| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Wei Xu, Mei-Ping Guan, Zong-Ji Zheng, Fang Gao, Yan-Mei Zeng, Yan Qin, Yao-Ming Xu. Exendin-4 alleviates high glucose-induced rat mesangial cell dysfunction through the AMPK pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 33. issue 2. 2014-10-15. PMID:24556697. |
glucagon-like peptide-1 (glp-1), which counteracts insulin resistance in humans with type 2 diabetes, has been shown to ameliorate diabetic nephropathy in experimental models. |
2014-10-15 |
2023-08-12 |
rat |
| Mark P Mattso. Interventions that improve body and brain bioenergetics for Parkinson's disease risk reduction and therapy. Journal of Parkinson's disease. vol 4. issue 1. 2014-10-14. PMID:24473219. |
insulin sensitizing glucagon-like peptide 1 (glp-1) analogs are beneficial in animal models of pd, and the results of an initial clinical trial in pd patients are promising. |
2014-10-14 |
2023-08-12 |
Not clear |
| Hee Young Kim, Jong-Ik Hwang, Mi Jin Moon, Jae Young Seon. A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth. Endocrinology and metabolism (Seoul, Korea). vol 29. issue 3. 2014-10-13. PMID:25309791. |
in the pancreas, glp-1 stimulates post-prandial insulin secretion, promotes insulin biosynthesis, and improves insulin sensitivity. |
2014-10-13 |
2023-08-13 |
Not clear |
| Javier T Gonzalez, Emma J Stevenso. Calcium co-ingestion augments postprandial glucose-dependent insulinotropic peptide(1-42), glucagon-like peptide-1 and insulin concentrations in humans. European journal of nutrition. vol 53. issue 2. 2014-10-09. PMID:23689561. |
this study determined whether calcium co-ingestion potentiates postprandial gip(1-42) and glp-1 concentrations in humans and the concomitant impact on insulin, appetite sensations and substrate metabolism. |
2014-10-09 |
2023-08-12 |
Not clear |
| Weidong Chai, Xingxing Zhang, Eugene J Barrett, Zhenqi Li. Glucagon-like peptide 1 recruits muscle microvasculature and improves insulin's metabolic action in the presence of insulin resistance. Diabetes. vol 63. issue 8. 2014-10-09. PMID:24658303. |
glucagon-like peptide 1 (glp-1) acutely recruits muscle microvasculature, increases muscle delivery of insulin, and enhances muscle use of glucose, independent of its effect on insulin secretion. |
2014-10-09 |
2023-08-12 |
rat |
| Weidong Chai, Xingxing Zhang, Eugene J Barrett, Zhenqi Li. Glucagon-like peptide 1 recruits muscle microvasculature and improves insulin's metabolic action in the presence of insulin resistance. Diabetes. vol 63. issue 8. 2014-10-09. PMID:24658303. |
to examine whether glp-1 modulates muscle microvascular and metabolic insulin responses in the setting of insulin resistance, we assessed muscle microvascular blood volume (mbv), flow velocity, and blood flow in control insulin-sensitive rats and rats made insulin-resistant acutely (systemic lipid infusion) or chronically (high-fat diet [hfd]) before and after a euglycemic-hyperinsulinemic clamp (3 mu/kg/min) with or without superimposed systemic glp-1 infusion. |
2014-10-09 |
2023-08-12 |
rat |
| Weidong Chai, Xingxing Zhang, Eugene J Barrett, Zhenqi Li. Glucagon-like peptide 1 recruits muscle microvasculature and improves insulin's metabolic action in the presence of insulin resistance. Diabetes. vol 63. issue 8. 2014-10-09. PMID:24658303. |
insulin significantly recruited muscle microvasculature and addition of glp-1 further expanded muscle mbv and increased insulin-mediated glucose disposal. |
2014-10-09 |
2023-08-12 |
rat |
| Weidong Chai, Xingxing Zhang, Eugene J Barrett, Zhenqi Li. Glucagon-like peptide 1 recruits muscle microvasculature and improves insulin's metabolic action in the presence of insulin resistance. Diabetes. vol 63. issue 8. 2014-10-09. PMID:24658303. |
glp-1 infusion potently recruited muscle microvasculature in the presence of either acute or chronic insulin resistance by increasing muscle mbv. |
2014-10-09 |
2023-08-12 |
rat |
| Weidong Chai, Xingxing Zhang, Eugene J Barrett, Zhenqi Li. Glucagon-like peptide 1 recruits muscle microvasculature and improves insulin's metabolic action in the presence of insulin resistance. Diabetes. vol 63. issue 8. 2014-10-09. PMID:24658303. |
we conclude that glp-1 infusion potently expands muscle microvascular surface area and improves insulin's metabolic action in the insulin-resistant states. |
2014-10-09 |
2023-08-12 |
rat |
| Justin J Wilkins, Michel Dubar, Bernard Sébastien, Christian Laveill. A drug and disease model for lixisenatide, a GLP-1 receptor agonist in type 2 diabetes. Journal of clinical pharmacology. vol 54. issue 3. 2014-10-06. PMID:24122776. |
incretin hormone analogs such as glucagon-like peptide-1 (glp-1) receptor agonists have emerged as promising new options for the treatment of type 2 diabetes mellitus (t2dm), targeting several of its pathophysiological traits, including reduced insulin sensitivity, inadequate insulin secretion, and loss of β-cell mass (bcm). |
2014-10-06 |
2023-08-12 |
Not clear |
| Christine Bernsmeier, Anne C Meyer-Gerspach, Lea S Blaser, Lia Jeker, Robert E Steinert, Markus H Heim, Christoph Beglinge. Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease. PloS one. vol 9. issue 1. 2014-10-06. PMID:24489924. |
the incretins glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are gastrointestinal peptide hormones regulating postprandial insulin release from pancreatic β-cells. |
2014-10-06 |
2023-08-12 |
mouse |
| Konrad Talbot, Hoau-Yan Wan. The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529520. |
studies on animal models of ad and on human brain tissue from mci cases at high risk of ad dementia have shown that brain insulin resistance and many other pathologic features and symptoms of ad may be greatly reduced or even reversed by treatment with fda-approved glucagon-like peptide-1 (glp-1) analogs such as liraglutide (victoza). |
2014-10-06 |
2023-08-12 |
human |
| b' Stefan Harmuth, Marlene Wewalka, Jens Juul Holst, Romina Nemecek, Sabine Thalhammer, Rainer Schmid, Klaus Sahora, Michael Gnant, Johannes Miholi\\xc4\\x8. Distal gastrectomy in pancreaticoduodenectomy is associated with accelerated gastric emptying, enhanced postprandial release of GLP-1, and improved insulin sensitivity. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 18. issue 1. 2014-10-01. PMID:24002756.' |
distal gastrectomy in pancreaticoduodenectomy is associated with accelerated gastric emptying, enhanced postprandial release of glp-1, and improved insulin sensitivity. |
2014-10-01 |
2023-08-12 |
Not clear |
| b' Stefan Harmuth, Marlene Wewalka, Jens Juul Holst, Romina Nemecek, Sabine Thalhammer, Rainer Schmid, Klaus Sahora, Michael Gnant, Johannes Miholi\\xc4\\x8. Distal gastrectomy in pancreaticoduodenectomy is associated with accelerated gastric emptying, enhanced postprandial release of GLP-1, and improved insulin sensitivity. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 18. issue 1. 2014-10-01. PMID:24002756.' |
this study aims to investigate the relationship between gastric emptying, postprandial glp-1 and insulin sensitivity after pancreaticoduodenectomy (pd). |
2014-10-01 |
2023-08-12 |
Not clear |
| J Gao, L Tian, G Weng, T D O'Brien, J Luo, Z Gu. Stimulating β-cell replication and improving islet graft function by AR231453, A GPR119 agonist. Transplantation proceedings. vol 43. issue 9. 2014-09-30. PMID:22099761. |
ar231453 is a selective small-molecular gpr119 agonist that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (glp-1) release. |
2014-09-30 |
2023-08-12 |
mouse |
| Susumu Watada, Yong-Ming Yu, Alan J Fischman, Tomohiro Kurihara, Chuan-An Shen, Ronald G Tompkins, Shawn Faga. Evaluation of intragastric vs intraperitoneal glucose tolerance tests in the evaluation of insulin resistance in a rodent model of burn injury and glucagon-like polypeptide-1 treatment. Journal of burn care & research : official publication of the American Burn Association. vol 35. issue 1. 2014-09-29. PMID:23511296. |
our previous studies using ipgtt have demonstrated burn injury-induced insulin resistance and the beneficial effects of glucagon-like polypeptide-1 (glp-1) in improving insulin resistance. |
2014-09-29 |
2023-08-12 |
rat |
| Susumu Watada, Yong-Ming Yu, Alan J Fischman, Tomohiro Kurihara, Chuan-An Shen, Ronald G Tompkins, Shawn Faga. Evaluation of intragastric vs intraperitoneal glucose tolerance tests in the evaluation of insulin resistance in a rodent model of burn injury and glucagon-like polypeptide-1 treatment. Journal of burn care & research : official publication of the American Burn Association. vol 35. issue 1. 2014-09-29. PMID:23511296. |
the goal of the present study is to compare the results of these two procedures under 1) burn injury-induced insulin resistance and 2) glp-1 treatment after burn. |
2014-09-29 |
2023-08-12 |
rat |
| Susumu Watada, Yong-Ming Yu, Alan J Fischman, Tomohiro Kurihara, Chuan-An Shen, Ronald G Tompkins, Shawn Faga. Evaluation of intragastric vs intraperitoneal glucose tolerance tests in the evaluation of insulin resistance in a rodent model of burn injury and glucagon-like polypeptide-1 treatment. Journal of burn care & research : official publication of the American Burn Association. vol 35. issue 1. 2014-09-29. PMID:23511296. |
in contrast, peak insulin levels of each burn with glp-1 group were similar. |
2014-09-29 |
2023-08-12 |
rat |
| Susumu Watada, Yong-Ming Yu, Alan J Fischman, Tomohiro Kurihara, Chuan-An Shen, Ronald G Tompkins, Shawn Faga. Evaluation of intragastric vs intraperitoneal glucose tolerance tests in the evaluation of insulin resistance in a rodent model of burn injury and glucagon-like polypeptide-1 treatment. Journal of burn care & research : official publication of the American Burn Association. vol 35. issue 1. 2014-09-29. PMID:23511296. |
1) both ipgtt and iggtt demonstrated burn injury-induced insulin resistance and the efficacy of glp-1 for reducing hyperglycemia after burn injury. |
2014-09-29 |
2023-08-12 |
rat |
| Susumu Watada, Yong-Ming Yu, Alan J Fischman, Tomohiro Kurihara, Chuan-An Shen, Ronald G Tompkins, Shawn Faga. Evaluation of intragastric vs intraperitoneal glucose tolerance tests in the evaluation of insulin resistance in a rodent model of burn injury and glucagon-like polypeptide-1 treatment. Journal of burn care & research : official publication of the American Burn Association. vol 35. issue 1. 2014-09-29. PMID:23511296. |
2) the observed differences in the plasma glucose and insulin levels between iggtt and ipgtt suggest that endogenously produced glp-1 during the iggtt may play a role in ameliorating insulin resistance after burn injury. |
2014-09-29 |
2023-08-12 |
rat |