| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| So Ra Kim, Dae-Hoon Kim, Soo Hyun Park, Young Seok Kim, Chun Hwa Kim, Tae-Young Ha, Jin Yang, Jae-Keol Rhe. In vivo efficacy of HD0471953: a novel GPR119 agonist for the treatment of type 2 diabetes mellitus. Journal of diabetes research. vol 2013. 2014-06-16. PMID:24386644. |
the expression of gpr119 on the pancreatic b cells and intestinal l cells provides a unique opportunity for a single drug to promote insulin and glp-1 secretion. |
2014-06-16 |
2023-08-12 |
mouse |
| So Ra Kim, Dae-Hoon Kim, Soo Hyun Park, Young Seok Kim, Chun Hwa Kim, Tae-Young Ha, Jin Yang, Jae-Keol Rhe. In vivo efficacy of HD0471953: a novel GPR119 agonist for the treatment of type 2 diabetes mellitus. Journal of diabetes research. vol 2013. 2014-06-16. PMID:24386644. |
single administration of hd0471953 showed improved glycemic control with a dose-dependent manner in ogtt with normal mice, and the insulin and glp-1 were also increased. |
2014-06-16 |
2023-08-12 |
mouse |
| Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, Samadhan Kshirsagar, Jaysukh Detroja, Kartikkumar Patel, Tejal Gandhi, Kirti Patel, Rajesh Bahekar, Mukul Jai. Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice. Pharmacological reports : PR. vol 65. issue 4. 2014-06-13. PMID:24145087. |
combination of omeprazole with glp-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice. |
2014-06-13 |
2023-08-12 |
mouse |
| Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, Samadhan Kshirsagar, Jaysukh Detroja, Kartikkumar Patel, Tejal Gandhi, Kirti Patel, Rajesh Bahekar, Mukul Jai. Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice. Pharmacological reports : PR. vol 65. issue 4. 2014-06-13. PMID:24145087. |
glp-1 agonist exendin-4 may have insulin-independent effects on amelioration of insulin resistance and hepatic steatosis by virtue of its action on hepatic glp-1 receptors, and these effects can be improved by combination with proton pump inhibitors. |
2014-06-13 |
2023-08-12 |
mouse |
| Sharmila C Subaran, Matthew A Sauder, Weidong Chai, Linda A Jahn, Dale E Fowler, Kevin W Aylor, Ananda Basu, Zhenqi Li. GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans. Clinical science (London, England : 1979). vol 127. issue 3. 2014-06-09. PMID:24552454. |
glp-1 (glucagon-like peptide-1) regulates glucose-dependent insulin secretion and has numerous extrapancreatic effects, including a salutary vascular action. |
2014-06-09 |
2023-08-12 |
Not clear |
| Sharmila C Subaran, Matthew A Sauder, Weidong Chai, Linda A Jahn, Dale E Fowler, Kevin W Aylor, Ananda Basu, Zhenqi Li. GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans. Clinical science (London, England : 1979). vol 127. issue 3. 2014-06-09. PMID:24552454. |
glp-1 infusion raised plasma glp-1 concentrations to the postprandial levels and suppressed plasma glucagon concentrations with a transient increase in plasma insulin concentrations. |
2014-06-09 |
2023-08-12 |
Not clear |
| Rhoda E Kuc, Janet J Maguire, Keith Siew, Sheena Patel, David R Derksen, V Margaret Jackson, Kevin M O'Shaughnessey, Anthony P Davenpor. Characterization of [¹²⁵I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide in murine aorta. Life sciences. vol 102. issue 2. 2014-06-08. PMID:24641952. |
glucagon-like peptide 1 (glp-1) is an insulin secretagogue, released in response to meal ingestion and efficiently lowers blood glucose in type 2 diabetic patients. |
2014-06-08 |
2023-08-12 |
mouse |
| Marina Tsoli, Aikaterini Chronaiou, Ioannis Kehagias, Fotis Kalfarentzos, Theodore K Alexandride. Hormone changes and diabetes resolution after biliopancreatic diversion and laparoscopic sleeve gastrectomy: a comparative prospective study. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. vol 9. issue 5. 2014-06-05. PMID:23466015. |
the objective of this study was to evaluate and compare prospectively the effects of bpd long limb (bpd) and laparoscopic sg on fasting, and glucose-stimulated insulin, glucagon, ghrelin, peptide yy (pyy), and glucagon-like peptide-1 (glp-1) secretion and also on remission of t2dm, hypertension, and dyslipidemia in morbidly obese patients with t2dm. |
2014-06-05 |
2023-08-12 |
Not clear |
| Paula L McClean, Christian Hölsche. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology. vol 76 Pt A. 2014-06-05. PMID:23973293. |
the incretin hormone glucagon-like peptide-1 (glp-1) facilitates insulin signalling, and long-lasting analogues such as liraglutide (victoza(®)) are on the market as type 2 diabetes treatments. |
2014-06-05 |
2023-08-12 |
mouse |
| Peter Stiefelhage. [When injectable diabetes therapy becomes necessary. Insulin or GLP-1 analogs?]. MMW Fortschritte der Medizin. vol 153. issue 1-2. 2014-06-03. PMID:24761480. |
insulin or glp-1 analogs? |
2014-06-03 |
2023-08-13 |
Not clear |
| Noriko Kameyama, Chizuko Maruyama, Sadako Matsui, Risa Araki, Yuichiro Yamada, Taro Maruyam. Effects of consumption of main and side dishes with white rice on postprandial glucose, insulin, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 responses in healthy Japanese men. The British journal of nutrition. vol 111. issue 9. 2014-06-02. PMID:24507870. |
the co-ingestion of protein, fat and fibre with carbohydrate reportedly affects postprandial glucose, insulin and incretin (glucose-dependent insulinotropic polypeptide (gip) and glucagon-like peptide-1 (glp-1)) responses. |
2014-06-02 |
2023-08-12 |
human |
| Noriko Kameyama, Chizuko Maruyama, Sadako Matsui, Risa Araki, Yuichiro Yamada, Taro Maruyam. Effects of consumption of main and side dishes with white rice on postprandial glucose, insulin, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 responses in healthy Japanese men. The British journal of nutrition. vol 111. issue 9. 2014-06-02. PMID:24507870. |
plasma glucose, gip and glp-1 and serum insulin concentrations were determined during a 3 h period after consumption of these meals. |
2014-06-02 |
2023-08-12 |
human |
| Yu-ting Alex Chiang, Tianru Ji. p21-Activated protein kinases and their emerging roles in glucose homeostasis. American journal of physiology. Endocrinology and metabolism. vol 306. issue 7. 2014-05-30. PMID:24368667. |
furthermore, we demonstrated that pak1 mediates the cross talk between insulin and wnt/β-catenin signaling pathways and hence regulates gut proglucagon gene expression and the production of the incretin hormone glucagon-like peptide-1 (glp-1). |
2014-05-30 |
2023-08-12 |
mouse |
| Rune E Kuhre, Fiona M Gribble, Bolette Hartmann, Frank Reimann, Johanne A Windeløv, Jens F Rehfeld, Jens J Hols. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. American journal of physiology. Gastrointestinal and liver physiology. vol 306. issue 7. 2014-05-29. PMID:24525020. |
in healthy humans, fructose intake caused a rise in blood glucose and plasma insulin and glp-1, albeit to a lower degree than isocaloric glucose. |
2014-05-29 |
2023-08-12 |
mouse |
| Qimin Zhang, Fan Zhang, Ake Sjöhol. BLX-1002 restores glucose sensitivity and enhances insulin secretion stimulated by GLP-1 and sulfonylurea in type 2 diabetic pancreatic islets. Physiological reports. vol 2. issue 5. 2014-05-29. PMID:24872354. |
blx-1002 restores glucose sensitivity and enhances insulin secretion stimulated by glp-1 and sulfonylurea in type 2 diabetic pancreatic islets. |
2014-05-29 |
2023-08-13 |
mouse |
| Qimin Zhang, Fan Zhang, Ake Sjöhol. BLX-1002 restores glucose sensitivity and enhances insulin secretion stimulated by GLP-1 and sulfonylurea in type 2 diabetic pancreatic islets. Physiological reports. vol 2. issue 5. 2014-05-29. PMID:24872354. |
to this end, dynamics of insulin secretion stimulated by glucose, glp-1, and the sulfonylurea tolbutamide were examined in pancreatic islets from nondiabetic wistar and type 2 diabetic goto-kakizaki rats ex vivo. |
2014-05-29 |
2023-08-13 |
mouse |
| Qimin Zhang, Fan Zhang, Ake Sjöhol. BLX-1002 restores glucose sensitivity and enhances insulin secretion stimulated by GLP-1 and sulfonylurea in type 2 diabetic pancreatic islets. Physiological reports. vol 2. issue 5. 2014-05-29. PMID:24872354. |
consistent with its effects on insulin secretion, blx-1002 also augmented insulin secretion and cytoplasmic-free ca(2+) concentrations ([ca(2+)]i) stimulated by high glucose, glp-1, and tolbutamide in islets from gk, but not wistar, rats. |
2014-05-29 |
2023-08-13 |
mouse |
| Hanne K J Gonnissen, Rick Hursel, Femke Rutters, Eveline A P Martens, Margriet S Westerterp-Planteng. Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men. The British journal of nutrition. vol 109. issue 4. 2014-05-27. PMID:22682471. |
blood samples were taken at baseline and continued hourly for the 24 h period to measure glucose, insulin, ghrelin, leptin, glucagon-like peptide 1 (glp-1) and melatonin concentrations. |
2014-05-27 |
2023-08-12 |
human |
| Hanne K J Gonnissen, Rick Hursel, Femke Rutters, Eveline A P Martens, Margriet S Westerterp-Planteng. Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men. The British journal of nutrition. vol 109. issue 4. 2014-05-27. PMID:22682471. |
in fragmented v. non-fragmented sleep, glucose concentrations did not change, while insulin secretion was decreased in the morning, and increased in the afternoon (p< 0·05), and glp-1 concentrations and fullness scores were lower (p< 0·05). |
2014-05-27 |
2023-08-12 |
human |
| Hanne K J Gonnissen, Rick Hursel, Femke Rutters, Eveline A P Martens, Margriet S Westerterp-Planteng. Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men. The British journal of nutrition. vol 109. issue 4. 2014-05-27. PMID:22682471. |
a single night of fragmented sleep, resulting in reduced rem sleep, induced a shift in insulin concentrations, from being lower in the morning and higher in the afternoon, while glp-1 concentrations and fullness scores were decreased. |
2014-05-27 |
2023-08-12 |
human |