| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Seino, K W Min, E Niemoeller, A Takam. Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia). Diabetes, obesity & metabolism. vol 14. issue 10. 2013-04-18. PMID:22564709. |
randomized, double-blind, placebo-controlled trial of the once-daily glp-1 receptor agonist lixisenatide in asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (getgoal-l-asia). |
2013-04-18 |
2023-08-12 |
Not clear |
| Cyprian Weaver, Nolan Turner, Jennifer Hal. Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain. Journal of chemical neuroanatomy. vol 45. issue 1-2. 2013-04-18. PMID:22796301. |
tcf7l2, some variants of which have been shown to impair glp-1-induced insulin secretion, was also found co-localize with glp-1 in adult tcf wild type progeny. |
2013-04-18 |
2023-08-12 |
mouse |
| Danny Wadden, Farrell Cahill, Peyvand Amini, Edward Randell, Sudesh Vasdev, Yanqing Yi, Jon Church, Guang Su. Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men. Nutrition & metabolism. vol 10. issue 1. 2013-04-18. PMID:23566334. |
glucagon-like peptide-1 (glp-1) is an incretin hormone secreted from the gastrointestinal tract that facilitates the glucose-dependent insulin response. |
2013-04-18 |
2023-08-12 |
Not clear |
| Weijuan Shao, Dingyan Wang, Yu-Ting Chiang, Wilfred Ip, Lingyun Zhu, Fenghao Xu, Joshua Columbus, Denise D Belsham, David M Irwin, Haibo Zhang, Xiaoyan Wen, Qinghua Wang, Tianru Ji. The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis. Diabetes. vol 62. issue 3. 2013-04-17. PMID:22966074. |
whereas peripheral glp-1 stimulates insulin secretion, brain glp-1 controls energy homeostasis through yet-to-be defined mechanisms. |
2013-04-17 |
2023-08-12 |
mouse |
| Ting-Ni Huang, Kan-Ni Lu, Yi-Ping Pai, Chin Hsu, Ching-Jang Huan. Role of GLP-1 in the Hypoglycemic Effects of Wild Bitter Gourd. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-04-17. PMID:23589719. |
a single oral dose of wes significantly decreased glucose and increased insulin and glp-1 in serum after 30 min. |
2013-04-17 |
2023-08-12 |
mouse |
| Miho Senda, Susumu Ogawa, Kazuhiro Nako, Masashi Okamura, Takuya Sakamoto, Sadayoshi It. The glucagon-like peptide-1 analog liraglutide suppresses ghrelin and controls diabetes in a patient with Prader-Willi syndrome. Endocrine journal. vol 59. issue 10. 2013-04-15. PMID:22785236. |
the metabolic parameters changed as follows: visceral fat area fell from 150.1 to 113.2 (cm(2)); plasma insulin rose from 108.1 to 277.0 (pmol/l); plasma active glp-1 dropped from 2.1 to 1.2 (fmol/l); plasma active ghrelin diminished from 137.0 to 27.7 (pmol/l). |
2013-04-15 |
2023-08-12 |
Not clear |
| Thomas Riedige. The receptive function of hypothalamic and brainstem centres to hormonal and nutrient signals affecting energy balance. The Proceedings of the Nutrition Society. vol 71. issue 4. 2013-04-04. PMID:22931748. |
glucose, amylin, insulin, leptin, peptide yy (pyy), glucagon-like peptide 1 (glp-1) and ghrelin. |
2013-04-04 |
2023-08-12 |
Not clear |
| Naichang Li, Jing Lu, Gary B Willar. Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor. PloS one. vol 7. issue 10. 2013-04-01. PMID:23094100. |
glucagon-like peptide-1 (glp-1) released from intestinal l cells in response to nutrients has many physiological effects but particularly enhances glucose-dependent insulin release through the glp-1 receptor (glp-1r). |
2013-04-01 |
2023-08-12 |
human |
| Radhika V Seimon, Ixchel M Brennan, Antonietta Russo, Tanya J Little, Karen L Jones, Scott Standfield, Judith M Wishart, Michael Horowitz, Christine Feinle-Bisse. Gastric emptying, mouth-to-cecum transit, and glycemic, insulin, incretin, and energy intake responses to a mixed-nutrient liquid in lean, overweight, and obese males. American journal of physiology. Endocrinology and metabolism. vol 304. issue 3. 2013-03-25. PMID:23211514. |
twenty lean, 20 overweight, and 20 obese males had measurements of ge, oro-cecal transit, and blood glucose, insulin, glp-1, and gip concentrations for 5 h after ingestion of a mixed-nutrient drink (500 ml, 532 kcal); ei at a subsequent buffet lunch was determined. |
2013-03-25 |
2023-08-12 |
human |
| Yuichiro Yamad. [Diabetes mellitus and osteoporosis. Incretin as a coordinator of glucose and bone metabolism]. Clinical calcium. vol 22. issue 9. 2013-03-20. PMID:22932289. |
glp-1 and gip play an important role as incretin to stimulate insulin secretion from pancreatic β-cells and to maintain the homeostasis of glucose metabolism. |
2013-03-20 |
2023-08-12 |
Not clear |
| Zhenhua Dong, Weidong Chai, Wenhui Wang, Lina Zhao, Zhuo Fu, Wenhong Cao, Zhenqi Li. Protein kinase A mediates glucagon-like peptide 1-induced nitric oxide production and muscle microvascular recruitment. American journal of physiology. Endocrinology and metabolism. vol 304. issue 2. 2013-03-12. PMID:23193054. |
glucagon-like peptide-1 (glp-1) causes vasodilation and increases muscle glucose uptake independent of insulin. |
2013-03-12 |
2023-08-12 |
rat |
| Grace B Flock, Xiemin Cao, Marlena Maziarz, Daniel J Drucke. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Diabetes. vol 62. issue 1. 2013-03-08. PMID:22933106. |
enteral progesterone administration increased plasma levels of glp-1, glucose-dependent insulinotropic polypeptide (gip), and insulin, and improved oral glucose tolerance in an ru486-insensitve manner in mice: however, systemic progesterone exposure did not improve glucose homeostasis. |
2013-03-08 |
2023-08-12 |
mouse |
| G da Silva Xavier, A Mondragon, G Sun, L Chen, J A McGinty, P M French, G A Rutte. Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia. vol 55. issue 10. 2013-03-07. PMID:22717537. |
individuals carrying type 2 diabetes risk alleles in tcf7l2 display decreased beta cell levels of t cell factor 7 like-2 (tcf7l2) immunoreactivity, and impaired insulin secretion and beta cell sensitivity to glucagon-like peptide 1 (glp-1). |
2013-03-07 |
2023-08-12 |
mouse |
| L Xie, D Zhu, H Y Gaisan. Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets. Diabetologia. vol 55. issue 10. 2013-03-07. PMID:22814762. |
glucagon-like peptide-1 (glp-1) can bypass these insulin-secretory defects in type 2 diabetes, but the mechanism of exocytotic events mediated by glp-1 in rescuing insulin secretion is unclear. |
2013-03-07 |
2023-08-12 |
mouse |
| Scott C Thomson, Ali Kashkouli, Prabhleen Sing. Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat. American journal of physiology. Renal physiology. vol 304. issue 2. 2013-03-06. PMID:23019232. |
the incretin hormone glucagon-like peptide-1 (glp-1) is released from the gut in response to fat or carbohydrate and contributes to negative feedback control of blood glucose by stimulating insulin secretion, inhibiting glucagon, and slowing gastric emptying. |
2013-03-06 |
2023-08-12 |
rat |
| Yuting Alex Chiang, Weijuan Shao, Xiao Xue Xu, Jonathan Chernoff, Tianru Ji. P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. Endocrinology. vol 154. issue 1. 2013-02-22. PMID:23183186. |
in gut endocrine l cells, the wnt signaling pathway effector β-catenin (β-cat)/transcription factor 7-like 2 mediates the stimulatory effect of insulin on proglucagon (gcg) expression and glucagon-like peptide-1 (glp-1) production. |
2013-02-22 |
2023-08-12 |
mouse |
| Yuting Alex Chiang, Weijuan Shao, Xiao Xue Xu, Jonathan Chernoff, Tianru Ji. P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. Endocrinology. vol 154. issue 1. 2013-02-22. PMID:23183186. |
these mice had lower circulating active glp-1 levels after a glucose challenge as well as reduced distal ileum glp-1 content after insulin treatment. |
2013-02-22 |
2023-08-12 |
mouse |
| Gonzalo Encina, Fernando Ezquer, Paulette Conget, Yedy Israe. Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene. Biological research. vol 44. issue 3. 2013-02-20. PMID:22688918. |
when the mouse enteroendocrine stc-1 cell line was transfected with the human preproinsulin gene, driven either by the k-cell specific gip promoter or by the constitutive cytomegalovirus (cmv) promoter, human insulin co-localizes in vesicles that contain gip (gip or cmv promoter) or glp-1 (cmv promoter). |
2013-02-20 |
2023-08-12 |
mouse |
| R Fukumori, T Mita, T Sugino, T Obitsu, K Taniguch. Plasma concentrations and effects of glucagon-like peptide-1 (7-36) amide in calves before and after weaning. Domestic animal endocrinology. vol 43. issue 4. 2013-02-19. PMID:22683323. |
basal plasma glp-1 concentrations were measured in calves around the weaning period, the effect of short-chain fatty acids (scfa) on plasma glp-1 concentrations was examined, and the effects of glp-1 administration on plasma insulin, glucagon, and glucose concentrations were measured. |
2013-02-19 |
2023-08-12 |
Not clear |
| R Fukumori, T Mita, T Sugino, T Obitsu, K Taniguch. Plasma concentrations and effects of glucagon-like peptide-1 (7-36) amide in calves before and after weaning. Domestic animal endocrinology. vol 43. issue 4. 2013-02-19. PMID:22683323. |
preprandial plasma samples were obtained from 5 calves once a week from week 0 to 13 to measure basal concentrations of plasma glp-1 and insulin (experiment 1). |
2013-02-19 |
2023-08-12 |
Not clear |