| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sucharita S Somkuwar, Mahesh Darna, Kathleen M Kantak, Linda P Dwoski. Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood. Biochemical pharmacology. vol 86. issue 2. 2013-09-03. PMID:23623751. |
methylphenidate, an inhibitor of dopamine and norepinephrine transporters (dat and net, respectively), is a standard treatment for adhd. |
2013-09-03 |
2023-08-12 |
rat |
| Sucharita S Somkuwar, Mahesh Darna, Kathleen M Kantak, Linda P Dwoski. Adolescence methylphenidate treatment in a rodent model of attention deficit/hyperactivity disorder: dopamine transporter function and cellular distribution in adulthood. Biochemical pharmacology. vol 86. issue 2. 2013-09-03. PMID:23623751. |
in both ofc and mpfc, no strain differences in vmax or km for dopamine uptake into synaptosomes were found between vehicle-treated shr, wky and wis. methylphenidate increased dat vmax in shr mpfc and decreased dat vmax in wky ofc. |
2013-09-03 |
2023-08-12 |
rat |
| Nicholas V Cozzi, Simon D Brandt, Paul F Daley, John S Partilla, Richard B Rothman, Andreas Tulzer, Harald H Sitte, Michael H Bauman. Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs. European journal of pharmacology. vol 699. issue 1-3. 2013-09-02. PMID:23178523. |
at the norepinephrine and dopamine transporters (net and dat), all tfmap isomers were less potent than methcathinone as uptake inhibitors and releasers. |
2013-09-02 |
2023-08-12 |
rat |
| Kyle C Schmitt, Richard B Rothman, Maarten E A Reit. Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates. The Journal of pharmacology and experimental therapeutics. vol 346. issue 1. 2013-08-30. PMID:23568856. |
the dopamine transporter (dat) is a sodium-coupled symporter protein responsible for modulating the concentration of extraneuronal dopamine in the brain. |
2013-08-30 |
2023-08-12 |
Not clear |
| Kyle C Schmitt, Richard B Rothman, Maarten E A Reit. Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates. The Journal of pharmacology and experimental therapeutics. vol 346. issue 1. 2013-08-30. PMID:23568856. |
whereas inhibitors block monoamine uptake by the dat but are not translocated across the membrane, substrates are actively translocated and trigger dat-mediated release of dopamine by reversal of the translocation cycle. |
2013-08-30 |
2023-08-12 |
Not clear |
| Kyle C Schmitt, Richard B Rothman, Maarten E A Reit. Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates. The Journal of pharmacology and experimental therapeutics. vol 346. issue 1. 2013-08-30. PMID:23568856. |
because both inhibitors and substrates increase extraneuronal dopamine levels, it is often assumed that all dat ligands possess an addictive liability equivalent to that of cocaine. |
2013-08-30 |
2023-08-12 |
Not clear |
| Joseph J Gallagher, Xiaowei Zhang, F Scott Hall, George R Uhl, Elaine L Bearer, Russell E Jacob. Altered reward circuitry in the norepinephrine transporter knockout mouse. PloS one. vol 8. issue 3. 2013-08-27. PMID:23469209. |
this is similar to previous results observed for the dopamine transporter (dat) knockout mouse, but dissimilar from work with serotonin transporter (sert) knockout mice where mn(2+) tracings extended to more posterior structures than in wildtype animals. |
2013-08-27 |
2023-08-12 |
mouse |
| Dominik K Biezonski, Brian J Piper, Nina M Shinday, Peter J Kim, Syed F Ali, Jerrold S Meye. Effects of a short-course MDMA binge on dopamine transporter binding and on levels of dopamine and its metabolites in adult male rats. European journal of pharmacology. vol 701. issue 1-3. 2013-08-22. PMID:23276666. |
the objective of this study was to determine the influence of mdma on subsequent levels of two different markers of dopaminergic function, the dopamine transporter (dat) as well as dopamine and its major metabolites. |
2013-08-22 |
2023-08-12 |
rat |
| Dominik K Biezonski, Brian J Piper, Nina M Shinday, Peter J Kim, Syed F Ali, Jerrold S Meye. Effects of a short-course MDMA binge on dopamine transporter binding and on levels of dopamine and its metabolites in adult male rats. European journal of pharmacology. vol 701. issue 1-3. 2013-08-22. PMID:23276666. |
importantly, dat expression may be more vulnerable to perturbation by mdma than dopamine itself. |
2013-08-22 |
2023-08-12 |
rat |
| Raymond F Anton, Konstantin K Voronin, Patrick K Randall, Hugh Myrick, Abraham Tiffan. Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes. Alcoholism, clinical and experimental research. vol 36. issue 11. 2013-08-20. PMID:22551036. |
this study investigated the effects of the oprm1 snp and dopamine transporter (dat) variable number of tandem repeat (vntr) genetic differences on drinking, alcohol effects, and naltrexone response under controlled conditions in nontreatment-seeking alcoholics. |
2013-08-20 |
2023-08-12 |
Not clear |
| Flavio Nobili, Mehrdad Naseri, Fabrizio De Carli, Susan Asenbaum, Jan Booij, Jacques Darcourt, Peter Ell, Ozlem Kapucu, Paul Kemp, Claus Svarer, Claus Varer, Silvia Morbelli, Marco Pagani, Osama Sabri, Klaus Tatsch, Livia Tossici-Bolt, Terez Sera, Tierry Vander Borght, Koen Van Laere, Andrea Varron. Automatic semi-quantification of [123I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database. European journal of nuclear medicine and molecular imaging. vol 40. issue 4. 2013-08-20. PMID:23232506. |
the aim of this study was to assess striatal dopamine transporter (dat) availability in a large group of normal subjects. |
2013-08-20 |
2023-08-12 |
human |
| R Ceravolo, D Frosini, M Poletti, L Kiferle, C Pagni, S Mazzucchi, D Volterrani, U Bonuccell. Mild affective symptoms in de novo Parkinson's disease patients: relationship with dopaminergic dysfunction. European journal of neurology. vol 20. issue 3. 2013-08-15. PMID:23078376. |
the investigation of the relationship between affective symptoms and dopamine transporter (dat) density provided conflicting data in both parkinson's disease (pd) and non-pd patients. |
2013-08-15 |
2023-08-12 |
Not clear |
| Lu-Tai Tien, Asuka Kaizaki, Yi Pang, Zhengwei Cai, Abhay J Bhatt, Lir-Wan Fa. Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. Toxicology. vol 308. 2013-08-13. PMID:23567316. |
to further investigate the enhanced adult susceptibility by neonatal lps exposure to rotenone neurotoxicity, we used our neonatal rat model of lps exposure (1mg/kg, intracerebral injection in postnatal day 5, p5, neonatal rats) to examine the protein levels of α-synuclein and dopamine transporters (dat) in the adult rat. |
2013-08-13 |
2023-08-12 |
rat |
| In-Uk Song, Young-Do Kim, Hyun-Ji Cho, Sung-Woo Chung, Yong-An Chun. An FP-CIT PET comparison of the differences in dopaminergic neuronal loss between idiopathic Parkinson disease with dementia and without dementia. Alzheimer disease and associated disorders. vol 27. issue 1. 2013-08-12. PMID:22354157. |
previous studies have demonstrated a decreased density of dopamine transporters (dat) in basal ganglia in patients with idiopathic parkinson disease (ipd) using i-n-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (fp-cit), and the reductions in striatal dat levels were inversely correlated with the severity of motor dysfunction in ipd. |
2013-08-12 |
2023-08-12 |
Not clear |
| Jay D Amsterdam, Andrew B Newberg, Irene Soeller, Justine Shult. Greater striatal dopamine transporter density may be associated with major depressive episode. Journal of affective disorders. vol 141. issue 2-3. 2013-08-12. PMID:22482744. |
we examined striatal dopamine transporter (dat) distribution volume ratio (dvr) values in subjects with unipolar or bipolar major depressive episode (versus non-depressed healthy volunteers) using the selective dat radioligand [(99m)tc]trodat-1 and single photon emission computed tomography (spect). |
2013-08-12 |
2023-08-12 |
human |
| Kao Chin Chen, Yen Kuang Yang, Oliver Howes, I Hui Lee, Sabine Landau, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Ru Band Lu, Anthony S David, Elvira Bramo. Striatal dopamine transporter availability in drug-naive patients with schizophrenia: a case-control SPECT study with [(99m)Tc]-TRODAT-1 and a meta-analysis. Schizophrenia bulletin. vol 39. issue 2. 2013-08-09. PMID:22156764. |
our study aimed to compare dopamine transporter (dat) availability between drug-naive patients with schizophrenia and controls using spect. |
2013-08-09 |
2023-08-12 |
Not clear |
| Fuat Balcı, Martin Wiener, Bilgehan Cavdaroğlu, H Branch Coslet. Epistasis effects of dopamine genes on interval timing and reward magnitude in humans. Neuropsychologia. vol 51. issue 2. 2013-08-09. PMID:22903038. |
these gene polymorphisms affected the expression of catechol-o-methyltransferase, which catabolizes synaptic dopamine primarily in the prefrontal cortex (comt val158met polymorphism), d2 dopamine receptors primarily in the striatum (drd2/ankk1-taq1a polymorphism), and dopamine transporters, which clear synaptic dopamine in the striatum (dat 3' vntr variant). |
2013-08-09 |
2023-08-12 |
human |
| Foteini Delis, Ada Mitsacos, Panagiotis Giompre. Lesion of the cerebellar paravermis increases dopamine D1 receptor levels in the contralateral striatum. Journal of chemical neuroanatomy. vol 47. 2013-08-09. PMID:23116569. |
the lesion produced a statistically significant increase in drd1 specific binding in the contralateral medial striatum and a bilateral decrease in dopamine transporter (dat) levels in the dorsolateral striatum. |
2013-08-09 |
2023-08-12 |
Not clear |
| Jeffrey H Meye. Neurochemical imaging and depressive behaviours. Current topics in behavioral neurosciences. vol 14. 2013-08-08. PMID:23018753. |
a similar mechanism may explain the association between neuroimaging indices of greater dorsal striatal d2 density, dat density and symptoms of motor retardation: greater mao-a level and relatively greater dat density lower extracellular dopamine in the dorsal striatum, leading to motor retardation. |
2013-08-08 |
2023-08-12 |
Not clear |
| Jonathan B Savitz, Wayne C Drevet. Neuroreceptor imaging in depression. Neurobiology of disease. vol 52. 2013-08-05. PMID:22691454. |
we also review pet studies of the serotonin transporter (5-htt), the dopamine transporter (dat), monoamine oxidase a (mao-a), and the muscarinic 2 receptor (m2). |
2013-08-05 |
2023-08-12 |
human |