| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Fukumori, T Mita, T Sugino, T Obitsu, K Taniguch. Plasma concentrations and effects of glucagon-like peptide-1 (7-36) amide in calves before and after weaning. Domestic animal endocrinology. vol 43. issue 4. 2013-02-19. PMID:22683323. |
another 4 calves were intravenously injected with glp-1 (1.0 μg/kg bw) to elucidate the response of plasma insulin, glucagon, and glucose concentrations in week 1, 2, 4, 6, 7, 9, 11, and 13 (experiment 3). |
2013-02-19 |
2023-08-12 |
Not clear |
| R Fukumori, T Mita, T Sugino, T Obitsu, K Taniguch. Plasma concentrations and effects of glucagon-like peptide-1 (7-36) amide in calves before and after weaning. Domestic animal endocrinology. vol 43. issue 4. 2013-02-19. PMID:22683323. |
preprandial insulin concentrations increased after weaning (p < 0.05), and glp-1 and insulin were more strongly correlated postweaning than preweaning. |
2013-02-19 |
2023-08-12 |
Not clear |
| R Fukumori, T Mita, T Sugino, T Obitsu, K Taniguch. Plasma concentrations and effects of glucagon-like peptide-1 (7-36) amide in calves before and after weaning. Domestic animal endocrinology. vol 43. issue 4. 2013-02-19. PMID:22683323. |
in experiment 3, intravenous glp-1 treatment decreased plasma glucose concentrations throughout the experiment (p < 0.05), but increased plasma insulin concentrations only after weaning (p < 0.05). |
2013-02-19 |
2023-08-12 |
Not clear |
| Christian Hölsche. Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection. CNS drugs. vol 26. issue 10. 2013-02-14. PMID:22938097. |
glucagon-like peptide-1 (glp-1) is a hormone that facilitates insulin release under high blood sugar conditions. |
2013-02-14 |
2023-08-12 |
mouse |
| Christian Hölsche. Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection. CNS drugs. vol 26. issue 10. 2013-02-14. PMID:22938097. |
interestingly, glp-1 also has very similar growth factor-like properties to insulin, and has been shown to reduce a range of degenerative processes. |
2013-02-14 |
2023-08-12 |
mouse |
| Johan Jendle, Sherry A Martin, Zvonko Milicevi. Insulin and GLP-1 analog combinations in type 2 diabetes mellitus: a critical review. Expert opinion on investigational drugs. vol 21. issue 10. 2013-02-13. PMID:22799463. |
insulin and glp-1 analog combinations in type 2 diabetes mellitus: a critical review. |
2013-02-13 |
2023-08-12 |
Not clear |
| Charlotte J Green, Tora I Henriksen, Bente K Pedersen, Thomas P J Solomo. Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia. PloS one. vol 7. issue 8. 2013-02-12. PMID:22937169. |
glucagon like peptide-1 (glp-1) stimulates insulin secretion from the pancreas but also has extra-pancreatic effects. |
2013-02-12 |
2023-08-12 |
human |
| Fang Zhang, Xialian Tang, Hongyi Cao, Qingguo Lü, Nali Li, Yupu Liu, Xiangxun Zhang, Yuwei Zhang, Mingming Cao, Jun Wan, Zhenmei An, Nanwei Ton. Impaired secretion of total glucagon-like peptide-1 in people with impaired fasting glucose combined impaired glucose tolerance. International journal of medical sciences. vol 9. issue 7. 2013-02-12. PMID:22991496. |
the relationships between total glp-1 level and islet β cell function, insulin resistance (ir) and insulin sensitivity (is) were also investigated. |
2013-02-12 |
2023-08-12 |
Not clear |
| R Stephen Smith, William R Fry, Frances H Philp, Allan S Philp, Stepheny D Berry, Stephen Helme. Mild hyperglycemia, but not glucagon-like peptide 1 predicts poor outcome after injury. American journal of surgery. vol 204. issue 6. 2013-02-05. PMID:23231933. |
glucagon-like peptide-1 (glp-1) is a gut-derived incretin hormone that stimulates insulin and decreases glucagon secretion. |
2013-02-05 |
2023-08-12 |
Not clear |
| A E Relling, K Lee, S C Loerch, C K Reynold. Effects of glucose, propionate and splanchnic hormones on neuropeptide mRNA concentrations in the ovine hypothalamus. Journal of animal physiology and animal nutrition. vol 96. issue 4. 2013-01-29. PMID:21732994. |
therefore, our objective was to measure the direct effect of metabolites (glucose and propionate) or hormones [insulin, cholecystokinin (cck), glucagon-like peptide-1 (glp-1) and polypeptide yy (pyy)] on hypothalamic mrna concentrations for neuropeptide y (npy), agouti-related peptide (agrp) and proopiomelanocortin (pomc) following in vitro incubation. |
2013-01-29 |
2023-08-12 |
Not clear |
| A E Relling, K Lee, S C Loerch, C K Reynold. Effects of glucose, propionate and splanchnic hormones on neuropeptide mRNA concentrations in the ovine hypothalamus. Journal of animal physiology and animal nutrition. vol 96. issue 4. 2013-01-29. PMID:21732994. |
treatments included a control dulbecco's modified eagle medium (dmem) containing 1 mm glucose or dmem with the following additions: 10 mm glucose, 1 mm propionate, 1 nm insulin, 120 pm glp-1, 100 pm pyy, 80 pm cck or 10 mm glucose plus 1 nm insulin. |
2013-01-29 |
2023-08-12 |
Not clear |
| Chisato Sugiyama, Michiyo Yamamoto, Tomomi Kotani, Fumitaka Kikkawa, Yoshiharu Murata, Yoshitaka Hayash. Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. PloS one. vol 7. issue 8. 2013-01-29. PMID:22928026. |
whereas glucagon stimulates hepatic glycogenolysis and gluconeogenesis, glp-1 stimulates insulin secretion to lower blood glucose and also supports ß-cell proliferation and protection from apoptotic stimuli. |
2013-01-29 |
2023-08-12 |
mouse |
| Claire M Issa, Sami T Aza. Possible role of GLP-1 and its agonists in the treatment of type 1 diabetes mellitus. Current diabetes reports. vol 12. issue 5. 2013-01-28. PMID:22767380. |
glp-1 increases insulin secretion in humans with existing beta cells; it also decreases glucagon secretion, and blunts appetite. |
2013-01-28 |
2023-08-12 |
Not clear |
| Rodrigo Muñoz, Jill S Carmody, Nicholas Stylopoulos, Philip Davis, Lee M Kapla. Isolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 10. 2013-01-25. PMID:22972837. |
els-10 rats also exhibited enhanced postprandial glp-1 secretion and improved glucose tolerance and insulin sensitivity out of proportion to the effects of weight loss alone. |
2013-01-25 |
2023-08-12 |
rat |
| Anthony Beucher, Elisabet Gjernes, Caitlin Collin, Monica Courtney, Aline Meunier, Patrick Collombat, Gérard Gradwoh. The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570716. |
these cells produce over ten different hormones including glp-1 and gip peptides known to promote insulin secretion. |
2013-01-24 |
2023-08-12 |
mouse |
| L Ahlkvist, J Vikman, G Pacini, B Ahré. Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice. Regulatory peptides. vol 178. issue 1-3. 2013-01-17. PMID:22750278. |
plasma was analyzed for glucose, insulin and intact glp-1 before and during oral challenges. |
2013-01-17 |
2023-08-12 |
mouse |
| L Ahlkvist, J Vikman, G Pacini, B Ahré. Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice. Regulatory peptides. vol 178. issue 1-3. 2013-01-17. PMID:22750278. |
in spite of this, the peak insulin response (p=0.02), the peak intact glp-1 levels (p=0.006) and the estimated β-cell function (p=0.005) were higher. |
2013-01-17 |
2023-08-12 |
mouse |
| L Ahlkvist, J Vikman, G Pacini, B Ahré. Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice. Regulatory peptides. vol 178. issue 1-3. 2013-01-17. PMID:22750278. |
furthermore, the peak insulin (p=0.004) and intact glp-1 (p=0.006) levels were higher after mixed meal ingestion than the sum of responses to individual macronutrients. |
2013-01-17 |
2023-08-12 |
mouse |
| L Ahlkvist, J Vikman, G Pacini, B Ahré. Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice. Regulatory peptides. vol 178. issue 1-3. 2013-01-17. PMID:22750278. |
compared to glucose alone, we conclude that there is a marked early insulin response to mixed meal ingestion, which emanates from a synergistic, rather than an additive, effect of the individual macronutrients in the mixed meal and is in part likely caused by increased levels of glp-1. |
2013-01-17 |
2023-08-12 |
mouse |
| Ashutosh Shukla, B P Srinivasa. 16,17-Dihydro-17b-hydroxy isomitraphylline alkaloid as an inhibitor of DPP-IV, and its effect on incretin hormone and β-cell proliferation in diabetic rat. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 47. issue 2. 2013-01-17. PMID:22820565. |
although, glp-1 is known to stimulate insulin secretion, insulin biosynthesis and dose insulin gene transcription, augmented supplies of insulin for secretion. |
2013-01-17 |
2023-08-12 |
rat |