| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel J Drucke. The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications. Diabetes. vol 67. issue 9. 2018-09-04. PMID:30135132. |
glucagon-like peptide 1 (glp-1) was originally identified as a gut-derived incretin hormone that lowered glycemia through potentiation of glucose-dependent insulin secretion. |
2018-09-04 |
2023-08-13 |
Not clear |
| Errol M Thomson, Shinjini Pilon, Josée Guénette, Andrew Williams, Alison C Hollowa. Ozone modifies the metabolic and endocrine response to glucose: Reproduction of effects with the stress hormone corticosterone. Toxicology and applied pharmacology. vol 342. 2018-08-27. PMID:29391239. |
we assessed acute effects of ozone, and stress axis involvement, on glucose tolerance and on the metabolic (triglyceride), endocrine/energy regulation (insulin, glucagon, glp-1, leptin, ghrelin, corticosterone), and inflammatory/endothelial (tnf, il-6, vegf, pai-1) response to exogenous glucose. |
2018-08-27 |
2023-08-13 |
human |
| Sarah Stano, Fatima Alam, Louis Wu, Roxanne Dutia, Sin-Nee Ng, Margarita Sala, James McGinty, Blandine Laferrèr. Effect of meal size and texture on gastric pouch emptying and glucagon-like peptide 1 after gastric bypass surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. vol 13. issue 12. 2018-08-22. PMID:29055668. |
roux-en-y gastric bypass (rygb) accelerates gastric pouch emptying, enhances postprandial glucagon-like peptide 1 (glp-1) and insulin, and lowers glucose concentrations. |
2018-08-22 |
2023-08-13 |
Not clear |
| Shunsuke Yamane, Nobuya Inagak. Regulation of glucagon-like peptide-1 sensitivity by gut microbiota dysbiosis. Journal of diabetes investigation. vol 9. issue 2. 2018-08-21. PMID:29034596. |
gut microbiota dysbiosis reduces expression of glp-1 receptor (glp-1r) and neuronal nitric oxide synthase (nnos) in the enteric nervous system and hampers glp-1-induced nitric oxide (no) production through a pattern recognition receptor (prr)-dependent mechanism, hence preventing activation of the gut-brain-periphery axis for control of insulin secretion and gastric emptying. |
2018-08-21 |
2023-08-13 |
Not clear |
| Kazuyo Suzuki, Kanako Iwasaki, Yuki Murata, Norio Harada, Shunsuke Yamane, Akihiro Hamasaki, Kimitaka Shibue, Erina Joo, Akiko Sankoda, Yuta Fujiwara, Yoshitaka Hayashi, Nobuya Inagak. Distribution and hormonal characterization of primary murine L cells throughout the gastrointestinal tract. Journal of diabetes investigation. vol 9. issue 1. 2018-08-15. PMID:28429513. |
glucagon-like peptide-1 (glp-1) secreted from enteroendocrine l cells is an incretin that potentiates insulin secretion and is already applied in therapies for type 2 diabetes. |
2018-08-15 |
2023-08-13 |
mouse |
| Daisuke Yabe, Yusuke Seino, Yutaka Sein. Incretin concept revised: The origin of the insulinotropic function of glucagon-like peptide-1 - the gut, the islets or both? Journal of diabetes investigation. vol 9. issue 1. 2018-08-15. PMID:28746743. |
incretins comprise a pair of gut hormones, glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1), which are secreted in response to food ingestion and enhance glucose-dependent insulin secretion from pancreatic β-cells. |
2018-08-15 |
2023-08-13 |
Not clear |
| Daisuke Yabe, Yusuke Seino, Yutaka Sein. Incretin concept revised: The origin of the insulinotropic function of glucagon-like peptide-1 - the gut, the islets or both? Journal of diabetes investigation. vol 9. issue 1. 2018-08-15. PMID:28746743. |
recent publications have revealed two novel mechanisms by which glp-1 exerts insulinotropic actions: (i) the gut-derived glp-1 activates receptors expressed in nodose ganglions, thereby potentiating glucose-dependent insulin secretion through the vagus nerves; and (ii) the pancreatic α-cell-derived glp-1 activates receptors expressed in β-cells in a paracrine manner. |
2018-08-15 |
2023-08-13 |
Not clear |
| Daisuke Yabe, Yusuke Seino, Yutaka Sein. Incretin concept revised: The origin of the insulinotropic function of glucagon-like peptide-1 - the gut, the islets or both? Journal of diabetes investigation. vol 9. issue 1. 2018-08-15. PMID:28746743. |
while the relative contributions of the two mechanisms under normal and pathological conditions remain unknown and mechanisms regulating glp-1 secretion from α-cells need to be investigated, the available data strongly indicate that the effects of glp-1 on insulin secretion are far more complex than previously believed, and the classical incretin concept regarding glp-1 should be revised. |
2018-08-15 |
2023-08-13 |
Not clear |
| Pengzhou Li, Liyong Zhu, Xiangwu Yang, Weizheng Li, Xulong Sun, Bo Yi, Shaihong Zh. Farnesoid X Receptor (FXR) Interacts with Camp Response Element Binding Protein (CREB) to Modulate Glucagon-Like Peptide-1 (7-36) Amide (GLP-1) Secretion by Intestinal L Cell. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 47. issue 4. 2018-08-15. PMID:29940597. |
glucagon-like peptide-1 (7-6) amide (glp-1) is a gut hormone released from the l cells which stimulates insulin secretion, and promotes insulin gene expression and β-cell growth and differentiation. |
2018-08-15 |
2023-08-13 |
mouse |
| Guillermo E Umpierrez, Timothy S Bailey, Danielle Carcia, Charles Shaefer, Jay H Shubrook, Neil Skolni. Improving postprandial hyperglycemia in patients with type 2 diabetes already on basal insulin therapy: Review of current strategies. Journal of diabetes. vol 10. issue 2. 2018-08-14. PMID:28581207. |
current treatment guidelines and strategies for improving ppg control are reviewed, including the efficacy, safety, and cost-effectiveness of rapid-acting insulin (rai) analogs, premixed insulin, glucagon-like peptide-1 (glp-1) receptor agonists (ras), dipeptidyl peptidase 4 inhibitors, sodium-glucose cotransporter 2 inhibitors, and α-glucosidase inhibitors. |
2018-08-14 |
2023-08-13 |
Not clear |
| Guillermo E Umpierrez, Timothy S Bailey, Danielle Carcia, Charles Shaefer, Jay H Shubrook, Neil Skolni. Improving postprandial hyperglycemia in patients with type 2 diabetes already on basal insulin therapy: Review of current strategies. Journal of diabetes. vol 10. issue 2. 2018-08-14. PMID:28581207. |
other approaches, such as combinations of newer basal insulin plus rai and a fixed-ratio combination of basal insulin and a glp-1 ra, are also described. |
2018-08-14 |
2023-08-13 |
Not clear |
| S Schauf, A Salas-Mani, C Torre, E Jimenez, M A Latorre, C Castrill. Effect of feeding a high-carbohydrate or a high-fat diet on subsequent food intake and blood concentration of satiety-related hormones in dogs. Journal of animal physiology and animal nutrition. vol 102. issue 1. 2018-08-10. PMID:28447374. |
in week 7 of each period, blood concentrations of active ghrelin, glucagon-like peptide (glp-1), peptide yy, insulin, and glucose were determined before and at 30, 60, 120, 180, and 360 min post-feeding. |
2018-08-10 |
2023-08-13 |
Not clear |
| Caroline Giezenaar, Amy T Hutchison, Natalie D Luscombe-Marsh, Ian Chapman, Michael Horowitz, Stijn Soene. Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. Nutrients. vol 10. issue 1. 2018-08-09. PMID:29267221. |
effect of age on blood glucose and plasma insulin, glucagon, ghrelin, cck, gip, and glp-1 responses to whey protein ingestion. |
2018-08-09 |
2023-08-13 |
Not clear |
| Caroline Giezenaar, Amy T Hutchison, Natalie D Luscombe-Marsh, Ian Chapman, Michael Horowitz, Stijn Soene. Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. Nutrients. vol 10. issue 1. 2018-08-09. PMID:29267221. |
at regular intervals over 180 min, blood glucose and plasma insulin, glucagon, ghrelin, cholecystokinin (cck), gastric inhibitory peptide (gip), and glucagon-like peptide-1 (glp-1) concentrations were measured. |
2018-08-09 |
2023-08-13 |
Not clear |
| Caroline Giezenaar, Amy T Hutchison, Natalie D Luscombe-Marsh, Ian Chapman, Michael Horowitz, Stijn Soene. Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion. Nutrients. vol 10. issue 1. 2018-08-09. PMID:29267221. |
plasma ghrelin was dose-dependently suppressed and insulin, glucagon, cck, gip, and glp-1 concentrations were dose-dependently increased by the whey protein ingestion, while blood glucose concentrations were comparable during all study days. |
2018-08-09 |
2023-08-13 |
Not clear |
| Fusun Oztay, Serap Sancar-Bas, Selda Gezginci-Oktayoglu, Merve Ercin, Sehnaz Bolken. Exendin-4 partly ameliorates - hyperglycemia-mediated tissue damage in lungs of streptozotocin-induced diabetic mice. Peptides. vol 99. 2018-08-01. PMID:29225158. |
glucagon-like peptide-1 (glp-1) stimulates insulin secretion, - plays anti-inflammatory role in atherosclerosis, and has surfactant-releasing effects in lungs. |
2018-08-01 |
2023-08-13 |
mouse |
| Giovanni Pacini, Bo Ahré. Glucagon-like peptide-1 and glucose-dependent insulinotropic peptide: effects alone and in combination on insulin secretion and glucose disappearance in mice. Physiological reports. vol 5. issue 11. 2018-07-31. PMID:28611149. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip) stimulate insulin secretion. |
2018-07-31 |
2023-08-13 |
mouse |
| Giovanni Pacini, Bo Ahré. Glucagon-like peptide-1 and glucose-dependent insulinotropic peptide: effects alone and in combination on insulin secretion and glucose disappearance in mice. Physiological reports. vol 5. issue 11. 2018-07-31. PMID:28611149. |
this study therefore investigated the effects on insulin secretion and glucose disappearance of glp-1 and gip when given together with intravenous glucose both alone and in combination in mice. |
2018-07-31 |
2023-08-13 |
mouse |
| Giovanni Pacini, Bo Ahré. Glucagon-like peptide-1 and glucose-dependent insulinotropic peptide: effects alone and in combination on insulin secretion and glucose disappearance in mice. Physiological reports. vol 5. issue 11. 2018-07-31. PMID:28611149. |
in conclusion, gip and glp-1 stimulate insulin secretion and glucose effectiveness in mice with no synergistic action, but with a dissociated contributory effector on glucose disposal: with glp-1 being more active on insulin-dependent processes and gip more active on noninsulin-dependent processes. |
2018-07-31 |
2023-08-13 |
mouse |
| Yoon Sin Oh, Hee-Sook Ju. Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling. International journal of molecular sciences. vol 19. issue 1. 2018-07-31. PMID:29271910. |
glucagon-like peptide-1 (glp-1) is an incretin hormone, which was originally found to increase insulin synthesis and secretion. |
2018-07-31 |
2023-08-13 |
Not clear |