| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fa-Fa Tian, Chang Zeng, Yun-Feng Ma, Ting-Hui Guo, Jin-Mei Chen, Ying Chen, Xiao-Feng Cai, Feng-Rong Li, Xin-Hua Wang, Wen-Jiao Huang, Yu-Zhong Wan. Potential roles of Cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model. Clinical laboratory. vol 56. issue 3-4. 2010-06-03. PMID:20476644. |
potential roles of cdk5/p35 and tau protein in hippocampal mossy fiber sprouting in the ptz kindling model. |
2010-06-03 |
2023-08-12 |
Not clear |
| Tohru Hasegawa, Nobuyuki Mikoda, Masashi Kitazawa, Frank M LaFerl. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098691. |
four-month-old prepathological 3xtg-ad mice exhibited higher levels of ha in the hippocampus than did age-matched nontransgenic mice, suggesting that ha accumulation may precede both abeta and tau pathologies. |
2010-05-20 |
2023-08-12 |
mouse |
| Silvia Josefina López-Pérez, Mónica Elisa Ureña-Guerrero, Alberto Morales-Villagrá. Monosodium glutamate neonatal treatment as a seizure and excitotoxic model. Brain research. vol 1317. 2010-05-19. PMID:20043888. |
glu levels and hippocampal total content of related amino acids (asp, glu, gln, gly, tau, ala and gaba) were estimated before, immediately and after each injection. |
2010-05-19 |
2023-08-12 |
rat |
| Alberto Serrano-Pozo, Christopher M William, Isidro Ferrer, Emmanuelle Uro-Coste, Marie-Bernadette Delisle, Claude-Alain Maurage, Christoph Hock, Roger M Nitsch, Eliezer Masliah, John H Growdon, Matthew P Frosch, Bradley T Hyma. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a journal of neurology. vol 133. issue Pt 5. 2010-05-17. PMID:20360050. |
anti-amyloid-beta immunization might also ameliorate the hippocampal tau pathology through a decrease in tau phosphorylation. |
2010-05-17 |
2023-08-12 |
human |
| Naoto Oikawa, Nobuyuki Kimura, Katsuhiko Yanagisaw. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain research. vol 1315. 2010-05-06. PMID:20004650. |
to examine the accumulation of deposited abeta, phosphorylated tau accumulation, intracellular tau accumulation, and neurofibrillary tangle formation, the brains, mainly temporal cortex and hippocampus, of 34 cynomolgus monkeys aged 6 to 36 years were studied by biochemical and histochemical analyses. |
2010-05-06 |
2023-08-12 |
monkey |
| Naoto Oikawa, Nobuyuki Kimura, Katsuhiko Yanagisaw. Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain research. vol 1315. 2010-05-06. PMID:20004650. |
histologically, intraneuronal and intraoligodendroglial tau accumulation was observed in temporal cortex and hippocampus of animals before the age of 20. |
2010-05-06 |
2023-08-12 |
monkey |
| Balu Chakravarthy, Chantal Gaudet, Michel Ménard, Trevor Atkinson, Leslie Brown, Frank M Laferla, Ubaldo Armato, James Whitfiel. Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. Journal of Alzheimer's disease : JAD. vol 19. issue 3. 2010-05-05. PMID:20157247. |
specifically, the level of the p75(ntr) receptor in the hippocampal membranes from 12-15 month old ad-triple transgenic mice (3xtg-ad) harboring ps1 (m146v), abetapp (swe), and tau (p301l) was nearly twice that in hippocampal membranes from age-matched wild-type mice. |
2010-05-05 |
2023-08-12 |
mouse |
| Vanessa J De-Paula, Evelin L Schaeffer, Leda L Talib, Wagner F Gattaz, Orestes V Forlenz. Inhibition of phospholipase A2 increases tau phosphorylation at Ser214 in embryonic rat hippocampal neurons. Prostaglandins, leukotrienes, and essential fatty acids. vol 82. issue 1. 2010-04-26. PMID:19726172. |
inhibition of phospholipase a2 increases tau phosphorylation at ser214 in embryonic rat hippocampal neurons. |
2010-04-26 |
2023-08-12 |
rat |
| Chun Lai Nie, Yan Wei, Xinyong Chen, Yan Ying Liu, Wen Dui, Ying Liu, Martyn C Davies, Saul J B Tendler, Rong Giao H. Formaldehyde at low concentration induces protein tau into globular amyloid-like aggregates in vitro and in vivo. PloS one. vol 2. issue 7. 2010-04-23. PMID:17637844. |
our previous results show that neuronal tau aggregates in formaldehyde solution and that aggregated tau induces apoptosis of sh-sy5y and hippocampal cells. |
2010-04-23 |
2023-08-12 |
cattle |
| Karelle Leroy, Kunie Ando, Céline Héraud, Zehra Yilmaz, Michèle Authelet, Jean-Marie Boeynaems, Luc Buée, Robert De Decker, Jean-Pierre Brio. Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110614. |
nevertheless, this study indicates that even a relatively short-term per os treatment leading to high blood concentration of lithium is effective in arresting the formation of nfts in the hippocampus and the spinal cord of a tau transgenic model. |
2010-04-06 |
2023-08-12 |
mouse |
| Yang-Yang Yin, Hao Liu, Xiao-Bin Cong, Zhao Liu, Qun Wang, Jian-Zhi Wang, Ling-Qiang Zh. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. Journal of Alzheimer's disease : JAD. vol 19. issue 2. 2010-04-06. PMID:20110616. |
inhibition of pp2a through hippocampal injection of okadaic acid (oa) induces tau hyperphosphorylation and memory impairment of rats. |
2010-04-06 |
2023-08-12 |
rat |
| Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, Sophie Croes, Annelies Termont, David Demedts, Peter Borghgraef, Herman Devijver, Robert K Filipkowski, Leszek Kaczmarek, Sebastian Kügler, Fred Van Leuve. AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. PloS one. vol 4. issue 10. 2010-03-12. PMID:19794916. |
here, we approached the problem in non-transgenic models by intracerebral injection of adeno-associated viral vectors to express protein tau or amyloid precursor protein in the hippocampus in vivo. |
2010-03-12 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-n-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. |
2010-03-09 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
neither neuropathological changes nor tau hyperphosphorylation was detected in the hippocampus in this study although the mercury concentration here was twice that in the cerebral cortex. |
2010-03-09 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
these findings suggest that mehg exposure induces tau hyperphosphorylation at specific sites of tau mainly through the activation of jnk pathways, leading to neuropathological changes in the cerebral cortex selectively, but not in the hippocampus of mouse brain. |
2010-03-09 |
2023-08-12 |
mouse |
| M T Capucchio, M Márquez, P Pregel, L Foradada, M Bravo, G Mattutino, C Torre, D Schiffer, D Catalano, F Valenza, F Guarda, M Pumarol. Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies. Journal of comparative pathology. vol 142. issue 1. 2010-02-25. PMID:19744668. |
some lesions described here, including some vascular changes, the presence of diffuse plaques and tau accumulation in hippocampal neurons, have not been described previously in the horse. |
2010-02-25 |
2023-08-12 |
Not clear |
| L Lecanu, G Rammouz, A McCourty, E K Sidahmed, J Greeson, V Papadopoulo. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. vol 165. issue 2. 2010-02-24. PMID:19850110. |
this recovery of cognitive function was accompanied by a reduction in hippocampal amyloid deposits, astrogliosis, neurodegeneration and tau protein phopshorylation. |
2010-02-24 |
2023-08-12 |
rat |
| Masaoki Takano, Mieko Otani, Akiko Sakai, Keiichi Kadoyama, Shogo Matsuyama, Akira Matsumoto, Mariko Takenokuchi, Miho Sumida, Taizo Taniguch. Use of a phosphosensor dye in proteomic analysis of human mutant tau transgenic mice. Neuroreport. vol 20. issue 18. 2010-02-01. PMID:19898260. |
to investigate how tau dysfunctions cause these features, we examined the expression and phosphorylation levels in sjlb mouse hippocampal proteins using a phosphosensor dye in two-dimensional poly acrylamide gel electrophoresis analysis and mass spectrometry. |
2010-02-01 |
2023-08-12 |
mouse |
| Bhumsoo Kim, Carey Backus, Sangsu Oh, John M Hayes, Eva L Feldma. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819959. |
tau phosphorylation is increased in the cortex and hippocampus of db/db mice compared with db+ control mouse brain. |
2010-01-19 |
2023-08-12 |
mouse |
| Steffen Albrecht, Nenad Bogdanovic, Bernardino Ghetti, Bengt Winblad, Andréa C LeBlan. Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations. Journal of neuropathology and experimental neurology. vol 68. issue 12. 2009-12-22. PMID:19915487. |
to determine whether casp-6 is also activated in familial ad, we performed an immunohistochemical analysis of active casp-6 and tau cleaved by casp-6 in temporal cortex and hippocampal tissue sections from cases of familial ad. |
2009-12-22 |
2023-08-12 |
Not clear |