| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John M Nolan, Ekaterina Loskutova, Alan N Howard, Rachel Moran, Riona Mulcahy, Jim Stack, Maggie Bolger, Jessica Dennison, Kwadwo Owusu Akuffo, Niamh Owens, David I Thurnham, Stephen Beatt. Macular pigment, visual function, and macular disease among subjects with Alzheimer's disease: an exploratory study. Journal of Alzheimer's disease : JAD. vol 42. issue 4. 2015-07-23. PMID:25024317. |
the macula (central retina) contains a yellow pigment, comprising the dietary carotenoids lutein (l), zeaxanthin (z), and meso-zeaxanthin, known as macular pigment (mp). |
2015-07-23 |
2023-08-13 |
human |
| John M Nolan, Ekaterina Loskutova, Alan N Howard, Rachel Moran, Riona Mulcahy, Jim Stack, Maggie Bolger, Jessica Dennison, Kwadwo Owusu Akuffo, Niamh Owens, David I Thurnham, Stephen Beatt. Macular pigment, visual function, and macular disease among subjects with Alzheimer's disease: an exploratory study. Journal of Alzheimer's disease : JAD. vol 42. issue 4. 2015-07-23. PMID:25024317. |
the concentrations of mp's constituent carotenoids in retina and brain tissue correlate, and there is a biologically-plausible rationale, supported by emerging evidence, that mp's constituent carotenoids are also important for cognitive function. |
2015-07-23 |
2023-08-13 |
human |
| Mohsen Sharifzadeh, Akira Obana, Yuko Gohto, Takahiko Seto, Werner Gellerman. Autofluorescence imaging of macular pigment: influence and correction of ocular media opacities. Journal of biomedical optics. vol 19. issue 9. 2015-05-14. PMID:25223707. |
the healthy adult human retina contains in its macular region a high concentration of blue-light absorbing carotenoid compounds, known as macular pigment (mp). |
2015-05-14 |
2023-08-13 |
human |
| Mohsen Sharifzadeh, Akira Obana, Yuko Gohto, Takahiko Seto, Werner Gellerman. Autofluorescence imaging of macular pigment: influence and correction of ocular media opacities. Journal of biomedical optics. vol 19. issue 9. 2015-05-14. PMID:25223707. |
consisting of the carotenoids lutein, zeaxanthin, and meso-zeaxanthin, the mp is thought to shield the vulnerable tissue layers in the retina from lightinduced damage through its function as an optical attenuator and to protect the tissue cells within its immediate vicinity through its function as a potent antioxidant. |
2015-05-14 |
2023-08-13 |
human |
| António M G Baptista, Sérgio M C Nasciment. Changes in spatial extent and peak double optical density of human macular pigment with age. Journal of the Optical Society of America. A, Optics, image science, and vision. vol 31. issue 4. 2014-12-10. PMID:24695208. |
the double optical density at 490 nm of the mp as a function of the location in the retina was obtained for 33 healthy subjects (ages: 21-60 years). |
2014-12-10 |
2023-08-13 |
human |
| Lisa M Renzi, Emily R Bovier, Billy R Hammon. A role for the macular carotenoids in visual motor response. Nutritional neuroscience. vol 16. issue 6. 2014-05-30. PMID:24148268. |
lutein (l), zeaxanthin (z), and meso-zeaxanthin are the dominant carotenoids within the central retina (there, termed macular pigment, mp). |
2014-05-30 |
2023-08-12 |
Not clear |
| Joanne Feeney, Ciarán Finucane, George M Savva, Hilary Cronin, Stephen Beatty, John M Nolan, Rose Anne Kenn. Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23769396. |
macular pigment (mp) is comprised of the carotenoids lutein (l), zeaxanthin (z), and meso-zeaxanthin (mz), which selectively accumulate at the macula (central retina) of the eye and are neuroprotective. |
2014-03-05 |
2023-08-12 |
Not clear |
| J M Nolan, K Meagher, S Kashani, S Beatt. What is meso-zeaxanthin, and where does it come from? Eye (London, England). vol 27. issue 8. 2014-02-06. PMID:23703634. |
the carotenoids lutein (l), zeaxanthin (z), and meso-zeaxanthin (mz) accumulate in the central retina, where they are collectively known as macular pigment (mp). |
2014-02-06 |
2023-08-12 |
Not clear |
| Ekaterina Loskutova, John Nolan, Alan Howard, Stephen Beatt. Macular pigment and its contribution to vision. Nutrients. vol 5. issue 6. 2014-01-22. PMID:23760061. |
three dietary carotenoids, lutein (l), zeaxanthin (z) and meso-zeaxanthin (mz) accumulate at the central retina (macula), where they are collectively referred to as macular pigment (mp). |
2014-01-22 |
2023-08-12 |
Not clear |
| M K J Klamann, A Grünert, A-K B Maier, J Gonnermann, A M Joussen, K K Hube. Comparison of functional and morphological diagnostics in glaucoma patients and healthy subjects. Ophthalmic research. vol 49. issue 4. 2013-11-15. PMID:23306647. |
to evaluate the diagnostic value of microperimetry (mp), blue-on-yellow perimetry (b/yp), confocal scanning laser ophthalmoscopy (heidelberg retina tomograph, hrt, iii) and optical coherence tomography (oct) in discriminating eyes with early glaucoma from healthy subjects. |
2013-11-15 |
2023-08-12 |
human |
| Estera Igras, James Loughman, Matthew Ratzlaff, Rónán O'Caoimh, Colm O'Brie. Evidence of lower macular pigment optical density in chronic open angle glaucoma. The British journal of ophthalmology. vol 97. issue 8. 2013-10-17. PMID:23686328. |
macular pigment (mp) plays an important role in visual function and in the protection of the retina from oxidative damage. |
2013-10-17 |
2023-08-12 |
Not clear |
| Katherine A Meagher, David I Thurnham, Stephen Beatty, Alan N Howard, Eithne Connolly, Wayne Cummins, John M Nola. Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration. The British journal of nutrition. vol 110. issue 2. 2013-08-26. PMID:23211762. |
the formulation containing all three macular carotenoids (group 2 supplement) was the most efficacious in terms of achieving the highest combined concentration of the three mp constituent carotenoids in serum, thereby potentially optimising the bioavailability of these compounds for capture by the target tissue (retina). |
2013-08-26 |
2023-08-12 |
human |
| Billy R Hammond, Laura M Fletche. Influence of the dietary carotenoids lutein and zeaxanthin on visual performance: application to baseball. The American journal of clinical nutrition. vol 96. issue 5. 2013-03-18. PMID:23053558. |
mp may serve to protect the retina from damage by absorbing actinic short-wave light (analogous to internal sunglasses) or by inactivating highly reactive free radicals and oxygen triplicates that are the by-product of light-driven cellular activity. |
2013-03-18 |
2023-08-12 |
Not clear |
| Wen-Chih Tasi, Simon M Petersen-Jones, Pei-Yun Huang, Chung-Tien Li. The neuroprotective effects of lidocaine and methylprednisolone in a rat model of retinal ischemia-reperfusion injury. The Journal of veterinary medical science. vol 74. issue 3. 2012-08-03. PMID:21997238. |
the functional analysis of the retina by erg revealed a 35.2% reduction of a-wave in the ir group, 49.7% reduction in the ldc group but no significant change in the mp group compared to normal controls. |
2012-08-03 |
2023-08-12 |
rat |
| Lisa M Renzi, Billy R Hammond, Melissa Dengler, Richard Robert. The relation between serum lipids and lutein and zeaxanthin in the serum and retina: results from cross-sectional, case-control and case study designs. Lipids in health and disease. vol 11. 2012-05-17. PMID:22375926. |
the xanthophyll carotenoids lutein (l) and zeaxanthin (z) are found in and around the macula of the primate retina, where they are termed macular pigment (mp). |
2012-05-17 |
2023-08-12 |
Not clear |
| Lisa M Renzi, Billy R Hammon. The relation between the macular carotenoids, lutein and zeaxanthin, and temporal vision. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). vol 30. issue 4. 2011-02-24. PMID:20492542. |
lutein (l) and zeaxanthin (z) are the dominant carotenoids within the central retina (there, termed macular pigment, mp) and brain (approximately 70% of total carotenoid concentration). |
2011-02-24 |
2023-08-12 |
human |
| Peter Charbel Issa, Rob L P van der Veen, Astrid Stijfs, Frank G Holz, Hendrik P N Scholl, Tos T J M Berendscho. Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2. Experimental eye research. vol 89. issue 1. 2009-10-08. PMID:19233170. |
the study suggests that in mactel type 2, there might be an inability to accumulate mp in the central retina. |
2009-10-08 |
2023-08-12 |
Not clear |
| Peter Charbel Issa, Rob L P van der Veen, Astrid Stijfs, Frank G Holz, Hendrik P N Scholl, Tos T J M Berendscho. Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2. Experimental eye research. vol 89. issue 1. 2009-10-08. PMID:19233170. |
this disease might serve as a model to further study abnormalities of mp distribution in retinal disorders and to elucidate the mechanisms of mp deposition in the retina. |
2009-10-08 |
2023-08-12 |
Not clear |
| John M Nolan, Philip O'Reilly, James Loughman, Jim Stack, Edward Loane, Eithne Connolly, Stephen Beatt. Augmentation of macular pigment following implantation of blue light-filtering intraocular lenses at the time of cataract surgery. Investigative ophthalmology & visual science. vol 50. issue 10. 2009-10-02. PMID:19628740. |
macular pigment (mp), consisting of the carotenoids lutein (l), zeaxanthin (z) and meso-z, has a maximum absorption at 460 nm and protects the retina from (photo)-oxidative injury. |
2009-10-02 |
2023-08-12 |
Not clear |
| Mohsen Sharifzadeh, Da-You Zhao, Paul S Bernstein, Werner Gellerman. Resonance Raman imaging of macular pigment distributions in the human retina. Journal of the Optical Society of America. A, Optics, image science, and vision. vol 25. issue 4. 2008-06-19. PMID:18382494. |
mp consists of the antioxidant carotenoid compounds lutein and zeaxanthin, is typically present in high concentrations in the healthy human macula relative to the peripheral retina, and is thought to protect this important central region from age-related macular degeneration. |
2008-06-19 |
2023-08-12 |
human |