| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyun-Ji Jang, Hye-Young Min, Yun Pyo Kang, Hye-Jin Boo, Jisung Kim, Jee Hwan Ahn, Seung Ho Oh, Jin Hwa Jung, Choon-Sik Park, Jong-Sook Park, Seog-Young Kim, Ho-Young Le. Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression. Nature communications. vol 15. issue 1. 2024-06-08. PMID:38851766. |
nb enhances glucose uptake in tumor-associated macrophages by increasing the expression and surface localization of glucose transporter (glut) 1 and 3, thereby leading to transcriptional upregulation of insulin-like growth factor 2 (igf2), which subsequently activates insulin receptor (ir) in lc cells in a paracrine manner, promoting its nuclear import. |
2024-06-08 |
2024-06-11 |
mouse |
| Ana Knezovic, Marija Piknjac, Jelena Osmanovic Barilar, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic-Petrisi. Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979662. |
the expression of tyrosine hydroxylase (th) and proteins involved in insulin (insulin receptor - ir, phosphoinositide 3 kinase - pi3k, extracellular signal-regulated kinases-erk) and glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptos-ampar, n-methyl-d-aspartate receptor - nmdar) signaling was assessed in the hippocampus (hpc), hypothalamus (hpt) and striatum (s) by immunofluorescence, western blot and enzyme-linked immunosorbent assay (elisa). |
2023-03-29 |
2023-08-14 |
rat |
| Ji Hyeong Baek, Hyeonwi Son, Jae Soon Kang, Dae Young Yoo, Hye Jin Chung, Dong Kun Lee, Hyun Joon Ki. Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment. Cells. vol 11. issue 24. 2022-12-23. PMID:36552776. |
in particular, levels of insulin receptor beta subunit (irβ), irs-1, vesicular glutamate transporter 1, glutamine transporter snat2, phosphate-activated glutaminase, and glut-3 were not changed by insulin. |
2022-12-23 |
2023-08-14 |
mouse |
| Sangeeta Maurya, Amitabh Krishna, Bechan Lal, Ajit Sing. Asprosin promotes steroidogenesis and spermatogenesis with improved glucose metabolism in adult mice testis. Andrologia. 2022-09-03. PMID:36056803. |
intratesticular administration of asprosin resulted into a significant increase in glucose and lactate levels along with enhanced expression of asprosin receptor olfr734, insulin receptor (ir), glucose transporter 8 (glut 8), lactate dehydrogenase (ldh) activity and monocorboxylate transporters (mct2 and 4). |
2022-09-03 |
2023-08-14 |
mouse |
| Lauren McClure Yauch, Kathleen Ennis-Czerniak, William H Frey Ii, Ivan Tkac, Raghavendra B Ra. Intranasal Insulin Attenuates the Long-term Adverse Effects of Neonatal Hyperglycemia on the Hippocampus in Rats. Developmental neuroscience. 2022-08-30. PMID:36041414. |
the acute effects on hippocampal neurochemical profile and transcript mrna expression of insulin receptor (insr), glucose transporters (glut1, glut 4 and glut8) and poly(adp-ribose)polymerase-1(parp1, a marker of oxidative stress) were determined on p7 using in vivo 1h mr spectroscopy (mrs) and qpcr. |
2022-08-30 |
2023-08-14 |
rat |
| Undurti N Da. Syntaxin interacts with arachidonic acid to prevent diabetes mellitus. Lipids in health and disease. vol 21. issue 1. 2022-08-18. PMID:35982452. |
aa enhances cell membrane fluidity, increases the expression of glut and insulin receptors, and brings about its anti-inflammatory actions at least in part by enhancing the formation of its metabolite lipoxin a4 (lxa4). |
2022-08-18 |
2023-08-14 |
Not clear |
| Julie E Finnell, Carrie R Ferrari. Intra-NAc insulin reduces the motivation for food and food intake without altering cue-triggered food-seeking. Physiology & behavior. 2022-06-26. PMID:35753434. |
furthermore, insulin receptor activation alters dopamine and glutamate transmission within mesolimbic regions that influence food-seeking and feeding including the nucleus accumbens (nac). |
2022-06-26 |
2023-08-14 |
rat |
| Eugene D Albrecht, Graham W Aberdeen, Jeffery S Babischkin, Steven J Prior, Terrie J Lynch, Irene A Baranyk, Gerald J Pep. Estrogen Promotes Microvascularization in the Fetus and thus Vascular Function and Insulin Sensitivity in Offspring. Endocrinology. 2022-03-24. PMID:35325097. |
we have shown that normal weight offspring born to estrogen-deprived baboons exhibited insulin resistance, although liver and adipose function and insulin receptor and glut transporter expression were unaltered. |
2022-03-24 |
2023-08-13 |
Not clear |
| Jennifer M Erichsen, Jennifer L Woodruff, Claudia A Grillo, Lawrence P Reagan, James R Fade. Molecular effects of intranasal insulin in the rodent brain: Examination of insulin receptor signaling and the glutamatergic system. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109179. |
to investigate the mechanistic basis for the pro-cognitive effects of ini, insulin receptor (ir) signaling and the expression of glutamate receptors and transporters, due to the role of the glutamatergic system in hippocampal synaptic transmission, was examined. |
2022-02-03 |
2023-08-13 |
Not clear |
| Tracy L Fetterly, Max F Oginsky, Allison M Nieto, Yanaira Alonso-Caraballo, Zuleirys Santana-Rodriguez, Carrie R Ferrari. Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 11. 2021-06-11. PMID:33514676. |
insulin bidirectionally alters nac glutamatergic transmission: interactions between insulin receptor activation, endogenous opioids, and glutamate release. |
2021-06-11 |
2023-08-13 |
human |
| Matthias Gralle, Simon Labrecque, Charleen Salesse, Paul De Koninc. Spatial dynamics of the insulin receptor in living neurons. Journal of neurochemistry. vol 156. issue 1. 2021-04-12. PMID:31886886. |
using colocalization with synaptic markers, we also show that in contrast to the glutamate receptor subunit glutamate receptor subunit a1, the dynamics of the insulin receptor are not affected by association with excitatory synapses; however, the insulin receptor is immobilized by components of inhibitory synapses. |
2021-04-12 |
2023-08-13 |
rat |
| Laura B James-Allan, Jaron Arbet, Stephanie B Teal, Theresa L Powell, Thomas Jansso. Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta. The Journal of clinical endocrinology and metabolism. 2021-01-09. PMID:31112275. |
the syncytiotrophoblast is the transporting epithelium in the human placenta, expressing glucose transporters (glut) and insulin receptors (ir) in its maternal-facing microvillous (mvm) and fetal-facing basal plasma membrane (bm). |
2021-01-09 |
2023-08-13 |
human |
| Eisuke Kat. Bioactive compounds in plant materials for the prevention of diabetesand obesity. Bioscience, biotechnology, and biochemistry. vol 83. issue 6. 2019-07-15. PMID:30773997. |
abbreviations: ac: adenylyl cyclase; ampk: amp-activated protein kinase; βar: β-adrenergic receptor; ca: catecholamine; camp: cyclic adenosine monophosphate; cgmp: cyclic guanosine monophosphate; dpp-4: dipeptidyl peptidase-4; erk: extracellular signal-regulated kinase; gc: guanylyl cyclase; gh: growth hormone; glp-1: glucagon-like peptide-1; glut: glucose transporter; hsl: hormone-sensitive lipase; ir: insulin receptor; irs: insulin receptor substrate; mapk: mitogen-activated protein kinase; mek: mapk/erk kinase; mg: maltase-glucoamylase; np: natriuretic peptide; npr: natriuretic peptide receptor; mtorc2: mechanistic target of rapamycin complex-2; pc: proanthocyanidin; pi3k: phosphoinositide 3-kinase; pka: camp-dependent protein kinase; pkb (akt): protein kinase b; pkg: cgmp-dependent protein kinase; pparγ: peroxisome proliferator-activated receptor-γ; sglt1: sodium-dependent glucose transporter 1; si: sucrase-isomaltase; t2dm: type 2 diabetes mellitus; tnfα: tumor necrosis factor-α. |
2019-07-15 |
2023-08-13 |
Not clear |
| O Tsave, M P Yavropoulou, M Kafantari, C Gabriel, J G Yovos, A Salifoglo. Comparative assessment of metal-specific adipogenic activity in zinc and vanadium-citrates through associated gene expression. Journal of inorganic biochemistry. vol 186. 2019-05-16. PMID:29966853. |
cellular maturation of pre-adipocytes to their mature form was pursued in the presence-absence of insulin and employment of closely linked genetic targets, key to adipocyte maturation (peroxisome proliferator-activated receptor gamma (ppar-γ), glucose transporter 1,3,4 (glut 1,3,4), adiponectin (adipoq), glucokinase (gck), and insulin receptor (ins-r)). |
2019-05-16 |
2023-08-13 |
Not clear |
| Brian E Leonar. Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence? Modern trends in pharmacopsychiatry. vol 31. 2019-05-06. PMID:28738351. |
this results in the synthesis of the nmda glutamate agonist, quinolinic acid, and kynurenine metabolites which initiate oxidative stress and insulin receptor resistance. |
2019-05-06 |
2023-08-13 |
Not clear |
| Anuradha, Amitabh Krishn. Adiposity associated changes in serum glucose and adiponectin levels modulate ovarian steroidogenesis during delayed embryonic development in the fruit bat, Cynopterus sphinx. General and comparative endocrinology. vol 262. 2018-07-23. PMID:29474936. |
the in vivo study showed increased glucose uptake by the adipose tissue during adipogenesis due to increased expression of insulin receptor (ir) and glucose transporter (glut) 4 proteins. |
2018-07-23 |
2023-08-13 |
Not clear |
| Jun-Mei Lu, Dong-Dong Liu, Zhao-Yang Li, Chen Ling, Yan-Ai Me. Neuritin Enhances Synaptic Transmission in Medial Prefrontal Cortex in Mice by Increasing CaV3.3 Surface Expression. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 7. 2018-05-21. PMID:28475719. |
incubation of mpfc slices with neuritin for 45 min significantly increased mepsc frequency and glutamate release as measured by high-performance liquid chromatography, which was mimicked by insulin and abrogated by an insulin receptor (ir) inhibitor. |
2018-05-21 |
2023-08-13 |
mouse |
| Benedetta Bigio, Aleksander A Mathé, Vasco C Sousa, Danielle Zelli, Per Svenningsson, Bruce S McEwen, Carla Nasc. Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 28. 2017-11-27. PMID:27354525. |
rna sequencing of the ventral dentate gyrus, a mood-regulatory region, identified metabolic factors as key markers predisposing to depression (insulin receptors insr, glucose transporters glut-4 and glut-12, and the regulator of appetite cartpt) and to lac responsiveness (leptin receptors lepr, metabotropic glutamate receptors-2 mglu2, neuropeptide-y npy, and mineralocorticoid receptors mr). |
2017-11-27 |
2023-08-13 |
human |
| Michelle A Keske, Renee M Dwyer, Ryan D Russell, Sarah J Blackwood, Aascha A Brown, Donghua Hu, Dino Premilovac, Stephen M Richards, Stephen Rattiga. Regulation of microvascular flow and metabolism: An overview. Clinical and experimental pharmacology & physiology. vol 44. issue 1. 2017-09-12. PMID:27797410. |
the classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin receptors on myocytes to stimulate glucose transporter 4 (glut 4) translocation to the cell surface membrane, enhancing glucose uptake. |
2017-09-12 |
2023-08-13 |
Not clear |
| Rachna Verma, Amitabh Krishn. Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study. General and comparative endocrinology. vol 241. 2017-09-07. PMID:26965948. |
letrozole-induced changes in testicular histology, cell proliferation (proliferating cell nuclear antigen; pcna), cell survival (b cell lymphoma factor-2; bcl2), apoptotic (cysteine-aspartic proteases; caspase-3), steroidogenic (side chain cleavage; scc, 3β-hydroxy steroid dehydrogenase enzyme; 3β hsd, steroidogenic acute regulatory protein; star, aromatase and luteinizing hormone receptor; lh-r) markers, glucose level, and rate of expression of glucose transporter (glut) 8 and insulin receptor (ir) proteins in the testis along with changes in serum e2 and testosterone (t) levels were evaluated. |
2017-09-07 |
2023-08-13 |
mouse |