| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordan T Lloyd, Alessandro Martini, Alice McDouall, Rahul Sood, Peter S Freestone, Nicola B Mercuri, Janusz Lipsk. Electrophysiological Characterization of Novel Effects of the Uptake-2 Blocker Decynium-22 (D-22) on Dopaminergic Neurons in the Substantia Nigra Pars Compacta. Neuroscience. vol 396. 2019-04-01. PMID:30447392. |
extracellular levels of dopamine (da) and other monoamines in the brain depend not only on the classic transporters encoded by slc6a gene family such as dat, net and sert, but also a more recently identified group of low-affinity/high-capacity 'uptake-2' transporters, mainly oct3 and pmat. |
2019-04-01 |
2023-08-13 |
mouse |
| Hui-Jun Yang, Seol Hoon Park, Minjung Seo, Young Cheol Weon, Yangho Ki. Neurotoxicology. vol 64. 2019-03-21. PMID:28259768. |
we report the clinical features and imaging findings of presynaptic dopamine transporter (dat) positron emission tomography (pet) in four of patients with liver cirrhosis and concurrent parkinsonism. |
2019-03-21 |
2023-08-13 |
Not clear |
| Yongchul Jang, Insu Kwon, Wankeun Song, Ludmila M Cosio-Lima, Youngil Le. Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy. Neuroscience. vol 379. 2019-03-18. PMID:29559387. |
our biochemical data showed that ee-induced neuroprotection occurs in combination with multiple synergic neuroprotective pathways: (1) increased neurogenesis shown by an increase in brdu-positive neurons; (2) diminished loss of dopaminergic neurons evidenced by upregulated tyrosine hydroxylase (th) and dopamine transporter (dat) levels; (3) increased antioxidant capacity (e.g., cuznsod, catalase, gpx1/2, ho-1, dj1 and prxiii); and (4) enhanced autophagy (lc3 ii, p62, beclin1, bnip3, lamp2, cathepsin l and tfeb). |
2019-03-18 |
2023-08-13 |
mouse |
| Sathiya Sekar, Sugumar Mani, Barathidasan Rajamani, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Abid Bhat, Bipul Ray, Musthafa Mohamed Essa, Gilles J Guillemin, Saravana Babu Chidambara. Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism. Neurotoxicity research. vol 34. issue 3. 2019-03-14. PMID:30006683. |
on the other hand, tel upregulated tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) expressions. |
2019-03-14 |
2023-08-13 |
mouse |
| Hwei-Hsien Chen, Pei-Chi Chang, Shiaw-Pyng Wey, Pei-Mei Chen, Chinpiao Chen, Ming-Huan Cha. Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30223096. |
recovery of motor function was correlated with reversal of nigrostriatal dopaminergic neuronal loss, accompanied by higher tyrosine hydroxylase (th) density, dopamine transporter (dat) expression and vesicular monoamine transporter-2 (vmat2) levels. |
2019-03-14 |
2023-08-13 |
mouse |
| Juan Zhen, Maarten E A Reit. Functional properties of dopamine transporter oligomers after copper linking. Journal of neurochemistry. vol 144. issue 2. 2019-03-12. PMID:29168892. |
dimers of dimers), it is not known whether the oligomeric organization of dat is a prerequisite for its ability to take up dopamine (da), or whether each dat protomer, the subunit of quaternary structure, functions independently in terms of da translocation. |
2019-03-12 |
2023-08-13 |
Not clear |
| Manon Dubol, Christian Trichard, Claire Leroy, Anca-Larisa Sandu, Mehdi Rahim, Bernard Granger, Eleni T Tzavara, Laurent Karila, Jean-Luc Martinot, Eric Artige. Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 4. 2019-03-11. PMID:28829051. |
dopamine transporter (dat) availability was assessed with pet and [ |
2019-03-11 |
2023-08-13 |
human |
| Francesca Romana Rizzo, Mauro Federici, Nicola Biagio Mercur. 3,4-Methylenedioxymethamphetamine (MDMA) Alters Synaptic Dopamine Release in the Dorsal Striatum Through Nicotinic Receptors and DAT Inhibition. Neuroscience. vol 377. 2019-03-11. PMID:29510210. |
3,4-methylenedioxymethamphetamine (mdma) alters synaptic dopamine release in the dorsal striatum through nicotinic receptors and dat inhibition. |
2019-03-11 |
2023-08-13 |
mouse |
| Brenda M Gannon, Michael H Baumann, Donna Walther, Cristian Jimenez-Morigosa, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:30305739. |
synthetic cathinones are common constituents of abused "bath salts" preparations and represent a large family of structurally related compounds that function as cocaine-like inhibitors or amphetamine-like substrates of dopamine (dat), norepinephrine (net), and serotonin (sert) transporters. |
2019-03-11 |
2023-08-13 |
rat |
| Carlo Purcaro, Nicola Vanacore, Federica Moret, Maria Elena Di Battista, Alfonso Rubino, Silvia Pierandrei, Marco Lucarelli, Giuseppe Meco, Francesco Fattapposta, Esterina Pascal. DAT gene polymorphisms (rs28363170, rs393795) and levodopa-induced dyskinesias in Parkinson's disease. Neuroscience letters. vol 690. 2019-03-11. PMID:30316985. |
the present study is aimed to investigate whether polymorphisms in the dopamine transporter gene (dat) are associated with the risk of developing lid. |
2019-03-11 |
2023-08-13 |
human |
| Marius Hienert, Gregor Gryglewski, Mara Stamenkovic, Siegfried Kasper, Rupert Lanzenberge. Striatal dopaminergic alterations in Tourette's syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies. Translational psychiatry. vol 8. issue 1. 2019-03-04. PMID:30072700. |
a total of 8 studies appraised the dopamine transporter (dat) with 111 tourette patients and 93 healthy controls, and could be included in a meta-analytic approach. |
2019-03-04 |
2023-08-13 |
Not clear |
| Clara L Essmann, Katie R Ryan, Muna Elmi, Kimberley Bryon-Dodd, Andrew Porter, Andrew Vaughan, Rachel McMullan, Stephen Nurris. Activation of RHO-1 in cholinergic motor neurons competes with dopamine signalling to control locomotion. PloS one. vol 13. issue 9. 2019-03-04. PMID:30240421. |
dopamine, which is negatively regulated by the dopamine re-uptake transporter (dat), has a central role in modulating locomotion in both humans and c. elegans. |
2019-03-04 |
2023-08-13 |
caenorhabditis_elegans |
| Terence K Y Lai, Ping Su, Hailong Zhang, Fang Li. Development of a peptide targeting dopamine transporter to improve ADHD-like deficits. Molecular brain. vol 11. issue 1. 2019-03-04. PMID:30413217. |
methylphenidate), which increase synaptic dopamine by directly blocking dopamine transporter (dat). |
2019-03-04 |
2023-08-13 |
Not clear |
| Terence K Y Lai, Ping Su, Hailong Zhang, Fang Li. Development of a peptide targeting dopamine transporter to improve ADHD-like deficits. Molecular brain. vol 11. issue 1. 2019-03-04. PMID:30413217. |
here, we investigated an interaction between dat and dopamine d2 receptor (d2r) as a novel target to develop potential therapeutics for the treatment of adhd by using an interfering peptide (tat-dat |
2019-03-04 |
2023-08-13 |
Not clear |
| Cody A Siciliano, Kaustuv Saha, Erin S Calipari, Steve C Fordahl, Rong Chen, Habibeh Khoshbouei, Sara R Jone. Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 2. 2019-02-28. PMID:29175958. |
cocaine abuse disrupts dopamine system function, and reduces cocaine inhibition of the dopamine transporter (dat), which results in tolerance. |
2019-02-28 |
2023-08-13 |
rat |
| Peijian Yue, Lin Gao, Xuejing Wang, Xuebing Ding, Junfang Ten. Ultrasound-triggered effects of the microbubbles coupled to GDNF- and Nurr1-loaded PEGylated liposomes in a rat model of Parkinson's disease. Journal of cellular biochemistry. vol 119. issue 6. 2019-02-27. PMID:29240240. |
the immunohistochemical staining of tyrosine hydroxylase (th) and dopamine transporter (dat) was used to assess the neuron loss. |
2019-02-27 |
2023-08-13 |
rat |
| Eduard R Mingazov, Gulnara R Khakimova, Elena A Kozina, Alexei E Medvedev, Olga A Buneeva, Ara S Bazyan, Michael V Ugrumo. MPTP Mouse Model of Preclinical and Clinical Parkinson's Disease as an Instrument for Translational Medicine. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28456940. |
in this study, we showed that despite the progressive loss of neurons in the substantia nigra at the presymptomatic and symptomatic stage, almost no change was observed in the main functional characteristics of this brain region, including dopamine (da) uptake and release, dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) expression, and activity of mao-a and mao-b. |
2019-02-26 |
2023-08-13 |
mouse |
| Kefu Liu, Jinlong Yu, Juan Zhao, Yanhong Zhou, Nian Xiong, Jie Xu, Tao Wang, Richard L Bell, Hong Qing, Zhicheng Li. Molecular neurobiology. vol 55. issue 7. 2019-02-26. PMID:28983843. |
regulated activity of slc6a3, which encodes the human dopamine transporter (dat), contributes to diseases such as substance abuse disorders (suds); however, the exact transcription mechanism remains poorly understood. |
2019-02-26 |
2023-08-13 |
human |
| Klaus Tatsch, Ralph Buchert, Peter Bartenstein, Henryk Barthel, Henning Boecker, Peter Brust, Alexander Drzezga, Christian la Fougère, Gerhard Gründer, Frank Grünwald, Bernd-J Krause, Torsten Kuwert, Karl-Josef Langen, Axel Rominger, Osama Sabri, Mathias Schreckenberger, Philipp T Meye. [Dopamine Transporter SPECT with I-123 labelled FP-CIT (DaTSCANTM)]. Nuklearmedizin. Nuclear medicine. vol 58. issue 1. 2019-02-22. PMID:30769368. |
the aim of the s1 guideline is to assist in establishing the indication and in performing, interpreting and reporting spect investigations of the dopamine transporter (dat) with datscan |
2019-02-22 |
2023-08-13 |
Not clear |
| J A Alcantara, S Vincentis, D S Kerr, B Dos Santos, R Alessi, H van der Linden, T Chaim, M H Serpa, G F Busatto, W F Gattaz, R Demarque, K D Valent. Association study of functional polymorphisms of dopaminergic pathway in epilepsy-related factors of temporal lobe epilepsy in Brazilian population. European journal of neurology. vol 25. issue 6. 2019-02-21. PMID:29575277. |
selected polymorphisms were: (i) the most expressed d2-like receptors in the limbic system (drd2/ankk1 taq-1a, d4_vntr and d4_rs1800955); (ii) the dopamine transporter (dat) 3'-untranslated region and intron 8; and (iii) two degrading enzymes regulating the synaptic activity, i.e. |
2019-02-21 |
2023-08-13 |
Not clear |