| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gui-Ying Zan, Qian Wang, Yu-Jun Wang, Yao Liu, Ai Hang, Xiao-Hong Shu, Jing-Gen Li. Antagonism of κ opioid receptor in the nucleus accumbens prevents the depressive-like behaviors following prolonged morphine abstinence. Behavioural brain research. vol 291. 2016-03-28. PMID:26049060. |
prodynorphin mrna and protein levels were increased in the nucleus accumbens (nac) after four weeks of morphine withdrawal. |
2016-03-28 |
2023-08-13 |
mouse |
| Changliang Liu, Xing Fang, Qianqian Wu, Guozhang Jin, Xuechu Zhe. Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area. Neuropharmacology. vol 95. 2016-03-24. PMID:25882828. |
using in vivo microdialysis, we find that inactivation of the pfc also reduces the morphine-induced elevation of da levels in the nucleus accumbens (nac). |
2016-03-24 |
2023-08-13 |
Not clear |
| Ivan Diamond, Lina Ya. From Ancient Chinese Medicine to a Novel Approach to Treat Cocaine Addiction. CNS & neurological disorders drug targets. vol 14. issue 6. 2016-03-23. PMID:26022266. |
we have synthesized highly selective novel aldh2 inhibitors (aldh2i) that block alcohol- and cocaine cue-induced surges in nucleus accumbens (nac) da and prevent reinstatement of alcohol heavy drinking, cocaine self-administration and reinstatement of cocaine relapse-like behavior. |
2016-03-23 |
2023-08-13 |
human |
| Yang Yang, Ying Zhang, Xin Hai Li, Yang Li, Ran Qian, Jun Li, Shi Lian X. Involvements of galanin and its receptors in antinociception in nucleus accumbens of rats with inflammatory pain. Neuroscience research. vol 97. 2016-03-21. PMID:25819845. |
this study tested the hypothesis that antinociceptive effects of galanin and its receptors in nucleus accumbens (nac) of rats with inflammatory pain provoked by subcutaneous injection of 0.1 ml of 2% carrageenin into the sole of the rat's left hindpaw. |
2016-03-21 |
2023-08-13 |
rat |
| Mario E Alburges, Amanda J Hoonakker, Nathaniel M Cordova, Christina M Robson, Lisa M McFadden, Amber L Martin, Glen R Hanso. Effect of low doses of methamphetamine on rat limbic-related neurotensin systems. Synapse (New York, N.Y.). vol 69. issue 8. 2016-03-21. PMID:25963809. |
for comparison, we tested the effect of low doses of meth, that are more like those used in therapy, on ntli in the core and shell of the nucleus accumbens (nac and nas), prefrontal cortex (pfc), ventral tegmental area (vta), the lateral habenula (hb) and basolateral amygdala (amyg). |
2016-03-21 |
2023-08-13 |
rat |
| Vincent Pascoli, Jean Terrier, Agnès Hiver, Christian Lüsche. Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction. Neuron. vol 88. issue 5. 2016-03-21. PMID:26586182. |
after weeks of abstinence, cue-induced relapse was observed in parallel with a potentiation of excitatory afferents onto d1 receptor-expressing neurons of the nucleus accumbens (nac). |
2016-03-21 |
2023-08-13 |
mouse |
| Brittni M Peterson, Paul G Mermelstein, Robert L Meise. Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5. Brain structure & function. vol 220. issue 4. 2016-03-18. PMID:24878822. |
because dendritic spine plasticity in the nucleus accumbens (nac) is linked to the addictive effects of drugs, we examined the influence of estradiol on dendritic spines in this region. |
2016-03-18 |
2023-08-13 |
human |
| Kevin R Coffey, David J Barker, Nick Gayliard, Julianna M Kulik, Anthony P Pawlak, Joshua P Stamos, Mark O Wes. Electrophysiological evidence of alterations to the nucleus accumbens and dorsolateral striatum during chronic cocaine self-administration. The European journal of neuroscience. vol 41. issue 12. 2016-03-16. PMID:25952463. |
two particular portions of the striatum, the nucleus accumbens (nac) and the dorsolateral striatum (dls), are known to undergo neurobiological changes from acute to chronic drug use. |
2016-03-16 |
2023-08-13 |
Not clear |
| Julie A Suyama, Farhana Sakloth, Renata Kolanos, Richard A Glennon, Matthew F Lazenka, S Stevens Negus, Matthew L Bank. Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin. The Journal of pharmacology and experimental therapeutics. vol 356. issue 1. 2016-03-15. PMID:26645638. |
the present study used in vivo microdialysis to determine the relationship between these previous measures and the in vivo neurochemical selectivity of these compounds to alter nucleus accumbens (nac) da and 5-ht levels. |
2016-03-15 |
2023-08-13 |
rat |
| Eric J Nestle. ∆FosB: a transcriptional regulator of stress and antidepressant responses. European journal of pharmacology. vol 753. 2016-03-14. PMID:25446562. |
such prolonged induction of Δfosb, within nucleus accumbens (nac), a key brain reward region, has been most studied in animal models of drug addiction, with considerable evidence indicating that Δfosb promotes reward and motivation and serves as a mechanism of drug sensitization and increased drug self-administration. |
2016-03-14 |
2023-08-13 |
mouse |
| Rhona Clarke, Louise Adermar. Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol. Neural plasticity. vol 2015. 2016-03-08. PMID:26246915. |
the ventral striatum (nucleus accumbens (nac)) and its reciprocal connection with the ventral tegmental area (vta) represent a primary component of the reward system, but reward-guided learning also involves the dorsal striatum and dopaminergic inputs from the substantia nigra. |
2016-03-08 |
2023-08-13 |
Not clear |
| Audrey E Padula, William C Griffin, Marcelo F Lopez, Sudarat Nimitvilai, Reginald Cannady, Natalie S McGuier, Elissa J Chesler, Michael F Miles, Robert W Williams, Patrick K Randall, John J Woodward, Howard C Becker, Patrick J Mulhollan. KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 8. 2016-03-08. PMID:25662840. |
alcohol preference and dependence qtls contain kcnn2 and kcnn3, and kcnn3 transcript levels in the nucleus accumbens (nac) of genetically diverse bxd strains of mice predicted voluntary alcohol consumption. |
2016-03-08 |
2023-08-13 |
mouse |
| Michael D Reed, David G C Hildebrand, Gabrielle Santangelo, Anthony Moffa, Ashley S Pira, Lisa Rycyna, Mia Radic, Katherine Price, Jonathan Archbold, Kristi McConnell, Lauren Girard, Kristen Morin, Anna Tang, Marcelo Febo, James R Stella. Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior. Drug and alcohol dependence. vol 153. 2016-03-02. PMID:26048642. |
the nucleus accumbens (nac) plays a key role in brain reward processes including drug seeking and reinstatement. |
2016-03-02 |
2023-08-13 |
Not clear |
| Gislaine Z Réus, Helena M Abelaira, Amanda L Maciel, Maria Augusta B Dos Santos, Anelise S Carlessi, Amanda V Steckert, Gabriela K Ferreira, Samira D De Prá, Emilio L Streck, Danielle S Macêdo, João Queved. Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress. Metabolic brain disease. vol 30. issue 2. 2016-03-01. PMID:25112549. |
the oxidative stress and energy metabolism parameters were assessed in the prefrontal cortex (pf), hippocampus (hip), amygdala (amy) and nucleus accumbens (nac). |
2016-03-01 |
2023-08-13 |
rat |
| Rahul Pandit, Esther M van der Zwaal, Mieneke C M Luijendijk, Maike A D Brans, Andrea J van Rozen, Ralph J A Oude Ophuis, Louk J M J Vanderschuren, Roger A H Adan, Susanne E la Fleu. Central melanocortins regulate the motivation for sucrose reward. PloS one. vol 10. issue 3. 2016-02-29. PMID:25811380. |
mc receptors are widely expressed in both hypothalamic and extra-hypothalamic brain regions, including nuclei involved in food reward and motivation, such as the nucleus accumbens (nac) and the ventral tegmental area. |
2016-02-29 |
2023-08-13 |
rat |
| Rosemary C Bagot, Eric M Parise, Catherine J Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A Bolaños-Guzmán, Joseph F Cheer, Joseph Cheer, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature communications. vol 6. 2016-02-29. PMID:25952660. |
enhanced glutamatergic transmission in the nucleus accumbens (nac), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. |
2016-02-29 |
2023-08-13 |
mouse |
| Don Wei, DaYeon Lee, Conor D Cox, Carley A Karsten, Olga Peñagarikano, Daniel H Geschwind, Christine M Gall, Daniele Piomell. Endocannabinoid signaling mediates oxytocin-driven social reward. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 45. 2016-02-29. PMID:26504214. |
here we report that social contact increases, whereas isolation decreases, the mobilization of the endogenous marijuana-like neurotransmitter, anandamide, in the mouse nucleus accumbens (nac), a brain structure that regulates motivated behavior. |
2016-02-29 |
2023-08-13 |
mouse |
| Eun Young Jang, Yeon-Hee Ryu, Bong Hyo Lee, Su-Chan Chang, Mi Jin Yeo, Sang Hyun Kim, Ryan J Folsom, Nathan D Schilaty, Kwang Joong Kim, Chae Ha Yang, Scott C Steffensen, Hee Young Ki. Involvement of reactive oxygen species in cocaine-taking behaviors in rats. Addiction biology. vol 20. issue 4. 2016-02-29. PMID:24975938. |
the aim of this study was to evaluate cocaine enhancement of brain metabolic activity and the effects of ros scavengers on cocaine self-administration behavior, cocaine-induced ros production in the nucleus accumbens (nac) and cocaine enhancement of da release in the nac. |
2016-02-29 |
2023-08-13 |
rat |
| Yvonne E Ogbonmwan, Natale R Sciolino, Jessica L Groves-Chapman, Kimberly G Freeman, Jason P Schroeder, Gaylen L Edwards, Philip V Holmes, David Weinshenke. The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex. Addiction biology. vol 20. issue 4. 2016-02-29. PMID:25053279. |
we found that galnon attenuated cocaine-induced motor activity, reinstatement and da overflow in the frontal cortex at a dose that did not reduce baseline motor activity, stable self-administration of cocaine, baseline extracellular da levels or cocaine-induced da overflow in the nucleus accumbens (nac). |
2016-02-29 |
2023-08-13 |
rat |
| Yu-Wei Chen, Kimberly A Fiscella, Samuel Z Bacharach, Gianluigi Tanda, Yavin Shaham, Donna J Cal. Effect of yohimbine on reinstatement of operant responding in rats is dependent on cue contingency but not food reward history. Addiction biology. vol 20. issue 4. 2016-02-29. PMID:25065697. |
we also used in vivo microdialysis to determine yohimbine's effect on dopamine levels in nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2016-02-29 |
2023-08-13 |
rat |