| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Tonack, Nicole Ramin, Sireesha Garimella, Rajnish Rao, Polani B Seshagiri, Bernd Fischer, Anne Navarrete Santo. Expression of glucose transporter isoforms and the insulin receptor during hamster preimplantation embryo development. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 191. issue 5. 2010-01-08. PMID:19615873. |
we therefore investigated glut isoform and insulin receptor (ir) expression in hamster preimplantation embryos cultured in glucose-free medium from the 8-cell stage onwards. |
2010-01-08 |
2023-08-12 |
Not clear |
| Ralf Dikow, Caroline Wasserhess, Katrin Zimmerer, Lars Philipp Kihm, Matthias Schaier, Vedat Schwenger, Stefan Hardt, Christiane Tiefenbacher, Hugo Katus, Martin Zeier, Lisa Marie Gros. Effect of insulin and glucose infusion on myocardial infarction size in uraemic rats. Basic research in cardiology. vol 104. issue 5. 2009-12-04. PMID:19288152. |
insulin receptor substrates (irs-1 and irs-2) and glucose transporter (glut 4) were studied by western blot in another seven snx and seven sham-operated controls without further intervention. |
2009-12-04 |
2023-08-12 |
rat |
| Chikage Nakashima, Masayoshi Yamaguch. Overexpression of regucalcin suppresses gene expression of insulin signaling-related proteins in cloned rat hepatoma H4-II-E cells: involvement of insulin resistance. International journal of molecular medicine. vol 20. issue 5. 2008-01-08. PMID:17912465. |
the expression of rat insulin receptor (insr), phosphatidylinositol 3-kinase (pi3k), glucose transporter 2 (glut 2), or glyceroaldehyde-3-phosphate dehydrogenase (g3pdh) mrnas was examined using reverse transcription-polymerase chain reaction analysis with specific primers. |
2008-01-08 |
2023-08-12 |
rat |
| I-Min Liu, Thing-Fong Tzeng, Shorong-Shii Liou, Ting-Wei La. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta medica. vol 73. issue 10. 2007-11-06. PMID:17694473. |
additionally, repeated myricetin treatments overturned the inability of insulin to increase the expression of glucose transporter subtype 4 (glut 4) and to increase the protein levels and phosphorylation of insulin receptor substrate-1 (irs-1) in soleus muscle of these obese rats. |
2007-11-06 |
2023-08-12 |
rat |
| Irina Giurgea, Christine Bellanné-Chantelot, Maria Ribeiro, Laurence Hubert, Christine Sempoux, Jean-Jacques Robert, Oliver Blankenstein, Kahlid Hussain, Francis Brunelle, Claire Nihoul-Fékété, Jacques Rahier, Francis Jaubert, Pascale de Lonla. Molecular mechanisms of neonatal hyperinsulinism. Hormone research. vol 66. issue 6. 2006-12-22. PMID:17003566. |
diffuse chi results from germ-line mutations in the sur1 or kir6.2 genes, but also from mutations in several other genes, namely glutamate dehydrogenase (with associated hyperammonaemia), glucokinase, short-chain l-3-hydroxyacyl-coa dehydrogenase, and insulin receptor gene. |
2006-12-22 |
2023-08-12 |
Not clear |
| Frankie B Stentz, Abbas E Kitabch. Palmitic acid-induced activation of human T-lymphocytes and aortic endothelial cells with production of insulin receptors, reactive oxygen species, cytokines, and lipid peroxidation. Biochemical and biophysical research communications. vol 346. issue 3. 2006-08-21. PMID:16782068. |
these cells in presence of palmitate, but not ufa, exhibited time, and concentration-dependent emergence of insulin receptors, glut 4 expression, generation of ros, cytokines, lipid peroxidation, and irs-1. |
2006-08-21 |
2023-08-12 |
human |
| Stéphanie A Bayol, Bigboy H Simbi, Neil C Sticklan. A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning. The Journal of physiology. vol 567. issue Pt 3. 2005-12-23. PMID:16020464. |
however, these pups exhibited reduced muscle cell proliferation (pcna) with reduced insulin receptor and a trend towards reduced glucose transporter (glut)-4 mrnas when compared with pups fed a balanced chow diet, indicating possible alterations in glucose uptake by muscle tissue. |
2005-12-23 |
2023-08-12 |
rat |
| P de Lonlay, I Giurgea, C Sempoux, G Touati, F Jaubert, J Rahier, M Ribeiro, F Brunelle, C Nihoul-Fékété, J-J Robert, J-M Saudubray, C Stanley, C Bellanné-Chantelo. Dominantly inherited hyperinsulinaemic hypoglycaemia. Journal of inherited metabolic disease. vol 28. issue 3. 2005-08-18. PMID:15868462. |
in contrast to focal islet-cell hyperplasia, always sporadic to our knowledge, diffuse hyperinsulinism is a heterogeneous disorder involving several genes, various mechanisms of pathogenic mutations and different transmissions: (i) channelopathy involving the genes encoding the sulphonylurea receptor (sur1) or the inward-rectifying potassium channel (kir6.2) in recessively inherited hi or more rarely dominantly inherited hi; (ii) metabolic disorders implicating the short-chain l-3-hydroxyacyl-coa dehydrogenase (schad) enzyme inrecessively inherited hi, the glucokinase gene (gk), the glutamate dehydrogenase gene (glud1) when hyperammonemia is associated, dominant exercise-induced hi with still-unknown mechanism, and more recently the human insulin receptor gene in dominantly inherited hyperinsulinism. |
2005-08-18 |
2023-08-12 |
human |
| Xueqing Liu, Jae-kyung Kim, Yunsheng Li, Jing Li, Fang Liu, Xiaozhuo Che. Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. The Journal of nutrition. vol 135. issue 2. 2005-04-14. PMID:15671208. |
we further detected that ta induced phosphorylation of the insulin receptor (ir) and akt, as well as translocation of glucose transporter 4 (glut 4), the protein factors involved in the signaling pathway of insulin-mediated glucose transport. |
2005-04-14 |
2023-08-12 |
Not clear |
| Anne Navarrete Santos, Sarah Tonack, Michaela Kirstein, Marie Pantaleon, Peter Kaye, Bernd Fische. Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts. Reproduction (Cambridge, England). vol 128. issue 5. 2005-01-31. PMID:15509697. |
we have previously described the expression of the insulin receptor (ir) and the insulin-responsive glucose transporters (glut) 4 and 8 in rabbit preimplantation embryos. |
2005-01-31 |
2023-08-12 |
rabbit |
| S E Ozanne, G S Olsen, L L Hansen, K J Tingey, B T Nave, C L Wang, K Hartil, C J Petry, A J Buckley, L Mosthaf-Seedor. Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle. The Journal of endocrinology. vol 177. issue 2. 2003-07-18. PMID:12740011. |
this impaired insulin action was not related to changes in expression of either the insulin receptor or glucose transporter 4 (glut 4). |
2003-07-18 |
2023-08-12 |
rat |
| S Zorad, V Golda, M Fickova, L Macho, L Pinterova, J Jurcovicov. Terguride treatment attenuated prolactin release and enhanced insulin receptor affinity and GLUT 4 content in obese spontaneously hypertensive female, but not male rats. Annals of the New York Academy of Sciences. vol 967. 2002-08-02. PMID:12079879. |
terguride treatment attenuated prolactin release and enhanced insulin receptor affinity and glut 4 content in obese spontaneously hypertensive female, but not male rats. |
2002-08-02 |
2023-08-12 |
mouse |
| S Zorad, V Golda, M Fickova, L Macho, L Pinterova, J Jurcovicov. Terguride treatment attenuated prolactin release and enhanced insulin receptor affinity and GLUT 4 content in obese spontaneously hypertensive female, but not male rats. Annals of the New York Academy of Sciences. vol 967. 2002-08-02. PMID:12079879. |
glucose tolerance, serum insulin, insulin receptors in epididymal fat tissue, and glut 4 content in muscle, as well as serum prolactin, were studied in obese and lean spontaneously hypertensive rats (shrs) of both sexes. |
2002-08-02 |
2023-08-12 |
mouse |
| S Zorad, V Golda, M Fickova, L Macho, L Pinterova, J Jurcovicov. Terguride treatment attenuated prolactin release and enhanced insulin receptor affinity and GLUT 4 content in obese spontaneously hypertensive female, but not male rats. Annals of the New York Academy of Sciences. vol 967. 2002-08-02. PMID:12079879. |
our results document downregulation of insulin receptors and glut 4 in obesity and suggest a role for prolactin in obesity-induced insulin resistance, particularly in female rats. |
2002-08-02 |
2023-08-12 |
mouse |
| R L McNeel, S T Ding, E O Smith, H J Mersman. Expression of porcine adipocyte transcripts during differentiation in vitro and in vivo. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 126. issue 3. 2001-02-08. PMID:11007171. |
transcript concentrations for the transcription factors, ccaat enhancer binding protein beta and alpha (c/ebpbeta and c/ebpalpha), plus the adipocyte-characteristic proteins, fatty acid synthase (fas), glucose transporter 4 (glut 4), hormone-sensitive lipase (hsl), insulin receptor (insr), lipoprotein lipase (lpl), and leptin were measured during differentiation of porcine stromal-vascular (s/v) cells in vitro. |
2001-02-08 |
2023-08-12 |
Not clear |
| S H Torre. [Obesity, insulin resistance and skeletal muscle characteristics]. Acta cientifica venezolana. vol 50. issue 1. 1999-12-29. PMID:10513036. |
the different factors that may impair insulin action and alter glucose uptake in skeletal muscle are: lower blood flow to muscle, produced by either decreased vasodilation or by increased sympathetic nerve activity; augmented diffusion distance from capillaries to muscle due to a decrease in capillary number or to enlarged muscle cells; decrease of insulin receptors; change in the fatty acid profile of major membrane structural phospholipids; decrease in glucose transporters (glut 4) and/or hexokinase; impairment in metabolic routes of glucose in muscle as reduction in glycogen synthase. |
1999-12-29 |
2023-08-12 |
Not clear |
| M Roques, H Vida. A phosphatidylinositol 3-Kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells. The Journal of biological chemistry. vol 274. issue 48. 1999-12-29. PMID:10567366. |
insulin (10(-7) m, 6 h of incubation) induced a 2-fold increase in p85alphapi 3-k mrna abundances (118 +/- 12 versus 233 +/- 35 amol/microgram total rna, n = 5, p < 0.01) without changing the expression levels of insulin receptor, irs-1, glycogen synthase, and glut 4 mrnas in differentiated myotubes from healthy subjects. |
1999-12-29 |
2023-08-12 |
human |
| J Rieusset, J Auwerx, H Vida. Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes. Biochemical and biophysical research communications. vol 265. issue 1. 1999-12-17. PMID:10548525. |
the mrna levels of insulin receptor, irs-1, glut 4, lipoprotein lipase, hormone-sensitive lipase, acylation-stimulating protein, fatty acid transport protein-1, angiotensinogen, plasminogen activator inhibitor-1, and ppargamma1 and gamma2 were not modified by rosiglitazone treatment. |
1999-12-17 |
2023-08-12 |
human |
| Y Le Marchand-Brustel, J F Tanti, M Cormont, J M Ricort, T Grémeaux, S Grill. From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance. Journal of receptor and signal transduction research. vol 19. issue 1-4. 1999-06-15. PMID:10071760. |
from insulin receptor signalling to glut 4 translocation abnormalities in obesity and insulin resistance. |
1999-06-15 |
2023-08-12 |
mouse |
| Y Le Marchand-Brustel, J F Tanti, M Cormont, J M Ricort, T Grémeaux, S Grill. From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance. Journal of receptor and signal transduction research. vol 19. issue 1-4. 1999-06-15. PMID:10071760. |
in order to better understand the abnormalities in glucose transport in insulin resistance, we have studied the pathway leading from the insulin receptor kinase stimulation to the translocation of the glut 4 containing vesicles. |
1999-06-15 |
2023-08-12 |
mouse |