| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia Herrou, Guillaume Mabilleau, Jean-Michel Lecerf, Thierry Thomas, Emmanuel Biver, Julien Pacco. Narrative Review of Effects of Glucagon-Like Peptide-1 Receptor Agonists on Bone Health in People Living with Obesity. Calcified tissue international. 2023-11-24. PMID:37999750. |
further studies are needed to investigate the bone impact of glp-1ra, dual- and triple-receptor agonists for glp-1, glucose-dependent insulin releasing polypeptide (gip), and glucagon in pwo. |
2023-11-24 |
2023-11-29 |
Not clear |
| Sara Becerril, Javier A Cienfuegos, Amaia Rodr\\xc3\\xadguez, Victoria Catal\\xc3\\xa1n, Beatriz Ram\\xc3\\xadrez, V\\xc3\\xadctor Valent\\xc3\\xad, Rafael Moncada, Xabier Unamuno, Javier G\\xc3\\xb3mez-Ambrosi, Gema Fr\\xc3\\xbchbec. Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model. Journal of physiology and biochemistry. 2023-11-07. PMID:37935948. |
body weight and food intake were weekly monitored, and 6\xc2\xa0weeks after interventions, fasting plasma glucose, oral glucose and insulin tolerance tests, plasma insulin, adiponectin, gip, glp-1, and ghrelin levels were determined.the body weight of sadi-s rats was significantly (p\xe2\x80\x89<\xe2\x80\x890.001) lower as compared to the sham-operated, sg, and pair-fed groups. |
2023-11-07 |
2023-11-20 |
rat |
| Bijayashree Sahu, Sunil Pani, Gourabamani Swalsingh, Unmod Senapati, Punyadhara Pani, Benudhara Pati, Subhasmita Rout, Rimjhim Trivedi, Ritu Raj, Suchanda Dey, Amar Jeet, Dinesh Kumar, Naresh C Ba. Long-term physical inactivity induces significant changes in biochemical pathways related to metabolism of proteins and glycerophospholipids in mice. Molecular omics. 2023-11-01. PMID:37909389. |
our data suggest that cytokines linked to glycemic excursions (insulin, c-peptide, glucagon) and their passive regulators (leptin, bdnf, active ghrelin, and gip) exhibit changes in the sed group. |
2023-11-01 |
2023-11-08 |
mouse |
| Mohammad Mukul Hossain, Juscelino Tovar, Lieselotte Cloetens, Anne Nilsso. Inclusion of Oat Polar Lipids in a Solid Breakfast Improves Glucose Tolerance, Triglyceridemia, and Gut Hormone Responses Postprandially and after a Standardized Second Meal: A Randomized Crossover Study in Healthy Subjects. Nutrients. vol 15. issue 20. 2023-10-30. PMID:37892464. |
test variables (blood glucose, serum insulin, triglyceride (tg), free fatty acids (ffa), ghrelin, glp-1, pyy, and gip) were measured at fasting and repeatedly during the 5.5 h after ingestion of the breakfast. |
2023-10-30 |
2023-11-08 |
human |
| Emily Pusch, Ma\\xc5\\x82gorzata Kr\\xc4\\x85\\xc5\\xbcek, Tatiana Wojciechowicz, Maciej Sassek, Pawe\\xc5\\x82 A Ko\\xc5\\x82odziejski, Mathias Z Strowski, Krzysztof W Nowak, Marek Skrzypsk. GIP_HUMAN [22-51] Peptide Encoded by the Glucose-Dependent Insulinotropic Polypeptide (GIP) Gene Suppresses Insulin Expression and Secretion in INS-1E Cells and Rat Pancreatic Islets. Genes. vol 14. issue 10. 2023-10-30. PMID:37895259. |
gip_human [22-51] peptide encoded by the glucose-dependent insulinotropic polypeptide (gip) gene suppresses insulin expression and secretion in ins-1e cells and rat pancreatic islets. |
2023-10-30 |
2023-11-08 |
mouse |
| Mona Mashayekhi, Hui Nian, Dustin Mayfield, Jessica K Devin, Jorge L Gamboa, Chang Yu, Heidi J Silver, Kevin Niswender, James M Luther, Nancy J Brow. Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals with Obesity and Pre-Diabetes. Diabetes. 2023-10-24. PMID:37874653. |
sitagliptin increased endogenous glp-1 and gip without altering insulin sensitivity or fasting glucose, but decreased post-prandial glucose and glucagon. |
2023-10-24 |
2023-11-08 |
Not clear |
| Jing Xu, Peng Chen, Dongzhi Wu, Qiang Zhou, Sijie Chen, Xiang Ding, Hongping Xion. The novel GLP-1/GIP dual agonist DA3-CH improves rat type 2 diabetes through activating AMPK/ACC signaling pathway. Aging. vol 15. 2023-10-18. PMID:37851373. |
da3-ch is a novel dual receptor agonist of glucagon like peptide-1 (glp-1) and glucose dependent insulin stimulating polypeptide (gip). |
2023-10-18 |
2023-11-08 |
rat |
| Christine B Christiansen, Per B Jeppesen, Kjeld Hermansen, S\\xc3\\xb8ren Gregerse. Aronia in the Type 2 Diabetes Treatment Regimen. Nutrients. vol 15. issue 19. 2023-10-14. PMID:37836472. |
pre- and post-treatment period, we did fasting blood samples, including hemoglobin a1c, fructosamine, insulin, glucose, glucagon-like peptide-1, glucose-dependent insulinotropic peptide (gip) and glucagon, oral glucose tolerance tests, and anthropometric measurements. |
2023-10-14 |
2023-10-15 |
human |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to \\xce\\xb1-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
histopathological examination of the pancreas, the expression levels of insulin, cd44, caspase-3, autophagy markers, p13k/akt, and pancreas/duodenum homeobox protein 1, in pancreatic tissue, and glucose-dependent insulinotropic polypeptide (gip) in the duodenum were detected by hematoxylin and eosin staining, immunofluorescence labeling, and by quantitative real-time polymerase chain reaction.\xc2\xa0the diabetic rats showed reduced insulin, hyperglycemia, nitrosative stress (no, cat), augmented apoptosis (caspase 3), impaired autophagy (p62/sqstm1, lc3), downregulated pi3k/akt pathway and increased gip expression, and degeneration of pancreatic islets. |
2023-10-05 |
2023-10-07 |
rat |
| Heba A Mubarak, Manal M Kamal, Yossra Mahmoud, Fatma S Abd-Elsamea, Eman Abdelbary, Marwa G Gamea, Reham I El-Mahd. The ameliorating effects of mesenchymal stem cells compared to \\xce\\xb1-tocopherol on apoptosis and autophagy in streptozotocin-induced diabetic rats: Implication of PI3K/Akt signaling pathway and entero-insular axis. Journal of cellular biochemistry. 2023-10-05. PMID:37796145. |
treatment with either bm-mscs or \xce\xb1-toc suppressed the nitrosative stress, reduced apoptosis, recovered autophagy, upregulated pi3k/akt pathway, and subsequently increased insulin levels, decreased blood glucose, and downregulated gip expression with partial restoration of pancreatic islets.\xc2\xa0based on our findings, the cytoprotective effects of bm-mscs and \xce\xb1-toc in type 1-induced diabetes appeared to be related to repaired autophagy and recovered pi3k/akt signaling. |
2023-10-05 |
2023-10-07 |
rat |
| Dina Medina-Vera, Emma N Zambrana-Infantes, Antonio J L\\xc3\\xb3pez-Gambero, Julia Verheul-Campos, Luis J Sant\\xc3\\xadn, Elena Baixeras, Juan Suarez, Francisco J Pavon, Cristina Rosell-Valle, Fernando Rodr\\xc3\\xadguez de Fonsec. Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice. Neurobiology of disease. 2023-09-17. PMID:37717663. |
dysregulation of both insulin and insulin secretion-regulating gip peptide were observed at 5\xe2\x80\xafmonths of age, disappearing later. |
2023-09-17 |
2023-10-07 |
mouse |
| Nan Wu, Guohua A. A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin. Journal of pharmaceutical sciences. 2023-09-16. PMID:37716531. |
a quantitative systems pharmacology model of the incretin hormones gip and glp1, glucagon, glucose, insulin, and the small molecule dpp-4 inhibitor, linagliptin. |
2023-09-16 |
2023-10-07 |
human |
| Nan Wu, Guohua A. A Quantitative Systems Pharmacology Model of the Incretin Hormones GIP and GLP1, Glucagon, Glucose, Insulin, and the Small Molecule DPP-4 Inhibitor, Linagliptin. Journal of pharmaceutical sciences. 2023-09-16. PMID:37716531. |
in the current study, we established a comprehensive quantitative systems pharmacology (qsp) model using linagliptin as the model drug, where drug disposition, drug intervention on dipeptidyl peptidase-4 (dpp-4), glucose-dependent insulinotropic peptide (gip), glucagon-like peptide-1 (glp-1), glucagon, glucose, and insulin are integrated together with the cross talk and feedback loops incorporated among the whole glycemic control system. |
2023-09-16 |
2023-10-07 |
human |
| Pamela Bowman, Kashyap A Patel, Timothy J McDonald, Jens J Holst, Bolette Hartmann, Maria Leveridge, Beverley M Shields, Suzie Hammersley, Steve R Spaull, Bridget A Knight, Sarah E Flanagan, Maggie H Shepherd, Rob C Andrews, Andrew T Hattersle. Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. Journal of diabetes investigation. 2023-08-21. PMID:37602910. |
the incretin hormones glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (su)-treated kcnj11 permanent neonatal diabetes. |
2023-08-21 |
2023-09-07 |
human |
| Philip N Newsome, Phil Amber. Incretins (GLP1 r agonists and dual, triple agonists) and the liver. Journal of hepatology. 2023-08-10. PMID:37562748. |
alongside glp-1ra, newer combinations with glucagon agonism and/or with glucose-dependent insulinotropic peptide (gip) agonism have been explored in related patient groups with evidence of improvements in weight loss, insulin resistance and non-invasive liver parameters. |
2023-08-10 |
2023-08-16 |
Not clear |
| Stine Smedegaard, Ulla Kampmann, Per G Ovesen, Henrik St\\xc3\\xb8vring, Nikolaj Ritti. Whey Protein Premeal Lowers Postprandial Glucose Concentrations in Adults Compared with Water-The Effect of Timing, Dose, and Metabolic Status: a Systematic Review and Meta-analysis. The American journal of clinical nutrition. vol 118. issue 2. 2023-08-03. PMID:37536867. |
the underlying mechanisms are only partly understood but may involve stimulation of glucagon-like peptide-1 (glp-1), glucose-dependent insulinotropic polypeptide (gip), and insulin secretion together with a slower gastric emptying rate. |
2023-08-03 |
2023-08-14 |
Not clear |
| Eleonora Grespan, Andrea Mar. Does glucose lowering restore GIP effects on insulin secretion? - Reply to Sten Madsbad, Filip K Knop and Jens J Holst. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2023-07-24. PMID:37487785. |
does glucose lowering restore gip effects on insulin secretion? |
2023-07-24 |
2023-08-14 |
Not clear |
| Danielle L Jones, Clive J Petry, Keith Burling, Peter Barker, Elizabeth H Turner, Laura C Kusinski, Claire L Mee. Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations. Acta diabetologica. 2023-07-13. PMID:37439859. |
incretin hormones glucagon-like peptide 1 (glp-1) and gastric inhibitory peptide (gip) cause increased insulin secretion in non-pregnant adults, but their role in pregnancy, where there are additional metabolically-active hormones from the placenta, is less clear. |
2023-07-13 |
2023-08-14 |
Not clear |
| Michael A Nauck, Timo D M\\xc3\\xbclle. Incretin hormones and type 2 diabetes. Diabetologia. 2023-07-10. PMID:37430117. |
this appears to be because of a reduced ability of gip to stimulate insulin secretion, related either to an overall impairment of beta cell function or to specific defects in the gip signalling pathway. |
2023-07-10 |
2023-08-14 |
Not clear |
| Akira Mima, Atsuo Nomura, Takeshi Fuji. Current findings on the efficacy of incretin-based drugs for diabetic kidney disease: A narrative review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-06-18. PMID:37331253. |
however, the insulin action after gip secretion is known to be drastically reduced in patients with type 2 diabetes. |
2023-06-18 |
2023-08-14 |
Not clear |