| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kim Mja Claessen, Alberto M Pereira, Nienke R Biermas. Outcome of complications in acromegaly patients after long-term disease remission. Expert review of endocrinology & metabolism. vol 10. issue 5. 2019-11-20. PMID:30298766. |
during active disease, gh excess is associated with a number of pathological conditions, such as hypertension, hypertrophic cardiomyopathy, sleep apnea, arthropathy, vertebral fractures and insulin resistance. |
2019-11-20 |
2023-08-13 |
Not clear |
| Daniel Landau, Yael Sege. Role of IGF-I in Type 2 diabetes: a focus on the mouse model. Expert review of endocrinology & metabolism. vol 3. issue 1. 2019-11-20. PMID:30743784. |
insulin resistance, the key mechanism in type 2 diabetes mellitus (t2dm) is also associated with the deregulation of other glucose homeostasis pathways, such as the growth hormone (gh)-igf-i system. |
2019-11-20 |
2023-08-13 |
mouse |
| Rakesh Amin, David B Dunge. Growth hormone hypothesis and development of diabetic nephropathy in Type 1 diabetes. Expert review of endocrinology & metabolism. vol 1. issue 5. 2019-11-20. PMID:30754096. |
in type 1 diabetes, the characteristic pattern of gh hypersecretion and low circulating igf-1 levels results from hepatic gh resistance owing to the lack of portal insulin. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rakesh Amin, David B Dunge. Growth hormone hypothesis and development of diabetic nephropathy in Type 1 diabetes. Expert review of endocrinology & metabolism. vol 1. issue 5. 2019-11-20. PMID:30754096. |
clinical data indicate that high gh and low igf-1 levels reduce insulin sensitivity and worsen glycemic control. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rakesh Amin, David B Dunge. Growth hormone hypothesis and development of diabetic nephropathy in Type 1 diabetes. Expert review of endocrinology & metabolism. vol 1. issue 5. 2019-11-20. PMID:30754096. |
although such data in humans are limited, preliminary trials show that interventions to increase igf-1 levels and reduce gh hypersecretion improve glycemic control and insulin sensitivity in the short term. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tamás Halmos, Ilona Sub. [The physiological role of growth hormone and insulin-like growth factors]. Orvosi hetilap. vol 160. issue 45. 2019-11-07. PMID:31680542. |
75% of the growth factors are produced in the liver by gh and insulin stimulation; their effects are expressed on specific receptors, and modified by specific binding proteins. |
2019-11-07 |
2023-08-13 |
Not clear |
| Vishva M Sharm. Emerging Mechanisms of GH-Induced Lipolysis and Insulin Resistance. Pediatric endocrinology reviews : PER. vol 17. issue 1. 2019-11-01. PMID:31599132. |
hence, a sustained release of high levels of gh contributes significantly to the development of insulin resistance by antagonizing the anti-lipolytic action of insulin. |
2019-11-01 |
2023-08-13 |
Not clear |
| Vishva M Sharm. Emerging Mechanisms of GH-Induced Lipolysis and Insulin Resistance. Pediatric endocrinology reviews : PER. vol 17. issue 1. 2019-11-01. PMID:31599132. |
this review discusses the physiological and metabolic actions of gh on adipose tissue as well as gh-mediated deregulation of the fsp27-pparγ axis which alters adipose tissue homeostasis and contributes to the development of insulin resistance and type 2 diabetes. |
2019-11-01 |
2023-08-13 |
Not clear |
| Verena Gounden, Yashna D Rampursat, Ishwarlal Jiala. Secretory tumors of the pituitary gland: a clinical biochemistry perspective. Clinical chemistry and laboratory medicine. vol 57. issue 2. 2019-10-28. PMID:30120907. |
acromegaly can be diagnosed by basal insulin growth-like factor 1 levels and the failure of growth hormone (gh) to suppress during an oral glucose tolerance test. |
2019-10-28 |
2023-08-13 |
Not clear |
| Peng Jia, Kai Cui, Tao Ma, Fan Wan, Wenyi Wang, Dong Yang, Yunfei Wang, Baolin Guo, Lifang Zhao, Qiyu Dia. Influence of dietary supplementation with Bacillus licheniformis and Saccharomyces cerevisiae as alternatives to monensin on growth performance, antioxidant, immunity, ruminal fermentation and microbial diversity of fattening lambs. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30420720. |
compared with the nc treatment, the other four supplementation treatments increased the concentration of growth hormone (gh), insulin-like growth factor i (igf-i) and insulin (ins) (p < 0.05). |
2019-10-28 |
2023-08-13 |
Not clear |
| Rita Sharma, Quyen Luong, Vishva M Sharma, Mitchell Harberson, Brian Harper, Andrew Colborn, Darlene E Berryman, Niels Jessen, Jens Otto Lunde Jørgensen, John J Kopchick, Vishwajeet Puri, Kevin Y Le. Growth hormone controls lipolysis by regulation of FSP27 expression. The Journal of endocrinology. vol 239. issue 3. 2019-09-11. PMID:30400015. |
growth hormone (gh) has long been known to stimulate lipolysis and insulin resistance; however, the molecular mechanisms underlying these effects are unknown. |
2019-09-11 |
2023-08-13 |
Not clear |
| Rita Sharma, Quyen Luong, Vishva M Sharma, Mitchell Harberson, Brian Harper, Andrew Colborn, Darlene E Berryman, Niels Jessen, Jens Otto Lunde Jørgensen, John J Kopchick, Vishwajeet Puri, Kevin Y Le. Growth hormone controls lipolysis by regulation of FSP27 expression. The Journal of endocrinology. vol 239. issue 3. 2019-09-11. PMID:30400015. |
taken together, these data decipher a molecular mechanism by which gh acutely regulates lipolysis and insulin resistance in adipocytes. |
2019-09-11 |
2023-08-13 |
Not clear |
| Lisa Sze, Oliver Tschopp, Marian C Neidert, René L Bernays, Claudia Ghirlanda, Cornelia Zwimpfer, Peter Wiesli, Christoph Schmi. Soluble delta-like 1 homolog decreases in patients with acromegaly following pituitary surgery: A potential mediator of adipogenesis suppression by growth hormone? Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 45. 2019-08-02. PMID:30818110. |
gh excess in acromegaly leads to lower fat mass and insulin resistance; both reverse following pituitary surgery. |
2019-08-02 |
2023-08-13 |
Not clear |
| Kevin C Corbit, João Paulo G Camporez, Jennifer L Tran, Camella G Wilson, Dylan A Lowe, Sarah M Nordstrom, Kirthana Ganeshan, Rachel J Perry, Gerald I Shulman, Michael J Jurczak, Ethan J Weis. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. JCI insight. vol 2. issue 3. 2019-06-21. PMID:28194444. |
for nearly 100 years, growth hormone (gh) has been known to affect insulin sensitivity and risk of diabetes. |
2019-06-21 |
2023-08-13 |
Not clear |
| Kevin C Corbit, João Paulo G Camporez, Jennifer L Tran, Camella G Wilson, Dylan A Lowe, Sarah M Nordstrom, Kirthana Ganeshan, Rachel J Perry, Gerald I Shulman, Michael J Jurczak, Ethan J Weis. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. JCI insight. vol 2. issue 3. 2019-06-21. PMID:28194444. |
however, the tissue governing the effects of gh signaling on insulin and glucose homeostasis remains unknown. |
2019-06-21 |
2023-08-13 |
Not clear |
| Kevin C Corbit, João Paulo G Camporez, Jennifer L Tran, Camella G Wilson, Dylan A Lowe, Sarah M Nordstrom, Kirthana Ganeshan, Rachel J Perry, Gerald I Shulman, Michael J Jurczak, Ethan J Weis. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. JCI insight. vol 2. issue 3. 2019-06-21. PMID:28194444. |
excess gh reduces fat mass and insulin sensitivity. |
2019-06-21 |
2023-08-13 |
Not clear |
| Kevin C Corbit, João Paulo G Camporez, Jennifer L Tran, Camella G Wilson, Dylan A Lowe, Sarah M Nordstrom, Kirthana Ganeshan, Rachel J Perry, Gerald I Shulman, Michael J Jurczak, Ethan J Weis. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. JCI insight. vol 2. issue 3. 2019-06-21. PMID:28194444. |
conversely, gh insensitivity (ghi) is associated with increased adiposity, augmented insulin sensitivity, and protection from diabetes. |
2019-06-21 |
2023-08-13 |
Not clear |
| Walter Bonfig, Reinhard W Hol. Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes. International journal of molecular sciences. vol 20. issue 3. 2019-06-03. PMID:30759741. |
in the state of insulin deficiency, the growth hormone-insulin-like growth factor-i (gh⁻igf-i) axis is altered due to hepatic gh resistance, which leads to gh hypersecretion and low circulating igf-i concentration. |
2019-06-03 |
2023-08-13 |
human |
| F Gloria-Bottini, E Antonacci, A Neri, A Magrini, E Bottin. Is there a relationship between stature and age of onset of type 2 Diabetes? Diabetes & metabolic syndrome. vol 13. issue 1. 2019-05-13. PMID:30641710. |
msp1a and msp1b polymorphic sites located in the gh genomic area have been found associated with gh response to insulin stimulation, with familiar short stature and with age at onset of type 2 diabetes (t2d). |
2019-05-13 |
2023-08-13 |
Not clear |
| Flavio A Cadegiani, Claudio E Kater, Matheus Gazol. Clinical and biochemical characteristics of high-intensity functional training (HIFT) and overtraining syndrome: findings from the EROS study (The EROS-HIFT). Journal of sports sciences. vol 37. issue 11. 2019-04-19. PMID:30786846. |
cf-atl yielded earlier and enhanced cortisol, gh, and prolactin responses to an insulin tolerance test (itt), increased neutrophils, lower lactate, increased testosterone, improved sleep quality, better psychological performance, increased measured-to-predicted basal metabolic rate (bmr) ratio and fat oxidation, and better hydration, when compared to npac. |
2019-04-19 |
2023-08-13 |
Not clear |