| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew F Covington, Natalie A McMillan, Ryan J Avery, Phillip H Ku. The semicolon sign: dopamine transporter imaging artifact from head tilt. Journal of nuclear medicine technology. vol 41. issue 2. 2014-01-15. PMID:23520210. |
dopamine transporter (dat) imaging is a valuable tool to aid in the diagnosis of parkinson disease and other parkinsonian syndromes. |
2014-01-15 |
2023-08-12 |
Not clear |
| Roxanne A Vaughan, James D Foste. Mechanisms of dopamine transporter regulation in normal and disease states. Trends in pharmacological sciences. vol 34. issue 9. 2014-01-10. PMID:23968642. |
the dopamine (da) transporter (dat) controls the spatial and temporal dynamics of da neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. |
2014-01-10 |
2023-08-12 |
Not clear |
| Jennie Garcia-Olivares, Delany Torres-Salazar, William A Owens, Tracy Baust, David P Siderovski, Susan G Amara, Jun Zhu, Lynette C Daws, Gonzalo E Torre. Inhibition of dopamine transporter activity by G protein βγ subunits. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555781. |
uptake through the dopamine transporter (dat) is the primary mechanism of terminating dopamine signaling within the brain, thus playing an essential role in neuronal homeostasis. |
2014-01-07 |
2023-08-12 |
mouse |
| Jennie Garcia-Olivares, Delany Torres-Salazar, William A Owens, Tracy Baust, David P Siderovski, Susan G Amara, Jun Zhu, Lynette C Daws, Gonzalo E Torre. Inhibition of dopamine transporter activity by G protein βγ subunits. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555781. |
over the last 15 years, several studies have revealed a plethora of mechanisms influencing the activity and cellular distribution of dat; suggesting that fine-tuning of dopamine homeostasis occurs via an elaborate interplay of multiple pathways. |
2014-01-07 |
2023-08-12 |
mouse |
| Pablo Pandolfo, Nuno J Machado, Attila Köfalvi, Reinaldo N Takahashi, Rodrigo A Cunh. Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 4. 2014-01-06. PMID:22561003. |
shr were hyperactive and had poorer performance in the attentional set-shifting and y-maze paradigms and also displayed increased dopamine transporter (dat) density and increased dopamine uptake in frontocortical and striatal terminals compared with wky rats. |
2014-01-06 |
2023-08-12 |
rat |
| Martin Niethammer, Chris C Tang, Yilong Ma, Paul J Mattis, Ji Hyun Ko, Vijay Dhawan, David Eidelber. Parkinson's disease cognitive network correlates with caudate dopamine. NeuroImage. vol 78. 2014-01-06. PMID:23578575. |
in this study, 17 non-demented pd patients underwent positron emission tomography (pet) imaging with [(18)f]-fluorodeoxyglucose to measure pdcp expression, and [(18)f]-fluoropropyl-β-cit (fpcit) to measure dopamine transporter (dat) binding. |
2014-01-06 |
2023-08-12 |
human |
| Candan Depboylu, Lukas Maurer, Andreas Matusch, Guido Hermanns, Andrea Windolph, Martin Béhé, Wolfgang H Oertel, Günter U Höglinge. Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry. NeuroImage. vol 79. 2014-01-06. PMID:23631981. |
a previous clinical trial studied the effect of long-term treatment with levodopa (ld) or the dopamine agonist pramipexole (ppx) on disease progression in parkinson disease using spect with the dopamine transporter (dat)-radioligand [(123)i]β-cit as surrogate marker. |
2014-01-06 |
2023-08-12 |
mouse |
| Jordy van Enkhuizen, Mark A Geyer, Klaas Kooistra, Jared W Youn. Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice. The international journal of neuropsychopharmacology. vol 16. issue 5. 2014-01-03. PMID:23164454. |
this abnormal profile is also observed in mice with reduced function of the dopamine transporter (dat) through either constitutive genetic [knockdown (kd)] or acute pharmacological (gbr12909) means. |
2014-01-03 |
2023-08-12 |
mouse |
| Craig F Ferris, Mathieu Marella, Brian Smerkers, Thomas M Barchet, Benjamin Gershman, Akemi Matsuno-Yagi, Takao Yag. A phenotypic model recapitulating the neuropathology of Parkinson's disease. Brain and behavior. vol 3. issue 4. 2014-01-01. PMID:24381808. |
levels of vesicular monoamine transporter 2 (vmat2) were significantly reduced in the dorsal striatum; however, there was an unexpected increase in dopamine transporter (dat) levels. |
2014-01-01 |
2023-08-12 |
rat |
| Luke R Gabriel, Sijia Wu, Patrick Kearney, Karl D Bellvé, Clive Standley, Kevin E Fogarty, Haley E Melikia. Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 45. 2013-12-30. PMID:24198373. |
the presynaptic dopamine (da) transporter (dat) recaptures released da, thereby limiting synaptic da availability and maintaining dopaminergic tone. |
2013-12-30 |
2023-08-12 |
mouse |
| Seyed Khosrow Tayebati, Daniele Tomassoni, Innocent Ejike Nwankwo, Antonio Di Stefano, Piera Sozio, Laura Serafina Cerasa, Francesco Ament. Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. CNS & neurological disorders drug targets. vol 12. issue 1. 2013-12-23. PMID:23244432. |
the present study was designed to assess the influence of treatment for 7 days with choline-equivalent doses (cdp-choline: 325 mg/kg/day; gpc: 150 mg/kg/day) of these compounds on brain dopamine (da), and serotonin (5-ht) levels and on da plasma membrane transporter (dat), vesicular monoamine transporters (vmat1 and vmat2), serotonin transporter (sert), and norepinephrine transporter (net) in the rat. |
2013-12-23 |
2023-08-12 |
rat |
| Cheng-Kuan Wu, Kao Chin Chen, Po See Chen, Nan-Tsing Chiu, Tzung Lieh Yeh, I Hui Lee, Yen Kuang Yan. No changes in striatal dopamine transporter in antidepressant-treated patients with major depression. International clinical psychopharmacology. vol 28. issue 3. 2013-12-23. PMID:23524636. |
eight participants with major depressive disorder were administered single-photon emission computed tomography with [(99m)tc] trodat-1 both before and after 24 weeks of antidepressant treatment to evaluate the change in striatal dopamine transporter (dat) availability. |
2013-12-23 |
2023-08-12 |
human |
| Meredith A Fox, Micaella G Panessiti, F Scott Hall, George R Uhl, Dennis L Murph. An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice. Psychopharmacology. vol 227. issue 4. 2013-12-18. PMID:23417514. |
an evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (dat) knockout mice. |
2013-12-18 |
2023-08-12 |
mouse |
| Meredith A Fox, Micaella G Panessiti, F Scott Hall, George R Uhl, Dennis L Murph. An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice. Psychopharmacology. vol 227. issue 4. 2013-12-18. PMID:23417514. |
mice lacking the dopamine transporter (dat) display major behavioral alterations that include hyperactivity, perseverative locomotor patterns, and reduced prepulse inhibition of the acoustic startle reflex. |
2013-12-18 |
2023-08-12 |
mouse |
| Susumu Hara, Shigeki Arawaka, Hiroyasu Sato, Youhei Machiya, Can Cui, Asuka Sasaki, Shingo Koyama, Takeo Kat. Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner. Molecular biology of the cell. vol 24. issue 11. 2013-12-17. PMID:23576548. |
however, wild-type and s129a α-syn equally increase the cell surface expression of dopamine transporter (dat) in sh-sy5y cells and nonneuronal hek293 cells. |
2013-12-17 |
2023-08-12 |
Not clear |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
the dopamine transporter (dat) clears the extracellular dopamine released during neurotransmission and is a major target for both therapeutic and addictive psychostimulant amphetamines. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
however, in dopamine neurons, the trafficking itinerary and fate of internalized dat has not been elucidated. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
by monitoring surface-labeled dat in transfected dopamine neurons from embryonic rat mesencephalic cultures, we find distinct sorting and fates of internalized dat after amphetamine or pma treatment. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
although both drugs promote dat internalization above constitutive endocytosis in dopamine neurons, pma induces ubiquitination of dat and leads to accumulation of dat on lamp1-positive endosomes. |
2013-12-16 |
2023-08-12 |
rat |
| Weimin C Hong, Susan G Amar. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 8. 2013-12-16. PMID:23612789. |
furthermore, quantitative assessment of dat recycling using an antibody-feeding assay reveals that significantly less dat returns to the surface of dopamine neurons after internalization by pma, compared with vehicle or amphetamine treatment. |
2013-12-16 |
2023-08-12 |
rat |