| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kent C Berridge, Morten L Kringelbac. Neuroscience of affect: brain mechanisms of pleasure and displeasure. Current opinion in neurobiology. vol 23. issue 3. 2014-01-06. PMID:23375169. |
pleasure 'liking' is especially generated by restricted hedonic hotspot circuits in nucleus accumbens (nac) and ventral pallidum. |
2014-01-06 |
2023-08-12 |
Not clear |
| Su Yeon Seo, Jeong Hwan Oh, Eun Sang Cho. Protein kinase G increases AMPA receptor GluR1 phosphorylation at serine 845 after repeated cocaine administration in the rat nucleus accumbens. Neuroscience letters. vol 544. 2014-01-06. PMID:23583340. |
the regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor glur1 subunit phosphorylation at serine 845 (glur1-ser845) by protein kinase g (pkg) activation was investigated in the nucleus accumbens (nac) after repeated cocaine administration. |
2014-01-06 |
2023-08-12 |
rat |
| Lucas Albrechet-Souza, Milene Cristina Carvalho, Marcus Lira Brandã. D(1)-like receptors in the nucleus accumbens shell regulate the expression of contextual fear conditioning and activity of the anterior cingulate cortex in rats. The international journal of neuropsychopharmacology. vol 16. issue 5. 2014-01-03. PMID:22964037. |
in fact, projection areas of the ventral tegmental area, such as the amygdala and hippocampus, are well established to be involved in the acquisition and expression of fear conditioning, while less is known about the role of the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) in these processes. |
2014-01-03 |
2023-08-12 |
rat |
| Lan Ma, Yu-Mei Wu, Yan-Yan Guo, Qi Yang, Bin Feng, Qian Song, Shui-Bing Liu, Da-Qing Zhao, Ming-Gao Zha. Nicotine addiction reduces the large-conductance Ca(2+)-activated potassium channels expression in the nucleus accumbens. Neuromolecular medicine. vol 15. issue 2. 2014-01-03. PMID:23242511. |
in the present study, a significant reduction in bkca channel expression was found in nucleus accumbens (nac) from nicotine addiction mice. |
2014-01-03 |
2023-08-12 |
mouse |
| Michael R Hagerty, Julian Isaacs, Leigh Brasington, Larry Shupe, Eberhard E Fetz, Steven C Crame. Case study of ecstatic meditation: fMRI and EEG evidence of self-stimulating a reward system. Neural plasticity. vol 2013. 2013-12-30. PMID:23738149. |
in particular, the extreme joy is associated not only with activation of cortical processes but also with activation of the nucleus accumbens (nac) in the dopamine/opioid reward system. |
2013-12-30 |
2023-08-12 |
human |
| Fabio Fumagalli, Federico Moro, Lucia Caffino, Alessandro Orrù, Chiara Cassina, Giuseppe Giannotti, Angelo Di Clemente, Giorgio Racagni, Marco A Riva, Luigi Cerv. Region-specific effects on BDNF expression after contingent or non-contingent cocaine i.v. self-administration in rats. The international journal of neuropsychopharmacology. vol 16. issue 4. 2013-12-27. PMID:23164369. |
brain-derived neurotrophic factor (bdnf) dynamic changes were investigated in the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) during use and the early phases of cocaine abstinence after 14 sessions (2 h self-administration/d; 0.25 mg/0.1 ml.6 s infusion) by employing a 'yoked control-operant paradigm'. |
2013-12-27 |
2023-08-12 |
rat |
| Brian R Lee, Yao-Ying Ma, Yanhua H Huang, Xiusong Wang, Mami Otaka, Masago Ishikawa, Peter A Neumann, Nicholas M Graziane, Travis E Brown, Anna Suska, Changyong Guo, Mary Kay Lobo, Susan R Sesack, Marina E Wolf, Eric J Nestler, Yavin Shaham, Oliver M Schlüter, Yan Don. Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nature neuroscience. vol 16. issue 11. 2013-12-27. PMID:24077564. |
this 'incubation of cocaine craving' is partially mediated by time-dependent adaptations at glutamatergic synapses in nucleus accumbens (nac). |
2013-12-27 |
2023-08-12 |
rat |
| J M Bessa, M Morais, F Marques, L Pinto, J A Palha, O F X Almeida, N Sous. Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens. Translational psychiatry. vol 3. 2013-12-23. PMID:23736119. |
there is accumulating evidence that the nucleus accumbens (nac) has an important role in the pathophysiology of depression. |
2013-12-23 |
2023-08-12 |
rat |
| A van Dijk, M Klanker, N van Oorschot, R Post, R Hamelink, M G P Feenstra, D Deny. Deep brain stimulation affects conditioned and unconditioned anxiety in different brain areas. Translational psychiatry. vol 3. 2013-12-23. PMID:23900312. |
deep brain stimulation (dbs) of the nucleus accumbens (nac) has proven to be an effective treatment for therapy refractory obsessive-compulsive disorder. |
2013-12-23 |
2023-08-12 |
rat |
| Clinton B McCracken, Anthony A Grac. Persistent cocaine-induced reversal learning deficits are associated with altered limbic cortico-striatal local field potential synchronization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 44. 2013-12-23. PMID:24174680. |
evidence suggests that these deficits are mediated in part by a circuit involving the medial prefrontal and orbitofrontal cortices (pfc and ofc), nucleus accumbens (nac), and basolateral amygdala (bla). |
2013-12-23 |
2023-08-12 |
rat |
| F Saint-Preux, L R Bores, I Tulloch, B Ladenheim, R Kim, P K Thanos, N D Volkow, J L Cade. Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats. Neuroscience. vol 243. 2013-12-17. PMID:23562942. |
chronic exposure to either nicotine or meth caused significant decreases in the expression of fosb, fra1, and fra2 in the nucleus accumbens (nac) but not in the dorsal striatum whereas the drug combination increased fra2 expression in both structures. |
2013-12-17 |
2023-08-12 |
rat |
| Yu Dong, John A Dani, Randy D Blakel. Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23939187. |
the firing of da neurons residing in the ventral tegmental area (vta), and the release of da by the projections of these neurons in the nucleus accumbens (nac), is under tight control by cholinergic signaling mediated by nicotinic acetylcholine (ach) receptors (nachrs). |
2013-12-17 |
2023-08-12 |
mouse |
| Ryo Kawahara, Fumio Soeda, Kazuaki Kawaura, Sokichi Honda, Risa Miki, Tetsuro Noguchi, Tetsuya Shirasaki, Kazuo Takaham. Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain. Brain research. vol 1513. 2013-12-16. PMID:23548603. |
here, the effect of a single injection of an antidepressive dose of tipepidine on fli was studied in seven areas of the rat brain including the central nucleus of the amygdala (cea) and the nucleus accumbens (nac). |
2013-12-16 |
2023-08-12 |
rat |
| Charlene Diepenbroek, Geoffrey van der Plasse, Leslie Eggels, Merel Rijnsburger, Matthijs G P Feenstra, Andries Kalsbeek, Damiaan Denys, Eric Fliers, Mireille J Serlie, Susanne E la Fleu. Alterations in blood glucose and plasma glucagon concentrations during deep brain stimulation in the shell region of the nucleus accumbens in rats. Frontiers in neuroscience. vol 7. 2013-12-16. PMID:24339800. |
deep brain stimulation (dbs) of the nucleus accumbens (nac) is an effective therapy for obsessive compulsive disorder (ocd) and is currently under investigation as a treatment for eating disorders. |
2013-12-16 |
2023-08-12 |
rat |
| Yu Ma, Ning Chen, Hui-Min Wang, Fan-Gang Meng, Jian-Guo Zhan. Inhibition of the reinstatement of morphine-induced place preference in rats by high-frequency stimulation of the bilateral nucleus accumbens. Chinese medical journal. vol 126. issue 10. 2013-12-13. PMID:23673114. |
many studies have identified a central role of the nucleus accumbens (nac) in addiction. |
2013-12-13 |
2023-08-12 |
rat |
| Juergen Voges, Ulf Müller, Bernhard Bogerts, Thomas Münte, Hans-Jochen Heinz. Deep brain stimulation surgery for alcohol addiction. World neurosurgery. vol 80. issue 3-4. 2013-12-05. PMID:22824557. |
motivated by an accidental observation, we used the nucleus accumbens (nac), which has a central position in the dopaminergic reward system for deep brain stimulation (dbs) of alcohol addiction. |
2013-12-05 |
2023-08-12 |
Not clear |
| Nan Li, Jing Wang, Xue-lian Wang, Chong-wang Chang, Shun-nan Ge, Li Gao, He-ming Wu, Hai-kang Zhao, Ning Geng, Guo-dong Ga. Nucleus accumbens surgery for addiction. World neurosurgery. vol 80. issue 3-4. 2013-12-05. PMID:23046915. |
multiple studies identify a central role of the nucleus accumbens (nac) in addiction; several studies note decreased addictive behavior after interventions in this area. |
2013-12-05 |
2023-08-12 |
Not clear |
| Andrew C Meyer, Nichole M Neugebauer, Guangrong Zheng, Peter A Crooks, Linda P Dwoskin, Michael T Bard. Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. Journal of neurochemistry. vol 127. issue 2. 2013-12-02. PMID:23875705. |
the current study determined the effects of vmat2 inhibitors lobeline (lob; 1 or 3 mg/kg) and n-(1,2r-dihydroxylpropyl)-2,6-cis-di(4-methoxyphenethyl)piperidine hydrochloride (gz-793a; 15 or 30 mg/kg) on meth-induced (0.5 mg/kg, sc) changes in extracellular dopamine (da) and its metabolite dihydroxyphenylacetic acid (dopac) in the reward-relevant nucleus accumbens (nac) shell using in vivo microdialysis. |
2013-12-02 |
2023-08-12 |
rat |
| David S Tukey, Michelle Lee, Duo Xu, Sarah E Eberle, Yossef Goffer, Toby R Manders, Edward B Ziff, Jing Wan. Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens. Molecular brain. vol 6. 2013-11-27. PMID:23835161. |
both pain and rewards, however, have been shown to alter synaptic activities in the nucleus accumbens (nac), a key component of the brain reward system. |
2013-11-27 |
2023-08-12 |
Not clear |
| Alessandro Ciccarelli, Arianna Calza, Francesca Santoru, Fabrizio Grasso, Alessandra Concas, Marco Sassoè-Pognetto, Maurizio Giustett. Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum. Neuropharmacology. vol 70. 2013-11-26. PMID:23347952. |
we found that naloxone-precipitated withdrawal, but not chronic morphine administration, caused a strong induction of phospho-histone h3 immunoreactivity in the nucleus accumbens (nac) shell/core and in the lateral septum (ls), a change that was accompanied by augmented h3 acetylation (lys14) in neurons of the nac shell. |
2013-11-26 |
2023-08-12 |
Not clear |