| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianglong Zhu, David Ottenheimer, Ralph J DiLeon. Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake. Frontiers in behavioral neuroscience. vol 10. 2016-05-05. PMID:27147989. |
the nucleus accumbens (nac) is one brain region that has received attention for its role in the regulation of energy balance; its d1 and d2 receptor containing neurons have distinct functions in regulating reward behavior and require further examination. |
2016-05-05 |
2023-08-13 |
human |
| Virpi Laukkanen, Olli Kärkkäinen, Hannu Kautiainen, Jari Tiihonen, Markus Storvi. Decreased [3H]naloxone Binding in the Dentate Gyrus of Cloninger Type 1 Anxiety-Prone Alcoholics: A Postmortem Whole-Hemisphere Autoradiography Study. Alcoholism, clinical and experimental research. vol 39. issue 8. 2016-05-02. PMID:26147003. |
enhanced mor function inhibits the gabaergic inhibition of the nucleus accumbens (nac), which leads to a release of dopamine in the nac. |
2016-05-02 |
2023-08-13 |
Not clear |
| Donald M Kuhn, Mariana Angoa-Pérez, David M Thoma. Nucleus accumbens invulnerability to methamphetamine neurotoxicity. ILAR journal. vol 52. issue 3. 2016-04-22. PMID:23382149. |
the nucleus accumbens (nac) is largely spared the damage that accompanies binge meth intoxication, but relatively subtle changes in the disposition of da in its nerve endings can lead to dramatic increases in meth-induced toxicity in the cpu and overcome the normal resistance of the nac to damage. |
2016-04-22 |
2023-08-12 |
human |
| Susana Mingote, Nao Chuhma, Sheila V Kusnoor, Bianca Field, Ariel Y Deutch, Stephen Raypor. Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 49. 2016-04-20. PMID:26658874. |
in the ventral tegmental area (vta), a subpopulation of dopamine neurons express vesicular glutamate transporter 2 and make glutamatergic connections to nucleus accumbens (nac) and olfactory tubercle (ot) neurons. |
2016-04-20 |
2023-08-13 |
mouse |
| Kelly A Zalocusky, Charu Ramakrishnan, Talia N Lerner, Thomas J Davidson, Brian Knutson, Karl Deisserot. Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making. Nature. vol 531. issue 7596. 2016-04-20. PMID:27007845. |
this activity occurred within dopamine receptor type-2 (d2r)-expressing cells in the nucleus accumbens (nac), signalled unfavourable outcomes from the recent past at a time appropriate for influencing subsequent decisions, and also predicted subsequent choices made. |
2016-04-20 |
2023-08-13 |
human |
| Bo Pan, Jiezhong Chen, Jiamei Lian, Xu-Feng Huang, Chao Den. Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats. PloS one. vol 10. issue 7. 2016-04-19. PMID:26162083. |
five brain regions--the prefrontal cortex (pfc), nucleus accumbens (nac), caudate putamen (cpu), ventral tegmental area (vta) and substantia nigra (sn) were collected. |
2016-04-19 |
2023-08-13 |
rat |
| Georgia E Hodes, Madeline L Pfau, Immanuel Purushothaman, H Francisca Ahn, Sam A Golden, Daniel J Christoffel, Jane Magida, Anna Brancato, Aki Takahashi, Meghan E Flanigan, Caroline Ménard, Hossein Aleyasin, Ja Wook Koo, Zachary S Lorsch, Jian Feng, Mitra Heshmati, Minghui Wang, Gustavo Turecki, Rachel Neve, Bin Zhang, Li Shen, Eric J Nestler, Scott J Russ. Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 50. 2016-04-19. PMID:26674863. |
in concert with these different behavioral responses, transcriptional analysis of nucleus accumbens (nac), a major brain reward region, by use of rna sequencing (rna-seq) revealed markedly different patterns of stress regulation of gene expression between the sexes. |
2016-04-19 |
2023-08-13 |
mouse |
| R J Wickham, W B Solecki, E J Nunes, N A Add. Distinct effects of ventral tegmental area NMDA and acetylcholine receptor blockade on conditioned reinforcement produced by food-associated cues. Neuroscience. vol 301. 2016-04-18. PMID:26093048. |
burst firing of vta dopamine (da) neurons and the subsequent phasic da release in the nucleus accumbens (nac) plays an important role in cue-mediated behavior and in the ability of cues to acquire reinforcing properties. |
2016-04-18 |
2023-08-13 |
human |
| Duo Xu, Chen Su, Hau-Yueh Lin, Toby Manders, Jing Wan. Persistent neuropathic pain increases synaptic GluA1 subunit levels in core and shell subregions of the nucleus accumbens. Neuroscience letters. vol 609. 2016-04-15. PMID:26477778. |
the nucleus accumbens (nac) is a key component of the brain reward system, and it is composed of core and shell subregions. |
2016-04-15 |
2023-08-13 |
Not clear |
| Negar Baharlouei, Abdolrahman Sarihi, Alireza Komaki, Siamak Shahidi, Abbas Haghparas. Blockage of acquisition and expression of morphine-induced conditioned place preference in rats due to activation of glutamate receptors type II/III in nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 135. 2016-04-12. PMID:26071679. |
numerous studies have shown that glutamate in the nucleus accumbens (nac) is an essential neurotransmitter for the extension of morphine-induced place preference. |
2016-04-12 |
2023-08-13 |
rat |
| Hossein Khaleghzadeh-Ahangar, Abbas Haghparas. Intra-accumbal CB1 receptor blockade reduced extinction and reinstatement of morphine. Physiology & behavior. vol 149. 2016-04-11. PMID:26057574. |
the limbic dopaminergic reward system is the main target of morphine-like drugs which begins from the ventral tegmental area (vta) and sends its dopaminergic projections to the nucleus accumbens (nac), amygdala, hippocampus and prefrontal cortex. |
2016-04-11 |
2023-08-13 |
rat |
| Gunnar Sørensen, India A Reddy, Pia Weikop, Devon L Graham, Gregg D Stanwood, Gitta Wortwein, Aurelio Galli, Anders Fink-Jense. The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice. Physiology & behavior. vol 149. 2016-04-11. PMID:26072178. |
glp-1 receptors are expressed in the brain, including within the ventral tegmental area (vta) and the nucleus accumbens (nac). |
2016-04-11 |
2023-08-13 |
mouse |
| Chen Su, James D'amour, Michelle Lee, Hau-Yeuh Lin, Toby Manders, Duo Xu, Sarah E Eberle, Yossef Goffer, Anthony H Zou, Maisha Rahman, Edward Ziff, Robert C Froemke, Dong Huang, Jing Wan. Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens. Molecular brain. vol 8. 2016-04-07. PMID:26260133. |
in rodent chronic neuropathic pain models, elevated levels of glua1 subunits of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors in the nucleus accumbens (nac) have been found to inhibit depressive symptoms. |
2016-04-07 |
2023-08-13 |
Not clear |
| Bo Xing, Xiao-Ping Liang, Peng Liu, Yan Zhao, Zheng Chu, Yong-Hui Dan. Valproate Inhibits Methamphetamine Induced Hyperactivity via Glycogen Synthase Kinase 3β Signaling in the Nucleus Accumbens Core. PloS one. vol 10. issue 6. 2016-04-06. PMID:26030405. |
although glycogen synthase kinase 3β (gsk3β) signaling in the nucleus accumbens (nac) plays a key role in mediating dopamine (da)-dependent behaviors, there is less direct evidence that how vpa acts on the gsk3β signaling in the functionally distinct sub-regions of the nac, the nac core (nacc) and the nac shell (nacsh), during psycho-stimulant-induced hyperactivity. |
2016-04-06 |
2023-08-13 |
rat |
| Paul M Klenowski, Masroor R Shariff, Arnauld Belmer, Matthew J Fogarty, Erica W H Mu, Mark C Bellingham, Selena E Bartlet. Prolonged Consumption of Sucrose in a Binge-Like Manner, Alters the Morphology of Medium Spiny Neurons in the Nucleus Accumbens Shell. Frontiers in behavioral neuroscience. vol 10. 2016-04-06. PMID:27047355. |
because sugar can cause the release of dopamine in the nucleus accumbens (nac) similarly to drugs of abuse, we investigated changes in the morphology of neurons in this brain region following short- (4 weeks) and long-term (12 weeks) binge-like sucrose consumption using an intermittent two-bottle choice paradigm. |
2016-04-06 |
2023-08-13 |
rat |
| Michael Loureiro, Justine Renard, Jordan Zunder, Steven R Laviolett. Hippocampal cannabinoid transmission modulates dopamine neuron activity: impact on rewarding memory formation and social interaction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25510937. |
activation of the ventral hippocampal subregion (vhipp) is known to increase both the activity of daergic neurons located in the ventral tegmental area (vta) and da levels in reward-related brain regions, particularly the nucleus accumbens (nac). |
2016-03-29 |
2023-08-13 |
rat |
| Kathryn B Holroyd, Martin F Adrover, Robert L Fuino, Roland Bock, Alanna R Kaplan, Christina M Gremel, Marcelo Rubinstein, Veronica A Alvare. Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547712. |
here, we show that selective loss of d2 autoreceptors impairs the feedback inhibition of da release and amplifies the effect of cocaine on da transmission in the nucleus accumbens (nac) in vitro. |
2016-03-29 |
2023-08-13 |
mouse |
| B Kalyanasundar, Claudia I Perez, Alvaro Luna, Jessica Solorio, Mario G Moreno, David Elias, Sidney A Simon, Ranier Gutierre. D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. Journal of neurophysiology. vol 114. issue 1. 2016-03-28. PMID:25972577. |
the nucleus accumbens (nac) shell receives dopaminergic inputs and is involved in feeding and motor activity. |
2016-03-28 |
2023-08-13 |
rat |
| Yukihiko Shirayama, Tamaki Ishima, Yasunori Oda, Naoe Okamura, Masaomi Iyo, Kenji Hashimot. Opposite roles for neuropeptide S in the nucleus accumbens and bed nucleus of the stria terminalis in learned helplessness rats. Behavioural brain research. vol 291. 2016-03-28. PMID:25986404. |
we examined the antidepressant-like effects of nps infusions into the shell or core regions of the nucleus accumbens (nac) and into the bed nucleus of the stria terminalis (bnst) of learned helplessness (lh) rats (an animal model of depression). |
2016-03-28 |
2023-08-13 |
rat |
| Justin R Yates, Mahesh Darna, Cassandra D Gipson, Linda P Dwoskin, Michael T Bard. Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency. Behavioural brain research. vol 291. 2016-03-28. PMID:26005123. |
upon completion of behavioral training, vmax and km were obtained from kinetic analysis of [(3)h]da and [(3)h]5-ht uptake using synaptosomes prepared from nucleus accumbens (nac), dorsal striatum (str), medial prefrontal cortex (mpfc), and orbitofrontal cortex (ofc) isolated from individual rats. |
2016-03-28 |
2023-08-13 |
rat |