| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sasuk Kim, Ji-Min Park, Jisook Moon, Hyun Jin Cho. Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress. Experimental neurology. vol 252. 2014-03-10. PMID:24252179. |
based on our previous study showing that overexpression of wild-type or mutant α-synuclein (α-syn) interferes with camp/pka-dependent transcriptional activation in norepinephrine (ne)-producing cells, the effect of wild-type and mutant α-syn on camp response element (cre)-mediated regulation of the ne-synthesizing enzyme dopamine β-hydroxylase (dbh) was evaluated in this study. |
2014-03-10 |
2023-08-12 |
mouse |
| Ho Jang Kwon, Myung Ho Li. Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children. Genetic testing and molecular biomarkers. vol 17. issue 7. 2014-02-12. PMID:23692268. |
the aim of the present study was to investigate the association between the genetic type and alleles for the dopamine beta-hydroxylase (dbh) gene in korean children with adhd. |
2014-02-12 |
2023-08-12 |
human |
| Daniel F Manvich, Lauren M DePoy, David Weinshenke. Dopamine β-hydroxylase inhibitors enhance the discriminative stimulus effects of cocaine in rats. The Journal of pharmacology and experimental therapeutics. vol 347. issue 3. 2014-01-23. PMID:24068832. |
inhibitors of dopamine β-hydroxylase (dbh), the enzyme that converts dopamine (da) to norepinephrine (ne) in noradrenergic cells, have shown promise for the treatment of cocaine abuse disorders. |
2014-01-23 |
2023-08-12 |
human |
| Alessandro Zaru, Paola Maccioni, Giancarlo Colombo, Gian Luigi Gess. The dopamine β-hydroxylase inhibitor, nepicastat, suppresses chocolate self-administration and reinstatement of chocolate seeking in rats. The British journal of nutrition. vol 110. issue 8. 2014-01-22. PMID:23561307. |
nepicastat is a selective dopamine β-hydroxylase (dbh) inhibitor that suppresses cocaine-primed reinstatement of cocaine seeking in rats. |
2014-01-22 |
2023-08-12 |
human |
| Li Hui, Xuan Zhang, Ya Qin Yu, Mei Han, Xu Feng Huang, Da Chun Chen, Zhi Ren Wang, Wei Li Du, Chang Gui Kou, Qiong Yu, Thomas R Kosten, Xiang Yang Zhan. Association between DBH 19 bp insertion/deletion polymorphism and cognition in first-episode schizophrenic patients. Schizophrenia research. vol 147. issue 2-3. 2014-01-17. PMID:23707643. |
many genes associated with dopamine (da) and norepinephrine (ne) systems influence cognitive deficits of schizophrenia patients, but one key enzyme is dopamine beta-hydroxylase (dbh), which converts da to ne and whose activity and levels are under strong genetic control. |
2014-01-17 |
2023-08-12 |
Not clear |
| Soo-Jeong Kim, Eun Sook Chung, Jun-Ho Lee, Chang Hoon Lee, Sun Kwang Kim, Hye-Jung Lee, Hyunsu Ba. Electroacupuncture Analgesia Is Improved by Adenoviral Gene Transfer of Dopamine Beta-hydroxylase into the Hypothalamus of Rats. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 6. 2014-01-01. PMID:24381499. |
the dopamine beta-hydroxylase (dbh) gene was more abundantly expressed in the hypothalamus of responder rats than non-responder rats. |
2014-01-01 |
2023-08-12 |
rat |
| Maja Mustapic, Paola Presecki, Nela Pivac, Ninoslav Mimica, Patrick R Hof, Goran Simic, Vera Folnegovic-Smalc, Dorotea Muck-Sele. Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 44. 2013-12-18. PMID:23416088. |
dopamine beta-hydroxylase (dbh) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (na) synthesis and turnover. |
2013-12-18 |
2023-08-12 |
Not clear |
| Na Zhou, Qiong Yu, Xiaokun Li, Yaqin Yu, Changgui Kou, Wenjun Li, Hongqin Xu, Xingguang Luo, Lingjun Zuo, Thomas R Kosten, Xiang Yang Zhan. Association of the dopamine β-hydroxylase 19 bp insertion/deletion polymorphism with positive symptoms but not tardive dyskinesia in schizophrenia. Human psychopharmacology. vol 28. issue 3. 2013-12-18. PMID:23559427. |
dopamine beta-hydroxylase (dbh) is a key enzyme in the conversion of dopamine to norepinephrine, and plasma dbh activity is altered in td patients. |
2013-12-18 |
2023-08-12 |
Not clear |
| J Zhang, X Liu, L Zhao, S Hu, S Li, F Pia. Subchronic exposure to arsenic disturbed the biogenic amine neurotransmitter level and the mRNA expression of synthetase in mice brains. Neuroscience. vol 241. 2013-12-12. PMID:23518225. |
the ultra-structural change of vesicles in the synapses of mice brains was observed by transmission electron microscopy; the mrna expressions of dopamine beta hydroxylase (dbh), tyrosine hydroxylase (th) and tryptophan hydroxylase (tph) as ne, da and 5-ht synthetases were quantitatively assessed by real time reverse transcription-polymerase chain reaction. |
2013-12-12 |
2023-08-12 |
mouse |
| Ji Ho Kim, Yeon Kyung Son, Gun Hee Kim, Keum Hee Hwan. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomolecules & therapeutics. vol 21. issue 3. 2013-11-22. PMID:24265870. |
xanthoangelol is a nonselective mao inhibitor, and a potent dopamine β-hydroxylase (dbh) inhibitor. |
2013-11-22 |
2023-08-12 |
Not clear |
| Georg M Stettner, Yanlin Lei, Kate Benincasa Herr, Leszek Kubi. Evidence that adrenergic ventrolateral medullary cells are activated whereas precerebellar lateral reticular nucleus neurons are suppressed during REM sleep. PloS one. vol 8. issue 4. 2013-11-12. PMID:23630631. |
most were found in the adrenergic c1 region and at sites located less than 50 µm from dopamine β-hydroxylase-positive (dbh(+)) neurons. |
2013-11-12 |
2023-08-12 |
rat |
| Thomas R Kosten, Coreen B Domingo, Sara C Hamon, David A Nielse. DBH gene as predictor of response in a cocaine vaccine clinical trial. Neuroscience letters. vol 541. 2013-09-03. PMID:23458673. |
we examined a pharmacogenetic association of the dopamine β-hydroxylase (dbh) gene with a response to an anti-cocaine vaccine that was tested in a recent clinical trial. |
2013-09-03 |
2023-08-12 |
human |
| Xiaohu Xie, Limin Xu, Huifen Liu, Weisheng Chen, Dingding Zhuang, Jianbing Zhang, Shiwei Duan, Wenhua Zho. Positive association between--1021TT genotype of dopamine beta hydroxylase gene and progressive behavior of injection heroin users. Neuroscience letters. vol 541. 2013-09-03. PMID:23510745. |
by balancing the ratios of dopamine and norepinephrine, dopamine beta hydroxylase (dbh) plays an important role in brain reward circuit that is involved with behavioral effects of heroin addiction. |
2013-09-03 |
2023-08-12 |
Not clear |
| Jayashri Ghosh, Sunil Pradhan, Balraj Mitta. Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility. Neuromolecular medicine. vol 15. issue 1. 2013-08-29. PMID:22875483. |
dopamine beta hydroxylase (dbh) is responsible for maintaining dopamine-to-norepinephrine ratio implicated in migraine pathophysiology. |
2013-08-29 |
2023-08-12 |
Not clear |
| Daniel P Czech, Joohyung Lee, Helena Sim, Clare L Parish, Eric Vilain, Vincent R Harle. The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22568433. |
in the human neuroblastoma cell line, m17, sry knockdown resulted in a reduction in th, ddc, dbh and mao-a expression; enzymes which control dopamine synthesis and metabolism. |
2013-08-14 |
2023-08-12 |
human |
| Daniel P Czech, Joohyung Lee, Helena Sim, Clare L Parish, Eric Vilain, Vincent R Harle. The human testis-determining factor SRY localizes in midbrain dopamine neurons and regulates multiple components of catecholamine synthesis and metabolism. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22568433. |
conversely, sry over-expression increased th, ddc, dbh, d2 r and mao-a levels, accompanied by increased extracellular dopamine levels. |
2013-08-14 |
2023-08-12 |
human |
| b' Jan Lochman, Vladimir J Balcar, Franti\\xc5\\xa1ek S\\xc5\\xa5astn\\xc3\\xbd, Omar Ser\\xc3\\xb. Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes. Psychiatry research. vol 205. issue 1-2. 2013-08-09. PMID:22940547.' |
eight single nucleotide polymorphisms (snps) in regulating or coding regions of genes for the alpha-2a adrenergic receptor (adra2a), dopamine receptors d1 and d3 (drd1 and drd3), dopamine β-hydroxylase (dbh) and snap-25 were genotyped in male patients with schizophrenia (n=192) and in healthy controls (n=213). |
2013-08-09 |
2023-08-12 |
Not clear |
| Jan Rodriguez Parkitna, Wojciech Solecki, Krystyna Gołembiowska, Krzysztof Tokarski, Jakub Kubik, Sławomir Gołda, Martin Novak, Rosanna Parlato, Grzegorz Hess, Rolf Sprengel, Ryszard Przewłock. Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. The international journal of neuropsychopharmacology. vol 15. issue 10. 2013-07-15. PMID:22040728. |
to investigate how noradrenergic system activity is controlled in the context associated with drug-induced behaviours, we generated a cre/loxp mouse model in which the essential glutamate nmda receptor subunit nr1 is ablated in cells expressing dopamine β-hydroxylase (dbh). |
2013-07-15 |
2023-08-12 |
mouse |
| D B Spronk, C P M Veth, M Arns, P R Schofield, C Dobson-Stone, J G Ramaekers, B Franke, E R A de Bruijn, R J Verke. DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 124. issue 5. 2013-06-12. PMID:23261162. |
the current study was conducted to determine whether functional variants of the catechol-o-methyltransferase (comt) and dopamine beta-hydroxylase (dbh) gene were associated with p300 amplitude and latency in an auditory oddball task. |
2013-06-12 |
2023-08-12 |
Not clear |
| Xiaohui Liu, Fengyuan Piao, Yachen L. Protective effect of taurine on the decreased biogenic amine neurotransmitter levels in the brain of mice exposed to arsenic. Advances in experimental medicine and biology. vol 776. 2013-06-12. PMID:23392890. |
the mrna expressions of dopamine beta hydroxylase (dbh), tyrosine hydroxylase (th), and tryptophan hydroxylase (tph) as ne, da, and 5-ht synzymes were also analyzed by real-time rt-pcr. |
2013-06-12 |
2023-08-12 |
mouse |