| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Zhang, Songyan Wang, Matthew D Puhl, Xuntian Jiang, Krzysztof L Hyrc, Erin Laciny, Michael J Wallendorf, Kirk L Pappan, Joseph T Coyle, Burton M Wic. Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans. Diabetes. vol 64. issue 4. 2015-05-22. PMID:25368100. |
glucose-dependent insulinotropic polypeptide (gip) and glp-1 are incretins secreted by respective k and l enteroendocrine cells after eating and amplify glucose-stimulated insulin secretion (gsis). |
2015-05-22 |
2023-08-13 |
mouse |
| T Wu, S S Thazhath, C S Marathe, M J Bound, K L Jones, M Horowitz, C K Rayne. Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutrition & diabetes. vol 5. 2015-05-19. PMID:25985092. |
we compared responses of plasma glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), insulin and glucagon, and blood glucose to a standardised glucose infusion into the proximal jejunum and duodenum in healthy humans. |
2015-05-19 |
2023-08-13 |
Not clear |
| T Wu, S S Thazhath, C S Marathe, M J Bound, K L Jones, M Horowitz, C K Rayne. Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males. Nutrition & diabetes. vol 5. 2015-05-19. PMID:25985092. |
plasma glp-1, gip and insulin responses, as well as the insulin:glucose ratio and the insulinogenic index 1 (igi1) were greater (p<0.05 for each) after intrajejunal (i.j.) |
2015-05-19 |
2023-08-13 |
Not clear |
| Kenneth Calvin Wiley, Ranti Akiyode, Gail Nunlee-Blan. Case Study: Use of GLP-1 Receptor Agonist in a Patient on Intensive Insulin Therapy. Diabetes spectrum : a publication of the American Diabetes Association. vol 28. issue 2. 2015-05-19. PMID:25987811. |
case study: use of glp-1 receptor agonist in a patient on intensive insulin therapy. |
2015-05-19 |
2023-08-13 |
Not clear |
| Alessandra Puddu, Roberta Sanguineti, Fabrizio Montecucco, Giorgio Luciano Vivian. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators of inflammation. vol 2014. 2015-05-15. PMID:25214711. |
their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective glucagon-like peptide-1 (glp-1) secretion. |
2015-05-15 |
2023-08-13 |
Not clear |
| Xu Sun, Meizhu Zheng, Maomin Song, Rixing Bai, Shi Cheng, Ying Xing, Huisheng Yuan, Pilin Wan. Ileal interposition reduces blood glucose levels and decreases insulin resistance in a type 2 diabetes mellitus animal model by up-regulating glucagon-like peptide-1 and its receptor. International journal of clinical and experimental pathology. vol 7. issue 7. 2015-05-14. PMID:25120793. |
enzyme-linked immunosorbent assay was used to detect plasma insulin concentration and fasting pancreas glucagon-like peptide-1 (glp-1) concentration changes. |
2015-05-14 |
2023-08-13 |
rat |
| Xu Sun, Meizhu Zheng, Maomin Song, Rixing Bai, Shi Cheng, Ying Xing, Huisheng Yuan, Pilin Wan. Ileal interposition reduces blood glucose levels and decreases insulin resistance in a type 2 diabetes mellitus animal model by up-regulating glucagon-like peptide-1 and its receptor. International journal of clinical and experimental pathology. vol 7. issue 7. 2015-05-14. PMID:25120793. |
it significantly decreased fasting blood glucose level and the oral glucose tolerance, and reduced insulin resistance of gk rats by increasing glp-1 concentration and glp-1r levels. |
2015-05-14 |
2023-08-13 |
rat |
| Xu Sun, Meizhu Zheng, Maomin Song, Rixing Bai, Shi Cheng, Ying Xing, Huisheng Yuan, Pilin Wan. Ileal interposition reduces blood glucose levels and decreases insulin resistance in a type 2 diabetes mellitus animal model by up-regulating glucagon-like peptide-1 and its receptor. International journal of clinical and experimental pathology. vol 7. issue 7. 2015-05-14. PMID:25120793. |
it significantly reduces blood glucose and decreases insulin resistance by up-regulating glp-1 concentrations and glp-1r levels, which may contribute to insulin secretion of pancreatic β-cells and decreases apoptosis of pancreatic β-cell. |
2015-05-14 |
2023-08-13 |
rat |
| Harry J Smolen, Daniel R Murphy, James C Gahn, Xueting Yu, Bradley H Curti. The evaluation of clinical and cost outcomes associated with earlier initiation of insulin in patients with type 2 diabetes mellitus. Journal of managed care & specialty pharmacy. vol 20. issue 9. 2015-05-14. PMID:25166296. |
eventually this progression leads to the use of basal insulin typically with concomitant treatments (e.g., metformin, a glp-1 ra [glucagon-like peptide-1 receptor agonist], a tzd [thiazolidinedione] or a dpp-4i [dipeptidyl peptidase 4 inhibitor]) and, ultimately, to basal-bolus insulin in some forms. |
2015-05-14 |
2023-08-13 |
Not clear |
| R Verhaeghe, C Zerrweck, T Hubert, B Tréchot, V Gmyr, M D'Herbomez, P Pigny, F Pattou, R Caiazz. Gastric bypass increases postprandial insulin and GLP-1 in nonobese minipigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. vol 52. issue 1-2. 2015-05-11. PMID:24557358. |
gastric bypass increases postprandial insulin and glp-1 in nonobese minipigs. |
2015-05-11 |
2023-08-12 |
Not clear |
| R Verhaeghe, C Zerrweck, T Hubert, B Tréchot, V Gmyr, M D'Herbomez, P Pigny, F Pattou, R Caiazz. Gastric bypass increases postprandial insulin and GLP-1 in nonobese minipigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. vol 52. issue 1-2. 2015-05-11. PMID:24557358. |
gastric bypass in obese patients induces a dramatic increase of postprandial insulin and glucagon-like peptide-1 (glp-1) secretion, independently of weight loss. |
2015-05-11 |
2023-08-12 |
Not clear |
| R Verhaeghe, C Zerrweck, T Hubert, B Tréchot, V Gmyr, M D'Herbomez, P Pigny, F Pattou, R Caiazz. Gastric bypass increases postprandial insulin and GLP-1 in nonobese minipigs. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. vol 52. issue 1-2. 2015-05-11. PMID:24557358. |
we explored postprandial insulin and glp-1 secretion in nonobese minipigs before and after rygb. |
2015-05-11 |
2023-08-12 |
Not clear |
| Xiaosong Ma, Youfei Guan, Xianxin Hu. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells. Journal of diabetes. vol 6. issue 5. 2015-05-11. PMID:24725840. |
glucagon-like peptide-1 (glp-1) is the primary incretin hormone secreted from the intestine upon uptake of food to stimulate insulin secretion from pancreatic β-cells. |
2015-05-11 |
2023-08-13 |
Not clear |
| Xiaosong Ma, Youfei Guan, Xianxin Hu. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells. Journal of diabetes. vol 6. issue 5. 2015-05-11. PMID:24725840. |
however, molecular mechanisms underlying how glp-1 potentiates diminished glucose-stimulated insulin secretion and β-cell proliferation under diabetic conditions are not well understood. |
2015-05-11 |
2023-08-13 |
Not clear |
| Xiaosong Ma, Youfei Guan, Xianxin Hu. Glucagon-like peptide 1-potentiated insulin secretion and proliferation of pancreatic β-cells. Journal of diabetes. vol 6. issue 5. 2015-05-11. PMID:24725840. |
here, we review the actions of glp-1 in regulation of insulin secretion and pancreatic β-cell proliferation. |
2015-05-11 |
2023-08-13 |
Not clear |
| Amy C Kelly, Leah V Steyn, Jenna P Kitzmann, Miranda J Anderson, Kate R Mueller, Nathaniel J Hart, Ronald M Lynch, Klearchos K Papas, Sean W Limesan. Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets. Xenotransplantation. vol 21. issue 4. 2015-05-11. PMID:24801676. |
glibenclamide, an anti-diabetic sulfonylurea, and exendin-4, a glp-1 mimetic, potentiated glucose-stimulated insulin secretion >2-fold. |
2015-05-11 |
2023-08-13 |
human |
| Na-Hyung Kim, Taeyang Yu, Dae Ho Le. The nonglycemic actions of dipeptidyl peptidase-4 inhibitors. BioMed research international. vol 2014. 2015-05-11. PMID:25140306. |
two important incretin hormones, glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic peptide (gip), enhance meal-stimulated insulin secretion from pancreatic β-cells, but are inactivated by dpp-4. |
2015-05-11 |
2023-08-13 |
Not clear |
| Kristian Karstoft, Stefan P Mortensen, Sine H Knudsen, Thomas P J Solomo. Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics. American journal of physiology. Endocrinology and metabolism. vol 308. issue 5. 2015-05-01. PMID:25564476. |
on the contrary, during hyperglycemia, gip increases femoral artery blood flow with no effect on glucose metabolism, whereas glp-1 increases glucose disposal, potentially due to increased insulin levels. |
2015-05-01 |
2023-08-13 |
Not clear |
| Lalitha Gudipaty, Nora K Rosenfeld, Carissa S Fuller, Robert Gallop, Mark H Schutta, Michael R Rickel. Effect of exenatide, sitagliptin, or glimepiride on β-cell secretory capacity in early type 2 diabetes. Diabetes care. vol 37. issue 9. 2015-04-30. PMID:24969577. |
agents that augment glp-1 effects enhance glucose-dependent β-cell insulin production and secretion and thus are hoped to prevent progressive impairment in insulin secretion characteristic of type 2 diabetes (t2d). |
2015-04-30 |
2023-08-13 |
Not clear |
| Niina Matikainen, Leonie H Bogl, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Jaakko Kaprio, Aila Rissanen, Jens J Holst, Kirsi H Pietiläine. GLP-1 responses are heritable and blunted in acquired obesity with high liver fat and insulin resistance. Diabetes care. vol 37. issue 1. 2015-04-22. PMID:23990519. |
glp-1 responses are heritable and blunted in acquired obesity with high liver fat and insulin resistance. |
2015-04-22 |
2023-08-12 |
Not clear |