All Relations between ide and insulin

Publication Sentence Publish Date Extraction Date Species
Fateme Binayi, Behnam Saeidi, Fatemeh Farahani, Mina Sadat Izadi, Farzaneh Eskandari, Fariba Azarkish, Mohammad Sahraei, Rasoul Ghasemi, Fariba Khodagholi, Homeira Zardoo. Sustained feeding of a diet high in fat resulted in a decline in the liver's insulin-degrading enzyme levels in association with the induction of oxidative and endoplasmic reticulum stress in adult male rats: Evaluation of 4-phenylbutyric acid. Heliyon. vol 10. issue 12. 2024-07-08. PMID:38975085. the current study explored the impact of high fat diet (hfd) on hepatic oxidative and endoplasmic reticulum (er) stress and its insulin degrading enzyme (ide) content with the injection of 4-phenyl butyric acid (4-pba) in adult male rats. 2024-07-08 2024-07-11 rat
Fateme Binayi, Behnam Saeidi, Fatemeh Farahani, Mina Sadat Izadi, Farzaneh Eskandari, Fariba Azarkish, Mohammad Sahraei, Rasoul Ghasemi, Fariba Khodagholi, Homeira Zardoo. Sustained feeding of a diet high in fat resulted in a decline in the liver's insulin-degrading enzyme levels in association with the induction of oxidative and endoplasmic reticulum stress in adult male rats: Evaluation of 4-phenylbutyric acid. Heliyon. vol 10. issue 12. 2024-07-08. PMID:38975085. plasma glucose and insulin levels, homa-β (homeostasis model assessment of β-cell), hepatic er and oxidative stress biomarkers and ide protein content were assessed. 2024-07-08 2024-07-11 rat
Azam Abedi, Tahereh Foroutan, Leila Mohaghegh Shalmani, Leila Dargah. Sex-dependent susceptibility to brain metabolic dysfunction and memory impairment in response to pre- and postnatal high-fat diet. The Journal of nutritional biochemistry. 2024-06-30. PMID:38945454. in adult offspring, peripheral insulin resistance parameters, spatial memory performance, and brain glucose metabolism (18f-fdg-pet scan and protein levels of ide and glut3) were assessed. 2024-06-30 2024-07-03 rat
Chatrawee Duangjan, Thalida Em Arpawong, Brett N Spatola, Sean P Curra. Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity. GeroScience. 2024-05-20. PMID:38767782. in the liver, insulin is degraded by the activity of the insulin-degrading enzyme (ide). 2024-05-20 2024-05-27 mouse
Chatrawee Duangjan, Thalida Em Arpawong, Brett N Spatola, Sean P Curra. Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity. GeroScience. 2024-05-20. PMID:38767782. wdr23ko mice have increased ide expression, reduced circulating insulin, and defective insulin responses. 2024-05-20 2024-05-27 mouse
Chatrawee Duangjan, Thalida Em Arpawong, Brett N Spatola, Sean P Curra. Hepatic WDR23 proteostasis mediates insulin homeostasis by regulating insulin-degrading enzyme capacity. GeroScience. 2024-05-20. PMID:38767782. genetically engineered human cell models lacking wdr23 also increase ide expression and display dysregulated phosphorylation of insulin signaling cascade proteins, irs-1, akt2, mapk, foxo, and mtor, similar to cells treated with insulin, which can be mitigated by chemical inhibition of ide. 2024-05-20 2024-05-27 mouse
Chatrawee Duangjan, Ronald W Irwin, Sean P Curra. Loss of the WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain. Cellular signalling. 2024-01-19. PMID:38242270. wdr23ko also increases the endogenous levels of insulin degrading enzyme (ide) and the relaxin-3 peptide (rln3), both of which have established roles in mediating mitochondrial metabolic and oxidative stress responses. 2024-01-19 2024-01-22 mouse
Xiao-Qi Liu, Tian Hu, Guang-Liang Wu, Li-Jun Qiao, Ye-Feng Cai, Qi Wang, Shi-Jie Zhan. Tanshinone IIA, the key compound in Salvia miltiorrhiza, improves cognitive impairment by upregulating Aβ-degrading enzymes in APP/PS1 mice. International journal of biological macromolecules. 2023-11-09. PMID:37944734. western blot results confirmed that the expressions of insulin degrading enzymes (ide) and neprilysin (nep) were significantly increased after tan iia treatment, which demonstrated that tan iia improved ad by increasing aβ-degrading enzymes. 2023-11-09 2023-11-20 mouse
Swapnali Vasant Birajdar, Farhan Mazahir, Md Imtiyaz Alam, Amit Kumar, Awesh K Yada. Repurposing and clinical attributes of antidiabetic drugs for the treatment of neurodegenerative disorders. European journal of pharmacology. 2023-10-31. PMID:37907134. insulin degrading enzyme (ide) plays a significant role in the amyloid β metabolism, aggregation, and deposition of misfolded proteins in the brain's hippocampal and cortical neuronal regions. 2023-10-31 2023-11-08 mouse
Swapnali Vasant Birajdar, Farhan Mazahir, Md Imtiyaz Alam, Amit Kumar, Awesh K Yada. Repurposing and clinical attributes of antidiabetic drugs for the treatment of neurodegenerative disorders. European journal of pharmacology. 2023-10-31. PMID:37907134. the insulin signaling via ip3 activation upregulates the ide and could be a promising approach to regulate neurodegeneration. 2023-10-31 2023-11-08 mouse
Swapnali Vasant Birajdar, Farhan Mazahir, Md Imtiyaz Alam, Amit Kumar, Awesh K Yada. Repurposing and clinical attributes of antidiabetic drugs for the treatment of neurodegenerative disorders. European journal of pharmacology. 2023-10-31. PMID:37907134. the repurposing of existing antidiabetic drugs such as metformin, dpp-4 inhibitors, thiazolidinediones, glucagon-like peptides (glp-1), sodium-glucose co-transport-2 (sgct-2) inhibitors, and insulin could be an alternative and effective strategy to treat neurodegeneration via modulating insulin signaling, insulin resistance, ide activity, oxidative stress, mitochondrial dysfunction, serum lipid profile and neuroinflammation in the brain. 2023-10-31 2023-11-08 mouse
Miriam Corraliza-Gomez, Teresa Bermejo, Jingtao Lilue, Noelia Rodriguez-Iglesias, Jorge Valero, Irene Cozar-Castellano, Eduardo Arranz, Diego Sanchez, Maria Dolores Ganfornin. Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging. Journal of neuroinflammation. vol 20. issue 1. 2023-10-10. PMID:37817156. besides insulin, ide is able to cleave many substrates in vitro, including amyloid beta peptides, making this enzyme a candidate pathophysiological link between alzheimer's disease (ad) and type 2 diabetes (t2d). 2023-10-10 2023-10-15 mouse
Joanna Żukowska, Stephen J Moss, Vasanta Subramanian, K Ravi Achary. Molecular basis of selective amyloid-β degrading enzymes in Alzheimer's disease. The FEBS journal. 2023-08-25. PMID:37622248. among several known ades, neprilysin (nep), endothelin-converting enzyme-1 (ece-1), insulin degrading enzyme (ide) and angiotensin-1 converting enzyme (ace) from the zinc metalloprotease family have been identified as important. 2023-08-25 2023-09-07 mouse
Shuaishuai Zhu, Emmanuelle Waeckel-Énée, Anna Moser, Marie-Andrée Bessard, Kevin Roger, Joanna Lipecka, Ayse Yilmaz, Barbara Bertocci, Julien Diana, Benjamin Saintpierre, Ida Chiara Guerrera, Stefania Francesconi, François-Xavier Mauvais, Peter van Ender. Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37503145. we examined beta cell adaptation to stress in mice deficient for insulin-degrading enzyme (ide), a ubiquitous protease with high affinity for insulin and genetic association with type 2 diabetes. 2023-07-28 2023-08-14 mouse
Merc M Kemeh, Noel D Laz. Modulation of the Activity of the Insulin-Degrading Enzyme by Aβ Peptides. ACS chemical neuroscience. 2023-07-27. PMID:37498802. the insulin-degrading enzyme (ide) is an evolutionarily conserved protease implicated in the degradation of insulin and amyloidogenic peptides. 2023-07-27 2023-08-14 Not clear
Merc M Kemeh, Noel D Laz. Modulation of the Activity of the Insulin-Degrading Enzyme by Aβ Peptides. ACS chemical neuroscience. 2023-07-27. PMID:37498802. most of the biochemical and biophysical characterization of ide's catalytic activity has been conducted using solutions containing a single substrate, i.e., insulin or aβ(1-40). 2023-07-27 2023-08-14 Not clear
Merc M Kemeh, Noel D Laz. Modulation of the Activity of the Insulin-Degrading Enzyme by Aβ Peptides. ACS chemical neuroscience. 2023-07-27. PMID:37498802. here, we show by a kinetic assay based on insulin's helical circular dichroic signal and maldi tof mass spectrometry that aβ peptides modulate ide's activity toward insulin in opposing ways. 2023-07-27 2023-08-14 Not clear
Merc M Kemeh, Noel D Laz. Modulation of the Activity of the Insulin-Degrading Enzyme by Aβ Peptides. ACS chemical neuroscience. 2023-07-27. PMID:37498802. aβ(1-40) enhances ide-dependent degradation of insulin, whereas aβ(pyroe3-42), the most pathogenic pyroglutamate-modified aβ peptide in ad, inhibits ide's activity. 2023-07-27 2023-08-14 Not clear
Ayse Yilmaz, Chiara Guerrera, Emmanuelle Waeckel-Énée, Joanna Lipecka, Barbara Bertocci, Peter van Ender. Insulin-Degrading Enzyme Interacts with Mitochondrial Ribosomes and Respiratory Chain Proteins. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371470. although ide can degrade insulin and some other low molecular weight substrates efficiently, its ubiquitous expression suggests additional functions supported by experimental findings, such as a role in stress responses and cellular protein homeostasis. 2023-06-28 2023-08-14 Not clear
Qian Su, Juan Huang, Xi Chen, Yijie Wang, Muqing Shao, Hongjia Yan, Caiyu Chen, Hongmei Ren, Fuwei Zhang, Yinxing Ni, Pedro A Jose, Jian Zhong, Jian Yan. Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway. Molecular nutrition & food research. 2023-02-02. PMID:36726048. the kidney is a major site of insulin clearance, where the insulin-degrading enzyme (ide) plays a vital role in the proximal tubule. 2023-02-02 2023-08-14 mouse