| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed Lotfy, Jaipaul Singh, Hameed Rashed, Saeed Tariq, Erika Zilahi, Ernest Adeghat. The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25115772. |
the results of this study show that glp-1 is co-localized with insulin and seems to exert its beneficial effects by increasing cellular concentrations of endogenous antioxidant genes and other genes involved in the maintenance of pancreatic beta cell structure and function. |
2015-06-25 |
2023-08-13 |
rat |
| Baptist Gallwit. Extra-pancreatic effects of incretin-based therapies. Endocrine. vol 47. issue 2. 2015-06-24. PMID:24604239. |
glucagon-like peptide-1 (glp-1) stimulates insulin secretion and inhibits glucagon secretion in the pancreatic islets of langerhans under hyperglycaemia. |
2015-06-24 |
2023-08-12 |
Not clear |
| Pablo Quintero, Margarita Pizarro, Nancy Solís, Juan Pablo Arab, Oslando Padilla, Arnoldo Riquelme, Marco Arres. Bile acid supplementation improves established liver steatosis in obese mice independently of glucagon-like peptide-1 secretion. Journal of physiology and biochemistry. vol 70. issue 3. 2015-06-22. PMID:24816727. |
intestinal l-cells secrete glucagon-like peptide-1 (glp-1) and can be activated by bile acids (ba) influencing insulin resistance and hepatic steatosis development and progression. |
2015-06-22 |
2023-08-13 |
mouse |
| S Al-Sabah, M Al-Fulaij, H A Ahme. Selectivity of peptide ligands for the human incretin receptors expressed in HEK-293 cells. European journal of pharmacology. vol 741. 2015-06-22. PMID:25179575. |
the increase in insulin response to oral glucose compared with glucose given by intravenous injection is termed the incretin effect and is mediated by two peptide hormones secreted from the gut in response to nutrient intake: glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip). |
2015-06-22 |
2023-08-13 |
human |
| Yoshie Fujii, Noriko Osaki, Tadashi Hase, Akira Shimotoyodom. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7-36)) amide in C57BL/6J mice. Journal of nutritional science. vol 4. 2015-06-22. PMID:26097706. |
glucagon-like peptide 1 (glp-1) is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. |
2015-06-22 |
2023-08-13 |
mouse |
| Yoshie Fujii, Noriko Osaki, Tadashi Hase, Akira Shimotoyodom. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1 (GLP-1(7-36)) amide in C57BL/6J mice. Journal of nutritional science. vol 4. 2015-06-22. PMID:26097706. |
although cpe administration did not affect diet-induced insulin secretion, it decreased postprandial hyperglycaemia, which indicates that higher glp-1 levels after the ingestion of cpe may improve insulin sensitivity. |
2015-06-22 |
2023-08-13 |
mouse |
| Christoffer Martinussen, Kirstine N Bojsen-Møller, Carsten Dirksen, Siv H Jacobsen, Nils B Jørgensen, Viggo B Kristiansen, Jens J Holst, Sten Madsba. Immediate enhancement of first-phase insulin secretion and unchanged glucose effectiveness in patients with type 2 diabetes after Roux-en-Y gastric bypass. American journal of physiology. Endocrinology and metabolism. vol 308. issue 6. 2015-06-15. PMID:25628424. |
during oral testing, glp-1 responses and insulin secretion increased regardless of glucose tolerance. |
2015-06-15 |
2023-08-13 |
Not clear |
| Christoffer Martinussen, Kirstine N Bojsen-Møller, Carsten Dirksen, Siv H Jacobsen, Nils B Jørgensen, Viggo B Kristiansen, Jens J Holst, Sten Madsba. Immediate enhancement of first-phase insulin secretion and unchanged glucose effectiveness in patients with type 2 diabetes after Roux-en-Y gastric bypass. American journal of physiology. Endocrinology and metabolism. vol 308. issue 6. 2015-06-15. PMID:25628424. |
therefore, in addition to increased insulin sensitivity and exaggerated postprandial glp-1 levels, diabetes remission after rygb involves early improvement of pancreatic β-cell function per se, reflected in enhanced first-phase insulin secretion to iv glucose and increased homa-β. |
2015-06-15 |
2023-08-13 |
Not clear |
| Fátima Higuera-de la Tijera, Alfredo I Servín-Caamañ. Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeutic targets. World journal of hepatology. vol 7. issue 10. 2015-06-08. PMID:26052375. |
glucagon-like peptide-1 (glp-1) is an intestinal mucosa-derived hormone which is secreted into the bloodstream in response to nutrient ingestion; it favors glucose-stimulated insulin secretion, inhibition of postprandial glucagon secretion and delayed gastric emptying. |
2015-06-08 |
2023-08-13 |
Not clear |
| Darleen A Sandoval, David A D'Alessi. Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiological reviews. vol 95. issue 2. 2015-06-03. PMID:25834231. |
the generally accepted model is that glp-1 improves glucose homeostasis indirectly via stimulation of nutrient-induced insulin release and by reducing glucagon secretion. |
2015-06-03 |
2023-08-13 |
Not clear |
| C Gonzalez, C Fagour, E Maury, B Cherifi, S Salandini, A Pierreisnard, P Masquefa-Giraud, H Gin, V Rigallea. Early changes in respiratory quotient and resting energy expenditure predict later weight changes in patients treated for poorly controlled type 2 diabetes. Diabetes & metabolism. vol 40. issue 4. 2015-05-27. PMID:24636224. |
this study looked at whether early changes in resting energy expenditure (ree) and respiratory quotient (rq) are correlated with later weight changes in patients with type 2 diabetes (t2d) being treated with insulin or glp-1 analogues, or diet. |
2015-05-27 |
2023-08-12 |
Not clear |
| Loek J M de Heide, Anke J Laskewitz, Jan A Aper. Treatment of severe postRYGB hyperinsulinemic hypoglycemia with pasireotide: a comparison with octreotide on insulin, glucagon, and GLP-1. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. vol 10. issue 3. 2015-05-26. PMID:24448101. |
treatment of severe postrygb hyperinsulinemic hypoglycemia with pasireotide: a comparison with octreotide on insulin, glucagon, and glp-1. |
2015-05-26 |
2023-08-12 |
Not clear |
| Francisca Araujo, Neha Shrestha, Pedro L Granja, Jouni Hirvonen, Hélder A Santos, Bruno Sarment. Antihyperglycemic potential of incretins orally delivered via nano and microsystems and subsequent glucoregulatory effects. Current pharmaceutical biotechnology. vol 15. issue 7. 2015-05-26. PMID:25219868. |
the main function of glp-1 is to induce insulin secretion and suppress glucagon secretion. |
2015-05-26 |
2023-08-13 |
Not clear |
| Xiao-Qing Dai, Aliya F Spigelman, Shara Khan, Matthias Braun, Jocelyn E Manning Fox, Patrick E MacDonal. SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells. The Journal of physiology. vol 592. issue 17. 2015-05-25. PMID:24907310. |
post-translational modification by the small ubiquitin-like modifier-1 (sumo1) limits insulin secretion from β-cells by inhibiting insulin exocytosis and glucagon-like peptide-1 (glp-1) receptor signalling. |
2015-05-25 |
2023-08-13 |
mouse |
| Xiao-Qing Dai, Aliya F Spigelman, Shara Khan, Matthias Braun, Jocelyn E Manning Fox, Patrick E MacDonal. SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells. The Journal of physiology. vol 592. issue 17. 2015-05-25. PMID:24907310. |
the secretion of glucagon from α-cells is regulated in a manner opposite to that of insulin; it is inhibited by elevated glucose and glp-1, and increased by adrenergic signalling. |
2015-05-25 |
2023-08-13 |
mouse |
| Susan J Melhorn, Vidhi Tyagi, Anne Smeraglio, Christian L Roth, Ellen A Schu. Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans. Appetite. vol 82. 2015-05-22. PMID:25049134. |
visual analog scale ratings of hunger and fullness and serial assessments of plasma glucose, insulin, and glp-1 concentrations were done throughout the experiment. |
2015-05-22 |
2023-08-13 |
human |
| Susan J Melhorn, Vidhi Tyagi, Anne Smeraglio, Christian L Roth, Ellen A Schu. Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans. Appetite. vol 82. 2015-05-22. PMID:25049134. |
ex-9 increased glucose, insulin, and endogenous glp-1, which may have counteracted any effects of ex-9 infusion to block satiety signaling. |
2015-05-22 |
2023-08-13 |
human |
| Harumi Takahashi, Tadao Shibasaki, Jae-Hyung Park, Shihomi Hidaka, Toshimasa Takahashi, Aika Ono, Dae-Kyu Song, Susumu Sein. Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion. Diabetes. vol 64. issue 4. 2015-05-22. PMID:25315008. |
a strong augmentation of insulin secretion by combination of glp-1 and glibenclamide or glimepiride, which was found in epac2a(+/+) mice, was markedly reduced in epac2a(-/-) mice. |
2015-05-22 |
2023-08-13 |
mouse |
| Harumi Takahashi, Tadao Shibasaki, Jae-Hyung Park, Shihomi Hidaka, Toshimasa Takahashi, Aika Ono, Dae-Kyu Song, Susumu Sein. Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion. Diabetes. vol 64. issue 4. 2015-05-22. PMID:25315008. |
in diet-induced obese mice, ablation of epac2a reduced the insulin secretory response to coadministration of the glp-1 receptor agonist liraglutide and glimepiride. |
2015-05-22 |
2023-08-13 |
mouse |
| Achint Kaur, Jay V Patankar, Willeke de Haan, Piers Ruddle, Nadeeja Wijesekara, Albert K Groen, C Bruce Verchere, Roshni R Singaraja, Michael R Hayde. Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1. Diabetes. vol 64. issue 4. 2015-05-22. PMID:25338812. |
glp-1, in turn, increases the biosynthesis and secretion of insulin from β-cells, leading to the improved glucose tolerance observed in the cyp8b1(-/-) mice. |
2015-05-22 |
2023-08-13 |
mouse |