| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ursula A White, Ann A Coulter, Tiffany K Miles, Jacqueline M Stephen. The STAT5A-mediated induction of pyruvate dehydrogenase kinase 4 expression by prolactin or growth hormone in adipocytes. Diabetes. vol 56. issue 6. 2007-06-14. PMID:17360981. |
both northern blot and western blot analyses were conducted on samples isolated from 3t3-l1 adipocytes after various treatments with prolactin (prl), growth hormone (gh), and/or insulin. |
2007-06-14 |
2023-08-12 |
Not clear |
| Juan-Pablo del Rincon, Keiji Iida, Bruce D Gaylinn, Carrie E McCurdy, J Wayne Leitner, Linda A Barbour, John J Kopchick, Jacob E Friedman, Boris Draznin, Michael O Thorne. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes. vol 56. issue 6. 2007-06-14. PMID:17363744. |
adipose tissue plays a critical role in the antagonistic effects of growth hormone (gh) on insulin actions on carbohydrate and lipid metabolism through changes in gene transcription. |
2007-06-14 |
2023-08-12 |
mouse |
| Juan-Pablo del Rincon, Keiji Iida, Bruce D Gaylinn, Carrie E McCurdy, J Wayne Leitner, Linda A Barbour, John J Kopchick, Jacob E Friedman, Boris Draznin, Michael O Thorne. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes. vol 56. issue 6. 2007-06-14. PMID:17363744. |
in conclusion, gh regulates p85alpha expression and pi 3-kinase activity in wat and provides a potential explanation for 1) the insulin hypersensitivity and associated obesity and hyperadiponectinemia of gh-deficient mice and 2) the insulin resistance and associated reduced fat mass and hypoadiponectinemia of mice with gh excess. |
2007-06-14 |
2023-08-12 |
mouse |
| Michal M Masternak, Khalid A Al-Regaiey, Marc Michael Del Rosario Lim, Vanesa Jimenez-Ortega, Jacob A Panici, Michael S Bonkowski, John J Kopchick, Zhihui Wang, Andrzej Bartk. Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Experimental gerontology. vol 41. issue 4. 2007-06-11. PMID:16524678. |
blockade of growth hormone (gh), decreased insulin-like growth factor-1 (igf1) action and increased insulin sensitivity are associated with life extension and an apparent slowing of the aging process. |
2007-06-11 |
2023-08-12 |
mouse |
| Robert D Murray, Martin Bidlingmaier, Christian J Strasburger, Stephen M Shale. The diagnosis of partial growth hormone deficiency in adults with a putative insult to the hypothalamo-pituitary axis. The Journal of clinical endocrinology and metabolism. vol 92. issue 5. 2007-06-06. PMID:17327383. |
similar to patients with severe gh deficiency (ghd), those with a more moderate impairment of gh secretion [gh insufficiency (ghi)] have abnormal body composition, dyslipidemia, and insulin resistance. |
2007-06-06 |
2023-08-12 |
Not clear |
| L C Gormsen, N Jessen, J Gjedsted, S Gjedde, H Nørrelund, S Lund, J S Christiansen, S Nielsen, O Schmitz, N Mølle. Dose-response effects of free fatty acids on glucose and lipid metabolism during somatostatin blockade of growth hormone and insulin in humans. The Journal of clinical endocrinology and metabolism. vol 92. issue 5. 2007-06-06. PMID:17341555. |
gh and other stress hormones stimulate lipolysis, which may result in free fatty acid (ffa)-mediated insulin resistance. |
2007-06-06 |
2023-08-12 |
Not clear |
| F Gloria-Bottini, A Amante, P Lucarelli, P Saccucci, R Martinoli, E Bottin. Functional aspects of genetic variability in the GH genomic region. The Journal of endocrinology. vol 193. issue 1. 2007-05-21. PMID:17400806. |
carriers of mspia*2 allele show a lower gh release as compared with mspia *1/*1 subjects on the provocative test by insulin, while carriers of bgliia*2 allele show a higher gh release as compared with bgliia *1/*1 subjects on the provocative test by clonidine. |
2007-05-21 |
2023-08-12 |
human |
| Jens O L Jørgensen, Louise Møller, Morten Krag, Nils Billestrup, Jens S Christianse. Effects of growth hormone on glucose and fat metabolism in human subjects. Endocrinology and metabolism clinics of North America. vol 36. issue 1. 2007-05-11. PMID:17336735. |
at the same time gh stimulates the turnover and oxidation of free fatty acid (ffa), and experimental evidence suggests a causal link between elevated ffa levels and insulin resistance in skeletal muscle. |
2007-05-11 |
2023-08-12 |
human |
| S Siyambalapitiya, V Ibbotson, A Doane, E Ghigo, M J Campbell, R J Ros. Combining growth hormone releasing hormone-arginine and synacthen testing diminishes the cortisol response. The Journal of clinical endocrinology and metabolism. vol 92. issue 3. 2007-05-10. PMID:17192289. |
the ghrh/arginine test and short synacthen test (sst) have been validated as safe alternatives to the insulin tolerance test for the assessment of the gh reserve and hypothalamic-pituitary-adrenal axis integrity, respectively. |
2007-05-10 |
2023-08-12 |
Not clear |
| A Ciresi, M C Amato, A Criscimanna, A Mattina, C Vetro, A Galluzzo, G D'Acquisto, C Giordan. Metabolic parameters and adipokine profile during GH replacement therapy in children with GH deficiency. European journal of endocrinology. vol 156. issue 3. 2007-04-30. PMID:17322495. |
our aim was to study the effects of gh replacement therapy on auxological data, lipid and glycemic profiles, insulin homeostasis (homa-ir) and serum adipokines in children. |
2007-04-30 |
2023-08-12 |
Not clear |
| H Soran, N Younis, F Joseph, Z Hayat, H Zakhour, A Scot. A case of haemangiopericytoma-associated hypoglycaemia: Beneficial effect of treatment with radiotherapy. International journal of clinical practice. vol 60. issue 10. 2007-04-26. PMID:16981978. |
local palliative radiotherapy resulted in the reduction of igfii level and igfii to igfi ratio and increased insulin, c-peptide and growth hormone (gh) level with long-term amelioration of hypoglycaemic episodes. |
2007-04-26 |
2023-08-12 |
Not clear |
| Chiho Kawashima, Minoru Sakaguchi, Takahiro Suzuki, Yoshihiko Sasamoto, Yoshiyuki Takahashi, Motozumi Matsui, Akio Miyamot. Metabolic profiles in ovulatory and anovulatory primiparous dairy cows during the first follicular wave postpartum. The Journal of reproduction and development. vol 53. issue 1. 2007-04-25. PMID:17043386. |
we used 16 primiparous holstein cows and obtained blood samples for the profiles of metabolites (glucose; non-esterified fatty acid, nefa; ketone body; total cholesterol; and aspartate aminotransferase), metabolic hormones (growth hormone, gh; insulin-like growth factor-i, igf-1; and insulin), and progesterone every other day from 1 to 21 days postpartum. |
2007-04-25 |
2023-08-12 |
Not clear |
| Chiho Kawashima, Minoru Sakaguchi, Takahiro Suzuki, Yoshihiko Sasamoto, Yoshiyuki Takahashi, Motozumi Matsui, Akio Miyamot. Metabolic profiles in ovulatory and anovulatory primiparous dairy cows during the first follicular wave postpartum. The Journal of reproduction and development. vol 53. issue 1. 2007-04-25. PMID:17043386. |
however, the gh levels, which enhance lipolysis for milk production, insulin and other metabolites did not differ between the two groups. |
2007-04-25 |
2023-08-12 |
Not clear |
| Masanobu Kawai, Noriyuki Namba, Sotaro Mushiake, Yuri Etani, Riko Nishimura, Makoto Makishima, Keiichi Ozon. Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway. Journal of molecular endocrinology. vol 38. issue 1-2. 2007-04-24. PMID:17242167. |
gh stimulated mdi (3-isobutyl-1-methylxanthine, dexamethasone, and insulin)-induced adipogenesis of 3t3-l1 cells with early induction of peroxisome proliferator-activated receptors (ppar)gamma2 expression. |
2007-04-24 |
2023-08-12 |
Not clear |
| Jaak Jürimäe, Peter Hofmann, Toivo Jürimäe, Reet Palm, Jarek Mäestu, Priit Purge, Karl Sudi, Klaus Rom, Serge P von Duvillar. Plasma ghrelin responses to acute sculling exercises in elite male rowers. European journal of applied physiology. vol 99. issue 5. 2007-04-20. PMID:17186298. |
ghrelin, leptin, gh, insulin, and glucose were measured before, immediately after, and after 30 min of recovery. |
2007-04-20 |
2023-08-12 |
Not clear |
| Jaak Jürimäe, Peter Hofmann, Toivo Jürimäe, Reet Palm, Jarek Mäestu, Priit Purge, Karl Sudi, Klaus Rom, Serge P von Duvillar. Plasma ghrelin responses to acute sculling exercises in elite male rowers. European journal of applied physiology. vol 99. issue 5. 2007-04-20. PMID:17186298. |
gh increased significantly immediately after exercise and remained elevated during the 30 min of recovery in both exercise conditions, while insulin decreased significantly immediately after exercise and remained significantly lower after the 30 min of recovery in both exercise intensities. |
2007-04-20 |
2023-08-12 |
Not clear |
| K C J Yuen, D B Dunge. Therapeutic aspects of growth hormone and insulin-like growth factor-I treatment on visceral fat and insulin sensitivity in adults. Diabetes, obesity & metabolism. vol 9. issue 1. 2007-04-17. PMID:17199714. |
paradoxically, gh deficient adults and those with acromegaly are both predisposed to insulin resistance, but one cannot extrapolate from these pathological conditions to determine the normal metabolic roles of gh and igf-i on glucose homeostasis. |
2007-04-17 |
2023-08-12 |
human |
| K C J Yuen, D B Dunge. Therapeutic aspects of growth hormone and insulin-like growth factor-I treatment on visceral fat and insulin sensitivity in adults. Diabetes, obesity & metabolism. vol 9. issue 1. 2007-04-17. PMID:17199714. |
high doses of gh treatment have major effects on lipolysis, which plays a crucial role in promoting its anti-insulin effects, whereas igf-i acts as an insulin sensitizer that does not exert any direct effect on lipolysis or lipogenesis. |
2007-04-17 |
2023-08-12 |
human |
| K C J Yuen, D B Dunge. Therapeutic aspects of growth hormone and insulin-like growth factor-I treatment on visceral fat and insulin sensitivity in adults. Diabetes, obesity & metabolism. vol 9. issue 1. 2007-04-17. PMID:17199714. |
however, the improvement in body composition does not necessarily translate into improvements in insulin sensitivity presumably due to the anti-insulin effects of high doses of gh therapy. |
2007-04-17 |
2023-08-12 |
human |
| K C J Yuen, D B Dunge. Therapeutic aspects of growth hormone and insulin-like growth factor-I treatment on visceral fat and insulin sensitivity in adults. Diabetes, obesity & metabolism. vol 9. issue 1. 2007-04-17. PMID:17199714. |
more recently, we have found that a very low dose gh therapy (0.1 mg/day) improved insulin sensitivity without affecting body composition in gh-deficient adults and in subjects with metabolic syndrome, and we postulate that these effects are mediated by its ability to increase free 'bioavailable' igf-i without the induction of lipolysis. |
2007-04-17 |
2023-08-12 |
human |