| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G H Starich, R S Bar, E L Mazzaferr. GIP increases insulin receptor affinity and cellular sensitivity in adipocytes. The American journal of physiology. vol 249. issue 6 Pt 1. 1986-01-24. PMID:3909828. |
we suggest that gip, a known potentiator of glucose-stimulated insulin secretion, may also modulate the effects of insulin by directly altering target tissue sensitivity to insulin. |
1986-01-24 |
2023-08-11 |
rat |
| M K Müller, T Scheck, P Demol, H Goebel. Interaction of acetylcholine and gastric inhibitory polypeptide on endocrine and exocrine rat pancreatic secretion: augmentation of acetylcholine-induced amylase and volume secretion by the insulinotropic action of gastric inhibitory polypeptide. Digestion. vol 33. issue 1. 1986-01-22. PMID:2415417. |
the effects of ach and gip on insulin secretion from the rat pancreas were additive at 0.05 x 10(-6) m ach and slightly, but not significantly less than additive at 0.25 or 2.5 x 10(-6) m ach. |
1986-01-22 |
2023-08-11 |
rat |
| M K Müller, T Scheck, P Demol, H Goebel. Interaction of acetylcholine and gastric inhibitory polypeptide on endocrine and exocrine rat pancreatic secretion: augmentation of acetylcholine-induced amylase and volume secretion by the insulinotropic action of gastric inhibitory polypeptide. Digestion. vol 33. issue 1. 1986-01-22. PMID:2415417. |
gip had an augmenting effect on amylase and volume secretion from the pancreas, when pancreatic secretion was stimulated by 2.5 x 10(-6) m ach, but not by 0.05 or 0.25 x 10(-6) m. exogenous rat insulin could exert an effect similar to that of gip, although a higher dose was required. |
1986-01-22 |
2023-08-11 |
rat |
| b' M Gutniak, V Grill, S Efendi\\xc4\\x8. Effects of insulin on fasting and meal-stimulated somatostatin-like immunoreactivity in noninsulin-dependent diabetes mellitus: evidence for more than one mechanism of action. The Journal of clinical endocrinology and metabolism. vol 62. issue 1. 1986-01-21. PMID:2866196.' |
furthermore feedback insulin infusion enhanced gip and decreased c-peptide responses, but did not affect the glucagon response to the meal. |
1986-01-21 |
2023-08-11 |
Not clear |
| b' M Gutniak, V Grill, S Efendi\\xc4\\x8. Effects of insulin on fasting and meal-stimulated somatostatin-like immunoreactivity in noninsulin-dependent diabetes mellitus: evidence for more than one mechanism of action. The Journal of clinical endocrinology and metabolism. vol 62. issue 1. 1986-01-21. PMID:2866196.' |
we conclude that in patients with niddm, insulin significantly lowers basal sli levels if normoglycemia is concomitantly attained; this action of insulin was partially dissociated from its hypoglycemic action; hyperglycemia per se inhibits a meal-induced sli response, and insulin effects on sli are not secondary to changes in glucagon or gip levels. |
1986-01-21 |
2023-08-11 |
Not clear |
| L M Morgan, J A Tredger, A Madden, P Kwasowski, V Mark. The effect of guar gum on carbohydrate-, fat- and protein-stimulated gut hormone secretion: modification of postprandial gastric inhibitory polypeptide and gastrin responses. The British journal of nutrition. vol 53. issue 3. 1985-12-31. PMID:4063284. |
postprandial insulin and gip levels were both significantly reduced by addition of guar gum to the carbohydrate meal. |
1985-12-31 |
2023-08-11 |
human |
| K Osei, J M Falko, T M O'Dorisio, D R Ada. Gastric inhibitory polypeptide (GIP) responses after oral glucose ingestion in hyperthyroidism. Diabetes care. vol 8. issue 5. 1985-12-13. PMID:3902421. |
gip stimulates insulin release in the presence of hyperglycemia and as such is considered a major enteroinsular hormone. |
1985-12-13 |
2023-08-11 |
human |
| K Osei, J M Falko, T M O'Dorisio, D R Ada. Gastric inhibitory polypeptide (GIP) responses after oral glucose ingestion in hyperthyroidism. Diabetes care. vol 8. issue 5. 1985-12-13. PMID:3902421. |
since elevated glucose and insulin levels are found in hyperthyroidism, we compared the gip responses to oral glucose ingestion in 12 hyperthyroid patients and 10 age-matched controls. |
1985-12-13 |
2023-08-11 |
human |
| K Osei, J M Falko, T M O'Dorisio, D R Ada. Gastric inhibitory polypeptide (GIP) responses after oral glucose ingestion in hyperthyroidism. Diabetes care. vol 8. issue 5. 1985-12-13. PMID:3902421. |
seventy-five grams of oral glucose was ingested after overnight fasting and samples were obtained at 0, 30, 60, 90, 120, and 180 min for serum glucose and immunoreactive insulin (iri) and gip (irgip). |
1985-12-13 |
2023-08-11 |
human |
| C K Lardinois, E L Mazzaferri, G H Starich, C B Hollenbeck, G M Reave. Increased gastric inhibitory polypeptide is not reduced in patients with noninsulin-dependent diabetes mellitus treated with intense insulin therapy. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:3902866. |
serum glucose and gastric inhibitory polypeptide (gip) responses during mixed test meals and primed continuous infusion of insulin using the insulin clamp technique were studied in nine patients with noninsulin-dependent diabetes mellitus (niddm) before and after vigorous insulin treatment. |
1985-12-13 |
2023-08-11 |
human |
| C K Lardinois, E L Mazzaferri, G H Starich, C B Hollenbeck, G M Reave. Increased gastric inhibitory polypeptide is not reduced in patients with noninsulin-dependent diabetes mellitus treated with intense insulin therapy. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:3902866. |
basal and meal-stimulated serum gip levels were not reduced after intense insulin therapy. |
1985-12-13 |
2023-08-11 |
human |
| C K Lardinois, E L Mazzaferri, G H Starich, C B Hollenbeck, G M Reave. Increased gastric inhibitory polypeptide is not reduced in patients with noninsulin-dependent diabetes mellitus treated with intense insulin therapy. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:3902866. |
furthermore, hyperinsulinemia at physiological (100 microu/ml) and superphysiological (1000 microu/ml) levels failed to reduce gip secretion before and after insulin therapy. |
1985-12-13 |
2023-08-11 |
human |
| C K Lardinois, E L Mazzaferri, G H Starich, C B Hollenbeck, G M Reave. Increased gastric inhibitory polypeptide is not reduced in patients with noninsulin-dependent diabetes mellitus treated with intense insulin therapy. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:3902866. |
before insulin therapy, seven patients had elevated basal gip levels and five had increased gip levels after meals compared to values in nondiabetic subjects. |
1985-12-13 |
2023-08-11 |
human |
| C K Lardinois, E L Mazzaferri, G H Starich, C B Hollenbeck, G M Reave. Increased gastric inhibitory polypeptide is not reduced in patients with noninsulin-dependent diabetes mellitus treated with intense insulin therapy. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:3902866. |
insulin administration did not alter these elevated gip levels. |
1985-12-13 |
2023-08-11 |
human |
| C K Lardinois, E L Mazzaferri, G H Starich, C B Hollenbeck, G M Reave. Increased gastric inhibitory polypeptide is not reduced in patients with noninsulin-dependent diabetes mellitus treated with intense insulin therapy. The Journal of clinical endocrinology and metabolism. vol 61. issue 6. 1985-12-13. PMID:3902866. |
these findings suggest that the increased meal-stimulated gip secretion in some patients with niddm is not due to a failure of insulin feedback on gip secretion. |
1985-12-13 |
2023-08-11 |
human |
| W Creutzfeldt, R Eber. New developments in the incretin concept. Diabetologia. vol 28. issue 8. 1985-12-06. PMID:3902545. |
gip (gastric inhibitory polypeptide; glucose dependent insulin releasing peptide) remains the strongest incretin factor. |
1985-12-06 |
2023-08-11 |
Not clear |
| W Creutzfeldt, R Eber. New developments in the incretin concept. Diabetologia. vol 28. issue 8. 1985-12-06. PMID:3902545. |
gip is unlikely to be the gut factor which regulates hepatic insulin extraction. |
1985-12-06 |
2023-08-11 |
Not clear |
| A Revhaug, I Lygren, T I Lundgren, R Jorde, P G Burhol, K E Giercksk. Changes in plasma levels of gastrointestinal regulatory peptides during hemorrhagic shock in pigs. Acta chirurgica Scandinavica. vol 151. issue 5. 1985-11-21. PMID:2864773. |
in an experimental study of hemorrhagic shock, systemic and portal plasma levels of vasoactive intestinal polypeptide (vip), somatostatin, pancreatic polypeptide (pp), gastric inhibitory peptide (gip), secretin and insulin were measured with radioimmunoassay methods. |
1985-11-21 |
2023-08-11 |
Not clear |
| A R Baer, J Dupr. Effects of gastric inhibitory polypeptide in the response to prolonged parenteral or enteral alimentation in rats. Diabetes. vol 34. issue 11. 1985-11-21. PMID:3930323. |
in the steady state, plasma immunoreactive insulin (iri) was significantly lower with ea (mean, 153 +/- 5 microu/ml) than with pa (mean, 226 +/- 15 microu/ml), which in turn was lower than with pa plus gip (mean, 375 +/- 23 microu/ml, p less than 0.001 by anova). |
1985-11-21 |
2023-08-11 |
rat |
| Z Chap, T Ishida, J Chou, R Lewis, C Hartley, M Entman, J B Fiel. Effects of atropine and gastric inhibitory polypeptide on hepatic glucose uptake and insulin extraction in conscious dogs. The Journal of clinical investigation. vol 76. issue 3. 1985-11-04. PMID:3900134. |
this study evaluated the effect of atropine blockade of the parasympathetic nervous system on the increased fractional hepatic extraction of insulin and the role of gastric inhibitory polypeptide (gip) on augmented hepatic uptake of oral glucose in conscious dogs with chronically implanted doppler flow probes on the portal vein and hepatic artery, and catheters in the portal and hepatic veins and carotid artery. |
1985-11-04 |
2023-08-11 |
Not clear |