| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miao-Kun Sun, Daniel L Alko. Pharmacology of protein kinase C activators: cognition-enhancing and antidementic therapeutics. Pharmacology & therapeutics. vol 127. issue 1. 2010-10-07. PMID:20382181. |
pkc activators not only increase activity of pkc isozymes and thereby restore pkc signaling activity, including neurotrophic activity, synaptic/structural remodeling, and synaptogenesis in the hippocampus and related cortical areas, but also reduce the accumulation of neurotoxic amyloid and tau protein hyperphosphorylation in the brain. |
2010-10-07 |
2023-08-12 |
Not clear |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
the formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. |
2010-09-13 |
2023-08-12 |
human |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
in primary hippocampal neurons where human tau was over-expressed both in the somato-dendritic compartment and the axon, the pathological epitopes recognized by the antibodies at8 (s199/s202/t205), at100 (t212/s214/t217), and at180 (t231/s235) were found in the somato-dendritic compartment but not in the axon where tau was either not phosphorylated (t205 and t217) or not simultaneously phosphorylated (t231 and s235) at sites included in the above epitopes. |
2010-09-13 |
2023-08-12 |
human |
| Johanne Bertrand, Patrick Sénéchal, Mathieu Zummo-Soucy, Vanessa Plouffe, Nicole Lecler. The formation of tau pathological phospho-epitopes in the axon is prevented by the dephosphorylation of selective sites in primary hippocampal neurons over-expressing human tau. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20550628. |
expression of tau mutants where one phosphorylation site included in the above epitopes was mutated in alanine showed that the formation of one of these epitopes was not required for the formation of the two others in primary hippocampal neurons. |
2010-09-13 |
2023-08-12 |
human |
| Jiqing Xu, Shinji Sato, Satoshi Okuyama, Russell J Swan, Michael T Jacobsen, Elena Strunk, Tsuneya Ikez. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354135. |
the bigenic mice show enhanced tau phosphorylation at multiple sites (at8, 12e8, phf-1, and ps422), tauc3-immunoreactive tau fragmentation, and accumulation of tau aggregates in cortical and hippocampal neurons at 12-13 mo of age. |
2010-09-07 |
2023-08-12 |
mouse |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
the present study investigated the effect of nicotine on tau phosphorylation and cognitive impairment induced by hippocampus injections of amyloid-beta (abeta) 25-35. |
2010-09-07 |
2023-08-12 |
rat |
| Juan Deng, Cheng Shen, Yan-Jiang Wang, Meng Zhang, Jing Li, Zhi-Qiang Xu, Chang-Yue Gao, Chuan-Qing Fang, Hua-Dong Zho. Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20363218. |
the data show that nicotine (1mg/kg in base weight) treatment significantly exacerbates cognitive impairment and tau phosphorylation at ser-202 and thr-231 in the hippocampus compared with abeta25-35 injection groups in the abeta rat model of alzheimer's disease. |
2010-09-07 |
2023-08-12 |
rat |
| Julie Allyson, Eve Dontigny, Yves Auberson, Michel Cyr, Guy Massicott. Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2010. 2010-08-24. PMID:20508838. |
blockade of nr2a-containing nmda receptors induces tau phosphorylation in rat hippocampal slices. |
2010-08-24 |
2023-08-12 |
rat |
| Julie Allyson, Eve Dontigny, Yves Auberson, Michel Cyr, Guy Massicott. Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2010. 2010-08-24. PMID:20508838. |
we observed, in acute hippocampal slice preparations, that blockade of nr2a-containing nmda receptors by the nr2a antagonist nvp-aam077 provoked the hyperphosphorylation of a residue located in the proline-rich domain of tau (i.e., ser199). |
2010-08-24 |
2023-08-12 |
rat |
| J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. |
the pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. |
2010-08-19 |
2023-08-12 |
human |
| J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. |
in the present study, human tau mutants in which disease-related sites associated with either an early (at8, t231 and s262) or intermediate (t217) stage of tau pathology were mutated in alanine to inhibit their phosphorylation were overexpressed in primary hippocampal neurons to examine their impact on the phosphorylation of other disease-related sites. |
2010-08-19 |
2023-08-12 |
human |
| J Bertrand, V Plouffe, P Sénéchal, N Lecler. The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394726. |
all together, our data show that the sites forming the at8 epitope could play a central role in regulating the phosphorylation of tau at disease-associated sites and that priming and feedback events take place to regulate the overall level of tau phosphorylation in rat hippocampal neurons. |
2010-08-19 |
2023-08-12 |
human |
| Giovanni B Frison. Alzheimer's disease neuroimaging initiative in Europe. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 6. issue 3. 2010-08-11. PMID:20451877. |
because the adni platform was first imported in europe, thanks to the pilot european adni, several adni-related initiatives have flourished, funded by the european commission's 7th framework programme, national governments, and the alzheimer's association aimed at: (i) collecting fresh data adni style (fp7 addneuromed, innovative medicine initiative pharma-cog/european adni, swedish adni, and italian adni); (ii) developing standard operational procedures for the collection of markers (international harmonization of csf abeta42 and tau, and european alzheimer's disease consortium-adni harmonization of hippocampal volumetry); and (iii) developing infrastructures for the treatment of adni data (fp7 neugrid and outgrid, and the french centre pour l'acquisition et le traitement de l'image). |
2010-08-11 |
2023-08-12 |
Not clear |
| N Li, Z L Yu, L Wang, Y T Zheng, J X Jia, Q Wang, M J Zhu, X L Liu, X Xia, W J L. Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure. Acta biologica Hungarica. vol 61. issue 2. 2010-08-10. PMID:20519167. |
the aim of this study was to investigate the effects of maternal lead exposure on the learning and memory ability and expression of tau protein phosphorylation (p-tau) and beta amyloid protein (abeta) in hippocampus of mice offspring. |
2010-08-10 |
2023-08-12 |
mouse |
| N Li, Z L Yu, L Wang, Y T Zheng, J X Jia, Q Wang, M J Zhu, X L Liu, X Xia, W J L. Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure. Acta biologica Hungarica. vol 61. issue 2. 2010-08-10. PMID:20519167. |
tau hyper-phosphorylation and abeta increase in the hippocampus of pups may contribute to the impairment of learning and memory associated with maternal pb exposure. |
2010-08-10 |
2023-08-12 |
mouse |
| Juan Perucho, Isabel Rubio, Maria J Casarejos, Ana Gomez, Jose A Rodriguez-Navarro, Rosa M Solano, Justo Garcia De Yébenes, Maria A Men. Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 19. issue 4. 2010-07-22. PMID:20308791. |
we have investigated the effects of repetitive anesthesia, twice a week, for 3 months, from 7 to 10 months of age, with isoflurane on survival, behavior, apoptosis in hippocampal cells, amyloid-beta (abeta) peptide and tau patterns, chaperones and autophagy in wt and abetapp{swe} mice. |
2010-07-22 |
2023-08-12 |
mouse |
| Yuan-Shih Hu, Peng Xu, Gustavo Pigino, Scott T Brady, John Larson, Orly Lazaro. Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20086049. |
enhanced neurogenesis was accompanied by a significant reduction in levels of hyperphosphorylated tau and oligomeric abeta, the precursors of ad hallmarks, in the hippocampus and cortex of enriched mice. |
2010-07-21 |
2023-08-12 |
mouse |
| Luis Escribano, Ana-María Simón, Esther Gimeno, Mar Cuadrado-Tejedor, Rakel López de Maturana, Ana García-Osta, Ana Ricobaraza, Alberto Pérez-Mediavilla, Joaquín Del Río, Diana Frechill. Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 7. 2010-07-09. PMID:20336061. |
in the hippocampus, neuropil threads containing phosphorylated tau, probably corresponding to dystrophic neurites, were also decreased by the drug. |
2010-07-09 |
2023-08-12 |
mouse |
| Ayodeji A Asuni, V Hugh Perry, Vincent O'Conno. Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease. Biochemical Society transactions. vol 38. issue 2. 2010-06-11. PMID:20298219. |
we have investigated the expression of hyperphosphorylated tau in the hippocampus of mice infected with the me7 prion agent. |
2010-06-11 |
2023-08-12 |
mouse |
| Gang Li, Nga Bien-Ly, Yaisa Andrews-Zwilling, Qin Xu, Aubrey Bernardo, Karen Ring, Brian Halabisky, Changhui Deng, Robert W Mahley, Yadong Huan. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell stem cell. vol 5. issue 6. 2010-06-04. PMID:19951691. |
tau phosphorylation, an alzheimer's disease characteristic, and levels of neurotoxic apoe fragments were both elevated in apoe4-ki hippocampal neurons concomitant with decreased gabaergic interneuron survival. |
2010-06-04 |
2023-08-12 |
mouse |