpfc), targeting two key areas: the basal lateral amygdala (bla) and nucleus accumbens (nac). |
2024-06-10 |
2024-06-14 |
Not clear |
| Richard Quansah Amissah, Hakan Kayir, Malik Asfandyaar Talhat, Ahmad Hassan, Yu Gu, Ron Johnson, Karolina Urban, Jibran Y Khokha. The Journal of pharmacology and experimental therapeutics. 2024-06-06. PMID:38844363. |
sprague-dawley rats (6 males, 7 females) were implanted with electrodes in the prefrontal cortex (pfc), dorsal hippocampus (dhipp), cingulate cortex (cg), and nucleus accumbens (nac). |
2024-06-06 |
2024-06-10 |
rat |
| Roghayeh Mozafari, Fariba Khodagholi, Neda Kaveh, Mohammad Esmail Zibaii, Peter Kalivas, Abbas Haghparas. Blockade of mGluR5 in nucleus accumbens modulates calcium sensor proteins, facilitates extinction, and attenuates reinstated morphine place preference in rats. Journal of psychiatric research. vol 176. 2024-06-04. PMID:38833749. |
here we focused on the role of mglur5 in the nucleus accumbens (nac) as a main site of glutamate action on the rewarding effects of morphine. |
2024-06-04 |
2024-06-07 |
rat |
| Yao Shen, Xinshuang Gong, Liyin Qian, Yuer Ruan, Shujun Lin, Zhaoying Yu, Zizhen Si, Wenting Wei, Yu Li. Inhibition of GSDMD-dependent pyroptosis decreased methamphetamine self-administration in rats. Brain, behavior, and immunity. 2024-06-04. PMID:38834156. |
the present study firstly investigated whether the membrane pore information induced by gsdmd-dependent pyroptosis was associated with the increased da levels in the ventral tegmental area (vat) and nucleus accumbens (nac) of rats self-administering meth and sy-sh5y cells treated by meth. |
2024-06-04 |
2024-06-07 |
rat |
| Megan Ulmer Carnes, Bryan C Quach, Linran Zhou, Shizhong Han, Ran Tao, Meisha Mandal, Amy Deep-Soboslay, Jesse A Marks, Grier P Page, Brion S Maher, Andrew E Jaffe, Hyejung Won, Laura J Bierut, Thomas M Hyde, Joel E Kleinman, Eric O Johnson, Dana B Hancoc. Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-06-03. PMID:38830989. |
we used genome-wide genotype, dna methylation, and rna sequencing data in postmortem human nucleus accumbens (nac) to identify cis-methylation/expression quantitative trait loci (meqtls/eqtls), investigate variant-by-cigarette smoking interactions across the genome, and overlay qtl evidence at smoking gwas-identified loci to evaluate their regulatory potential. |
2024-06-03 |
2024-06-06 |
human |
| Benjamin C Reiner, Samar N Chehimi, Riley Merkel, Sylvanus Toikumo, Wade H Berrettini, Henry R Kranzler, Sandra Sanchez-Roige, Rachel L Kember, Heath D Schmidt, Richard C Cris. A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826289. |
neural processing of rewarding stimuli involves several distinct regions, including the nucleus accumbens (nac). |
2024-06-03 |
2024-06-05 |
mouse |
| Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Orbitostriatal encoding of reward delayed gratification and impulsivity in chronic pain. Brain research. 2024-05-31. PMID:38821332. |
preclinical and clinical studies have shown the importance of pain-induced dysfunction in both orbitofrontal cortex (ofc) and nucleus accumbens (nac) brain regions for the emergence of cognitive deficits. |
2024-05-31 |
2024-06-02 |
Not clear |
| Young-Jung Kim, Su Jeong Choi, Sa-Ik Hong, Jung-Cheol Park, Youyoung Lee, Shi-Xun Ma, Kwang-Hyun Hur, Young Lee, Kyeong-Man Kim, Hyung Kyu Kim, Hee Young Kim, Seok-Yong Lee, Se-Young Choi, Choon-Gon Jan. The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens. Molecular psychiatry. 2024-05-31. PMID:38822069. |
because the connection between pleasure and drug use becomes hard-wired in the nucleus accumbens (nac), which interfaces motivation, effective therapies need to modulate this mesolimbic reward system. |
2024-05-31 |
2024-06-02 |
mouse |
| Ashley E Copenhaver, Tara A LeGate. Sex-specific mechanisms underlie long-term potentiation at hippocampus-medium spiny neuron synapses in the medial shell of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-05-28. PMID:38806250. |
the connection between the hippocampus (hipp) and nucleus accumbens (nac) is a crucial site where modulation of neuronal activity mediates reward-related behavior. |
2024-05-28 |
2024-06-03 |
mouse |
| Devin P Hagarty, Adam Dawoud, Alfonso Brea Guerrero, Kaynas Phillips, Caroline E Strong, Sarah Dollie Jennings, Michelle Crawford, Katherine Martinez, Olivia Csernecky, Samantha K Saland, Mohamed Kabba. Exploring Ketamine's Reinforcement, Cue-Induced Reinstatement, and Nucleus Accumbens cFos Activation in Male and Female Long Evans Rats. Neuropharmacology. 2024-05-26. PMID:38797243. |
neuronal activation was assessed using the protein expression of the immediate early gene cfos in the nucleus accumbens (nac), an important brain area implicated in reward, reinforcement and reinstatement to most drug-related cues. |
2024-05-28 |
2024-05-31 |
rat |
| Vladimir Visocky, Carleigh J Turner, Matthew H Lowrie, Anthony Alibro, Fany Messanvi, Yogita Chudasam. Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine. bioRxiv : the preprint server for biology. 2024-05-26. PMID:38766011. |
the basolateral amygdala (bla) and nucleus accumbens (nac) are stress sensitive brain areas that alter extracellular levels of norepinephrine (ne) and dopamine (da), respectively. |
2024-05-26 |
2024-05-27 |
rat |
| Devin P Hagarty, Adam Dawoud, Alfonso Brea Guerrero, Kaynas Phillips, Caroline E Strong, Sarah Dollie Jennings, Michelle Crawford, Katherine Martinez, Olivia Csernecky, Samantha K Saland, Mohamed Kabba. Exploring Ketamine's Reinforcement, Cue-Induced Reinstatement, and Nucleus Accumbens cFos Activation in Male and Female Long Evans Rats. Neuropharmacology. 2024-05-26. PMID:38797243. |
neuronal activation was assessed using the protein expression of the immediate early gene cfos in the nucleus accumbens (nac), an important brain area implicated in reward, reinforcement and reinstatement to most drug-related cues. |
2024-05-26 |
2024-05-31 |
rat |
| Camilla Morosini, Fabio Vivarelli, Laura Rullo, Emilia Volino, Loredana Maria Losapio, Moreno Paolini, Patrizia Romualdi, Donatella Canistro, Sanzio Candelett. Unburned Tobacco Smoke Affects Neuroinflammation-Related Pathways in the Rat Mesolimbic System. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791298. |
this study investigated the impact of prolonged nicotine exposure via a heat-not-burn (hnb) device on selected genes and signaling proteins involved in inflammatory processes in the rat ventral tegmental area (vta) and nucleus accumbens (nac), two brain regions associated with addiction to different drugs, including nicotine. |
2024-05-25 |
2024-05-27 |
rat |
| Sanae Inokuchi-Sakata, Ryo Narita, Yukari Takahashi, Yozo Ishiuji, Akihiko Asahina, Fusao Kat. Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice - a model-free multivariate analysis. Molecular brain. vol 17. issue 1. 2024-05-24. PMID:38783364. |
to address this issue, we targeted the "reward center" of the brain, the nucleus accumbens (nac), in which itch-responsive neurons have been found in rodents. |
2024-05-24 |
2024-05-27 |
mouse |
| Qiaowei Xie, Mark D Namba, Lauren A Buck, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Effects of Antiretroviral Treatment on Central and Peripheral Immune Response in Mice with EcoHIV Infection. Cells. vol 13. issue 10. 2024-05-24. PMID:38786105. |
thus, these experiments used multiplexed chemokine/cytokine arrays to assess peripheral (plasma) and brain (nucleus accumbens; nac) expression of immune targets in the presence and absence of art treatment in the ecohiv mouse model. |
2024-05-24 |
2024-05-27 |
mouse |
| Jiajia Li, Chi Pan, Bingwu Huang, Jiani Qiu, Chenchen Jiang, Zhanglei Dong, Jun Li, Qingquan Lian, Binbin W. NMDA receptor within nucleus accumbens shell regulates propofol self-administration through D1R/ERK/CREB signalling pathway. Addiction biology. vol 29. issue 5. 2024-05-23. PMID:38782631. |
the nucleus accumbens (nac) shell (nash) in the brain, along with the interactions between n-methyl-d-aspartate receptor (nmdar) and the dopamine d1 receptor (d1r), as well as their downstream erk/creb signalling pathway in the nac, are integral in regulating reward-seeking behaviour. |
2024-05-23 |
2024-05-27 |
rat |
| Arlene Martínez-Rivera, Robert N Fetcho, Lizzie Birmingham, Jin X Jiu, Ruirong Yang, Careen Foord, Diego Scala-Chávez, Narmin Mekawy, Kristen Pleil, Virginia M Pickel, Conor Liston, Carlos M Castorena, Joshua Levitz, Ying-Xian Pan, Lisa A Briand, Anjali M Rajadhyaksha, Francis S Le. Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38766079. |
using fiber photometry with fluorescent sensors for calcium and dopamine (da), we find that enhancing 2-ag levels diminishes opioid reward-related nucleus accumbens (nac) activity and da neurotransmission. |
2024-05-20 |
2024-05-27 |
mouse |
| Shervin Assari, Payam Sheikhattar. Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events. Journal of mental health & clinical psychology. vol 8. issue 2. 2024-05-18. PMID:38751734. |
these events may influence substance use by altering brain reward systems, especially the nucleus accumbens (nac), which plays a key role in motivated behaviors and reward processing. |
2024-05-18 |
2024-05-27 |
Not clear |