| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nanjaiah Lalitha, Bettadahalli Sadashivaiah, Talahalli Ravichandra Ramaprasad, Sridevi Annapurna Sing. Anti-hyperglycemic activity of myricetin, through inhibition of DPP-4 and enhanced GLP-1 levels, is attenuated by co-ingestion with lectin-rich protein. PloS one. vol 15. issue 4. 2020-07-16. PMID:32282828. |
in this investigation, we aimed to study the effect of myr, singly, and in the presence of co-nutrient horsegram protein (hp) on dpp-4 activity and its consequential impact on glp-1, insulin, and nlrp3 inflammasome in high-fat diet and single low dose streptozotocin (stz)-induced diabetic male wistar rats. |
2020-07-16 |
2023-08-13 |
rat |
| Nanjaiah Lalitha, Bettadahalli Sadashivaiah, Talahalli Ravichandra Ramaprasad, Sridevi Annapurna Sing. Anti-hyperglycemic activity of myricetin, through inhibition of DPP-4 and enhanced GLP-1 levels, is attenuated by co-ingestion with lectin-rich protein. PloS one. vol 15. issue 4. 2020-07-16. PMID:32282828. |
specifically, myr decreased dpp-4 activity and its expression levels with enhanced circulating glp-1 and insulin levels. |
2020-07-16 |
2023-08-13 |
rat |
| Nanjaiah Lalitha, Bettadahalli Sadashivaiah, Talahalli Ravichandra Ramaprasad, Sridevi Annapurna Sing. Anti-hyperglycemic activity of myricetin, through inhibition of DPP-4 and enhanced GLP-1 levels, is attenuated by co-ingestion with lectin-rich protein. PloS one. vol 15. issue 4. 2020-07-16. PMID:32282828. |
myr proved to be a potent inhibitor of dpp-4 in vitro and in vivo, resulting in enhanced circulating glp-1 and insulin levels, thereby improving diabetic conditions. |
2020-07-16 |
2023-08-13 |
rat |
| Lawrence Blonde, Julio Rosenstock, Stefano Del Prato, Robert Henry, Naim Shehadeh, Juan Frias, Elisabeth Niemoeller, Elisabeth Souhami, Chen Ji, Vanita R Arod. Switching to iGlarLixi Versus Continuing Daily or Weekly GLP-1 RA in Type 2 Diabetes Inadequately Controlled by GLP-1 RA and Oral Antihyperglycemic Therapy: The LixiLan-G Randomized Clinical Trial. Diabetes care. vol 42. issue 11. 2020-07-08. PMID:31530665. |
fixed-ratio combinations of basal insulin plus glucagon-like peptide 1 receptor agonist (glp-1 ra) allow concomitant administration of two proven complementary injectable therapies for type 2 diabetes. |
2020-07-08 |
2023-08-13 |
Not clear |
| Lawrence Blonde, Julio Rosenstock, Stefano Del Prato, Robert Henry, Naim Shehadeh, Juan Frias, Elisabeth Niemoeller, Elisabeth Souhami, Chen Ji, Vanita R Arod. Switching to iGlarLixi Versus Continuing Daily or Weekly GLP-1 RA in Type 2 Diabetes Inadequately Controlled by GLP-1 RA and Oral Antihyperglycemic Therapy: The LixiLan-G Randomized Clinical Trial. Diabetes care. vol 42. issue 11. 2020-07-08. PMID:31530665. |
this study investigated switching to a titratable fixed-ratio combination of insulin glargine plus lixisenatide (iglarlixi) in patients with type 2 diabetes receiving daily or weekly glp-1 ra therapy. |
2020-07-08 |
2023-08-13 |
Not clear |
| Yehuda Handelsman, Marcel H A Muskiet, Graydon S Meneill. Combining GLP-1 Receptor Agonists and Basal Insulin in Older Adults with Type 2 Diabetes: Focus on Lixisenatide and Insulin Glargine. Advances in therapy. vol 36. issue 12. 2020-06-30. PMID:31646466. |
combining glp-1 receptor agonists and basal insulin in older adults with type 2 diabetes: focus on lixisenatide and insulin glargine. |
2020-06-30 |
2023-08-13 |
Not clear |
| Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha, Paul Valens. Issues of Cardiovascular Risk Management in People With Diabetes in the COVID-19 Era. Diabetes care. vol 43. issue 7. 2020-06-30. PMID:32409501. |
although not only ace inhibitors and angiotensin 2 receptor blockers but also sglt2 inhibitors, glp-1 receptor agonists, pioglitazone, and probably insulin seem to increase the number of ace2 receptors on the cells utilized by sars-cov-2 for penetration, no evidence presently exists that shows this might be harmful in terms of acquiring or worsening covid-19. |
2020-06-30 |
2023-08-13 |
Not clear |
| T D Müller, B Finan, S R Bloom, D D'Alessio, D J Drucker, P R Flatt, A Fritsche, F Gribble, H J Grill, J F Habener, J J Holst, W Langhans, J J Meier, M A Nauck, D Perez-Tilve, A Pocai, F Reimann, D A Sandoval, T W Schwartz, R J Seeley, K Stemmer, M Tang-Christensen, S C Woods, R D DiMarchi, M H Tschö. Glucagon-like peptide 1 (GLP-1). Molecular metabolism. vol 30. 2020-06-23. PMID:31767182. |
among the numerous metabolic effects of glp-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation. |
2020-06-23 |
2023-08-13 |
Not clear |
| Chi-Long Hao, Hui-Li Lin, Liang-Yin Ke, Hsueh-Wei Yen, Kuo-Ping She. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Journal of food biochemistry. vol 43. issue 3. 2020-06-22. PMID:31353547. |
in the hfd group, higher body and liver weight gain, hyperglycemia, hba1c, and insulin; higher tg, tc, ldl-c, non-hdl, atherosclerosis index, lower hdl, adiponectin in blood; higher tg in the liver; higher tg, bile acid in feces; and lower protein levels of amp-activated protein kinase, insulin receptor, insulin receptor substrate-1, insulin receptor substrate-2, peroxisome proliferator-activated receptor-γ, phosphatidylinositol-3-kinase, akt/pkb, glucose transporter-1, glucose transporter-4, glucokinase in the skeletal muscle; lower glucagon-like peptide 1 (glp-1) in the intestine; higher sterol regulatory element-binding protein-1 (srebp-1), stearoyl-coa desaturase 1 (scd-1), fatty acid synthase (fas), 3-hydroxy-3-methylglutaryl-coa reductase, proprotein convertase subtilisin/kexin type 9 (pcsk9), and lower ppar-α, low-density lipoprotein receptor, cholesterol-7α-hydroxylase in the liver; higher srebp-1, scd-1, fas, and lower ppar-α, adiponectin in the adipose tissue were found. |
2020-06-22 |
2023-08-13 |
mouse |
| Marzieh Salehi, Jonathan Q Purnel. The Role of Glucagon-Like Peptide-1 in Energy Homeostasis. Metabolic syndrome and related disorders. vol 17. issue 4. 2020-06-17. PMID:30720393. |
initial studies of glucagon-like peptide-1 (glp-1), a gut hormone released in response to the ingestion of nutrients, focused on its incretin actions to improve postprandial glucose homeostasis by enhancing meal-induced insulin secretion. |
2020-06-17 |
2023-08-13 |
Not clear |
| Sha Sha, Xiaoming Liu, Ruxing Zhao, Li Qing, Qin He, Lei Sun, Li Che. Effects of glucagon-like peptide-1 analog liraglutide on the systemic inflammation in high-fat-diet-induced mice. Endocrine. vol 66. issue 3. 2020-06-08. PMID:31542859. |
it has been reported that glp-1 could regulate insulin resistance. |
2020-06-08 |
2023-08-13 |
mouse |
| Tina Jorsal, Nicolai J Wewer Albrechtsen, Marie M Christensen, Brynjulf Mortensen, Erik Wandall, Ebbe Langholz, Steffen Friis, Dorte Worm, Cathrine Ørskov, René K Støving, Alin Andries, Claus B Juhl, Frederik Sørensen, Julie L Forman, Mechthilde Falkenhahn, Petra B Musholt, Stefan Theis, Philip J Larsen, Jens J Holst, Niels Vrang, Jacob Jelsing, Tina Vilsbøll, Filip K Kno. Investigating Intestinal Glucagon After Roux-en-Y Gastric Bypass Surgery. The Journal of clinical endocrinology and metabolism. vol 104. issue 12. 2020-06-04. PMID:31276156. |
this occurs despite concomitant improved glucose tolerance and increased circulating plasma concentrations of insulin and the glucagon-inhibiting hormone glucagon-like peptide 1 (glp-1). |
2020-06-04 |
2023-08-13 |
Not clear |
| Alécia A Oliveira-Santos, Roberto Salvatori, Monica C Nogueira, Ana C Bueno, Cynthia S Barros-Oliveira, Ângela C G B Leal, Cindi G Marinho, Nayra P Damascena, Djane A Oliveira, Manuela A Melo, Carla R P Oliveira, Flavia O da Costa, Jéssica S S Dos Santos, Paula F C Santos, Viviane C Campos, Elenilde G Santos, Enaldo V Melo, Meirielly L A Barbosa, Ivina E S Rocha, Margaret de Castro, Manuel H Aguiar-Oliveir. Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation. The Journal of clinical endocrinology and metabolism. vol 104. issue 7. 2020-06-01. PMID:30860584. |
enteroendocrine connections exist between the gh-igf-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (glp-1). |
2020-06-01 |
2023-08-13 |
Not clear |
| Chelsea R Hutch, Karen Roelofs, April Haller, Joyce Sorrell, Kyle Leix, David D D'Alessio, Robert Augustin, Randy J Seeley, Thomas Klein, Darleen A Sandova. The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice. Diabetologia. vol 62. issue 10. 2020-06-01. PMID:31414143. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are two peptides that function to promote insulin secretion. |
2020-06-01 |
2023-08-13 |
mouse |
| Jukkrapong Pinyo, Tohru Hira, Hiroshi Har. Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats. The British journal of nutrition. vol 122. issue 4. 2020-05-27. PMID:31352909. |
glucagon-like peptide-1 (glp-1) is an incretin hormone that regulates postprandial glycaemic response by enhancing insulin secretion. |
2020-05-27 |
2023-08-13 |
rat |
| Jukkrapong Pinyo, Tohru Hira, Hiroshi Har. Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats. The British journal of nutrition. vol 122. issue 4. 2020-05-27. PMID:31352909. |
meal tolerance tests (mtt) were performed to assess postprandial glucose, insulin and glp-1 responses to a liquid diet administration (15 kcal (63 kj)/10 ml per kg body weight) every 2 weeks. |
2020-05-27 |
2023-08-13 |
rat |
| Jukkrapong Pinyo, Tohru Hira, Hiroshi Har. Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats. The British journal of nutrition. vol 122. issue 4. 2020-05-27. PMID:31352909. |
the auc of postprandial glucose in the hfs group was similar to the control group in both mtt (p = 0·9665 and p = 0·3475, respectively), whereas auc of postprandial glp-1 (after 4 weeks,p = 0·0457) and of insulin (after 2 and 4 weeks, p = 0·0486 and p = 0·0110) was higher in the hfs group compared with the control group. |
2020-05-27 |
2023-08-13 |
rat |
| Camilla Krizhanovskii, Anders Franco-Cereced. Diabetes, Incretin Therapy and Thoracic Aortic Aneurysm - What Does the Evidence Show? Current vascular pharmacology. vol 17. issue 5. 2020-05-25. PMID:30156160. |
in addition to potentiation of meal-stimulated insulin secretion, glp-1 signaling exerts numerous pleiotropic effects on various tissues, including protective effects on the myocardium and vascular endothelium. |
2020-05-25 |
2023-08-13 |
Not clear |
| Yanyan Liu, Shin-Ichi Harashima, Yu Wang, Kazuyo Suzuki, Shinsuke Tokumoto, Ryota Usui, Hisato Tatsuoka, Daisuke Tanaka, Daisuke Yabe, Norio Harada, Yoshitaka Hayashi, Nobuya Inagak. Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 5. 2020-05-18. PMID:30789757. |
we find here that skip is also expressed in intestinal k- and l-cells and that secretion of gastric inhibitory polypeptide (gip) and glucagon-like peptide-1 (glp-1) as well as insulin are significantly increased, and blood glucose levels are decreased in skip-deficient (skip |
2020-05-18 |
2023-08-13 |
Not clear |
| Scott C Brakenridge, Frederick A Moore, Nicole R Mercier, Michael Cox, Quron Wu, Lyle L Moldawer, Alicia M Mohr, Philip A Efron, R Stephen Smit. Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes. Journal of the American College of Surgeons. vol 229. issue 1. 2020-05-18. PMID:30991107. |
glucagon-like peptide-1 (glp-1) is a gut-derived incretin hormone that stimulates insulin secretion, cellular glucose uptake, and has immune-regulatory functions. |
2020-05-18 |
2023-08-13 |
Not clear |