| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luis M Colon-Perez, Jose A Pino, Kaustuv Saha, Marjory Pompilus, Sherman Kaplitz, Nafisa Choudhury, Darin A Jagnarine, Jean R Geste, Brandon A Levin, Isaac Wilks, Barry Setlow, Adriaan W Bruijnzeel, Habibeh Khoshbouei, Gonzalo E Torres, Marcelo Feb. Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone. Neuropharmacology. vol 137. 2019-02-20. PMID:29729891. |
at the molecular level, mdpv downregulated the dopamine transporter (dat) in striatum and produced a shift in its subcellular distribution, an effect likely to involve rapid internalization at the membrane. |
2019-02-20 |
2023-08-13 |
rat |
| Julian Maier, Felix P Mayer, Dino Luethi, Marion Holy, Kathrin Jäntsch, Harald Reither, Lena Hirtler, Marius C Hoener, Matthias E Liechti, Christian Pifl, Simon D Brandt, Harald H Sitt. The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters. Neuropharmacology. vol 138. 2019-02-13. PMID:29908239. |
we used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-dmar on human high-affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2019-02-13 |
2023-08-13 |
human |
| Carmelo Sgobio, Junbing Wu, Wang Zheng, Xi Chen, Jing Pan, Armando G Salinas, Margaret I Davis, David M Lovinger, Huaibin Ca. Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum. Scientific reports. vol 7. issue 1. 2019-02-12. PMID:28706191. |
additionally, the presence of pd-related human α-synuclein a53t mutant or dopamine transporter (dat) blockers also differentially affects the dopamine output in striosomes and matrix. |
2019-02-12 |
2023-08-13 |
mouse |
| G Pagano, T Yousaf, H Wilson, F Niccolini, S Polychronis, K R Chaudhuri, M Politi. Constipation is not associated with dopamine transporter pathology in early drug-naïve patients with Parkinson's disease. European journal of neurology. vol 25. issue 2. 2019-02-04. PMID:29078029. |
the aim of the study was to investigate whether constipation is associated with dopaminergic pathology on dopamine transporter (dat) single-photon emission computed tomography in early drug-naïve patients with pd. |
2019-02-04 |
2023-08-13 |
Not clear |
| Danielle O Sambo, Joseph J Lebowitz, Habibeh Khoshboue. The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. Pharmacology & therapeutics. vol 186. 2019-02-04. PMID:29360540. |
meth is a potent psychostimulant that increases extracellular dopamine levels by targeting the dopamine transporter (dat) and alters neuronal activity in the reward centers of the brain. |
2019-02-04 |
2023-08-13 |
Not clear |
| Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar, Wouter Koek, Harald H Sitte, Paul D Callaghan, Benjamin H Fraser, Lynette C Daw. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. European journal of pharmacology. vol 842. 2019-02-04. PMID:30473490. |
here, we extend these findings to determine the affinity of these analogs for oct2, oct3 and pmat, as well as serotonin, norepinephrine and dopamine transporters (sert, net and dat) using a combination of uptake competition with [ |
2019-02-04 |
2023-08-13 |
mouse |
| Shreesh Raj Sammi, Zeynep Sena Agim, Jason R Canno. From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis elegans. Toxicological sciences : an official journal of the Society of Toxicology. vol 161. issue 2. 2019-01-30. PMID:29069497. |
blocking transport through the dopamine transporter (dat) was not neuroprotective, suggesting that harmane is unlikely to enter the cell through dat. |
2019-01-30 |
2023-08-13 |
caenorhabditis_elegans |
| Arman Rahmim, Peng Huang, Nikolay Shenkov, Sima Fotouhi, Esmaeil Davoodi-Bojd, Lijun Lu, Zoltan Mari, Hamid Soltanian-Zadeh, Vesna Soss. Improved prediction of outcome in Parkinson's disease using radiomics analysis of longitudinal DAT SPECT images. NeuroImage. Clinical. vol 16. 2019-01-29. PMID:29868437. |
dopamine transporter (dat) spect imaging is widely used for diagnostic purposes in pd. |
2019-01-29 |
2023-08-13 |
human |
| Sonia Abad, Carla Ramon, David Pubill, Jorge Camarasa, Antonio Camins, Elena Escubed. Adolescent exposure to MDMA induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of APPswe/PS1dE9 mice. Biochimica et biophysica acta. vol 1862. issue 9. 2019-01-28. PMID:27344237. |
shortly after the injury, wild-type animals showed a decrease in the locomotor activity and apparent da depletion in striatum, however in the app/ps1 mice neither the locomotor activity nor the da levels were modified, but a reduction in dopamine transporter (dat) expression and a higher levels of oxidative stress were observed. |
2019-01-28 |
2023-08-13 |
mouse |
| Kathrine Louise Jensen, Gunnar Sørensen, Ditte Dencker, William Anthony Owens, Troels Rahbek-Clemmensen, Michael Brett Lever, Annika H Runegaard, Nikolaj Riis Christensen, Pia Weikop, Gitta Wörtwein, Anders Fink-Jensen, Kenneth L Madsen, Lynette Daws, Ulrik Gether, Mattias Rickha. PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. eNeuro. vol 5. issue 3. 2019-01-25. PMID:29911172. |
protein interacting with c-kinase 1 (pick1) is a widely expressed scaffold protein known to interact via its psd-95/discs-large/zo-1 (pdz)-domain with several membrane proteins including the dopamine (da) transporter (dat), the primary target for cocaine's reinforcing actions. |
2019-01-25 |
2023-08-13 |
mouse |
| Freja Herborg, Thorvald F Andreassen, Frida Berlin, Claus J Loland, Ulrik Gethe. Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes. The Journal of biological chemistry. vol 293. issue 19. 2019-01-22. PMID:29559554. |
the dopamine transporter (dat) has received continuous attention as a potential risk factor for psychiatric disease, as it is critical for dopamine homeostasis and serves as principal target for adhd medications. |
2019-01-22 |
2023-08-13 |
Not clear |
| Shiqi Ma, Mary H Cheng, Daryl A Guthrie, Amy H Newman, Ivet Bahar, Alexander Sorki. Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter. Scientific reports. vol 7. issue 1. 2019-01-15. PMID:28710426. |
dopamine transporter (dat) has been shown to accumulate in filopodia in neurons and non-neuronal cells. |
2019-01-15 |
2023-08-13 |
Not clear |
| Gabriel Núñez-Vivanco, Angélica Fierro, Pablo Moya, Patricio Iturriaga-Vásquez, Miguel Reyes-Parad. 3D similarities between the binding sites of monoaminergic target proteins. PloS one. vol 13. issue 7. 2019-01-11. PMID:30028869. |
in this work, we evaluated the possible existence of similarities among the binding sites of the serotonin transporter (sert), the dopamine transporter (dat), mao-a and mao-b. |
2019-01-11 |
2023-08-13 |
Not clear |
| Keiko Iwat. Studies of a Neuronal Cell Line as a Model of Psychiatric Disorders. Methods in molecular biology (Clifton, N.J.). vol 1735. 2018-12-31. PMID:29380316. |
in the described method, the sh-sy5y neuroblastoma cell line is differentiated to neuronal cell which expresses nse, neuronal marker, and dopamine transporter (dat) by treatment with all-trans-retinoic acid. |
2018-12-31 |
2023-08-13 |
Not clear |
| Han Soo Yoo, Seok Jong Chung, Soo-Jong Kim, Jung Su Oh, Jae Seung Kim, Byoung Seok Ye, Young Ho Sohn, Phil Hyu Le. The role of 18F-FP-CIT PET in differentiation of progressive supranuclear palsy and frontotemporal dementia in the early stage. European journal of nuclear medicine and molecular imaging. vol 45. issue 9. 2018-12-12. PMID:29728749. |
the purpose of this study was to evaluate whether the pattern of striatal dopamine transporter (dat) availability could differentiate between progressive supranuclear palsy (psp) and frontotemporal dementia (ftd) in the first few years of the disease. |
2018-12-12 |
2023-08-13 |
Not clear |
| Erin S Calipari, Barbara Juarez, Carole Morel, Deena M Walker, Michael E Cahill, Efrain Ribeiro, Ciorana Roman-Ortiz, Charu Ramakrishnan, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Dopaminergic dynamics underlying sex-specific cocaine reward. Nature communications. vol 8. 2018-12-11. PMID:28072417. |
during oestrus, ventral tegmental area (vta) dopamine neuron activity is enhanced and drives post translational modifications at the dopamine transporter (dat) to increase the ability of cocaine to inhibit its function, an effect mediated by estradiol. |
2018-12-11 |
2023-08-13 |
mouse |
| Jun Zhu, Subramaniam Ananthan, Chang-Guo Zha. The role of human dopamine transporter in NeuroAIDS. Pharmacology & therapeutics. vol 183. 2018-12-11. PMID:28987321. |
the presynaptic dopamine (da) transporter (dat) is essential for da homeostasis and dopaminergic modulation of the brain function including cognition. |
2018-12-11 |
2023-08-13 |
human |
| Anna Maria Górska, Katarzyna Kamińska, Agnieszka Wawrzczak-Bargieła, Giulia Costa, Micaela Morelli, Ryszard Przewłocki, Grzegorz Kreiner, Krystyna Gołembiowsk. Neurochemical and Neurotoxic Effects of MDMA (Ecstasy) and Caffeine After Chronic Combined Administration in Mice. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29134560. |
mdma acts at dopamine (da) transporter (dat) and serotonin (5-ht) transporter (sert) and is known to induce damage of dopamine and serotonin neurons. |
2018-12-11 |
2023-08-13 |
mouse |
| Sugumar Mani, Sathiya Sekar, Rajamani Barathidasan, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Murugan Sevanan, Saravana Babu Chidambaram, Musthafa Mohamed Essa, Gilles J Guillemin, Meena Kishore Sakharka. Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29427283. |
the ngn significantly downregulated syn and upregulated dopamine transporter (dat) and tyrosine hydroxylase (th) protein expressions. |
2018-12-11 |
2023-08-13 |
mouse |
| Haruka Takeshige, Sachiko Nakayama, Kenya Nishioka, Yuanzhe Li, Yumiko Motoi, Nobutaka Hattor. Marked Reduction in the Striatal Dopamine Transporter Uptake During the Early Stage of Motor Symptoms in Patients with the MAPT N279K Mutation. Internal medicine (Tokyo, Japan). vol 57. issue 20. 2018-12-11. PMID:29877269. |
we herein report two patients harboring the mutation n279k in microtubule-associated protein tau (mapt), who showed parkinsonism with a disease duration within three years from the onset, evaluated by dopamine transporter (dat) [ |
2018-12-11 |
2023-08-13 |
Not clear |