| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaofeng Xu, Wenqi Xu, Siqi Dong, Delong Liu, Wanbin Zhan. RuPHOX-Ru Catalyzed Asymmetric Cascade Hydrogenation of 3-Substituted Chromones for the Synthesis of Corresponding Chiral Chromanols. Chemistry (Weinheim an der Bergstrasse, Germany). 2024-05-02. PMID:38695858. |
an efficient ruphox-ru catalyzed asymmetric cascade hydrogenation of 3-substituted chromones has been achieved under mild reaction conditions, affording the corresponding chiral 3-substituted chromanols in high yields with excellent enantio- and diastereoselectivities (up to 99% yield, >99% ee and >20:1 dr). |
2024-05-02 |
2024-05-04 |
Not clear |
| Arindam Khatua, Debgopal Jana, Monosij Nandy, Pranay Shyamal, Alakesh Bisa. Total Synthesis of (+)- and (-)-Calycanthine by Means of Thio-Urea-Catalyzed Sequential Michael Reactions of Bis-oxindoles. The Journal of organic chemistry. 2024-03-28. PMID:38544463. |
a unified catalytic asymmetric approach to naturally occurring piperidinoindoline and pyrrololidinoindoline alkaloids has been realized via the development of a thio-urea-catalyzed sequential michael addition of bis-oxindole onto nitroethylene (up to 93% ee and >20:1 dr). |
2024-03-28 |
2024-03-30 |
Not clear |
| Kun Wang, Saisai Niu, Weijun Tang, Dong Xue, Jianliang Xiao, Hongfeng Li, Chao Wan. Ru-catalyzed asymmetric hydrogenation of α,β-unsaturated ketones Chemical communications (Cambridge, England). 2024-03-28. PMID:38545855. |
ru-catalyzed asymmetric hydrogenation of α,β-unsaturated ketones ru-catalyzed asymmetric hydrogenation of α-substituted α,β-unsaturated ketones has been developed for the enantioselective synthesis of chiral α-substituted secondary alcohols with high diastereo- and enantioselectivities (up to >99 : 1 dr, 98% ee). |
2024-03-28 |
2024-03-30 |
Not clear |
| Jingli He, Zhaodi Li, Ruhui Li, Xuezhen Kou, Delong Liu, Wanbin Zhan. Bimetallic Ru/Ru-Catalyzed Asymmetric One-Pot Sequential Hydrogenations for the Stereodivergent Synthesis of Chiral Lactones. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-03-21. PMID:38509867. |
asymmetric sequential hydrogenations of α-methylene γ- or δ-keto carboxylic acids are established in one-pot using a bimetallic ru/ru catalyst system, achieving the stereodivergent synthesis of all four stereoisomers of both chiral γ- and δ-lactones with two non-vicinal carbon stereocenters in high yields (up to 99%) and with excellent stereoselectivities (up to >99% ee and >20:1 dr). |
2024-03-21 |
2024-03-23 |
Not clear |
| Yao-Bin Shen, Hui-Ling Qian, Lei Yang, Shun Zhou, Han-Wen Rao, Zhen-Hua Wang, Yong You, Yan-Ping Zhang, Jun-Qing Yin, Jian-Qiang Zhao, Wenjing Zhang, Wei-Cheng Yua. Cu-Catalyzed Direct Asymmetric Mannich Reaction of 2-Alkylazaarenes and Isatin-Derived Ketimines. Organic letters. 2024-02-22. PMID:38385527. |
the asymmetric addition of 2-alkylpyridines to isatin-derived ketimines proceeded smoothly to afford α,β-functionalized 2-substituted pyridines bearing 3-amino-3,3-disubstituted oxindole motifs with excellent results (≤99% yield, 99:1 dr, and 98% ee). |
2024-02-22 |
2024-02-24 |
Not clear |
| Liang Bai, Jian-Sheng Wei, Ling-Yi Zhong, Ao-Qiang Ma, Jian Wang, Zhi-Qiang Du, Ai-Bao Xia, Dan-Qian X. Enantioselective α-Amination of Amides by One-Pot Organo-/Iodine Sequential Catalysis. Organic letters. 2023-12-29. PMID:38157251. |
this methodology exhibited strong asymmetric induction, resulting in a typical enantiomeric excess value exceeding 99% and diastereoselectivity up to >99:1 dr. |
2023-12-29 |
2024-01-05 |
Not clear |
| Jixin Pian, Zhifei Zhao, Yujie Zhao, Lin He, Xiong-Li Liu, Yongsheng Li, Shi-Wu L. Asymmetric Synthesis of Tertiary α-Hydroxylation-Cyclopentanones via Synergetic Catalysis of Chiral-at-Metal Rhodium(III) Complexes/Pyrrolidine. The Journal of organic chemistry. 2023-12-28. PMID:38154059. |
catalytic and asymmetric domino michael/aldol reaction of 1,2-dicarbonyl compounds with α,β-unsaturated ketones under the synergetic catalysis of chiral-at-metal rhodium complexes and pyrrolidine to deliver tertiary α-hydroxylation-cyclopentanones (45-89% yields with 81-99% ee and up to >20:1 dr) bearing three contiguous stereogenic centers had been established. |
2023-12-28 |
2023-12-31 |
Not clear |
| Wenkun Chen, Jijun Jiang, Jun Wan. Asymmetric Ruthenium-Catalyzed C-H Activation by a Versatile Chiral-Amide-Directing Strategy. Angewandte Chemie (International ed. in English). 2023-12-16. PMID:38102747. |
asymmetric c-h activation of the related chiral benzamides with various olefins, aldehydes and propargylic alcohols has been accomplished with high stereoselectivities, affording a series of chiral products including 3,4-dihydroisocoumarins (up to 96% ee), isocoumarins (up to 92% ee), phthalides (up to 99% ee), chiral bicyclo[2.2.1]heptanes (>20:1 dr), 4-alkylidene-3,4-dihydroisocoumarins (up to 97% ee) and allenes (>20:1 dr). |
2023-12-16 |
2023-12-18 |
Not clear |
| Michał Błaszkiewicz, Agata Walulik, Kamila Florek, Ignacy Górecki, Olga Sławatyniec, Krzysztof Gomułk. Advances and Perspectives in Relation to the Molecular Basis of Diabetic Retinopathy-A Review. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001952. |
specifically, we focus on advanced glycation end products, vascular endothelial growth factor (vegf), asymmetric dimethylarginine, endothelin-1, and the epigenetic regulation mediated by micrornas (mirnas) in the context of dr. |
2023-11-25 |
2023-11-28 |
Not clear |
| Yurim Kim, Yoseop Kim, Sung-Gon Ki. [4+2]-Cycloaddition of 2-Aminophenyl Enones with Cyclic N-Sulfimines to Access Enantioenriched Ring-Fused Aminals. Chemistry, an Asian journal. 2023-11-20. PMID:37984888. |
furthermore, an organocatalytic asymmetric [4+2]-cycloaddition was successfully achieved using a squaramide-based catalyst, enabling the enantioselective synthesis of chiral ring-fused tetrahydroquinazolines with high yields and enantio- as well as diastereoselectivities (up to 89% yield, 94% ee, and >30:1 dr). |
2023-11-20 |
2023-11-29 |
Not clear |
| Liangzhi Pang, Chun Wang, Congyue Ma, Jiaojiao Liu, Mengke Shi, Chuanzhi Yao, Jie Yu, Qiankun L. Palladium-Catalyzed Modular Assembly of P-Stereogenic and Axially Chiral Phosphinooxazoles (PHOX) Ligands by C-P Bond Cleavage/Intermolecular C(sp Organic letters. 2023-10-13. PMID:37831783. |
here, modular assembly of diverse p-stereogenic and axially chiral phosphinooxazoles ligands is achieved through palladium-catalyzed asymmetric cleavage of c-p bond/intermolecular c-h bond functionalization in high atroposelectivities and diastereoselectivities of up to >99% ee and >25:1 dr. |
2023-10-13 |
2023-10-15 |
Not clear |
| Subhankar Biswas, Siddhartha K Purkayastha, Ankur K Guha, Subhas Chandra Pa. Sequential organo and metal catalyzed reaction between 3-pyrrolyloxindoles and linear nitroenynes: access to cyclic aza-spirooxindoles. Chemical communications (Cambridge, England). 2023-09-23. PMID:37740344. |
an asymmetric michael addition/hydroarylation reaction sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a combination of silver and gold salts, provides a new series of cyclic aza-spirooxindole derivatives in excellent yields (up to 94%) and high diastero- and enantioselectivities (up to 7 : 1 dr, up to >99% ee). |
2023-09-23 |
2023-10-07 |
Not clear |
| Ai-Fang Wang, Jin-Miao Tian, Xiao-Jing Zhao, Zi-Hao Li, Ye Zhang, Ka Lu, Hong Wang, Shu-Yu Zhang, Yongqiang Tu, Tong-Mei Ding, Yu-Yang Xi. Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems. Angewandte Chemie (International ed. in English). 2023-07-18. PMID:37462217. |
an asymmetric intramolecular hydroalkylation of unactivated internal olefins with tethered cyclic ketones was realized by the cooperative catalysis of a newly designed chiral amine (spd-nh2) and pd(ii) complex, providing straightforward access to either bridged or fused bicyclic systems containing three stereogenic centers with excellent enantioselectivity (up to 99% ee) and diastereoselectivity (up to >20:1 dr). |
2023-07-18 |
2023-08-14 |
Not clear |
| Zhenli Luo, Zhewei Li, Haoqiang Zhao, Ji Yang, Lijin Xu, Ming Lei, Qinghua Fan, Patrick Joseph Wals. Borane-Catalyzed Tandem Cyclization/Hydrosilylation Towards Enantio- and Diastereoselective Construction of trans-2,3-Disubstituted-1,2,3,4-Tetrahydroquinoxalines. Angewandte Chemie (International ed. in English). 2023-06-20. PMID:37338222. |
herein we report that a frustrated lewis pair-based catalyst generated via in situ hydroboration of 2-vinylnaphthalene with hb(c6f5)2 allows for the one-pot tandem cyclization/hydrosilylation of 1,2-diaminobenzenes and 1,2-diketones with commercially available phsih3 to exclusively afford trans-2,3-disubstituted 1,2,3,4-tetrahydroquinoxalines in high yields with excellent diastereoselectivities (>20:1 dr). furthermore, this reaction can be rendered asymmetric by using an enantioenriched borane-based catalyst derived from hb(c6f5)2 and a binaphthyl-based chiral diene to give rise to enantioenriched trans-2,3-disubstituted 1,2,3,4-tetrahydroquinoxalines in high yields with almost complete diastereo- and enantiocontrol (>20:1 dr, up to >99% ee). |
2023-06-20 |
2023-08-14 |
Not clear |
| Li-Xia Liu, Yu-Qing Bai, Xiang Li, Chang-Bin Yu, Yong-Gui Zho. Palladium-catalyzed asymmetric allenylic alkylation: construction of multiple chiral thiochromanone derivatives. Chemical science. vol 14. issue 20. 2023-05-26. PMID:37234894. |
herein, by the combination of base-promoted retro-sulfa-michael addition and palladium-catalyzed asymmetric allenylic alkylation, the streamlined synthesis of chiral thiochromanones containing two central chiralities (including a quaternary stereogenic center) and an axial chirality (allene unit) was successfully realized with up to 98% yield, 49.0 : 1 dr and >99% ee. |
2023-05-26 |
2023-08-14 |
Not clear |
| Jingxin Wang, Yongjie Shi, Fangyuan Wang, Fanping Huang, Shaotao Bai, Yu Zhao, Xumu Zhan. Concise Synthesis of Chiral Tricyclic Lactams by Tandem Dynamic Kinetic Asymmetric Reductive Amination/Lactamization Using Ammonium Salts. Angewandte Chemie (International ed. in English). 2023-04-22. PMID:37086028. |
this ru-catalyzed system operates through an efficient tandem dynamic kinetic asymmetric reductive amination (ara)/lactamization, and produces chiral fused tricyclic lactams in high yields and excellent diastereo- and enantioselectivities (up to >99% ee, >20:1 dr and 98% yield). |
2023-04-22 |
2023-08-14 |
Not clear |
| Hao Jiang, Xiang-Kui He, Xuan Jiang, Wei Zhao, Liang-Qiu Lu, Ying Cheng, Wen-Jing Xia. Photoinduced Cobalt-Catalyzed Desymmetrization of Dialdehydes to Access Axial Chirality. Journal of the American Chemical Society. 2023-03-15. PMID:36920031. |
herein, we report two visible light-induced cobalt-catalyzed asymmetric reductive couplings of biaryl dialdehydes to synthesize axially chiral aldehydes (60 examples, up to 98% yield, >19:1 dr, and >99% ee). |
2023-03-15 |
2023-08-14 |
Not clear |
| Pengwei Ji, Xiaopei Liu, Jiwei Xu, Xu Zhang, Jianhua Guo, Wen-Wen Chen, Baoguo Zha. Direct Asymmetric α-C-H Addition of N-unprotected Propargylic Amines to Trifluoromethyl Ketones by Carbonyl Catalysis. Angewandte Chemie (International ed. in English). 2022-10-09. PMID:36210342. |
by using a chiral pyridoxal as carbonyl catalyst, we have successfully realized direct asymmetric a-c-h addition of n-unprotected propargylic amines to trifluoromethyl ketones, producing a broad range of chiral alkynyl b-aminoalcohols in 54~84% yields with excellent stereoselectivities (up to 20:1 dr and 99% ee). |
2022-10-09 |
2023-08-14 |
Not clear |
| Jesse J Jung, Shen Yi Lim, Xavier Chan, Srinivas R Sadda, Quan V Hoan. Correlation of Diabetic Disease Severity to Degree of Quadrant Asymmetry in En Face OCTA Metrics. Investigative ophthalmology & visual science. vol 63. issue 9. 2022-08-09. PMID:35943732. |
to determine if diabetic retinopathy (dr) severity affects quadrant asymmetry (qa) of optical coherence tomography angiography (octa) metrics differentially. |
2022-08-09 |
2023-08-14 |
Not clear |
| Wei Wang, Fangqing Zhang, Yangbin Liu, Xiaoming Fen. Diastereo- and Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters via Iridium/Europium Bimetallic Catalysis. Angewandte Chemie (International ed. in English). 2022-08-02. PMID:35916194. |
we here report a synergistic bimetallic catalysis via a chiral n,n' -dioxide-europium (eu) complex and a phosphoramidite-iridium (ir) catalyst for the asymmetric allylation of oxindole derivatives by using challenging trisubstituted allylic esters. the allylated products bearing vicinal all-carbon quaternary stereocenters were obtained with good diastereoselectivities (up to 20:1 dr) and excellent enantioselectivities (up to 99% ee). |
2022-08-02 |
2023-08-14 |
Not clear |