| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emilie Normand, Anita Franco, Alain Moreau, Valérie Marci. Dipeptidyl Peptidase-4 and Adolescent Idiopathic Scoliosis: Expression in Osteoblasts. Scientific reports. vol 7. issue 1. 2018-12-27. PMID:28600546. |
human cells were incubated with glucose, insulin, glp-1 and butyrate. |
2018-12-27 |
2023-08-13 |
human |
| Véronique Gingras, Nadine Taleb, Amélie Roy-Fleming, Laurent Legault, Rémi Rabasa-Lhore. The challenges of achieving postprandial glucose control using closed-loop systems in patients with type 1 diabetes. Diabetes, obesity & metabolism. vol 20. issue 2. 2018-12-27. PMID:28675686. |
multi-hormone cls (eg, dual-hormone combining insulin with glucagon or pramlintide) and adjunctive therapy (eg, glp-1 and sglt2 inhibitors) also represent promising options. |
2018-12-27 |
2023-08-13 |
Not clear |
| Sameer Agarwal, Santosh Sasane, Jeevan Kumar, Prashant Deshmukh, Hitesh Bhayani, Poonam Giri, Suresh Giri, Shubhangi Soman, Neelima Kulkarni, Mukul Jai. Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes. Bioorganic & medicinal chemistry letters. vol 28. issue 10. 2018-12-27. PMID:29655980. |
activation of tgr5 promotes secretion of glucagon-like peptide-1 (glp-1), which activates insulin secretion. |
2018-12-27 |
2023-08-13 |
Not clear |
| M A Scuderi, M Ribeiro Petito, S Unniappan, C Waldner, S Mehain, C J McMillian, E C Snea. Safety and efficacy assessment of a GLP-1 mimetic: insulin glargine combination for treatment of feline diabetes mellitus. Domestic animal endocrinology. vol 65. 2018-12-27. PMID:30015124. |
safety and efficacy assessment of a glp-1 mimetic: insulin glargine combination for treatment of feline diabetes mellitus. |
2018-12-27 |
2023-08-13 |
Not clear |
| Graziele Freitas de Bem, Cristiane Aguiar Costa, Izabelle Barcellos Santos, Viviane da Silva Cristino Cordeiro, Lenize Costa Reis Marins de Carvalho, Marcelo Augusto Vieira de Souza, Ricardo de Andrade Soares, Pergentino José da Cunha Sousa, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Mour. Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction. PloS one. vol 13. issue 6. 2018-12-26. PMID:29920546. |
ase increased the expression of insulin signaling proteins in skeletal muscle and adipose tissue and plasma glp-1 levels. |
2018-12-26 |
2023-08-13 |
rat |
| Rana K El-Asfar, Mohamed M Kamal, Rania S Abd El-Razek, Ebtehal El-Demerdash, Hala O El-Mesallam. Obestatin can potentially differentiate Wharton's jelly mesenchymal stem cells into insulin-producing cells. Cell and tissue research. vol 372. issue 1. 2018-12-24. PMID:29159483. |
in gsis, ipcs generated using either glp-1 or obestatin showed higher secretion of insulin as compared to those generated using exendin-4 under low-glucose conditions but failed to show a significant response to increased glucose. |
2018-12-24 |
2023-08-13 |
Not clear |
| Sudesna Chatterjee, Melanie J Davies, Kamlesh Khunt. What have we learnt from "real world" data, observational studies and meta-analyses. Diabetes, obesity & metabolism. vol 20 Suppl 1. 2018-12-17. PMID:29364585. |
the incretin therapies glucagon-like peptide-1 receptor agonists (glp-1 ra) and dipeptidyl peptidase-iv (dpp-iv) inhibitors are now well-established as second and third-line therapies and in combination with insulin for the treatment of type 2 diabetes. |
2018-12-17 |
2023-08-13 |
Not clear |
| Rodrigo Carlessi, Younan Chen, Jordan Rowlands, Vinicius F Cruzat, Kevin N Keane, Lauren Egan, Cyril Mamotte, Rebecca Stokes, Jenny E Gunton, Paulo Ivo Homem de Bittencourt, Philip Newsholm. GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation. Scientific reports. vol 7. issue 1. 2018-12-14. PMID:28572610. |
glucagon-like peptide-1 (glp-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. |
2018-12-14 |
2023-08-13 |
Not clear |
| Rodrigo Carlessi, Younan Chen, Jordan Rowlands, Vinicius F Cruzat, Kevin N Keane, Lauren Egan, Cyril Mamotte, Rebecca Stokes, Jenny E Gunton, Paulo Ivo Homem de Bittencourt, Philip Newsholm. GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation. Scientific reports. vol 7. issue 1. 2018-12-14. PMID:28572610. |
since glp-1-induced insulin secretion requires glucose metabolism, we aimed to address the hypothesis that glp-1 receptor (glp-1r) signalling can modulate glucose uptake and utilization in β-cells. |
2018-12-14 |
2023-08-13 |
Not clear |
| Rodrigo Carlessi, Younan Chen, Jordan Rowlands, Vinicius F Cruzat, Kevin N Keane, Lauren Egan, Cyril Mamotte, Rebecca Stokes, Jenny E Gunton, Paulo Ivo Homem de Bittencourt, Philip Newsholm. GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation. Scientific reports. vol 7. issue 1. 2018-12-14. PMID:28572610. |
considering the central role of glucose catabolism for stimulus-secretion coupling in β-cells, our findings suggest that chronic glp-1 actions on insulin secretion include elevated β-cell glucose metabolism. |
2018-12-14 |
2023-08-13 |
Not clear |
| Rodrigo Carlessi, Younan Chen, Jordan Rowlands, Vinicius F Cruzat, Kevin N Keane, Lauren Egan, Cyril Mamotte, Rebecca Stokes, Jenny E Gunton, Paulo Ivo Homem de Bittencourt, Philip Newsholm. GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation. Scientific reports. vol 7. issue 1. 2018-12-14. PMID:28572610. |
moreover, our data reveal novel aspects of glp-1 stimulated insulin secretion involving de novo gene expression. |
2018-12-14 |
2023-08-13 |
Not clear |
| Ichiro Horie, Ai Haraguchi, Ayaka Sako, Junya Akeshima, Tetsuro Niri, Riyoko Shigeno, Ayako Ito, Aya Nozaki, Shoko Natsuda, Satoru Akazawa, Yoshitaka Mori, Takao Ando, Atsushi Kawakami, Norio Abir. Predictive factors of efficacy of combination therapy with basal insulin and liraglutide in type 2 diabetes when switched from longstanding basal-bolus insulin: Association between the responses of β- and α-cells to GLP-1 stimulation and the glycaemic control at 6 months after switching therapy. Diabetes research and clinical practice. vol 144. 2018-12-14. PMID:30194951. |
predictive factors of efficacy of combination therapy with basal insulin and liraglutide in type 2 diabetes when switched from longstanding basal-bolus insulin: association between the responses of β- and α-cells to glp-1 stimulation and the glycaemic control at 6 months after switching therapy. |
2018-12-14 |
2023-08-13 |
Not clear |
| Zhiqiang Cheng, Guozhi Liu, Xiang Zhang, Dongsong Bi, Sanyuan H. Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30298865. |
energy intake, body weight, serum insulin, glucose tolerance, insulin sensitivity, glp-1, and total serum bas were measured at week 2 and week 12. |
2018-12-12 |
2023-08-13 |
rat |
| Zhiqiang Cheng, Guozhi Liu, Xiang Zhang, Dongsong Bi, Sanyuan H. Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30298865. |
results at week 2 there were no significant differences in body weight, daily energy intake, glucose tolerance, serum insulin, insulin sensitivity, glp-1, or fasting total serum bas between the 3 groups. |
2018-12-12 |
2023-08-13 |
rat |
| Zhiqiang Cheng, Guozhi Liu, Xiang Zhang, Dongsong Bi, Sanyuan H. Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-12. PMID:30298865. |
at week 12, fasting blood glucose and intragastric glucose tolerance were better in the h-tca group, with significantly greater insulin and glp-1 secretion and better insulin sensitivity; no significant differences in body weight, energy intake, or total fasting serum bas were observed. |
2018-12-12 |
2023-08-13 |
rat |
| Lidia Castagneto Gissey, James Casella Mariolo, Geltrude Mingron. Intestinal peptide changes after bariatric and minimally invasive surgery: Relation to diabetes remission. Peptides. vol 100. 2018-12-11. PMID:29412812. |
however, while there is unambiguous evidence that glp-1 stimulates insulin secretion, its direct action in lowering insulin resistance, independently of the effect on weight loss secondary to its satiety action, is utterly controversial. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ben Jones, Stephen R Bloom, Teresa Buenaventura, Alejandra Tomas, Guy A Rutte. Control of insulin secretion by GLP-1. Peptides. vol 100. 2018-12-11. PMID:29412835. |
control of insulin secretion by glp-1. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ben Jones, Stephen R Bloom, Teresa Buenaventura, Alejandra Tomas, Guy A Rutte. Control of insulin secretion by GLP-1. Peptides. vol 100. 2018-12-11. PMID:29412835. |
stimulation of insulin secretion by glucagon-like peptide-1 (glp-1) and other gut-derived peptides is central to the incretin response to ingesting nutriments. |
2018-12-11 |
2023-08-13 |
Not clear |
| Ben Jones, Teresa Buenaventura, Nisha Kanda, Pauline Chabosseau, Bryn M Owen, Rebecca Scott, Robert Goldin, Napat Angkathunyakul, Ivan R Corrêa, Domenico Bosco, Paul R Johnson, Lorenzo Piemonti, Piero Marchetti, A M James Shapiro, Blake J Cochran, Aylin C Hanyaloglu, Asuka Inoue, Tricia Tan, Guy A Rutter, Alejandra Tomas, Stephen R Bloo. Targeting GLP-1 receptor trafficking to improve agonist efficacy. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29686402. |
compared to a panel of fda-approved glp-1 mimetics, compounds that retain glp-1r at the plasma membrane produce greater long-term insulin release, which is dependent on a reduction in β-arrestin recruitment and faster agonist dissociation rates. |
2018-12-11 |
2023-08-13 |
mouse |
| Simone Esposito, Maria Lucia de Leonibus, Raffaele Ingenito, Elisabetta Bianchi, Laura Orsatti, Edith Monteagud. A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides. Journal of pharmaceutical and biomedical analysis. vol 159. 2018-12-11. PMID:30041153. |
the assay was developed and validated using known peptides including human insulin and four glp-1 analogues (lixisenatide, exenatide, liraglutide and semaglutide). |
2018-12-11 |
2023-08-13 |
human |