| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karen Meathrel, Tamara Adamek, Jane Batt, Daniela Rotin, Laurie C Doerin. Protein tyrosine phosphatase sigma-deficient mice show aberrant cytoarchitecture and structural abnormalities in the central nervous system. Journal of neuroscience research. vol 70. issue 1. 2002-11-22. PMID:12237861. |
architectural abnormalities in the brain and spinal cord were confirmed by immunoreactivity to neurofilament and glial fibrillary acidic protein (gfap) antibodies. |
2002-11-22 |
2023-08-12 |
mouse |
| S J Medhurst, K Walker, M Bowes, B L Kidd, M Glatt, M Muller, M Hattenberger, J Vaxelaire, T O'Reilly, G Wotherspoon, J Winter, J Green, L Urba. A rat model of bone cancer pain. Pain. vol 96. issue 1-2. 2002-08-06. PMID:11932069. |
although the pathophysiology of cancer pain is largely unknown, significant enhancement of glial fibrillary acidic protein (gfap) staining in the corresponding segments of the ipsilateral spinal cord highlights the possible involvement of astrocytes. |
2002-08-06 |
2023-08-12 |
rat |
| M C González Deniselle, S L González, A F De Nicol. Cellular basis of steroid neuroprotection in the wobbler mouse, a genetic model of motoneuron disease. Cellular and molecular neurobiology. vol 21. issue 3. 2002-02-19. PMID:11569536. |
in common with the spinal cord of als patients, wobbler mice present astrocytosis with hyperexpression of glial fibrillary acidic protein (gfap), and increased expression of nitric oxide synthase (nos) and growth-associated protein (gap-43) in motoneurons. |
2002-02-19 |
2023-08-12 |
mouse |
| Phillip J Albrecht, John P Dahl, Olivia K Stoltzfus, Robert Levenson, Steven W Leviso. Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival. Experimental neurology. vol 173. issue 1. 2002-02-04. PMID:11771938. |
here, we demonstrate that direct injection of cntf into the spinal cord increases gfap expression and astroglial size and that primary cultures of spinal cord astrocytes treated with cntf, il-1beta, or leukemia inhibitory factor exhibit nuclear hypertrophy comparable to that observed in vivo. |
2002-02-04 |
2023-08-12 |
Not clear |
| S K Ray, D D Matzelle, G G Wilford, E L Hogan, N L Bani. Inhibition of calpain-mediated apoptosis by E-64 d-reduced immediate early gene (IEG) expression and reactive astrogliosis in the lesion and penumbra following spinal cord injury in rats. Brain research. vol 916. issue 1-2. 2002-01-14. PMID:11597598. |
we examined calpain content and activity, regulation of immediate early genes (iegs) such as c-jun and c-fos, reactive astrogliosis as the expression of glial fibrillary acidic protein (gfap), and apoptosis-related features such as caspase-3 mrna expression and internucleosomal dna fragmentation in 1-cm long spinal cord segments (s1, distant rostral; s2, adjacent rostral; s3, lesion or injury; s4, adjacent caudal; and s5, distant caudal) following sci in rats. |
2002-01-14 |
2023-08-12 |
rat |
| G R Schmidt, R S Yemm, K D Childs, J P O'Callaghan, K L Hossne. The detection of central nervous system tissue on beef carcasses and in comminuted beef. Journal of food protection. vol 64. issue 12. 2002-01-10. PMID:11770636. |
bovine spinal cord and brain demonstrate dose-response curves that are parallel to gfap standards, whereas peripheral sciatic nerve and cervical ganglia also cross-react at high tissue levels. |
2002-01-10 |
2023-08-12 |
cattle |
| G R Schmidt, R S Yemm, K D Childs, J P O'Callaghan, K L Hossne. The detection of central nervous system tissue on beef carcasses and in comminuted beef. Journal of food protection. vol 64. issue 12. 2002-01-10. PMID:11770636. |
occasional samples contained higher levels of gfap, probably because of contamination by the carcass-splitting saw, incomplete removal of the spinal cord, or a chance sampling of a major nerve. |
2002-01-10 |
2023-08-12 |
cattle |
| S Giannetti, L Lauretti, E Fernandez, F Salvinelli, G Tamburrini, R Pallin. Acrylic hydrogel implants after spinal cord lesion in the adult rat. Neurological research. vol 23. issue 4. 2001-12-04. PMID:11428522. |
two to four months after implantation, the spinal cord was removed and processed for histology, and s100 and gfap immunohistochemistry. |
2001-12-04 |
2023-08-12 |
rat |
| R J Leme, G Chad. Distant microglial and astroglial activation secondary to experimental spinal cord lesion. Arquivos de neuro-psiquiatria. vol 59. issue 3-A. 2001-12-04. PMID:11588623. |
morphometric analysis of the area and microdensitometric analysis of the intensity of the gfap and ox42 immunoreactivities showed reactive astrocytes and microglia in the entire spinal cord white and gray matters 7 days and 3 months after surgery. |
2001-12-04 |
2023-08-12 |
rat |
| b' M Anderov\\xc3\\xa1, S Kubinov\\xc3\\xa1, T Mazel, A Chv\\xc3\\xa1tal, C Eliasson, M Pekny, E Sykov\\xc3\\xa. Effect of elevated K(+), hypotonic stress, and cortical spreading depression on astrocyte swelling in GFAP-deficient mice. Glia. vol 35. issue 3. 2001-10-04. PMID:11494410.' |
to assess its function in astrocyte swelling, we compared astrocyte membrane properties and swelling in spinal cord slices of 8- to 10-day-old wild-type control (gfap(+/+)) and gfap-knockout (gfap(-/-)) mice. |
2001-10-04 |
2023-08-12 |
mouse |
| b' M Anderov\\xc3\\xa1, S Kubinov\\xc3\\xa1, T Mazel, A Chv\\xc3\\xa1tal, C Eliasson, M Pekny, E Sykov\\xc3\\xa. Effect of elevated K(+), hypotonic stress, and cortical spreading depression on astrocyte swelling in GFAP-deficient mice. Glia. vol 35. issue 3. 2001-10-04. PMID:11494410.' |
no differences in alpha and lambda in the spinal cord or cortex of gfap(+/+) and gfap(-/-) mice were found; however, the application of either 50 mm k(+) or hs in spinal cord, or sd in cortex, evoked a large decrease in alpha and an increase in lambda in gfap(+/+) mice only. |
2001-10-04 |
2023-08-12 |
mouse |
| K Barami, J Zhao, F G Diaz, W D Lyma. Comparison of neural precursor cell fate in second trimester human brain and spinal cord. Neurological research. vol 23. issue 2-3. 2001-09-06. PMID:11320606. |
in contrast, cells that emerged from spinal cord derived spheres were only immunoreactive for gfap. |
2001-09-06 |
2023-08-12 |
human |
| P Bigini, A Bastone, T Mennin. Glutamate transporters in the spinal cord of the wobbler mouse. Neuroreport. vol 12. issue 9. 2001-08-23. PMID:11435904. |
glial fibrillar acid protein (gfap), a marker of reactive gliosis, was significantly higher in the cervical spinal cord of wobbler mice aged 4 weeks than in controls and the differences were more marked at 12 weeks; no differences were found in the lumbar spinal cord. |
2001-08-23 |
2023-08-12 |
mouse |
| P Song, Z Q Zha. The involvement of glial cells in the development of morphine tolerance. Neuroscience research. vol 39. issue 3. 2001-06-14. PMID:11248367. |
once daily for 9 consecutive days led to significant increase in gfap immunostaining density in the spinal cord, posterior cingulate cortex and hippocampus but not in the thalamus. |
2001-06-14 |
2023-08-12 |
Not clear |
| A Baborie, E M Dunn, L R Bridges, J M Bamfor. Primary diffuse leptomeningeal gliomatosis predominantly affecting the spinal cord: case report and review of the literature. Journal of neurology, neurosurgery, and psychiatry. vol 70. issue 2. 2001-03-29. PMID:11160482. |
histology disclosed diffuse leptomeningeal gliomatosis (gfap positive, cytokeratin negative) over the brain, optic nerves, and spinal cord without parenchymal involvement. |
2001-03-29 |
2023-08-12 |
Not clear |
| N Wilson, E Esfandiary, K S Bed. Cryosections of pre-irradiated adult rat spinal cord tissue support axonal regeneration in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2001-03-22. PMID:11154843. |
after an appropriate incubation period, cultures were fixed in 2% paraformaldehyde and immunolabelled to visualise both the spinal cord substrate using anti-glial fibrillary acidic protein (gfap) and the growing drg neurons using anti-growth associated protein (gap-43). |
2001-03-22 |
2023-08-12 |
rat |
| M Lazzari, V Franceschin. Glial fibrillary acidic protein and vimentin immunoreactivity of astroglial cells in the central nervous system of adult Podarcis sicula (Squamata, Lacertidae). Journal of anatomy. vol 198. issue Pt 1. 2001-03-01. PMID:11215769. |
the present immunoperoxidase cytochemical study describes the distribution of glial intermediate filament molecular markers, glial fibrillary acidic protein (gfap) and vimentin, in the brain and spinal cord of the adult lizard, podarcis sicula. |
2001-03-01 |
2023-08-12 |
Not clear |
| M Lazzari, V Franceschin. Glial fibrillary acidic protein and vimentin immunoreactivity of astroglial cells in the central nervous system of adult Podarcis sicula (Squamata, Lacertidae). Journal of anatomy. vol 198. issue Pt 1. 2001-03-01. PMID:11215769. |
while vimentin immunoreactive elements are almost completely absent in the brain except for a few diencephalic radial fibres, the spinal cord ependyma exhibits a clearly vimentin positivity and no gfap staining. |
2001-03-01 |
2023-08-12 |
Not clear |
| L F Eng, R S Ghirnikar, Y L Le. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochemical research. vol 25. issue 9-10. 2001-02-15. PMID:11059815. |
studies showing that mice lacking gfap are hypersensitive to cervical spinal cord injury caused by sudden acceleration of the head have provided more direct evidence for a structural role of gfap. |
2001-02-15 |
2023-08-12 |
mouse |
| T V Damodaran, M B Abou-Doni. Alterations in levels of mRNAs coding for glial fibrillary acidic protein (GFAP) and vimentin genes in the central nervous system of hens treated with diisopropyl phosphorofluoridate (DFP). Neurochemical research. vol 25. issue 6. 2000-12-07. PMID:10943999. |
the gfap transcript levels reached near control levels (88% and 95%) at 20 days post dfp treatment after an initial down-regulation (60% and 73%) in highly susceptible tissues like spinal cord and brainstem respectively. |
2000-12-07 |
2023-08-12 |
human |