| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie Uebelhoer, M Luisa Iruela-Arisp. Cross-talk between signaling and metabolism in the vasculature. Vascular pharmacology. vol 83. 2017-06-05. PMID:27291139. |
efficient glucose uptake by the endothelium requires insulin receptor activation to deliver glut receptors to the cell surface. |
2017-06-05 |
2023-08-13 |
Not clear |
| Arjunan Sundaresan, Thangaiyan Radhiga, Kodukkur Viswanathan Pugalend. Ursolic acid and rosiglitazone combination improves insulin sensitivity by increasing the skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat diet-fed C57BL/6J mice. Journal of physiology and biochemistry. vol 72. issue 2. 2017-03-06. PMID:27090933. |
these results strongly suggest that combination treatment (ua/rsg) activates irs-pi3-kinase-akt-dependent signaling pathways to induce glut 4 translocation and increases the expression of insulin receptor to improve glucose intolerance. |
2017-03-06 |
2023-08-13 |
mouse |
| Kyoung Min Kim, Kuy-Sook Lee, Gha Young Lee, Hyunjin Jin, Eunice Sung Durrance, Ho Seon Park, Sung Hee Choi, Kyong Soo Park, Young-Bum Kim, Hak Chul Jang, Soo Li. Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3β inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance. Molecular and cellular endocrinology. vol 409. 2016-02-09. PMID:25802191. |
glucose excursion decreased significantly by kicg1338-treated oletf rats, accompanied by increase in insulin receptor substrate-1 and glucose transporter (glut)-4 expressions in muscle and decreased glut-2 expression in liver. |
2016-02-09 |
2023-08-13 |
mouse |
| Sanni Kinnunen, Satu Mänttäri, Karl-Heinz Herzig, Petteri Nieminen, Anne-Mari Mustonen, Seppo Saarel. Maintenance of skeletal muscle energy homeostasis during prolonged wintertime fasting in the raccoon dog (Nyctereutes procyonoides). Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 185. issue 4. 2016-01-14. PMID:25652584. |
total and phosphorylated ampk and acetyl-coa carboxylase (acc), glucose transporter 4 (glut 4), insulin receptor and protein kinase b (akt) protein expressions of hind limb muscles were determined by western blot after 10 weeks of fasting. |
2016-01-14 |
2023-08-13 |
human |
| Sanni Kinnunen, Satu Mänttäri, Karl-Heinz Herzig, Petteri Nieminen, Anne-Mari Mustonen, Seppo Saarel. Maintenance of skeletal muscle energy homeostasis during prolonged wintertime fasting in the raccoon dog (Nyctereutes procyonoides). Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 185. issue 4. 2016-01-14. PMID:25652584. |
fasting did not influence glut 4, insulin receptor or akt expression, but akt phosphorylation was lower in m. flexor digitorum superficialis and m. extensor digitorum longus. |
2016-01-14 |
2023-08-13 |
human |
| Xuan Wu, Hongchen Liu, Lingling E, Zhenchun L. [Expression of glucose transporter-1 and insulin receptor alpha1 in osteoblast obtained from diabetic rats' mandibles]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology. vol 29. issue 4. 2015-06-07. PMID:21932649. |
to explore the expression of glucose transporter (glut)-1 and insulin receptor (ir) alpha1 in osteoblast obtained from diabetic rats' mandibles. |
2015-06-07 |
2023-08-12 |
rat |
| Arnab Banerjee, Anuradha, Kaustab Mukherjee, Amitabh Krishn. Testicular glucose and its transporter GLUT 8 as a marker of age-dependent variation and its role in steroidogenesis in mice. Journal of experimental zoology. Part A, Ecological genetics and physiology. vol 321. issue 9. 2015-05-29. PMID:25078271. |
the changes in glucose, glucose transporter (glut), and insulin receptor (ir) level in the testis were evaluated and compared with the testicular steroidogenic parameters such as steroidogenic acute regulatory protein (star), 3β-hydroxy steroid dehydrogenase (3β-hsd) and circulating testosterone levels. |
2015-05-29 |
2023-08-13 |
mouse |
| Hanaa S Sallam, Batbayar Tumurbaatar, Wen-Ru Zhang, Demidmaa Tuvdendorj, Manisha Chandalia, Filippo Tempia, Fernanda Laezza, Giulio Taglialatela, Nicola Abat. Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses. Journal of neurochemistry. vol 133. issue 1. 2015-05-27. PMID:25640170. |
these changes were associated with impaired basal synaptic transmission at the schaffer collaterals to hippocampal cornu ammonis 1 (ca1) synapses, decreased phosphorylation of the glun1 glutamate receptor subunit, down-regulation of insulin receptor expression, and up-regulation of the free fatty acid receptor 1. |
2015-05-27 |
2023-08-13 |
mouse |
| Wei Zhang, Lindsay H Sumners, Paul B Siegel, Mark A Cline, Elizabeth R Gilber. Quantity of glucose transporter and appetite-associated factor mRNA in various tissues after insulin injection in chickens selected for low or high body weight. Physiological genomics. vol 45. issue 22. 2014-05-30. PMID:24046279. |
insulin was associated with reduced blood glucose in all populations (p < 0.05) and reduced mrna of insulin receptor (ir) and glut 2 and 3 in liver (p < 0.05). |
2014-05-30 |
2023-08-12 |
Not clear |
| Mohammad Shamsul Ol. Effect of hyperglycemia on insulin receptor signaling in the cultured retinal Müller glial cells. Biochemical and biophysical research communications. vol 444. issue 2. 2014-04-30. PMID:24462861. |
hydrogen peroxide increased the tyrosine phosphorylation of insulin receptor proteins but excess glutamate could not affect the insulin receptor proteins indicating that glutamate may not cause oxidative stress in tr-mul cells. |
2014-04-30 |
2023-08-12 |
Not clear |
| Atsushi Kurabayashi, Yoshihiko Kakinuma, Taku Morita, Keiji Inoue, Takayuki Sato, Mutsuo Furihat. Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor. PloS one. vol 8. issue 7. 2014-02-24. PMID:23874892. |
by focusing on insulin-like growth factor i (igf-i), which has a similar effect on glucose metabolism as the insulin receptor, we demonstrated that igf-i receptor (igf-ir) protein expression in the liver was upregulated in vhl-ko mice compared to that in the mice without vhl deletion, as was the expression of glucose transporter (glut) 1. |
2014-02-24 |
2023-08-12 |
mouse |
| P J Sake. Mutation Screening Using PCR-SSCP : Silver Staining and Isotopic Protocols. Methods in molecular medicine. vol 16. 2012-10-02. PMID:21390774. |
it has the ability of detecting a single base change, and has been applied to a number of genes, including the insulin receptor (2), glut 4 (3), glucokinase (4), and the mitochondrial genome (5). |
2012-10-02 |
2023-08-12 |
Not clear |
| Banerjee Arnab, Krishna Amitab. Altered glucose transport to utero-embryonic unit in relation to delayed embryonic development in the Indian short-nosed fruit bat, Cynopterus sphinx. Molecular and cellular endocrinology. vol 333. issue 1. 2011-08-15. PMID:21134414. |
the results showed a significantly decreased concentration of glucose in the utero-embryonic unit due to decline in the expression of insulin receptor (ir) and glut 3, 4 and 8 proteins in the utero-embryonic unit during delayed period. |
2011-08-15 |
2023-08-12 |
Not clear |
| Jeong-Kwon Park, Sang-Pyo Kim, Dae-Kyu Son. Ameliorating effects of sulfonylurea drugs on insulin resistance in Otsuka long-evans Tokushima Fatty rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 12. issue 1. 2011-07-14. PMID:20157388. |
on immunohistochemistry analysis for the kir6.2 subunit of k(atp) channels, insulin receptor beta-subunits, and glucose transporters (glut) type 2 and 4 in liver, fat and skeletal muscle tissues, the sulfonylurea drugs (glimepiride and gliclazide) were more effective than repaglinide in recovery from their decreased expressions in oletf rats. |
2011-07-14 |
2023-08-12 |
rat |
| Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Lucas Siqueira Trindade, Haruyoshi Yamaza, Takuya Chiba, Isao Shimokaw. Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling. Experimental gerontology. vol 44. issue 10. 2011-03-14. PMID:19646410. |
in control w-al rats, the levels of serum insulin, phosphorylated (p) insulin receptor (py-ir), p-akt, and the expression of glucose transporter (glut) 4 in the membrane fraction were greater in the glucose-injected group than in the saline-injected group, indicating significant activation of insulin signaling in response to glucose loading. |
2011-03-14 |
2023-08-12 |
rat |
| Clare Stretton, Ashleigh Evans, Harinder S Hunda. Cellular depletion of atypical PKC{lambda} is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells. American journal of physiology. Endocrinology and metabolism. vol 299. issue 3. 2010-10-06. PMID:20530734. |
depletion of pkclambda (>95%) had no significant effect on the expression of proteins participating in insulin signaling [i.e., insulin receptor, irs-1, phosphatidylinositol 3-kinase (pi 3-kinase), pkb, or phosphate and tensin homolog deleted on chromosome 10] or those involved in glucose transport [akt substrate of 160 kda, glucose transporter (glut)1, or glut4]. |
2010-10-06 |
2023-08-12 |
rat |
| Cynthia L Blanco, Hanyu Liang, Joaquin Joya-Galeana, Ralph A DeFronzo, Donald McCurnin, Nicolas Mus. The ontogeny of insulin signaling in the preterm baboon model. Endocrinology. vol 151. issue 5. 2010-06-08. PMID:20233798. |
to test the hypothesis that the insulin transduction pathway is underdeveloped with prematurity, fetal baboons were delivered, anesthetized, and euthanized at 125 d gestational age (ga), 140 d ga, or near term at 175 d ga. vastus lateralis muscle and liver tissues were obtained, and protein content of insulin signaling molecules [insulin receptor (ir)-beta, ir substate-1, p85 subunit of phosphatidylinositol 3-kinase, akt, and as160] and glucose transporters (glut)-1 and glut4 was measured by western blotting. |
2010-06-08 |
2023-08-12 |
Not clear |
| Raj Kamal Srivastava, Amitabh Krishn. Melatonin modulates glucose homeostasis during winter dormancy in a vespertilionid bat, Scotophilus heathi. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 155. issue 3. 2010-04-13. PMID:20026417. |
the high circulating melatonin levels during the period of maximum body fat at the beginning of winter prepare the bats for winter dormancy by modulating the glucose homeostasis through affecting blood glucose levels, muscle and liver glycogen stores, insulin receptor and glucose transporter 4 (glut 4) expression. |
2010-04-13 |
2023-08-12 |
Not clear |
| Raj Kamal Srivastava, Amitabh Krishn. Melatonin modulates glucose homeostasis during winter dormancy in a vespertilionid bat, Scotophilus heathi. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 155. issue 3. 2010-04-13. PMID:20026417. |
this is also confirmed by in vivo study in which melatonin injection improves the glucose tolerance, increases muscle insulin receptor and glut 4 expression, and enhances glucose clearance from the blood. |
2010-04-13 |
2023-08-12 |
Not clear |
| Ana M Rodríguez, Juana Sánchez, Aixa Tobaruela, Teresa Priego, Catalina Picó, Andreu Palo. Time-course effects of increased fatty acid supply on the expression of genes involved in lipid/glucose metabolism in muscle cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 25. issue 2-3. 2010-04-08. PMID:20110694. |
mrna levels of muscle carnitine palmitoyl transferase 1 (mcpt1), glut 4, insulin receptor (insr), myod1, peroxisome proliferator activated receptor (ppar) gamma coactivator 1alpha (pgc1alpha) and beta (pgc1beta), pparalpha, ppardelta, pyruvate dehydrogenase kinase 4 (pdk4) and uncoupling proteins (ucps) 2 and 3 were analyzed by quantitative rt-pcr. |
2010-04-08 |
2023-08-12 |
rat |