| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R C Hresko, H Heimberg, M M Chi, M Mueckle. Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. The Journal of biological chemistry. vol 273. issue 32. 1998-09-10. PMID:9685425. |
reduction of intracellular atp using azide inhibited glut 1 and glut 4 translocation from the ldm to the plasma membrane, insulin receptor autophosphorylation, and irs-1 tyrosine phosphorylation. |
1998-09-10 |
2023-08-12 |
Not clear |
| P R Shepherd, N J Crowther, M Desai, C N Hales, S E Ozann. Altered adipocyte properties in the offspring of protein malnourished rats. The British journal of nutrition. vol 78. issue 1. 1997-09-24. PMID:9292765. |
the amount of insulin receptor present in adipocyte membranes was increased in the three animal groups that had been exposed to the low-protein diets while levels of the insulin responsive glucose transporter (glut 4) were similar in adipocyte membranes from all groups. |
1997-09-24 |
2023-08-12 |
rat |
| D M Thomas, S D Rogers, K W Ng, J D Bes. Dexamethasone modulates insulin receptor expression and subcellular distribution of the glucose transporter GLUT 1 in UMR 106-01, a clonal osteogenic sarcoma cell line. Journal of molecular endocrinology. vol 17. issue 1. 1997-01-02. PMID:8863182. |
dexamethasone modulates insulin receptor expression and subcellular distribution of the glucose transporter glut 1 in umr 106-01, a clonal osteogenic sarcoma cell line. |
1997-01-02 |
2023-08-12 |
Not clear |
| D M Thomas, S D Rogers, K W Ng, J D Bes. Dexamethasone modulates insulin receptor expression and subcellular distribution of the glucose transporter GLUT 1 in UMR 106-01, a clonal osteogenic sarcoma cell line. Journal of molecular endocrinology. vol 17. issue 1. 1997-01-02. PMID:8863182. |
by northern and western blot analysis, dex was shown to stimulate insulin receptor mrna and protein by up to 5.6-fold, but it had no effect on expression of the glucose transporter glut 1 mrna or protein under basal conditions. |
1997-01-02 |
2023-08-12 |
Not clear |
| M Laville, D Auboeuf, Y Khalfallah, N Vega, J P Riou, H Vida. Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle. The Journal of clinical investigation. vol 98. issue 1. 1996-08-26. PMID:8690802. |
using reverse transcription-competitive pcr, we have measured the mrnas encoding the two insulin receptor variants, the insulin receptor substrate-1, the p85alpha subunit of phosphatidylinositol-3-kinase, ras associated to diabetes (rad), the glucose transporter glut 4, glycogen synthase, 6-phosphofructo-l-kinase, lipoprotein lipase, and the hormone-sensitive lipase. |
1996-08-26 |
2023-08-12 |
human |
| Z W Yu, A Wickman, J W Eriksso. Cryptic receptors for insulin-like growth factor II in the plasma membrane of rat adipocytes--a possible link to cellular insulin resistance. Biochimica et biophysica acta. vol 1282. issue 1. 1996-08-20. PMID:8679660. |
taken together, these data indicate that camp, similar to its effects on the glucose transporter glut 4 and the insulin receptor, may increase the proportion of functionally cryptic igf-ii receptors in the pm through mechanisms involving serine phosphorylation, possibly of a docking or coupling protein. |
1996-08-20 |
2023-08-12 |
rat |
| M Kern, C Mondon, J C Butte, S Azha. Glucose transporter (GLUT 4) content and insulin receptor kinase activity in muscles of the LA/N-cp rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 26. issue 3. 1994-07-21. PMID:8005559. |
glucose transporter (glut 4) content and insulin receptor kinase activity in muscles of the la/n-cp rat. |
1994-07-21 |
2023-08-12 |
rat |
| M Kern, C Mondon, J C Butte, S Azha. Glucose transporter (GLUT 4) content and insulin receptor kinase activity in muscles of the LA/N-cp rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 26. issue 3. 1994-07-21. PMID:8005559. |
in this study we compared insulin binding activity, insulin receptor tyrosine kinase activity, and glut 4 protein content in six muscles from la/n-cp rats and their lean controls. |
1994-07-21 |
2023-08-12 |
rat |
| F Dela, A Handberg, K J Mikines, J Vinten, H Galb. GLUT 4 and insulin receptor binding and kinase activity in trained human muscle. The Journal of physiology. vol 469. 1994-01-31. PMID:8271219. |
glut 4 and insulin receptor binding and kinase activity in trained human muscle. |
1994-01-31 |
2023-08-12 |
human |
| F Dela, A Handberg, K J Mikines, J Vinten, H Galb. GLUT 4 and insulin receptor binding and kinase activity in trained human muscle. The Journal of physiology. vol 469. 1994-01-31. PMID:8271219. |
this study examines if this effect of physical training is due to increased insulin receptor function or increased total concentration of insulin-recruitable glucose transporter protein (glut 4). |
1994-01-31 |
2023-08-12 |
human |
| S O'Rahilly, A Krook, R Morgan, A Rees, J S Flier, D E Molle. Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population. Diabetologia. vol 35. issue 5. 1992-10-13. PMID:1521731. |
insulin receptor and insulin-responsive glucose transporter (glut 4) mutations and polymorphisms in a welsh type 2 (non-insulin-dependent) diabetic population. |
1992-10-13 |
2023-08-11 |
human |
| S O'Rahilly, A Krook, R Morgan, A Rees, J S Flier, D E Molle. Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population. Diabetologia. vol 35. issue 5. 1992-10-13. PMID:1521731. |
we have recently examined the exons encoding the insulin receptor tyrosine kinase domain and glut 4 in 30 subjects with type 2 (non-insulin-dependent) diabetes mellitus using a molecular scanning approach. |
1992-10-13 |
2023-08-11 |
human |
| S O'Rahilly, A Krook, R Morgan, A Rees, J S Flier, D E Molle. Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population. Diabetologia. vol 35. issue 5. 1992-10-13. PMID:1521731. |
the variant sequences val-met985 and lys-glu1068 of the insulin receptor and val-ile383 of glut 4 were each separately found in three different diabetic subjects. |
1992-10-13 |
2023-08-11 |
human |
| S Bader, R Scholz, M Kellerer, S Tippmer, K Rett, S Mathaei, P Freund, H U Härin. Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats. Diabetologia. vol 35. issue 8. 1992-09-30. PMID:1324860. |
normal insulin receptor tyrosine kinase activity and glucose transporter (glut 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats. |
1992-09-30 |
2023-08-11 |
rat |
| S Bader, R Scholz, M Kellerer, S Tippmer, K Rett, S Mathaei, P Freund, H U Härin. Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats. Diabetologia. vol 35. issue 8. 1992-09-30. PMID:1324860. |
to elucidate whether in analogy to other insulin resistant animal models an inactivity of the insulin receptor kinase or an alteration of the glucose transporter (glut 4) level in the skeletal muscle might contribute to the pathogenesis of insulin resistance we determined insulin receptor kinase activity and glut 4 level in the hindlimbs of spontaneous hypertensive rats and normotensive control rats. |
1992-09-30 |
2023-08-11 |
rat |
| N Kotliar, P F Pilc. Expression of the glucose transporter isoform GLUT 4 is insufficient to confer insulin-regulatable hexose uptake to cultured muscle cells. Molecular endocrinology (Baltimore, Md.). vol 6. issue 3. 1992-06-18. PMID:1584210. |
these results suggest that acute insulin stimulation of glucose transport is not solely dependent on the presence of the insulin receptor and the glut 4 protein, and that the presence of some additional protein(s) must be required. |
1992-06-18 |
2023-08-11 |
Not clear |
| T Gremeaux, J F Tanti, E Van Obberghen, Y Le Marchand-Bruste. Alteration of insulin receptor kinase in obese, insulin-resistant mice. Biochimie. vol 69. issue 4. 1987-11-18. PMID:3115317. |
insulin receptors, partially purified by wheat germ agglutinin--agarose chromatography, were studied in a cell-free system for autophosphorylation, for their ability to phosphorylate a synthetic glutamate--tyrosine copolymer and for their binding characteristics. |
1987-11-18 |
2023-08-11 |
mouse |