| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junki Miyamoto, Keita Watanabe, Satsuki Taira, Mayu Kasubuchi, Xuan Li, Junichiro Irie, Hiroshi Itoh, Ikuo Kimur. Barley β-glucan improves metabolic condition via short-chain fatty acids produced by gut microbial fermentation in high fat diet fed mice. PloS one. vol 13. issue 4. 2018-07-31. PMID:29698465. |
moreover, the secretion of the gut hormones pyy and glp-1 increased in hbg-fed mice, thereby reducing food intake and improving insulin sensitivity by changing the gut microbiota and increasing scfas (especially, butyrate) under conventional condition. |
2018-07-31 |
2023-08-13 |
mouse |
| Hiroaki Motoyama, Akira Kobayashi, Takahide Yokoyama, Akira Shimizu, Hiroshi Sakai, Tsuyoshi Notake, Kentaro Fukushima, Shin-Ichi Miyagaw. Treatment with specific soluble factors promotes the functional maturation of transcription factor-mediated, pancreatic transdifferentiated cells. PloS one. vol 13. issue 5. 2018-07-31. PMID:29768476. |
treatment with an n2 supplement in combination with three soluble factors (glucagon-like peptide-1 [glp-1] receptor agonist, notch inhibitor, and transforming growth factor-β [tgf-β] inhibitor) enhanced liver-to-pancreas transdifferentiation based on the following findings: i) the incidence of c-peptide-positive cells increased by approximately 1.2-fold after the aforementioned treatment; ii) the c-peptide expression level in the treated cells increased by approximately 12-fold as compared with the level in the untreated cells; iii) the treated cells secreted insulin in a glucose-dependent manner, whereas the untreated cells did not; and iv) transplantation of treated-transdifferentiated cells into streptozotocin-induced immunodeficient diabetic mice led to the amelioration of hyperglycemia. |
2018-07-31 |
2023-08-13 |
mouse |
| Javier O Morales, David J Brayde. Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles. Current opinion in pharmacology. vol 36. 2018-07-26. PMID:28800417. |
it is likely however that printed film designs with lower molecular weight stable biotech payloads including lipophilic glucagon-like 1 (glp-1) agonists and macrocycles with long half-lives will generate greater efficacy than was achieved to date for insulin. |
2018-07-26 |
2023-08-13 |
Not clear |
| Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zhen. Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 8. 2018-07-25. PMID:29924135. |
exenatide, a glucagon-like peptide-1 (glp-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. |
2018-07-25 |
2023-08-13 |
Not clear |
| Michal Lipš, Miloš Mráz, Jana Kloučková, Petr Kopecký, Miloš Dobiáš, Jarmila Křížová, Jaroslav Lindner, Michaela Diamant, Martin Haluzí. Effect of continuous exenatide infusion on cardiac function and peri-operative glucose control in patients undergoing cardiac surgery: A single-blind, randomized controlled trial. Diabetes, obesity & metabolism. vol 19. issue 12. 2018-07-20. PMID:28581209. |
we performed a randomized controlled trial with the glucagon-like peptide-1 (glp-1) receptor agonist exenatide as add-on to standard peri-operative insulin therapy in patients undergoing elective cardiac surgery. |
2018-07-20 |
2023-08-13 |
human |
| K E McCool, A J Rudinsky, V J Parker, C O Herbert, C Gilo. The effect of diet, adiposity, and weight loss on the secretion of incretin hormones in cats. Domestic animal endocrinology. vol 62. 2018-07-20. PMID:29128557. |
glucose, insulin, glucagon-like peptide-1 (glp-1), and glucose-dependent insulinotropic peptide (gip) concentrations were measured immediately before and over 6 h after feeding the smt. |
2018-07-20 |
2023-08-13 |
mouse |
| K E McCool, A J Rudinsky, V J Parker, C O Herbert, C Gilo. The effect of diet, adiposity, and weight loss on the secretion of incretin hormones in cats. Domestic animal endocrinology. vol 62. 2018-07-20. PMID:29128557. |
area under the curve (auc) was compared for glp-1, gip, and insulin concentrations using 2-way analysis of variance. |
2018-07-20 |
2023-08-13 |
mouse |
| Anne Ørgaard, Jens J Hols. The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice. Diabetologia. vol 60. issue 9. 2018-07-17. PMID:28551699. |
whereas the effect of glp-1 on insulin secretion is clearly dependent on ambient glucose concentrations and has been described in detail, the mechanism responsible for the inhibitory effect of glp-1 on glucagon secretion is heavily debated. |
2018-07-17 |
2023-08-13 |
mouse |
| Ángela Vinué, Jorge Navarro, Andrea Herrero-Cervera, Marta García-Cubas, Irene Andrés-Blasco, Sergio Martínez-Hervás, José T Real, Juan F Ascaso, Herminia González-Navarr. The GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype. Diabetologia. vol 60. issue 9. 2018-07-17. PMID:28608285. |
in the present study, the impact of glp-1 analogues and their potential underlying molecular mechanisms in insulin resistance and atherosclerosis are investigated. |
2018-07-17 |
2023-08-13 |
mouse |
| Sophie Molnos, Simone Wahl, Mark Haid, E Marelise W Eekhoff, René Pool, Anna Floegel, Joris Deelen, Daniela Much, Cornelia Prehn, Michaela Breier, Harmen H Draisma, Nienke van Leeuwen, Annemarie M C Simonis-Bik, Anna Jonsson, Gonneke Willemsen, Wolfgang Bernigau, Rui Wang-Sattler, Karsten Suhre, Annette Peters, Barbara Thorand, Christian Herder, Wolfgang Rathmann, Michael Roden, Christian Gieger, Mark H H Kramer, Diana van Heemst, Helle K Pedersen, Valborg Gudmundsdottir, Matthias B Schulze, Tobias Pischon, Eco J C de Geus, Heiner Boeing, Dorret I Boomsma, Anette G Ziegler, P Eline Slagboom, Sandra Hummel, Marian Beekman, Harald Grallert, Søren Brunak, Mark I McCarthy, Ramneek Gupta, Ewan R Pearson, Jerzy Adamski, Leen M 't Har. Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study. Diabetologia. vol 61. issue 1. 2018-07-17. PMID:28936587. |
in this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (glp-1) and arginine stimulation. |
2018-07-17 |
2023-08-13 |
Not clear |
| Jonas Ronn, Elisa P Jensen, Nicolai J Wewer Albrechtsen, Jens Juul Holst, Charlotte M Sorense. Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors. Physiological reports. vol 5. issue 23. 2018-07-17. PMID:29233907. |
glucagon-like peptide-1 (glp-1) is an incretin hormone increasing postprandial insulin release. |
2018-07-17 |
2023-08-13 |
rat |
| Jonas Ronn, Elisa P Jensen, Nicolai J Wewer Albrechtsen, Jens Juul Holst, Charlotte M Sorense. Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors. Physiological reports. vol 5. issue 23. 2018-07-17. PMID:29233907. |
these results suggest that the acute renal effects of glp-1 in shr are caused either by extrarenal glp-1 receptors activating other mechanisms (e.g., insulin) to induce the renal changes observed or possibly by an alternative renal glp-1 receptor. |
2018-07-17 |
2023-08-13 |
rat |
| Robert E Steinert, Sina S Ullrich, Nori Geary, Lori Asarian, Marco Bueter, Michael Horowitz, Christine Feinle-Bisse. Comparative effects of intraduodenal amino acid infusions on food intake and gut hormone release in healthy males. Physiological reports. vol 5. issue 21. 2018-07-16. PMID:29138359. |
to compare the effects of intraduodenal infusions of l-tryptophan (trp), l-leucine (leu), l-phenylalanine (phe) and l-glutamine (gln) on appetite, gastrointestinal hormone responses (including ghrelin, cholecystokinin (cck), peptide yy (pyy) and glucagon-like peptide-1 [glp-1]), glycemia (glucagon, insulin and glucose) and test meal size in healthy males, we retrospectively analyzed data from four published independent, randomized, double-blind, placebo-controlled studies of 90-min intraduodenal infusions of the individual aas. |
2018-07-16 |
2023-08-13 |
Not clear |
| Siying Weng, Jianyang Zhou, Xiabo Chen, Yihong Sun, Zhujun Mao, Kefu Cha. Prevalence and factors associated with nonalcoholic fatty pancreas disease and its severity in China. Medicine. vol 97. issue 26. 2018-07-16. PMID:29953011. |
its development and progression was related to nafld, t2dm, insulin resistance, dyslipidemia, and glp-1 levels. |
2018-07-16 |
2023-08-13 |
human |
| David R Owens, Louis Monnier, Anthony H Barnet. Future challenges and therapeutic opportunities in type 2 diabetes: Changing the paradigm of current therapy. Diabetes, obesity & metabolism. vol 19. issue 10. 2018-07-12. PMID:28432748. |
therefore, to achieve near normoglycaemia, additional treatment with prandial insulin or a glucagon-like peptide-1 receptor agonist (glp-1 ra) is often required. |
2018-07-12 |
2023-08-13 |
Not clear |
| David R Owens, Louis Monnier, Anthony H Barnet. Future challenges and therapeutic opportunities in type 2 diabetes: Changing the paradigm of current therapy. Diabetes, obesity & metabolism. vol 19. issue 10. 2018-07-12. PMID:28432748. |
long- or short-acting glp-1 ras offer effective alternatives to basal or prandial insulin in patients inadequately controlled with other therapies or basal insulin alone, respectively. |
2018-07-12 |
2023-08-13 |
Not clear |
| David R Owens, Louis Monnier, Anthony H Barnet. Future challenges and therapeutic opportunities in type 2 diabetes: Changing the paradigm of current therapy. Diabetes, obesity & metabolism. vol 19. issue 10. 2018-07-12. PMID:28432748. |
this review highlights the limitations of current algorithms, and proposes an alternative based on the early introduction of insulin therapy and the rationale for the sequential or fixed combination of glp-1 ras with insulin ("treat-to-success" paradigm). |
2018-07-12 |
2023-08-13 |
Not clear |
| Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang, Huiqin Ma, Shangwu Che. Recombinant Lactococcus lactis expressing bioactive exendin-4 to promote insulin secretion and beta-cell proliferation in vitro. Applied microbiology and biotechnology. vol 101. issue 19. 2018-07-09. PMID:28828521. |
in vitro treatment with rexd4 significantly enhanced insulin secretion of ins-1 cells and activated the pi3-k/akt signal pathway with protein levels of akt and p-akt increasing 1.6- to 1.8-fold compared to negative controls, similar to the positive glp-1 controls. |
2018-07-09 |
2023-08-13 |
Not clear |
| Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang, Huiqin Ma, Shangwu Che. Recombinant Lactococcus lactis expressing bioactive exendin-4 to promote insulin secretion and beta-cell proliferation in vitro. Applied microbiology and biotechnology. vol 101. issue 19. 2018-07-09. PMID:28828521. |
our data suggest that the rexd4 secreted by l. lactis is a bioactive insulinotropic peptide and functional glp-1 receptor agonist that enhances glucose-dependent insulin secretion and activates the pi3-k/akt signal pathway; furthermore, it may be involved in improving proliferation and inhibiting apoptosis of ins-1 cells in in vitro treatments. |
2018-07-09 |
2023-08-13 |
Not clear |
| José Alberto González-Regueiro, Lidia Moreno-Castañeda, Misael Uribe, Norberto C Chávez-Tapi. The Role of Bile Acids in Glucose Metabolism and Their Relation with Diabetes. Annals of hepatology. vol 16. issue Suppl. 1: s3-105.. 2018-07-09. PMID:29118282. |
recent studies had revealed the way these receptors participate in regulating gluconeogenesis, peripheral insulin sensitivity, glycogen synthesis, glucagon like peptide 1 (glp-1) and insulin secretion. |
2018-07-09 |
2023-08-13 |
Not clear |