| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| André J Schee. GLP-1 receptor agonists or DPP-4 inhibitors: how to guide the clinician? Annales d'endocrinologie. vol 74. issue 5-6. 2014-08-24. PMID:23570814. |
gliptins may represent a valuable alternative to a sulfonylurea or a glitazone after failure of monotherapy with metformin while glp-1 receptor agonists may be considered as a good alternative to insulin (especially in obese patients) after failure of a dual oral therapy. |
2014-08-24 |
2023-08-12 |
Not clear |
| Srividya Vasu, Neville H McClenaghan, Jane T McCluskey, Peter R Flat. Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia. Islets. vol 5. issue 4. 2014-08-20. PMID:23985558. |
insulin release stimulated by alanine, glp-1, kcl, elevated ca (2+) and forskolin was also markedly reduced after exposure to hyperglycemia (p<0.001). |
2014-08-20 |
2023-08-12 |
human |
| Masayuki Arakawa, Chie Ebat. Efficacy of liraglutide as a follow-up therapy after resolution of glucotoxicity with intensive insulin therapy. Diabetes & metabolic syndrome. vol 7. issue 4. 2014-08-12. PMID:24290089. |
to assess the utility of liraglutide, a glp-1 receptor agonist, as additional therapy following resolution of glucotoxicity with insulin therapy. |
2014-08-12 |
2023-08-12 |
Not clear |
| Sriparna Ghosal, Brent Myers, James P Herma. Role of central glucagon-like peptide-1 in stress regulation. Physiology & behavior. vol 122. 2014-08-11. PMID:23623992. |
glucagon-like peptide 1 (glp-1) is best known as an incretin hormone, secreted from l cells in the intestine in response to nutrient ingestion to stimulate glucose-dependent insulin secretion. |
2014-08-11 |
2023-08-12 |
Not clear |
| Paul Richards, Helen E Parker, Alice E Adriaenssens, Joshua M Hodgson, Simon C Cork, Stefan Trapp, Fiona M Gribble, Frank Reiman. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes. vol 63. issue 4. 2014-08-06. PMID:24296712. |
therapies based on glp-1 are highly effective because they increase glucose-dependent insulin secretion in people with type 2 diabetes, but many reports suggest that glp-1 has additional beneficial or, in some cases, potentially dangerous actions on other tissues, including the heart, vasculature, exocrine pancreas, liver, and central nervous system. |
2014-08-06 |
2023-08-12 |
mouse |
| Anna Masajtis-Zagajewska, Ilona Kurnatowska, Małgorzata Wajdlich, Marta Jagodzińska, Michał Nowick. Influence of hemodialysis on incretin hormones and insulin secretion in diabetic and non-diabetic patients. International urology and nephrology. vol 45. issue 6. 2014-07-31. PMID:23670285. |
the aim of the study was to assess the effect of the commencement of chronic hemodialysis (hd) therapy on serum glp-1 and gip, and insulin sensitivity in diabetic and non-diabetic patients. |
2014-07-31 |
2023-08-12 |
Not clear |
| Tina Akhavan, Bohdan L Luhovyy, Shirin Panahi, Ruslan Kubant, Peter H Brown, G Harvey Anderso. Mechanism of action of pre-meal consumption of whey protein on glycemic control in young adults. The Journal of nutritional biochemistry. vol 25. issue 1. 2014-07-29. PMID:24314863. |
however, compared with glucose, wp resulted in higher post-meal glp-1 and peptide tyrosine-tyrosine (pyy) and lower insulin concentrations, without altering insulin secretion and extraction rates. |
2014-07-29 |
2023-08-12 |
Not clear |
| Tina Akhavan, Bohdan L Luhovyy, Shirin Panahi, Ruslan Kubant, Peter H Brown, G Harvey Anderso. Mechanism of action of pre-meal consumption of whey protein on glycemic control in young adults. The Journal of nutritional biochemistry. vol 25. issue 1. 2014-07-29. PMID:24314863. |
for the total duration of this study (0-230 min), wp resulted in lower mean plasma glucose, insulin and c-peptide, but higher glp-1 and pyy concentrations than the glucose preloads. |
2014-07-29 |
2023-08-12 |
Not clear |
| Klaus-Peter Knoch, Suchita Nath-Sain, Antje Petzold, Hendryk Schneider, Mike Beck, Carolin Wegbrod, Anke Sönmez, Carla Münster, Anne Friedrich, Merja Roivainen, Michele Solimen. PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells. Molecular metabolism. vol 3. issue 5. 2014-07-25. PMID:25061557. |
glucose and glp-1 stimulate not only insulin secretion, but also the post-transcriptional induction of insulin granule biogenesis. |
2014-07-25 |
2023-08-13 |
Not clear |
| Noemi González-Abuín, Neus Martínez-Micaelo, Mayte Blay, Anna Ardévol, Montserrat Pinen. Grape-seed procyanidins prevent the cafeteria-diet-induced decrease of glucagon-like peptide-1 production. Journal of agricultural and food chemistry. vol 62. issue 5. 2014-07-18. PMID:24410268. |
because glucagon-like peptide-1 (glp-1) is involved in glucose homeostasis, the preventive effects of gspe on glp-1 production, secretion, and elimination were evaluated in a model of diet-induced insulin resistance. |
2014-07-18 |
2023-08-12 |
rat |
| Ying-Chun Hu, Dong-Ming Hao, Lu-Xian Zhou, Zhe Zhang, Nan Huang, Michael Hoptroff, Yan-Hua L. 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone protects the impaired insulin secretion induced by glucotoxicity in pancreatic β-cells. Journal of agricultural and food chemistry. vol 62. issue 7. 2014-07-15. PMID:24437980. |
it was demonstrated that dmc increased insulin secretion against glucotoxicity by simulating the effect of glp-1 and enhancing the expression of glp-1r, followed by activating the signal pathway of pdx-1, pre-ins, and glut2-gck. |
2014-07-15 |
2023-08-12 |
Not clear |
| Hiroto Hayashi, Ren Yamada, Siddhartha Shankar Das, Taiki Sato, Aki Takahashi, Masahiro Hiratsuka, Noriyasu Hirasaw. Glucagon-like peptide-1 production in the GLUTag cell line is impaired by free fatty acids via endoplasmic reticulum stress. Metabolism: clinical and experimental. vol 63. issue 6. 2014-07-15. PMID:24680601. |
glucagon-like peptide-1 (glp-1) is secreted from intestinal l cells, enhances glucose-stimulated insulin secretion, and protects pancreas beta cells. |
2014-07-15 |
2023-08-12 |
mouse |
| Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, Samadhan Kshirsagar, Kartik Patel, Rajesh Bahekar, Gaurang Shah, Mukul Jai. Co-agonist of glucagon and GLP-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese C57 mice. Canadian journal of physiology and pharmacology. vol 91. issue 12. 2014-07-14. PMID:24289070. |
co-agonist of glucagon and glp-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese c57 mice. |
2014-07-14 |
2023-08-12 |
mouse |
| Soraya P Shirazi-Beechey, Kristian Daly, Miran Al-Rammahi, Andrew W Moran, David Brav. Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing. The British journal of nutrition. vol 111 Suppl 1. 2014-07-14. PMID:24382171. |
glp-1 and gip enhance insulin secretion; glp-2 increases intestinal growth and glucose absorption. |
2014-07-14 |
2023-08-12 |
Not clear |
| A Cignarelli, F Giorgino, R Vetto. Pharmacologic agents for type 2 diabetes therapy and regulation of adipogenesis. Archives of physiology and biochemistry. vol 119. issue 4. 2014-07-10. PMID:23724947. |
indeed, specific currently available diabetes therapies can cause weight gain, including insulin and its analogues, sulphonylureas, and thiazolidinediones, while others, such as metformin and the glp-1 receptor agonists, can promote weight loss. |
2014-07-10 |
2023-08-12 |
Not clear |
| Prashant Nadkarni, Oleg G Chepurny, George G Hol. Regulation of glucose homeostasis by GLP-1. Progress in molecular biology and translational science. vol 121. 2014-07-10. PMID:24373234. |
glucagon-like peptide-1(7-36)amide (glp-1) is a secreted peptide that acts as a key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric emptying, to enhance pancreatic insulin secretion, and to suppress pancreatic glucagon secretion. |
2014-07-10 |
2023-08-12 |
Not clear |
| Anita Wichmann, Ava Allahyar, Thomas U Greiner, Hubert Plovier, Gunnel Östergren Lundén, Thomas Larsson, Daniel J Drucker, Nathalie M Delzenne, Patrice D Cani, Fredrik Bäckhe. Microbial modulation of energy availability in the colon regulates intestinal transit. Cell host & microbe. vol 14. issue 5. 2014-07-07. PMID:24237703. |
scfas are proposed to stimulate secretion of the proglucagon (gcg)-derived incretin hormone glp-1, which stimulates insulin secretion (incretin response) and inhibits gastric emptying. |
2014-07-07 |
2023-08-12 |
mouse |
| Rushika Conroy, Gerardo Febres, Donald J McMahon, Michael O Thorner, Bruce D Gaylinn, Irene Conwell, Louis Aronne, Judith Korne. Recombinant human leptin does not alter gut hormone levels after gastric bypass but may attenuate sweet cravings. International journal of endocrinology. vol 2014. 2014-07-02. PMID:24987413. |
glucose, insulin, c-peptide, glp-1, pyy, glucagon, and ghrelin (total, acyl, and desacyl) were measured fasting and postprandially. |
2014-07-02 |
2023-08-13 |
human |
| Jie Shen, Zhi Chen, Chaofeng Chen, Xiao Zhu, Yajuan Ha. Impact of incretin on early-phase insulin secretion and glucose excursion. Endocrine. vol 44. issue 2. 2014-07-01. PMID:23283820. |
plasma glucose, insulin, glucagon, total glucose-dependent insulinotropic polypeptide (gip), and glucagon-like peptide-l (glp-1) levels were measured at 30-min increments for 2 h after glucose intake. |
2014-07-01 |
2023-08-12 |
human |
| Jie Shen, Zhi Chen, Chaofeng Chen, Xiao Zhu, Yajuan Ha. Impact of incretin on early-phase insulin secretion and glucose excursion. Endocrine. vol 44. issue 2. 2014-07-01. PMID:23283820. |
incretin may ameliorate glucose excursions, and glp-1 may exert them by promoting early-phase insulin secretion. |
2014-07-01 |
2023-08-12 |
human |