| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Paschos, K Paleta. Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia. vol 13. issue 1. 2010-06-17. PMID:19240815. |
recent studies emphasize the role of insulin resistance, oxidative stress and subsequent lipid peroxidation, proinflammatory cytokines, adipokines and mitochondrial dysfunction in the development and progression of nafld. |
2010-06-17 |
2023-08-12 |
Not clear |
| Stephen O Adewole, John A O Ojewol. Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 6. issue 1. 2010-05-20. PMID:20162039. |
the findings of this laboratory animal study suggest that a. muricata extract has a protective, beneficial effect on hepatic tissues subjected to stz-induced oxidative stress, possibly by decreasing lipid peroxidation and indirectly enhancing production of insulin and endogenous antioxidants. |
2010-05-20 |
2023-08-12 |
human |
| Patrick Schrauwen, Vera Schrauwen-Hinderling, Joris Hoeks, Matthijs K C Hesselin. Mitochondrial dysfunction and lipotoxicity. Biochimica et biophysica acta. vol 1801. issue 3. 2010-05-04. PMID:19782153. |
indeed, increased lipid peroxidation has been reported in insulin resistant skeletal muscle and the mitochondrial uncoupling protein-3, which has been suggested to prevent lipid-induced mitochondrial damage, is reduced in subjects with an impaired glucose tolerance and in type 2 diabetic patients. |
2010-05-04 |
2023-08-12 |
human |
| Yasser Fouad Kilany, Sahar A Abou Holw, Mohamed Fathy Abouel-Nour, Ayman T A Mors. Early development of osteoporosis in male smokers with hypoandrogenism due to fascioliasis with or without schistosomiasis added by life style. Journal of the Egyptian Society of Parasitology. vol 39. issue 3. 2010-02-23. PMID:20120745. |
monitoring of clinical picture and biochemical assessments of osteoporotic indices (osteocolcin, bone alkaline phosphatase, parathyroid hormone, urinary cyclic amp), hypoandrogenism (dehydroepiandrosterane sulphate or dheas & testosterone) glycemic determinant (insulin) immuno-inflammatory response (interleukein-6, tumor necrosis factor alpha, e-selectin, ceruloplasmin) smoking index (serum cotinine), total antioxidant capacity (aoc) and lipid peroxidation (malonedialdehyde) was done before and after 6 months therapeutic program involving supplement of dheas, mirazid, chromium picolinate, and megavit zinc alongside smoking cessation and physical exercise daily for at least 30 minutes. |
2010-02-23 |
2023-08-12 |
Not clear |
| Kunga Mohan Ramkumar, Ponnirul Ponmanickam, Shanmugam Velayuthaprabhu, Govindaraju Archunan, Palanisamy Rajagur. Protective effect of Gymnema montanum against renal damage in experimental diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 10. 2009-12-01. PMID:19616598. |
the glet and glibenclamide were administered orally for 3 weeks and the effects on glucose, insulin, renal markers including urea, creatinine and uric acid, lipid peroxidation markers including thiobarbituric reactive substances (tbars) and hydroperoxides and antioxidant enzymes superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx) and glutathione-s-transferase (gst) activities in kidney were studied. |
2009-12-01 |
2023-08-12 |
rat |
| Rameshwar Jatwa, Anand Ka. Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation. Fundamental & clinical pharmacology. vol 23. issue 4. 2009-10-30. PMID:19500155. |
we studied the influence of diacerein administration on the changes in carrageenan-induced thyroid dysfunction; hepatic, renal and cardiac lpo as well as serum glucose, thyroid hormones and insulin concentrations in wistar rats. |
2009-10-30 |
2023-08-12 |
rat |
| Rameshwar Jatwa, Anand Ka. Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation. Fundamental & clinical pharmacology. vol 23. issue 4. 2009-10-30. PMID:19500155. |
while a decrease in the level of serum thyroid hormones and hdl-c and in tissue gsh content was observed in carrageenan-treated animals, it increased paw volume, the concentration of other serum lipids, glucose and insulin as well as tissue lpo. |
2009-10-30 |
2023-08-12 |
rat |
| G Kumar, Sharmila Banu, A G Murugesa. Influence of Helicteres isora administration for diabetes mellitus: Its effect on erythrocyte membrane and antioxidant status. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 8. 2009-10-19. PMID:19406193. |
administration of bark extract to diabetic rats showed a decrease in the levels of glucose, glycosylated haemoglobin, lipid peroxidation markers and vitamin e. in addition the levels of insulin, haemoglobin, enzymatic antioxidants, vitamin c, and gsh and the activities of membrane bound enzymes also were increased in h. isora treated diabetic rats. |
2009-10-19 |
2023-08-12 |
rat |
| Solange Adéchian, Silvana Giardina, Didier Rémond, Isabelle Papet, Daniela Buonocore, Claire Gaudichon, Dominique Dardevet, Fulvio Marzatico, Laurent Moson. Excessive energy intake does not modify fed-state tissue protein synthesis rates in adult rats. Obesity (Silver Spring, Md.). vol 17. issue 7. 2009-10-08. PMID:19247270. |
at the end of the experiment, we measured body composition, metabolic parameters (plasma amino acid, lipid, insulin, and glucose levels), inflammatory parameter (plasma alpha2-macroglobulin), oxidative stress parameters (antioxidant enzyme activities, lipoperoxidation (lpo), protein carbonyl content in liver and muscle), and in vivo fed-state fractional protein synthesis rates (fsrs) in muscle and liver. |
2009-10-08 |
2023-08-12 |
rat |
| Solange Adéchian, Silvana Giardina, Didier Rémond, Isabelle Papet, Daniela Buonocore, Claire Gaudichon, Dominique Dardevet, Fulvio Marzatico, Laurent Moson. Excessive energy intake does not modify fed-state tissue protein synthesis rates in adult rats. Obesity (Silver Spring, Md.). vol 17. issue 7. 2009-10-08. PMID:19247270. |
liver and muscle fsrs, plasma levels of lipids, glucose, insulin and alpha2-macroglobulin, soleus and liver glutathione reductase and peroxidase activities, mnsod activity, lpo, and protein carbonyl content were not altered by the hf diet. |
2009-10-08 |
2023-08-12 |
rat |
| Rameshwar Jatwa, Anand Ka. Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice. Phytotherapy research : PTR. vol 23. issue 8. 2009-09-23. PMID:19170137. |
administration caused hyperglycemia with a parallel increase in renal lipid peroxidation (lpo), relative risk ratio (rr), and the concentrations of serum insulin; total cholesterol (tc); low-density lipoprotein cholesterol (ldl-c); very low-density lipoprotein cholesterol (vldl-c) and triglycerides (tg). |
2009-09-23 |
2023-08-12 |
mouse |
| Rameshwar Jatwa, Anand Ka. Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice. Phytotherapy research : PTR. vol 23. issue 8. 2009-09-23. PMID:19170137. |
it also reduced renal lpo, rr, serum concentrations of insulin; glucose and ldl-c with a parallel increase in cellular antioxidants. |
2009-09-23 |
2023-08-12 |
mouse |
| Jiyin Zhou, Shiwen Zhou, Jianlin Tang, Kebin Zhang, Lixia Guang, Yongping Huang, Ying Xu, Yi Ying, Le Zhang, Dandan L. Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. European journal of pharmacology. vol 606. issue 1-3. 2009-09-01. PMID:19374872. |
these findings suggest that berberine has protective effect for diabetes through increasing insulin expression, beta cell regeneration, antioxidant enzyme activity and decreasing lipid peroxidation. |
2009-09-01 |
2023-08-12 |
rat |
| Hamendra Singh Parmar, Anand Ka. Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats. BioFactors (Oxford, England). vol 33. issue 1. 2009-05-08. PMID:19276533. |
in the second experiment rats were maintained on pre-standardized atherogenic diet cct (supplemented with 4% cholesterol, 1% cholic acid and 0.5% 2-thiouracil) to induce dyslipidemia, hypothyroidism and diabetes mellitus and the effects of the test peel extracts (200 mg/kg of mi and 100 mg/kg for cm and cv for 10 consecutive days) were studied by examining the changes in tissue lpo (in heart, liver and kidney), concentrations of serum lipids, thyroid hormones, insulin and glucose. |
2009-05-08 |
2023-08-12 |
rat |
| Hamendra Singh Parmar, Anand Ka. Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats. BioFactors (Oxford, England). vol 33. issue 1. 2009-05-08. PMID:19276533. |
rats, treated simultaneously with either of the peel extracts reversed the cct-diet induced increase in the levels of tissue lpo, serum lipids, glucose, creatinine kinase-mb and decrease in the levels of thyroid hormones and insulin indicating their potential to ameliorate the diet induced alterations in serum lipids, thyroid dysfunctions and hyperglycemia/diabetes mellitus. |
2009-05-08 |
2023-08-12 |
rat |
| Laleh Razavi Nematollahi, Abbas E Kitabchi, Abbas Eghbal Kitabchi, Frankie B Stentz, Jim Y Wan, Bagher A Larijani, Mohammad Mohajer Tehrani, Mohammad Hossein Gozashti, Kobra Omidfar, Eghbal Taher. Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects. Metabolism: clinical and experimental. vol 58. issue 4. 2009-04-20. PMID:19303962. |
to investigate if other conditions besides hyperglycemia could evoke such a prompt increase in cytokine levels, lipid peroxidation, and oxidative stress markers, we induced hypoglycemic stress by standard insulin tolerance test and measured proinflammatory cytokines, markers of lipid peroxidation, reactive oxygen species (ros), and counterregulatory hormones. |
2009-04-20 |
2023-08-12 |
human |
| Laleh Razavi Nematollahi, Abbas E Kitabchi, Abbas Eghbal Kitabchi, Frankie B Stentz, Jim Y Wan, Bagher A Larijani, Mohammad Mohajer Tehrani, Mohammad Hossein Gozashti, Kobra Omidfar, Eghbal Taher. Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects. Metabolism: clinical and experimental. vol 58. issue 4. 2009-04-20. PMID:19303962. |
at baseline and at 30, 45, 60, 120, and 240 minutes after insulin injection, the following parameters were measured: glucose, cortisol, corticotropin, epinephrine (ep), norepinephrine (ne), growth hormone, tumor necrosis factor (tnf)-alpha, interleukin (il) 1beta, il-6, il-8, free fatty acids, white blood cells, lipid peroxidation markers by thiobarbituric acid assay, and ros by dichlorofluorescein method. |
2009-04-20 |
2023-08-12 |
human |
| Khaled Hamden, Mohamed Ali Boujbiha, Hatem Masmoudi, Fatma Makni Ayadi, Kamel Jamoussi, Abdelfattah Elfek. Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 63. issue 2. 2009-04-10. PMID:18358681. |
the aim of the present study is to determine if a combination of vitamins (c and e) has any advantage over insulin therapy on lipid peroxidation, antioxidant activity, liver dysfunction parameters, and histological changes in the alloxan-induced diabetic rats. |
2009-04-10 |
2023-08-12 |
rat |
| O R Rebolledo, C A Marra, A Raschia, S Rodriguez, J J Gagliardin. Abdominal adipose tissue: early metabolic dysfunction associated to insulin resistance and oxidative stress induced by an unbalanced diet. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 40. issue 11. 2009-02-13. PMID:18622897. |
the glucose (g), triglyceride (tg), and insulin (i) plasma levels, and the activity of antioxidant enzymes, lyposoluble antioxidants, total glutathione (gsh), lipid peroxidation as tbars, fatty acid (fa) composition of aat-tg as well as their release by incubated pieces of aat were measured. |
2009-02-13 |
2023-08-12 |
rat |
| Hamendra Singh Parmar, Anand Ka. Protective role of Mangifera indica, Cucumis melo and Citrullus vulgaris peel extracts in chemically induced hypothyroidism. Chemico-biological interactions. vol 177. issue 3. 2009-02-10. PMID:19059228. |
pre-standardized doses (200mg/kg of mi and 100mg/kg both of cv and cm), based on the maximum inhibition in hepatic lpo, were administered to wistar albino male rats for 10 consecutive days and the changes in tissue (heart, liver and kidney) lpo and in the concentrations of serum triiodothyronine (t(3)), thyroxin (t(4)), insulin, glucose, alpha-amylase and different lipids were examined. |
2009-02-10 |
2023-08-12 |
rat |