| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Schwartz, H M Goodma. Refractoriness to the insulin-like effects of growth hormone depends upon calcium. Endocrinology. vol 127. issue 1. 1990-08-08. PMID:2113862. |
these agents did not interfere with stimulation of incorporation of d-[3-3h]glucose into lipid by gh (100 ng/ml) or insulin (100 microu/ml) but restored sensitivity to the insulin-like effects of gh in otherwise refractory cells. |
1990-08-08 |
2023-08-11 |
human |
| Y Schwartz, H M Goodma. Refractoriness to the insulin-like effects of growth hormone depends upon calcium. Endocrinology. vol 127. issue 1. 1990-08-08. PMID:2113862. |
when freshly isolated, and hence refractory, cells were incubated for 1 h in calcium-free medium that contained 0.5 mm egta, gh stimulated lipogenesis by 30% (p less than 0.001) even though the response to insulin was markedly decreased in the absence of calcium. |
1990-08-08 |
2023-08-11 |
human |
| Y Schwartz, H M Goodma. Refractoriness to the insulin-like effects of growth hormone depends upon calcium. Endocrinology. vol 127. issue 1. 1990-08-08. PMID:2113862. |
conversely, when added to sensitive cells in the presence of normal extracellular ca2+ concentrations during the 4th h of incubation, the calcium ionophore, a23187 (1.0 microm) produced an apparent refractoriness to the insulin-like effect of gh but had no effect on the response to insulin. |
1990-08-08 |
2023-08-11 |
human |
| Y Schwartz, H M Goodma. Refractoriness to the insulin-like effects of growth hormone depends upon calcium. Endocrinology. vol 127. issue 1. 1990-08-08. PMID:2113862. |
since changes in responsiveness to gh were not paralleled by changes in responsiveness to insulin, it is suggested that the calcium dependent process responsible for refractoriness must lie at an early step in the signaling pathway. |
1990-08-08 |
2023-08-11 |
human |
| I M Dickerson, R E Main. Cell-type specific posttranslational processing of peptides by different pituitary cell lines. Endocrinology. vol 127. issue 1. 1990-08-08. PMID:2193796. |
the residence time of pronpy and npy in gh3 cells was dramatically increased by treatment with insulin, estradiol, and epidermal growth factor, in concert with the expected increase in prl synthesis and decrease in gh synthesis; increased residence time in the cells did not result in an increase in the extent of cleavage of pronpy to npy. |
1990-08-08 |
2023-08-11 |
Not clear |
| G Pagani, M Montini, D Gianola, M D Pagani, F Tengattini, P Dominoni, G Ghilardi, L Cortesi, A Pedroncelli, G P Tonnarell. Medical management of acromegaly: effects of SMS 201-995 in 30 patients. Endocrinologia experimentalis. vol 24. issue 1-2. 1990-08-08. PMID:2361459. |
blood samples for gh, insulin and blood glucose were taken hourly from 04:00 to 20:00 h before treatment, after 15 days and then monthly or fortnightly. |
1990-08-08 |
2023-08-11 |
Not clear |
| J Eriksson, I Gause-Nilsson, P Lönnroth, U Smit. The insulin-like effect of growth hormone on insulin-like growth factor II receptors is opposed by cyclic AMP. Evidence for a common post-receptor pathway for growth hormone and insulin action. The Biochemical journal. vol 268. issue 2. 1990-08-06. PMID:2163609. |
beta-adrenergic stimulation with isoprenaline or addition of the non-metabolizable cyclic amp-analogue n6-monobutyryl cyclic amp induced a cellular resistance to both gh and insulin and also reduced the responsiveness to these hormones. |
1990-08-06 |
2023-08-11 |
rat |
| J Eriksson, I Gause-Nilsson, P Lönnroth, U Smit. The insulin-like effect of growth hormone on insulin-like growth factor II receptors is opposed by cyclic AMP. Evidence for a common post-receptor pathway for growth hormone and insulin action. The Biochemical journal. vol 268. issue 2. 1990-08-06. PMID:2163609. |
it is concluded that: (1) beta-adrenergic stimulation and cyclic amp induce a cellular gh resistance at a level distal to the gh-binding site, and (2) the insulin-like effect of gh shares a common pathway with insulin which occurs at the post-binding level. |
1990-08-06 |
2023-08-11 |
rat |
| V G Pursel, D J Bolt, K F Miller, C A Pinkert, R E Hammer, R D Palmiter, R L Brinste. Expression and performance in transgenic pigs. Journal of reproduction and fertility. Supplement. vol 40. 1990-07-26. PMID:2192041. |
elevation of growth hormone (gh) in expressing transgenic pigs enhanced plasma concentrations of insulin-like growth factor-i (igf-i), insulin, and glucose, improved feed efficiency about 15%, and markedly reduced subcutaneous fat compared to nontransgenic siblings. |
1990-07-26 |
2023-08-11 |
Not clear |
| C A Conove. Regulation of insulin-like growth factor (IGF)-binding protein synthesis by insulin and IGF-I in cultured bovine fibroblasts. Endocrinology. vol 126. issue 6. 1990-07-13. PMID:1693568. |
insulin and igf-i were potent stimuli for igfbp production by bovine fibroblasts, whereas bovine gh, epidermal growth factor, or steroid treatment had little or no effect. |
1990-07-13 |
2023-08-11 |
cattle |
| R Gama, J D Teale, V Mark. The effect of synthetic very low calorie diets on the GH-IGF-1 axis in obese subjects. Clinica chimica acta; international journal of clinical chemistry. vol 188. issue 1. 1990-07-12. PMID:2189601. |
plasma gh and insulin responses to stimulation with oral glucose were measured in 7 healthy normal weight individuals and both before and after energy restriction in 7 obese individuals. |
1990-07-12 |
2023-08-11 |
human |
| R Gama, J D Teale, V Mark. The effect of synthetic very low calorie diets on the GH-IGF-1 axis in obese subjects. Clinica chimica acta; international journal of clinical chemistry. vol 188. issue 1. 1990-07-12. PMID:2189601. |
plasma insulin levels fell (both fasting and integrated concentrations p less than 0.05 and less than 0.005, respectively) and stimulated plasma gh responses increased (both peak and integrated values p less than 0.01 and less than 0.05, respectively) in the obese individuals following 3 wk treatment with a synthetic very low energy diet. |
1990-07-12 |
2023-08-11 |
human |
| A B Foot, K Davidson, J A Edge, J A Wass, D B Dunge. The growth hormone releasing hormone (GHRH) response to a mixed meal is blunted in young adults with insulin-dependent diabetes mellitus whereas the somatostatin response is normal. Clinical endocrinology. vol 32. issue 2. 1990-07-11. PMID:1971774. |
these results indicate that glucose and insulin may play a role in the regulation of ghrh release following a mixed meal but circulating levels of ghrh and sms are unlikely to be relevant to the abnormal regulation of gh in iddm. |
1990-07-11 |
2023-08-11 |
human |
| E J Schoenle, Q R Qing, M Zachman. Growth hormone requirement for a normal human adipocyte glucose carrier function. The Journal of clinical endocrinology and metabolism. vol 70. issue 6. 1990-07-11. PMID:2189888. |
after gh administration during several months to ghd patients, glucose transport was again slow in the basal state (t/2 = 3.2 min) and could be stimulated by insulin (t/2 = 0.7 min). |
1990-07-11 |
2023-08-11 |
human |
| E J Schoenle, Q R Qing, M Zachman. Growth hormone requirement for a normal human adipocyte glucose carrier function. The Journal of clinical endocrinology and metabolism. vol 70. issue 6. 1990-07-11. PMID:2189888. |
these results confirm our earlier findings in rat adipocytes for human adipocytes: gh in vivo is responsible for a glucose transport-limiting factor in the plasma membrane that restricts basal glucose transport and is acutely inhibited by insulin resulting in enhanced glucose transport. |
1990-07-11 |
2023-08-11 |
human |
| E J Schoenle, Q R Qing, M Zachman. Growth hormone requirement for a normal human adipocyte glucose carrier function. The Journal of clinical endocrinology and metabolism. vol 70. issue 6. 1990-07-11. PMID:2189888. |
these results demonstrate the physiological importance of gh for a normal function of the insulin transmembrane signaling system in fat tissue and indicate a possible benefit of gh administration in adult ghd patients. |
1990-07-11 |
2023-08-11 |
human |
| G P Bernini, G F Argenio, M S Vivaldi, C Del Corso, R Birindelli, M Luisi, F Franch. Impaired growth hormone response to insulin-induced hypoglycaemia in obese patients: restoration blocked by ritanserin after fenfluramine administration. Clinical endocrinology. vol 32. issue 4. 1990-07-06. PMID:2112069. |
both controls and obese patients showed similar normal basal gh levels before each test and insulin administration always effectively reduced glucose levels to values lower than 2.2 mmol/l. |
1990-07-06 |
2023-08-11 |
Not clear |
| G P Bernini, G F Argenio, M S Vivaldi, C Del Corso, R Birindelli, M Luisi, F Franch. Impaired growth hormone response to insulin-induced hypoglycaemia in obese patients: restoration blocked by ritanserin after fenfluramine administration. Clinical endocrinology. vol 32. issue 4. 1990-07-06. PMID:2112069. |
however, in comparison with the basal test, ff administration significantly (p less than 0.001) enhanced gh response to insulin hypoglycaemia (peak value 33.4 +/- 4; auc 150 +/- 14.6), reaching values not significantly different from those of the controls. |
1990-07-06 |
2023-08-11 |
Not clear |
| C Bertoldi, P Riva, M E Bonat. [The growth hormone/somatomedin C system from the first years of life to young adulthood. Physiological aspects and physiopathologic involvement in diabetic syndrome]. Minerva endocrinologica. vol 14. issue 4. 1990-06-29. PMID:2576885. |
the hormonal gh system interacts with the functional pattern of insulin and other hormones, and in addition with entire maturation process. |
1990-06-29 |
2023-08-11 |
human |
| R J Madon, D M Ensor, D J Flin. Hypoinsulinaemia in the lactating rat is caused by a decreased glycaemic stimulus to the pancreas. The Journal of endocrinology. vol 125. issue 1. 1990-06-18. PMID:2187052. |
when virgin rats were pretreated for 5 days in vivo with gh or prolactin, insulin responses in vitro were unchanged. |
1990-06-18 |
2023-08-11 |
rat |