| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroshi Hashizume, Maria D Rutkowski, James N Weinstein, Joyce A DeLe. Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica. Pain. vol 87. issue 2. 2000-10-11. PMID:10924809. |
the l5 spinal cord segments were harvested for assessment of immunohistochemical glial activation using the antibodies ox-42 (microglial marker) and glial fibrillary acidic protein (gfap: astrocytic marker) and for the presence of major histocompatibility complex (mhc) class ii expression. |
2000-10-11 |
2023-08-12 |
rat |
| Y Q Li, C S Won. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiation research. vol 154. issue 3. 2000-09-28. PMID:10956432. |
no evidence of gfap or factor viii-related antigen-positive apoptotic cells was observed, and there was a small number of apoptotic microglial cells (lectin-rca1 positive) in the neonatal and adult rat spinal cord. |
2000-09-28 |
2023-08-12 |
rat |
| F Labombarda, S Gonzalez, P Roig, A Lima, R Guennoun, M Schumacher, A F De Nicol. Modulation of NADPH-diaphorase and glial fibrillary acidic protein by progesterone in astrocytes from normal and injured rat spinal cord. The Journal of steroid biochemistry and molecular biology. vol 73. issue 3-4. 2000-09-25. PMID:10925216. |
to study its potential effects in the spinal cord, we investigated p4 modulation (4 mg/kg/day for 3 days) of two proteins responding to injury: nadph-diaphorase, an enzyme with nitric oxide synthase activity, and glial fibrillary acidic protein (gfap), a marker of astrocyte reactivity. |
2000-09-25 |
2023-08-12 |
rat |
| M C González Deniselle, S Lavista-Llanos, M G Ferrini, A E Lima, A G Roldán, A F De Nicol. In vitro differences between astrocytes of control and wobbler mice spinal cord. Neurochemical research. vol 24. issue 12. 2000-01-10. PMID:10591403. |
we suggest that tgf-beta1 may play a role in the reactive gliosis and gfap hyperexpression found in the degenerating spinal cord of this model of als. |
2000-01-10 |
2023-08-12 |
mouse |
| Z Hao, J Yeung, L Wolf, R Doucette, A Nazaral. Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Developmental dynamics : an official publication of the American Association of Anatomists. vol 216. issue 2. 1999-11-30. PMID:10536059. |
double labeling studies with an antibody against glial fibrillary acidic protein (gfap, an astrocyte-specific intermediate filament protein) showed that within the adult spinal cord, astrocytes rarely expressed the hoxa-2 protein. |
1999-11-30 |
2023-08-12 |
mouse |
| S Nakamura, T Todo, Y Motoi, S Haga, T Aizawa, A Ueki, K Iked. Glial expression of fibroblast growth factor-9 in rat central nervous system. Glia. vol 28. issue 1. 1999-11-22. PMID:10498823. |
in addition to the neuronal localization of fgf-9 immunoreactivity that we reported previously, the present double-label immunohistochemistry clearly demonstrated that the immunoreactivity was present in glial fibrillary acidic protein (gfap)-positive astrocytes preferentially present in the white matter of spinal cord and brainstem of adult rats and in cnpase-positive oligodendrocytes that were arranged between the fasciculi of nerve fibers in cerebellar white matter and corpus callosum of both adult and young rats. |
1999-11-22 |
2023-08-12 |
rat |
| G R Schmidt, K L Hossner, R S Yemm, D H Gould, J P O'Callagha. An enzyme-linked immunosorbent assay for glial fibrillary acidic protein as an indicator of the presence of brain or spinal cord in meat. Journal of food protection. vol 62. issue 4. 1999-09-21. PMID:10419214. |
in contrast, high levels of gfap (55 to 220 microg/ mg) were present in spinal cord, cerebral cortex (17 microg/mg), and whole brain (9 to 55 microg/mg). |
1999-09-21 |
2023-08-12 |
cattle |
| P Rezaie, K Patel, D K Mal. Microglia in the human fetal spinal cord--patterns of distribution, morphology and phenotype. Brain research. Developmental brain research. vol 115. issue 1. 1999-08-03. PMID:10366704. |
in order to determine the extent of microglial influx into the nervous system, we have examined their distribution within the human fetal spinal cord in relation to astrocytic and vascular development between 9 and 16 weeks of gestation, using conventional immunohistochemistry [cd11b; cd45; cd64; cd68; icam-1; icam-2; vcam-1; pecam; gfap; vimentin] and lectin histochemistry [rca-1]. |
1999-08-03 |
2023-08-12 |
human |
| T Watanabe, T Yamamoto, Y Abe, N Saito, T Kumagai, H Kayam. Differential activation of microglia after experimental spinal cord injury. Journal of neurotrauma. vol 16. issue 3. 1999-06-09. PMID:10195473. |
immediately to 4 weeks after injury, each spinal cord was fixed and cut into longitudinal frozen sections, and was immunostained with ox42 for resident and activated microglia, ox-6 for activated microglia, gfap for activated astrocytes, and biotinylated bs-i, a lectin for both resident and activated microglia. |
1999-06-09 |
2023-08-12 |
rat |
| A G Rabchevsky, J M Weinitz, M Coulpier, C Fages, M Tinel, M P Junie. A role for transforming growth factor alpha as an inducer of astrogliosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 24. 1999-02-25. PMID:9852591. |
in the striatum, the hippocampus, and the cervical spinal cord, the three cns areas monitored, transgenic mice displayed enhanced gfap mrna and protein levels and elevated vimentin protein levels. |
1999-02-25 |
2023-08-12 |
mouse |
| A B Schmitt, G A Brook, A Buss, W Nacimiento, J Noth, G W Kreutzber. Dynamics of microglial activation in the spinal cord after cerebral infarction are revealed by expression of MHC class II antigen. Neuropathology and applied neurobiology. vol 24. issue 3. 1998-11-06. PMID:9717181. |
to assess the response of glial cells after lesions of supraspinal descending tracts, hla-dr, cd68 and gfap were studied immunohistochemically on spinal cord tissue of 5 patients who died after unilateral infarction of the middle cerebral artery territory, and 5 control cases. |
1998-11-06 |
2023-08-12 |
Not clear |
| Y Matsuyama, K Sato, M Kamiya, J Yano, H Iwata, K Isob. Nitric oxide: a possible etiologic factor in spinal cord cavitation. Journal of spinal disorders. vol 11. issue 3. 1998-09-16. PMID:9657552. |
spinal cord specimens were subjected to glial fibrillary acidic protein (gfap) immunostaining, which is selective for astrocytes. |
1998-09-16 |
2023-08-12 |
mouse |
| Y Nagata, K Fujita, M Yamauchi, T Kato, M Ando, M Hond. Neurochemical changes in the spinal cord in degenerative motor neuron diseases. Molecular and chemical neuropathology. vol 33. issue 3. 1998-09-10. PMID:9642676. |
we found marked increases in fragmented glial fibrillary acidic protein (gfap), a filamentous protein specifically associated with reactive astrocytes, in the als spinal cord relative to non-als tissue. |
1998-09-10 |
2023-08-12 |
mouse |
| A F De Nicola, M Ferrini, S L Gonzalez, M C Gonzalez Deniselle, C A Grillo, G Piroli, F Saravia, E R de Kloe. Regulation of gene expression by corticoid hormones in the brain and spinal cord. The Journal of steroid biochemistry and molecular biology. vol 65. issue 1-6. 1998-08-27. PMID:9699880. |
in an animal model of neurodegeneration (the wobbler mouse) showing pronounced astrogliosis of the spinal cord, in vivo gc treatment down-regulated gfap immunoreactivity, whereas the membrane-active steroid antioxidant u-74389f up-regulated this protein. |
1998-08-27 |
2023-08-12 |
mouse |
| A F De Nicola, M Ferrini, S L Gonzalez, M C Gonzalez Deniselle, C A Grillo, G Piroli, F Saravia, E R de Kloe. Regulation of gene expression by corticoid hormones in the brain and spinal cord. The Journal of steroid biochemistry and molecular biology. vol 65. issue 1-6. 1998-08-27. PMID:9699880. |
it is likely that variations in gfap protein expression affect spinal cord neurodegeneration in wobbler mice. |
1998-08-27 |
2023-08-12 |
mouse |
| T Kommers, L Vinadé, C Pereira, C A Gonçalves, S Wofchuk, R Rodnigh. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. Neuroscience letters. vol 248. issue 2. 1998-08-17. PMID:9654363. |
regulation of the phosphorylation of glial fibrillary acidic protein (gfap) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. |
1998-08-17 |
2023-08-12 |
rat |
| T Kommers, L Vinadé, C Pereira, C A Gonçalves, S Wofchuk, R Rodnigh. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. Neuroscience letters. vol 248. issue 2. 1998-08-17. PMID:9654363. |
the effect of glutamate and lack of external ca2+ on the phosphorylation of the astrocyte cell marker glial fibrillary acidic protein (gfap) was studied in slices of hippocampus and thoracic spinal cord from immature (p12-16) rats. |
1998-08-17 |
2023-08-12 |
rat |
| T Kommers, L Vinadé, C Pereira, C A Gonçalves, S Wofchuk, R Rodnigh. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. Neuroscience letters. vol 248. issue 2. 1998-08-17. PMID:9654363. |
by contrast in slices of immature thoracic spinal cord, glutamate had no effect on gfap phosphorylation and in media lacking ca2+ phosphorylation of gfap was inhibited. |
1998-08-17 |
2023-08-12 |
rat |
| T Kommers, L Vinadé, C Pereira, C A Gonçalves, S Wofchuk, R Rodnigh. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. Neuroscience letters. vol 248. issue 2. 1998-08-17. PMID:9654363. |
since gfap phosphorylation is ca2+-dependent and is not stimulated by glutamate in slices of adult hippocampus, the present results suggest that astrocytic functions in the rat spinal cord mature more rapidly than in the hippocampus. |
1998-08-17 |
2023-08-12 |
rat |
| T Kommers, L Vinadé, C Pereira, C A Gonçalves, S Wofchuk, R Rodnigh. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. Neuroscience letters. vol 248. issue 2. 1998-08-17. PMID:9654363. |
the possibility that the difference in the control of gfap phosphorylation in the two structures is related to differences in the control of gfap dephosphorylation was investigated by incubating spinal cord slices with the calcineurin inhibitor fk506 in the presence of ca2+. |
1998-08-17 |
2023-08-12 |
rat |